{"title":"咖啡消费可能抑制类风湿关节炎患者代谢综合征的发展。","authors":"Yoshinari Matsumoto, Yuko Sugioka, Masahiro Tada, Tadashi Okano, Kenji Mamoto, Kentaro Inui, Daiki Habu, Tatsuya Koike","doi":"10.1093/mr/roaf016","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to clarify the associations between metabolic syndrome (MetS) and rheumatoid arthritis (RA), and between MetS and dietary factors in RA patients.</p><p><strong>Methods: </strong>Data were analysed from a prospective cohort study that began in 2010, comprising 208 RA patients and 205 gender- and age-matched controls. The MetS components (blood pressure, lipid metabolism, glucose metabolism, and waist circumference) were evaluated up to 2017. Dietary intake was assessed in 2011. The effect of covariates for development of MetS among participants without MetS in 2010 was tested using Cox proportional hazard modelling.</p><p><strong>Results: </strong>In an analysis of overall subjects, RA was not significantly associated with development of MetS [Hazard ratio (HR): 0.86, 95% confidential intervals (CI): 0.51, 1.46]. In RA patients, regularly consuming coffee (<1 cup/day: HR 0.24, 95% CI 0.09, 0.64; ≥1 cup/day: HR 0.25, 95% CI 0.10, 0.62) was significantly associated with a suppressive effect on development of MetS, compared with noncoffee drinkers. In a complementary analysis, total coffee consumption (filter, instant, and decaffeinated) ≥1 cup/day, was significantly associated with development of MetS (HR 0.33, 95% CI 0.13, 0.82).</p><p><strong>Conclusions: </strong>RA was not significantly associated with development of MetS and coffee intake may be associated with absence of MetS in RA patients.</p>","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"650-657"},"PeriodicalIF":1.9000,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Coffee consumption may suppress development of metabolic syndrome in patients with rheumatoid arthritis-TOMORROW study.\",\"authors\":\"Yoshinari Matsumoto, Yuko Sugioka, Masahiro Tada, Tadashi Okano, Kenji Mamoto, Kentaro Inui, Daiki Habu, Tatsuya Koike\",\"doi\":\"10.1093/mr/roaf016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aimed to clarify the associations between metabolic syndrome (MetS) and rheumatoid arthritis (RA), and between MetS and dietary factors in RA patients.</p><p><strong>Methods: </strong>Data were analysed from a prospective cohort study that began in 2010, comprising 208 RA patients and 205 gender- and age-matched controls. The MetS components (blood pressure, lipid metabolism, glucose metabolism, and waist circumference) were evaluated up to 2017. Dietary intake was assessed in 2011. The effect of covariates for development of MetS among participants without MetS in 2010 was tested using Cox proportional hazard modelling.</p><p><strong>Results: </strong>In an analysis of overall subjects, RA was not significantly associated with development of MetS [Hazard ratio (HR): 0.86, 95% confidential intervals (CI): 0.51, 1.46]. In RA patients, regularly consuming coffee (<1 cup/day: HR 0.24, 95% CI 0.09, 0.64; ≥1 cup/day: HR 0.25, 95% CI 0.10, 0.62) was significantly associated with a suppressive effect on development of MetS, compared with noncoffee drinkers. In a complementary analysis, total coffee consumption (filter, instant, and decaffeinated) ≥1 cup/day, was significantly associated with development of MetS (HR 0.33, 95% CI 0.13, 0.82).</p><p><strong>Conclusions: </strong>RA was not significantly associated with development of MetS and coffee intake may be associated with absence of MetS in RA patients.</p>\",\"PeriodicalId\":18705,\"journal\":{\"name\":\"Modern Rheumatology\",\"volume\":\" \",\"pages\":\"650-657\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-07-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Modern Rheumatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/mr/roaf016\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Modern Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/mr/roaf016","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
Coffee consumption may suppress development of metabolic syndrome in patients with rheumatoid arthritis-TOMORROW study.
Objectives: This study aimed to clarify the associations between metabolic syndrome (MetS) and rheumatoid arthritis (RA), and between MetS and dietary factors in RA patients.
Methods: Data were analysed from a prospective cohort study that began in 2010, comprising 208 RA patients and 205 gender- and age-matched controls. The MetS components (blood pressure, lipid metabolism, glucose metabolism, and waist circumference) were evaluated up to 2017. Dietary intake was assessed in 2011. The effect of covariates for development of MetS among participants without MetS in 2010 was tested using Cox proportional hazard modelling.
Results: In an analysis of overall subjects, RA was not significantly associated with development of MetS [Hazard ratio (HR): 0.86, 95% confidential intervals (CI): 0.51, 1.46]. In RA patients, regularly consuming coffee (<1 cup/day: HR 0.24, 95% CI 0.09, 0.64; ≥1 cup/day: HR 0.25, 95% CI 0.10, 0.62) was significantly associated with a suppressive effect on development of MetS, compared with noncoffee drinkers. In a complementary analysis, total coffee consumption (filter, instant, and decaffeinated) ≥1 cup/day, was significantly associated with development of MetS (HR 0.33, 95% CI 0.13, 0.82).
Conclusions: RA was not significantly associated with development of MetS and coffee intake may be associated with absence of MetS in RA patients.
期刊介绍：
Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery.
Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered.
Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions
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