日本主要稳定型anca相关血管炎患者的健康相关生活质量和工作效率:一项多中心横断面研究

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Shinya Hirahara, Yasuhiro Katsumata, Ken-Ei Sada, Hiroko Nagafuchi, Eiichi Tanaka, Masayoshi Harigai
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引用次数: 0

摘要

目的:我们旨在调查日本抗中性粒细胞细胞质抗体(ANCA)相关血管炎(AAV)患者的健康相关生活质量(HRQoL)和工作效率。方法:我们使用HRQoL和工作效率和活动障碍问卷对三所大学医院的日本AAV患者进行了横断面研究。结果:92例AAV患者参与。AAV患者的医学结局研究简表-36 (SF-36)和5级EuroQoL 5维度问卷(EQ-5D-5L)的8个分量量表得分、身体成分总结(PCS)和角色成分总结(RCS)得分均显著低于日本人群标准。伯明翰血管炎活动性评分和血管炎损伤指数与sf - 36pcs评分呈弱负相关。在25例有偿工作的AAV患者中,AAV导致的缺勤率和出勤率分别为17%和32%,与SF-36 PCS和RCS评分以及EQ-5D-5L指数值呈轻至中度负相关。结论:日本AAV患者的HRQoL较一般人群差,与疾病活动性和损害累积有一定关系。在受雇患者中,观察到工作效率受损,并与HRQoL呈负相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Health-related quality of life and work productivity in Japanese patients with primarily stable ANCA-associated vasculitis: a multicenter cross-sectional study.

Objectives: We aimed to investigate the health-related quality of life (HRQoL) and work productivity of Japanese patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

Methods: We conducted a cross-sectional study of Japanese patients with AAV at three university hospitals using the HRQoL and Work Productivity and Activity Impairment questionnaires.

Results: Ninety-two patients with AAV participated. The values of all eight subscale scores and physical component summary (PCS) and role component summary (RCS) scores of the Medical Outcomes Study Short Form-36 (SF-36) and the 5-level EuroQoL 5-Dimensions Questionnaire (EQ-5D-5L) index values of the AAV patients were significantly lower than the Japanese population norms. The Birmingham Vasculitis Activity Score and Vasculitis Damage Index were weakly and negatively correlated with the SF-36 PCS scores. Among the 25 patients with AAV who worked for pay, the absenteeism and presenteeism due to AAV were 17% and 32%, respectively, and were mild-to-moderately and negatively correlated with the SF-36 PCS and RCS scores and the EQ-5D-5L index values.

Conclusion: The HRQoL of Japanese patients with AAV was poorer than that of the general population and was partly associated with disease activity and damage accrual. In employed patients, impaired work productivity was observed and negatively associated with HRQoL.

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来源期刊
Modern Rheumatology
Modern Rheumatology RHEUMATOLOGY-
CiteScore
4.90
自引率
9.10%
发文量
146
审稿时长
1.5 months
期刊介绍: Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery. Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered. Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions
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