Modern Rheumatology最新文献_第5页

RNA-Seq analysis of lymphocyte-specific gene expression patterns in IgG4-related disease: comparison of submandibular glands and peripheral blood. igg4相关疾病中淋巴细胞特异性基因表达模式的RNA-Seq分析：颌下腺和外周血的比较

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-09 DOI: 10.1093/mr/roaf059

Hiroto Tsuboi, Fumika Honda, Hiromitsu Asashima, Hirofumi Toko, Ayako Kitada, Saori Abe, Yuito Tanaka, Ayako Ohyama, Mizuki Yagishita, Haruka Miki, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto

{"title":"RNA-Seq analysis of lymphocyte-specific gene expression patterns in IgG4-related disease: comparison of submandibular glands and peripheral blood.","authors":"Hiroto Tsuboi, Fumika Honda, Hiromitsu Asashima, Hirofumi Toko, Ayako Kitada, Saori Abe, Yuito Tanaka, Ayako Ohyama, Mizuki Yagishita, Haruka Miki, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto","doi":"10.1093/mr/roaf059","DOIUrl":"https://doi.org/10.1093/mr/roaf059","url":null,"abstract":"Objective: To clarify T/B cell-specific gene expression patterns using RNA-Seq in IgG4-related disease (IgG4-RD).Methods: Pathologically confirmed submandibular gland (SMG) (n=3) and PBMC (n=4) from 4 treatment-naïve patients with definite IgG4-RD, as well as PBMCs from primary Sjögren syndrome (pSS) (n=3) and healthy controls (HCs) (n=3), were collected, and subsequently Pan T and CD19+ B cells were sorted. We conducted RNA sequencing to compare the gene expressions of Pan T and CD19+ B cells in SMGs and PBMCs in IgG4-RD or IgG4-RD versus pSS and HCs in PBMCs. IPA and qPCR validation were performed for DEGs.Results: PCA results showed the gene expression patterns of Pan T and CD19+ B cells derived from SMGs differed from those derived from PBMCs in IgG4-RD. However, the gene expression patterns of Pan T and CD19+ B cells derived from PBMCs were not clustered between groups. 214 upregulated and 50 downregulated DEGs in Pan T cells and 630 upregulated and 109 downregulated DEGs in CD19+ B cells were identified in SMGs compared with PBMCs in IgG4-RD. The upregulated DEGs in SMGs of IgG4-RD included cytokines, chemokines, and transcription regulators. IPA for these DEGs clarified immune system-related pathways were positively regulated in SMGs compared with PBMCs in IgG4-RD. qPCR validated significantly increased mRNA expression of IL-21 and EGR2 by Pan T cells in SMGs compared with PBMCs of IgG4-RD.Conclusion: RNA-Seq clarified the DEGs of Pan T and CD19+ B cells from SMGs in comparison with PBMCs, which might contribute to the pathogenesis of IgG4-RD.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated serum heparin-binding protein levels in patients with gout flare. 痛风发作患者血清肝素结合蛋白水平升高。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-08 DOI: 10.1093/mr/roaf063

Nana Ding, Dexian Zhang, Weiwei Ye

{"title":"Elevated serum heparin-binding protein levels in patients with gout flare.","authors":"Nana Ding, Dexian Zhang, Weiwei Ye","doi":"10.1093/mr/roaf063","DOIUrl":"https://doi.org/10.1093/mr/roaf063","url":null,"abstract":"Objectives: Proinflammatory substances from neutrophils pay essential role in gout flare. This study aimed to compare the levels of heparin-binding protein (HBP), released by neutrophils, between patients with gout, patients with osteoarthritis (OA), patients with asymptomatic hyperuricemia (HUA), and healthy controls (HCs).Methods: We enrolled 102 patients diagnosed with gout, 26 patients with OA, 25 patients with asymptomatic HUA and 23 healthy controls (HCs). Serum HBP was measured by enzyme-linked immunosorbent assay (ELISA).Results: We found that level of HBP were significantly elevated in patients experiencing gout flare compared with those in patients with relieving gout after taking nonsteroidal anti-inflammatory drugs (NSAIDs), patients with intercritical gout and other control groups. Serum HBP was significantly different between patients who experienced gout relieving after NSAIDs and patients with intercritical gout. Receiver operating characteristic (ROC) curve showed HBP could distinguish gout flare from relieving gout after NSAIDs. The area under the curve (AUC) was 0.8130, sensitivity was 0.9412, and specificity was 0.6286 at the cutoff HBP value of 42.09 ng/ml. The HBP cutoff for differentiating relieving gout after NSAIDs from intercritical gout was 19.75 ng/ml, which had an AUC of 0.8971, a sensitivity of 0.8485, and a specificity of 0.9118. Moreover, serum HBP levels are positive correlated with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white blood cell (WBC), absolute neutrophil count (ANC) and neutrophil ratio (NE%).Conclusions: Taken together, our results showed elevated HBP levels in patients with gout flare.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-08 DOI: 10.1093/mr/roaf061

Kenji Oku, Hidehiro Yamada, Tatsuyoshi Ikenoue, Masashi Akizuki, Hiroyuki Hagiyama, Haruko Ideguchi, Atsushi Ihata, Takuya Kakutani, Kimito Kawahata, Toshihiro Matsui, Junichi Obata, Shigeru Ohno, Shinji Sato, Naoki Sawa, Akiko Suda, Hiroaki Taguchi, Mitsuhiro Takeno, Atsuhisa Ueda, Masaomi Yamasaki, Kunihiro Yamaoka

{"title":"Vaccine-related environments and patient preferences in Japanese patients with autoimmune rheumatic diseases.","authors":"Kenji Oku, Hidehiro Yamada, Tatsuyoshi Ikenoue, Masashi Akizuki, Hiroyuki Hagiyama, Haruko Ideguchi, Atsushi Ihata, Takuya Kakutani, Kimito Kawahata, Toshihiro Matsui, Junichi Obata, Shigeru Ohno, Shinji Sato, Naoki Sawa, Akiko Suda, Hiroaki Taguchi, Mitsuhiro Takeno, Atsuhisa Ueda, Masaomi Yamasaki, Kunihiro Yamaoka","doi":"10.1093/mr/roaf061","DOIUrl":"https://doi.org/10.1093/mr/roaf061","url":null,"abstract":"Objectives: To evaluate vaccination rates and identify factors associated with vaccine uptake among patients with autoimmune inflammatory rheumatic diseases (AIRD) in Kanagawa Prefecture, Japan.Methods: An anonymous survey was conducted between January and May 2023 using Google Forms™. Adult AIRD patients and rheumatologists were asked about demographics, disease characteristics, vaccination status, and attitudes towards vaccination. Logistic regression and Random Forest analyses were used to identify factors influencing vaccination rates.Results: A total of 1637 AIRD patients responded. Vaccination rates were as follows: herpes zoster (HZ) 8.8%, influenza 86.7%, pneumococcus 29.7%, HPV 4.3%, HBV 8.7%, and SARS-CoV-2 92.2%. Physician recommendations were significantly associated with higher vaccination rates. Although knowledge of vaccine efficacy correlated with increased uptake, it did not fully alleviate vaccine hesitancy. Major barriers included concerns about adverse effects and lack of sufficient information.Conclusions: Physician recommendations and providing comprehensive vaccine information are essential for improving vaccination rates among AIRD patients. Addressing concerns about vaccine safety and efficacy through targeted educational interventions and communication strategies is crucial to enhancing vaccine uptake.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concordance between treatment guideline and daily practice in the management of eosinophilic granulomatosis with polyangiitis: A cross-sectional web-questionnaire survey. 治疗指南与日常实践在嗜酸性肉芽肿病合并多血管炎管理中的一致性：一项横断面网络问卷调查。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-08 DOI: 10.1093/mr/roaf064

Ryu Watanabe, Takao Fujii, Yoshia Miyawaki, Haruki Koike, Masashi Bando, Motomu Hashimoto, Naoto Tamura

{"title":"Concordance between treatment guideline and daily practice in the management of eosinophilic granulomatosis with polyangiitis: A cross-sectional web-questionnaire survey.","authors":"Ryu Watanabe, Takao Fujii, Yoshia Miyawaki, Haruki Koike, Masashi Bando, Motomu Hashimoto, Naoto Tamura","doi":"10.1093/mr/roaf064","DOIUrl":"https://doi.org/10.1093/mr/roaf064","url":null,"abstract":"Objectives: To examine real-world clinical practices in the treatment of eosinophilic granulomatosis with polyangiitis (EGPA) across Japan and evaluate concordance with national treatment guidelines.Methods: A cross-sectional, web-based survey was conducted between February 14 and 19, 2024. Physicians from rheumatology, pulmonology, and neurology departments who had treated EGPA within the past 24 months were invited to complete a 17-item questionnaire. The survey assessed actual prescribing behavior, future treatment preferences, responses to two clinical scenarios, and the frequency of guideline use.Results: Among 220 respondents (110 rheumatologists, 55 neurologists, 55 pulmonologists), cyclophosphamide (77.3%) and mepolizumab (73.2%) were frequently used with glucocorticoids (GCs) for remission induction. GC monotherapy was the most commonly selected option overall (31.4%), but its use decreased to 14.8% for severe cases. GC + mepolizumab was the most frequently selected regimen for both maintenance and relapse. Responses to clinical scenarios revealed partial divergence from guideline-based recommendations, particularly regarding the limited use of immunosuppressants and the preferential use of mepolizumab.Conclusion: This study identified a modest but clear evidence-practice gap in EGPA management in Japan. Broader dissemination of updated guidelines and enhanced interdisciplinary collaboration may help align clinical practice with evidence-based standards and improve patient care.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Caveolin-1/NF-κB signalling pathway is involved in Kawasaki disease vasculitis induced by Lactobacillus casei cell wall extract. Caveolin-1/NF-κB信号通路参与干酪乳杆菌细胞壁提取物诱导川崎病血管炎。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-08 DOI: 10.1093/mr/roaf062

Shamin Wu, Xipo Chen, Kaixuan Wang, Fang Sheng

{"title":"The Caveolin-1/NF-κB signalling pathway is involved in Kawasaki disease vasculitis induced by Lactobacillus casei cell wall extract.","authors":"Shamin Wu, Xipo Chen, Kaixuan Wang, Fang Sheng","doi":"10.1093/mr/roaf062","DOIUrl":"https://doi.org/10.1093/mr/roaf062","url":null,"abstract":"Objectives: Kawasaki disease (KD) is an acute vasculitis and its pathogenesis is complex. Caveolin-1 (Cav-1) is the main structural protein of caveolae and is involved in the pathogenesis of many vascular diseases. A clinical study revealed that the Cav-1 serum level in children significantly increases in the acute phase of KD, but the role of Cav-1 in KD is still unclear. We aimed to explore whether and how Cav-1 is involved in the KD pathogenesis.Methods: KD vasculitis was induced by Lactobacillus casei cell wall extract (LCWE) intraperitoneal injection in mice, and Cav-1 expression was inhibited by AAV-Cav-1 shRNA. Cardiovascular lesions was assessed via haematoxylin & eosin (HE) staining. Proinflammatory cytokine and MMP-9 levels were measured via quantitative real-time polymerase chain reaction (qRT-PCR). Endothelial cell adhesion molecule expression was evaluated by immunohistochemistry. Cav-1 expression and NF-κB pathway activation were evaluated by Western blotting (WB).Results: Mice with LCWE-induced KD vasculitis exhibited severe heart vessel inflammation and increased Cav-1, proinflammatory cytokine, MMP-9, and endothelial cell adhesion molecule expression, which were reversed after Cav-1 inhibition. Moreover, NF-κB activation of KD vasculitis model mice was suppressed after Cav-1 inhibition.Conclusion: Cav-1 participates in KD vasculitis pathogenesis by regulating the NF-κB signalling pathway.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of social frailty and physical function on laughter frequency in rheumatoid arthritis patients: data from a multicenter observational study (T-FLAG). 社交脆弱和身体功能对类风湿关节炎患者笑声频率的影响：来自一项多中心观察研究（T-FLAG）的数据。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-08 DOI: 10.1093/mr/roaf065

Mochihito Suzuki, Shuji Asai, Yoshifumi Ohashi, Yasumori Sobue, Kenya Terabe, Ryo Sato, Junya Hasegawa, Yusuke Ohno, Takaya Sugiura, Shiro Imagama

{"title":"The impact of social frailty and physical function on laughter frequency in rheumatoid arthritis patients: data from a multicenter observational study (T-FLAG).","authors":"Mochihito Suzuki, Shuji Asai, Yoshifumi Ohashi, Yasumori Sobue, Kenya Terabe, Ryo Sato, Junya Hasegawa, Yusuke Ohno, Takaya Sugiura, Shiro Imagama","doi":"10.1093/mr/roaf065","DOIUrl":"https://doi.org/10.1093/mr/roaf065","url":null,"abstract":"Objective: This study aimed to evaluate the relationship between laughter frequency, disease activity, physical function, and frailty in rheumatoid arthritis (RA) patients.Methods: A total of 679 consecutive RA patients from a multicenter observational study conducted in 2023 were included. Laughter frequency was assessed using a standardized questionnaire, and patients were divided into the following four laughter frequency groups: 'almost every day,' '1-5 days per week,' '1-3 days per month,' and 'never or almost never.' Patient characteristics for each frequency group were compared by analysis of variance. Multivariable logistic regression analyses were conducted to identify factors associated with frequent laughter.Results: Laughter frequency was 'almost every day' in 48.6% of patients, '1-5 days per week' in 34.7%, '1-3 days per month' in 9.9%, and 'almost never' in 6.8%. Laughter frequency was significantly associated with the Health Assessment Questionnaire-Disability Index (HAQ-DI) and social frailty. However, no significant correlation was observed between laughter frequency and disease activity. Patients with social frailty laughed less frequently than those without, and higher HAQ-DI scores were associated with less frequent laughter.Conclusion: Laughter frequency in RA patients is more strongly influenced by physical function and social frailty than by disease activity.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coffee consumption may suppress development of metabolic syndrome in patients with rheumatoid arthritis-TOMORROW study. 咖啡消费可能抑制类风湿关节炎患者代谢综合征的发展。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roaf016

Yoshinari Matsumoto, Yuko Sugioka, Masahiro Tada, Tadashi Okano, Kenji Mamoto, Kentaro Inui, Daiki Habu, Tatsuya Koike

{"title":"Coffee consumption may suppress development of metabolic syndrome in patients with rheumatoid arthritis-TOMORROW study.","authors":"Yoshinari Matsumoto, Yuko Sugioka, Masahiro Tada, Tadashi Okano, Kenji Mamoto, Kentaro Inui, Daiki Habu, Tatsuya Koike","doi":"10.1093/mr/roaf016","DOIUrl":"10.1093/mr/roaf016","url":null,"abstract":"Objectives: This study aimed to clarify the associations between metabolic syndrome (MetS) and rheumatoid arthritis (RA), and between MetS and dietary factors in RA patients.Methods: Data were analysed from a prospective cohort study that began in 2010, comprising 208 RA patients and 205 gender- and age-matched controls. The MetS components (blood pressure, lipid metabolism, glucose metabolism, and waist circumference) were evaluated up to 2017. Dietary intake was assessed in 2011. The effect of covariates for development of MetS among participants without MetS in 2010 was tested using Cox proportional hazard modelling.Results: In an analysis of overall subjects, RA was not significantly associated with development of MetS [Hazard ratio (HR): 0.86, 95% confidential intervals (CI): 0.51, 1.46]. In RA patients, regularly consuming coffee (<1 cup/day: HR 0.24, 95% CI 0.09, 0.64; ≥1 cup/day: HR 0.25, 95% CI 0.10, 0.62) was significantly associated with a suppressive effect on development of MetS, compared with noncoffee drinkers. In a complementary analysis, total coffee consumption (filter, instant, and decaffeinated) ≥1 cup/day, was significantly associated with development of MetS (HR 0.33, 95% CI 0.13, 0.82).Conclusions: RA was not significantly associated with development of MetS and coffee intake may be associated with absence of MetS in RA patients.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"650-657"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood monocyte fraction and computed tomography attenuation value of bone marrow in fever of unknown origin: A retrospective analysis for differentiating adult-onset Still's disease and intravascular large B-cell lymphoma. 不明原因发热患者的血单核细胞比例和骨髓计算机断层扫描衰减值：用于区分成人型斯蒂尔病和血管内大B细胞淋巴瘤的回顾性分析。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roaf009

Nobuhiro Oda, Hiroki Matsui, Ryo Hazue, Kosei Matsue, Katsushige Takagishi, Ryo Rokutanda

{"title":"Blood monocyte fraction and computed tomography attenuation value of bone marrow in fever of unknown origin: A retrospective analysis for differentiating adult-onset Still's disease and intravascular large B-cell lymphoma.","authors":"Nobuhiro Oda, Hiroki Matsui, Ryo Hazue, Kosei Matsue, Katsushige Takagishi, Ryo Rokutanda","doi":"10.1093/mr/roaf009","DOIUrl":"10.1093/mr/roaf009","url":null,"abstract":"Objectives: To investigate the factors affecting laboratory data and computed tomography (CT) attenuation values of L1 trabecular and femoral bone marrow, potential markers for differentiating between adult-onset Still's disease (AOSD) and intravascular large B-cell lymphoma (IVLBL).Methods: We conducted a retrospective observational study on patients diagnosed with AOSD or IVLBCL. Clinical and laboratory data, and CT attenuation values of the bone marrow were compared. An exploratory analysis was conducted to identify factors useful for discriminating between the two groups.Results: Thirty patients with AOSD and 14 with IVLBCL were included; among them, 17 and 14 patients, respectively, underwent plain CT. No significant differences in CT attenuation values were noted; however, significant differences in various clinical and laboratory data, including neutrophil counts and soluble interleukin 2 receptor levels, were observed. Exploratory analysis of the monocyte fraction, guided by previous reports, suggested a cutoff of ≥ 9.65% for IVLBCL, with a sensitivity of 64.3% and specificity of 96.7%.Conclusion: This study suggests that, besides neutrophil counts and soluble interleukin 2 receptor levels, monocyte fractionation is a useful differentiation criterion between AOSD and IVLBCL.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"731-737"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antinuclear antibodies staining patterns and titres in juvenile idiopathic arthritis. 幼年特发性关节炎的抗核抗体染色模式和滴度。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roaf011

Seher Sener, Ezgi Deniz Batu, Emil Aliyev, Ozge Basaran, Zeynep Saribas, Yelda Bilginer, Burcin Sener, Seza Ozen

{"title":"Antinuclear antibodies staining patterns and titres in juvenile idiopathic arthritis.","authors":"Seher Sener, Ezgi Deniz Batu, Emil Aliyev, Ozge Basaran, Zeynep Saribas, Yelda Bilginer, Burcin Sener, Seza Ozen","doi":"10.1093/mr/roaf011","DOIUrl":"10.1093/mr/roaf011","url":null,"abstract":"Objectives: In our study, we evaluated the antinuclear antibodies (ANA) staining patterns and titres in juvenile idiopathic arthritis (JIA) patients.Methods: JIA patients were retrospectively assessed. ANA was identified by using indirect immunofluorescence assay on HEp-2 cells, with a positivity threshold set at a titre of ≥1/100.Results: Eight hundred-five patients were evaluated [oligoarticular JIA (n = 396), enthesitis-related arthritis (n = 195), polyarticular JIA (n = 132), systemic JIA (n = 53), psoriatic arthritis (n = 20), and unclassified JIA (n = 9)]. The most frequently observed ANA nuclear staining patterns were AC-4/5 (fine or large speckled) in 29.7% of patients and AC-1 (homogeneous) in 25.9%. The most common ANA cytoplasmic staining pattern was AC-19 (dense, fine speckled) (17.6%). Most systemic and unclassified JIA patients were ANA negative. The most frequently detected ANA titre in oligoarticular JIA and enthesitis-related arthritis patients was 1/160 (P = .026 and P = .018, respectively), while in psoriatic arthritis patients, it was 1/320 (P < .001). In addition, uveitis and inflammatory bowel disease were most frequently associated with AC-4/5 & AC-19 patterns and an ANA titre of 1/160 (all P < .001).Conclusions: Our study showed that many JIA subtypes and JIA-related comorbidities were associated with the AC-4/5, AC-1, and AC-19 ANA patterns. However, multicentre studies in larger cohorts are needed to generalize these results.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"762-766"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for cytomegalovirus reactivation during the treatment of ANCA-associated vasculitis: A retrospective cohort study of the J-CANVAS study. anca相关性血管炎治疗期间巨细胞病毒再激活的危险因素：J-CANVAS研究的回顾性队列研究

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roaf008

Kazutaka Kawamori, Nao Oguro, Kunika Shimizu, Takashi Kida, Satoshi Omura, Daiki Nakagomi, Yoshiyuki Abe, Masatoshi Kadoya, Naoho Takizawa, Atsushi Nomura, Yuji Kukida, Naoya Kondo, Yasuhiko Yamano, Takuya Yanagida, Koji Endo, Shintaro Hirata, Kiyoshi Matsui, Tohru Takeuchi, Kunihiro Ichinose, Masaru Kato, Ryo Yanai, Yusuke Matsuo, Yasuhiro Shimojima, Ryo Nishioka, Ryota Okazaki, Tomoaki Takata, Takafumi Ito, Mayuko Moriyama, Ayuko Takatani, Yoshia Miyawaki, Toshiko Ito-Ihara, Takashi Kawaguchi, Yutaka Kawahito, Nobuyuki Yajima

{"title":"Risk factors for cytomegalovirus reactivation during the treatment of ANCA-associated vasculitis: A retrospective cohort study of the J-CANVAS study.","authors":"Kazutaka Kawamori, Nao Oguro, Kunika Shimizu, Takashi Kida, Satoshi Omura, Daiki Nakagomi, Yoshiyuki Abe, Masatoshi Kadoya, Naoho Takizawa, Atsushi Nomura, Yuji Kukida, Naoya Kondo, Yasuhiko Yamano, Takuya Yanagida, Koji Endo, Shintaro Hirata, Kiyoshi Matsui, Tohru Takeuchi, Kunihiro Ichinose, Masaru Kato, Ryo Yanai, Yusuke Matsuo, Yasuhiro Shimojima, Ryo Nishioka, Ryota Okazaki, Tomoaki Takata, Takafumi Ito, Mayuko Moriyama, Ayuko Takatani, Yoshia Miyawaki, Toshiko Ito-Ihara, Takashi Kawaguchi, Yutaka Kawahito, Nobuyuki Yajima","doi":"10.1093/mr/roaf008","DOIUrl":"10.1093/mr/roaf008","url":null,"abstract":"Objectives: Cytomegalovirus (CMV) reactivation during immunosuppressive therapy poses a risk of severe infections. This study aimed to investigate the risk factors of CMV reactivation in patients with microscopic polyangiitis and granulomatosis with polyangiitis using a nationwide cohort in Japan.Methods: This retrospective cohort study used data from the Japan Collaborative Registry of antineutrophil cytoplasmic antibody-associated vasculitis. The outcome was as CMV reactivation up to 48 weeks after treatment initiation. We explored the risk factors for CMV reactivation by comparing the two groups.Results: Of the 454 patients, CMV reactivation occurred in 89 (19.6%). The univariate analysis showed that patients with CMV reactivation were older (P < .001), had higher Birmingham Vasculitis Activity Scores (BVAS) (P = .004) and BVAS renal scores (P < .001), and had received glucocorticoid pulse (P = .004). The logistic regression analysis showed that hypoalbuminemia (odds ratio: 0.55, 95% confidence interval: 0.31-0.98), and low serum IgG (OR: 0.94, 95% CI: 0.89-1.00) were risk factors for CMV reactivation.Conclusions: Hypoalbuminemia and low serum IgG levels were risk factors for CMV reactivation. It is necessary to accurately identify high-risk patients and closely monitor their condition.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"691-696"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0