日本首次慢性复发性多灶性骨髓炎的全国流行病学调查。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Yukako Maeda, Eitaro Hiejima, Kazushi Izawa, Kenichi Nishimura, Yasuo Yazawa, Naomi Iwata, Masahito Michikura, Hideki Ishikawa, Shuichi Ito, Yoshikazu Nakamura, Ryuta Nishikomori, Takahiro Yasumi
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引用次数: 0

摘要

目的:慢性非细菌性骨髓炎(CNO)/慢性复发性多灶性骨髓炎(CRMO)是一种以骨组织无菌性炎症为特征的自身炎症性疾病。日本CNO/CRMO的患者数量和临床情况尚不清楚;因此,我们进行了第一次全国流行病学调查。方法:在初步调查中,调查2015 - 2019年各机构儿科、风湿科、骨科和皮肤科诊断为CNO/CRMO的患者人数。在第二次调查中,对这些患者的临床表现进行评估。结果:初步调查报告289例患者,全国估计患者数为434例(95%置信区间为367-501)。第二项调查分析了205名患者。放射学骨病变的中位数为3个,最常受影响的骨是胫骨。肿瘤坏死因子抑制剂比非甾体抗炎药或双磷酸盐具有更高的疗效和更低的复发率。对tocilizumab和canakinumab有反应的病例也有报道。早期诊断与最后一次随访时无症状或无药物状态的较高比率相关。结论:这是日本第一个全国性的研究,也是世界上最大的多中心研究之一,提供了关于CNO/CRMO的全面流行病学数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The first nationwide epidemiological survey of chronic recurrent multifocal osteomyelitis in Japan.

Objectives: Chronic nonbacterial osteomyelitis (CNO)/chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory disorder characterised by aseptic inflammation of bone tissue. The number of patients and the clinical picture of CNO/CRMO in Japan is unknown; therefore, we conducted the first nationwide epidemiological survey.

Methods: In the primary survey, the number of patients diagnosed with CNO/CRMO between 2015 and 2019 in paediatrics, rheumatology, orthopaedic surgery and dermatology departments of various institutions was investigated. In the second survey, the clinical pictures of these patients were assessed.

Results: The primary survey reported 289 patients, and the estimated number of patients nationwide was 434 (95% confidence interval, 367-501). The second survey analysed 205 patients. The median number of radiological bone lesions was three and the bone affected most frequently was the tibia. Tumour necrosis factor inhibitors showed higher efficacy and lower relapse rates than NSAIDs or bisphosphonates. Cases that responded to tocilizumab and canakinumab were also reported. Earlier diagnosis was associated with higher rates of symptom- or drug-free status at the last follow-up visit.

Conclusions: This is the first nationwide study in Japan, and one of the largest multi-centre studies worldwide, to provide comprehensive epidemiological data about CNO/CRMO.

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来源期刊
Modern Rheumatology
Modern Rheumatology RHEUMATOLOGY-
CiteScore
4.90
自引率
9.10%
发文量
146
审稿时长
1.5 months
期刊介绍: Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery. Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered. Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions
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