系统性红斑狼疮患者睡眠呼吸障碍与中度至重度抑郁之间的关系：TRUMP2-SLE研究

IF 1.9 4区医学 Q3 RHEUMATOLOGY

Modern Rheumatology Pub Date : 2025-05-30 DOI:10.1093/mr/roaf047

Yuichi Ishikawa, Nao Oguro, Takanori Ichikawa, Dai Kishida, Natsuki Sakurai, Chiharu Hidekawa, Kenta Shidahara, Keigo Hayashi, Yoshia Miyawaki, Yasuhiro Shimojima, Ryusuke Yoshimi, Ken-Ei Sada, Nobuyuki Yajima, Noriaki Kurita

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引用次数: 0

摘要

目的：抑郁症是系统性红斑狼疮（SLE）患者常见的情绪障碍，影响患者的生活质量和药物依从性。众所周知，睡眠呼吸障碍（SDB）在一般人群中是导致抑郁的一个因素，但其在SLE患者中的患病率及其对抑郁的影响尚不清楚。本研究旨在探讨SDB的患病率及其与抑郁症的关系。方法：对来自5所大学医院的414名SLE患者进行横断面研究。主要暴露为高危SDB，采用柏林问卷进行评估。主要结果是使用患者健康问卷-9评估中度至重度抑郁症。具有稳健误差方差的泊松回归模型估计校正患病率（aPRs）。结果：患者平均年龄47.5岁，BMI为22.1 kg/m2。高危SDB和中重度抑郁症患病率分别为15.2%（95%可信区间：11.9% ~ 19.0%）和19.1% （95% CI: 15.4% ~ 23.2%）。高危SDB与中度至重度抑郁相关（aPR 2.63, 95% CI 1.62-4.27），根据阳性风险类别的数量呈剂量依赖关系。结论：SDB在SLE中常见，并与抑郁相关。伴有SDB症状的SLE患者应同时进行抑郁症筛查。

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Association between sleep-disordered breathing and moderate to severe depression in systemic lupus erythematosus: the TRUMP2-SLE study.

Objectives: Depression is a common mood disorder in systemic lupus erythematosus (SLE) patients, affecting quality of life and medication adherence. Sleep-disordered breathing (SDB) is a known contributor to depression in the general population, but its prevalence and impact on depression in SLE remain unclear. This study aimed to investigate the prevalence of SDB and its association with depression.

Methods: A cross-sectional study was conducted among 414 Japanese adults with SLE from five university hospitals. The main exposure was high-risk SDB, assessed with the Berlin Questionnaire. The main outcome was moderate to severe depression evaluated using the Patient Health Questionnaire-9. Poisson regression models with robust error variance estimated adjusted prevalence ratios (aPRs).

Results: The mean age and BMI were 47.5 years and 22.1 kg/m2. The prevalence of high-risk SDB and moderate to severe depression were 15.2% (95% confidence interval: 11.9%-19.0%) and 19.1% (95% CI: 15.4%-23.2%). High-risk SDB was associated with moderate to severe depression (aPR 2.63, 95% CI 1.62-4.27), with a dose-dependent relationship according to the number of positive risk categories.

Conclusions: SDB is common in SLE and is associated with depression. SLE patients with SDB symptoms should undergo concurrent depression screening.

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来源期刊

Modern Rheumatology RHEUMATOLOGY-

CiteScore

4.90

自引率

9.10%

发文量

146

审稿时长

1.5 months

期刊介绍： Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery. Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered. Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions