Elevated serum heparin-binding protein levels in patients with gout flare.

IF 1.9 4区医学 Q3 RHEUMATOLOGY

Modern Rheumatology Pub Date : 2025-07-08 DOI:10.1093/mr/roaf063

Nana Ding, Dexian Zhang, Weiwei Ye

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Abstract

Objectives: Proinflammatory substances from neutrophils pay essential role in gout flare. This study aimed to compare the levels of heparin-binding protein (HBP), released by neutrophils, between patients with gout, patients with osteoarthritis (OA), patients with asymptomatic hyperuricemia (HUA), and healthy controls (HCs).

Methods: We enrolled 102 patients diagnosed with gout, 26 patients with OA, 25 patients with asymptomatic HUA and 23 healthy controls (HCs). Serum HBP was measured by enzyme-linked immunosorbent assay (ELISA).

Results: We found that level of HBP were significantly elevated in patients experiencing gout flare compared with those in patients with relieving gout after taking nonsteroidal anti-inflammatory drugs (NSAIDs), patients with intercritical gout and other control groups. Serum HBP was significantly different between patients who experienced gout relieving after NSAIDs and patients with intercritical gout. Receiver operating characteristic (ROC) curve showed HBP could distinguish gout flare from relieving gout after NSAIDs. The area under the curve (AUC) was 0.8130, sensitivity was 0.9412, and specificity was 0.6286 at the cutoff HBP value of 42.09 ng/ml. The HBP cutoff for differentiating relieving gout after NSAIDs from intercritical gout was 19.75 ng/ml, which had an AUC of 0.8971, a sensitivity of 0.8485, and a specificity of 0.9118. Moreover, serum HBP levels are positive correlated with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white blood cell (WBC), absolute neutrophil count (ANC) and neutrophil ratio (NE%).

Conclusions: Taken together, our results showed elevated HBP levels in patients with gout flare.

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痛风发作患者血清肝素结合蛋白水平升高。

目的：来自中性粒细胞的促炎物质在痛风发作中起重要作用。本研究旨在比较痛风患者、骨关节炎（OA）患者、无症状高尿酸血症（HUA）患者和健康对照（hc）患者之间中性粒细胞释放的肝素结合蛋白（HBP）水平。方法：我们招募了102例诊断为痛风的患者，26例OA患者，25例无症状HUA患者和23例健康对照（hc）。采用酶联免疫吸附试验（ELISA）测定血清HBP。结果：我们发现，与服用非甾体抗炎药（NSAIDs）缓解痛风的患者、危重期痛风患者和其他对照组相比，痛风发作患者HBP水平显著升高。非甾体抗炎药治疗后痛风缓解的患者与急性间期痛风患者血清HBP差异有统计学意义。受试者工作特征（ROC）曲线显示HBP可以区分非甾体抗炎药后痛风发作和缓解痛风。曲线下面积（AUC）为0.8130，灵敏度为0.9412，特异性为0.6286，临界值为42.09 ng/ml。区分非甾体抗炎药后痛风缓解与临界间痛风的HBP临界值为19.75 ng/ml， AUC为0.8971，敏感性为0.8485，特异性为0.9118。此外，血清HBP水平与红细胞沉降率（ESR）、c反应蛋白（CRP）、白细胞（WBC）、绝对中性粒细胞计数（ANC）和中性粒细胞比率（NE%）呈正相关。结论：综上所述，我们的结果显示痛风发作患者的HBP水平升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Modern Rheumatology RHEUMATOLOGY-

CiteScore

4.90

自引率

9.10%

发文量

146

审稿时长

1.5 months

期刊介绍： Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery. Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered. Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions