Isso Saito, Yusho Ishii, Hiroko Sato, Tsuyoshi Shirai, Hiroshi Fujii
{"title":"behaperet综合征合并妇科疾病患者胃肠道受累的患病率增加。","authors":"Isso Saito, Yusho Ishii, Hiroko Sato, Tsuyoshi Shirai, Hiroshi Fujii","doi":"10.1093/mr/roaf048","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the clinical significance of coexisting gynaecological disorders (GD) in patients with Behçet's syndrome (BS).</p><p><strong>Methods: </strong>This study included patients with BS who visited Department of Rheumatology in the Tohoku University Hospital from 2022 to 2023. Among these patients, the manifestation and the treatment of BS were investigated.</p><p><strong>Results: </strong>This group included 37 female patients with BS and GD (BS-FG), 36 female patients with BS without any GD (BS-FWG) and 67 male patients with BS (BS-M). The prevalence of gastrointestinal involvement was significantly higher in BS-FG (48.6%) than in BS-FWG (22.2%, p = 0.041) and BS-M (17.9%, p = 0.0043). The prevalence of ocular involvement was lower in BS-FG (35.1%) than in BS-FWG (50%, p = 0.24) and BS-M (64.2%, p = 0.022). The frequency of anti-TNFα antibody usage was lower among patients in the BS-FWG group than those in the BS-M and BS-FG groups (p = 0.0055 and p = 0.20). The maximum prednisolone dosage and the rates of surgery for BS tended to be higher in BS-FG and BS-M than in BS-FWG.</p><p><strong>Conclusions: </strong>Our study revealed that gastrointestinal involvement is more common in BS-FG, and BS-FG frequently requires intensive treatment similar to BS-M.</p>","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Increased Prevalence of Gastrointestinal involvement in Behçet's Syndrome Patients with Gynaecological Disorders.\",\"authors\":\"Isso Saito, Yusho Ishii, Hiroko Sato, Tsuyoshi Shirai, Hiroshi Fujii\",\"doi\":\"10.1093/mr/roaf048\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aimed to investigate the clinical significance of coexisting gynaecological disorders (GD) in patients with Behçet's syndrome (BS).</p><p><strong>Methods: </strong>This study included patients with BS who visited Department of Rheumatology in the Tohoku University Hospital from 2022 to 2023. Among these patients, the manifestation and the treatment of BS were investigated.</p><p><strong>Results: </strong>This group included 37 female patients with BS and GD (BS-FG), 36 female patients with BS without any GD (BS-FWG) and 67 male patients with BS (BS-M). The prevalence of gastrointestinal involvement was significantly higher in BS-FG (48.6%) than in BS-FWG (22.2%, p = 0.041) and BS-M (17.9%, p = 0.0043). The prevalence of ocular involvement was lower in BS-FG (35.1%) than in BS-FWG (50%, p = 0.24) and BS-M (64.2%, p = 0.022). The frequency of anti-TNFα antibody usage was lower among patients in the BS-FWG group than those in the BS-M and BS-FG groups (p = 0.0055 and p = 0.20). The maximum prednisolone dosage and the rates of surgery for BS tended to be higher in BS-FG and BS-M than in BS-FWG.</p><p><strong>Conclusions: </strong>Our study revealed that gastrointestinal involvement is more common in BS-FG, and BS-FG frequently requires intensive treatment similar to BS-M.</p>\",\"PeriodicalId\":18705,\"journal\":{\"name\":\"Modern Rheumatology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Modern Rheumatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/mr/roaf048\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Modern Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/mr/roaf048","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
Increased Prevalence of Gastrointestinal involvement in Behçet's Syndrome Patients with Gynaecological Disorders.
Objectives: This study aimed to investigate the clinical significance of coexisting gynaecological disorders (GD) in patients with Behçet's syndrome (BS).
Methods: This study included patients with BS who visited Department of Rheumatology in the Tohoku University Hospital from 2022 to 2023. Among these patients, the manifestation and the treatment of BS were investigated.
Results: This group included 37 female patients with BS and GD (BS-FG), 36 female patients with BS without any GD (BS-FWG) and 67 male patients with BS (BS-M). The prevalence of gastrointestinal involvement was significantly higher in BS-FG (48.6%) than in BS-FWG (22.2%, p = 0.041) and BS-M (17.9%, p = 0.0043). The prevalence of ocular involvement was lower in BS-FG (35.1%) than in BS-FWG (50%, p = 0.24) and BS-M (64.2%, p = 0.022). The frequency of anti-TNFα antibody usage was lower among patients in the BS-FWG group than those in the BS-M and BS-FG groups (p = 0.0055 and p = 0.20). The maximum prednisolone dosage and the rates of surgery for BS tended to be higher in BS-FG and BS-M than in BS-FWG.
Conclusions: Our study revealed that gastrointestinal involvement is more common in BS-FG, and BS-FG frequently requires intensive treatment similar to BS-M.
期刊介绍：
Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery.
Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered.
Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions
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