Acta Medico-Biotechnica最新文献_第9页

Analysis of pregnant women with the diagnosis of gestational diabetes mellitus without oral glucose tolerance test confirmation in early pregnancy 妊娠早期未经口服糖耐量试验证实的妊娠期糖尿病孕妇分析

Acta Medico-Biotechnica Pub Date : 2021-11-29 DOI: 10.18690/actabiomed.159

A. Zavratnik, M. Krajnc

{"title":"Analysis of pregnant women with the diagnosis of gestational diabetes mellitus without oral glucose tolerance test confirmation in early pregnancy","authors":"A. Zavratnik, M. Krajnc","doi":"10.18690/actabiomed.159","DOIUrl":"https://doi.org/10.18690/actabiomed.159","url":null,"abstract":"Purpose: The aim of this analysis was to determine the proportion of pregnant women referred by gynaecologists to the outpatient diabetes clinic of the University Medical Centre Maribor with a diagnosis of gestational diabetes mellitus (GDM) based on inappropriately measured fasting plasma glucose (FPG). Additionally, we wanted to compare pregnancy outcomes in subgroups diagnosed later as having GDM vs. no–GDM with oral glucose tolerance testing (OGTT) in the 24th to 28th week of pregnancy, but declared as “probably not having GDM” in early pregnancy. \u0000Methods: We reviewed retrospectively data on 81 pregnancies referred to our centre, from August 2013 to July 2014, with a diagnosis of early GDM that we did not con-firm with OGTT retesting. After retesting, women were followed up routinely by a gynaecologist, but those with a diagnostic OGTT, performed in the 24th to 28th week, were referred back to a diabetologist. \u0000Results: The age of the entire cohort was 30.5±4.7 years, and 91% were ≥25 years old; 40% were overweight before pregnancy. The period of fasting before FPG measurement was less than 8 hours in 36%. When comparing the GDM vs. no–GDM subgroups, a higher proportion of women with GDM were fasted for less than 8 hours before FPG measurement (75% vs. 32%; p=0.022), and birth weight was higher for women with GDM (3778±588 g vs. 3316±618 g; p=0.048). There were no differences in macrosomia, eclampsia, Caesarean delivery and birth trauma. \u0000Conclusion: The accuracy of the diagnosis of early pregnancy GDM can be improved by following the FPG measurement protocol. When a single FPG in early pregnancy is near normal we suggest retesting with an OGTT. This approach probably has no adverse effect on pregnancy outcomes.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124963577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Unintentional common carotid artery cannulation during attempted internal jugular venous catheter insertion 在试图插入颈内静脉导管时，意外插入颈总动脉

Acta Medico-Biotechnica Pub Date : 2021-11-29 DOI: 10.18690/actabiomed.171

J. Janež, Dragica Marksl Janež

引用次数: 0

Contrast–enhanced ultrasound imaging of the optic nerve sheath diameter – a proof of concept study 对比增强的视神经鞘直径超声成像-概念研究的证明

Acta Medico-Biotechnica Pub Date : 2021-11-29 DOI: 10.18690/actabiomed.151

A. Bergauer, G. Prosen, N. Kobilica, V. Flis, M. Jevšek, T. Šeruga

{"title":"Contrast–enhanced ultrasound imaging of the optic nerve sheath diameter – a proof of concept study","authors":"A. Bergauer, G. Prosen, N. Kobilica, V. Flis, M. Jevšek, T. Šeruga","doi":"10.18690/actabiomed.151","DOIUrl":"https://doi.org/10.18690/actabiomed.151","url":null,"abstract":"Purpose: The present proof of concept study was performed to evaluate the consistency between measurements of the optic nerve sheath taken using contrast– enhanced sonography and high– resolution magnetic resonance imaging (MRI). The main goal was to devise a novel candidate method to measure the optic nerve sheath diameter that is easy to perform, straightforward to interpret, and highly reproducible. \u0000Methods: The approval of the National Medical Ethics Committee of the Republic of Slovenia was obtained; the study was registered under No. 30/03/12. Nine healthy young adults were examined with high–resolution MRI and contrast–enhanced ultrasound (CEUS). Measurements of the optic nerve sheath diameter were performed 3 mm behind the bulb, using both methods. The datasets were anonymized and the readers, blinded. Statistical analysis included evaluation of agreement using Bland–Altman plots. The assessment of inter– rater reliability was achieved by calculation of the intra class correlation coefficient. \u0000Results: Bland–Altman plots showed favorable overall agreement between both methods, with clinically acceptable limits of agreement. The intra class correlation coefficient calculated for both methods suggests that the CEUS method was at least as reproducible as high–resolution MRI. \u0000Conclusion: The described method, using CEUS to measure the optic nerve sheath diameter, facilitates the identification of the surrounding anatomy. When CEUS is employed, the measurement points can be easily and reliably set, and retro bulbar artifacts are less confounding. Based on results from a relatively small sample, this method seems to be comparable with high–resolution MRI. Evaluation of the method on a larger sample of healthy subjects and patients with increased intracranial pressure is needed.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133231892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strain indicators in the assessment of systolic myocardial function in aboy with hypertrophic cardiomyopathy: a case report 应变指标评价男孩肥厚性心肌病收缩心肌功能1例

Acta Medico-Biotechnica Pub Date : 2021-11-29 DOI: 10.18690/actabiomed.197

N. Chernykh, A. Tarasova, O. Groznova

引用次数: 0

Surgical treatment in severely immunocompromised patient with invasive fungal infection 侵袭性真菌感染严重免疫功能低下患者的外科治疗

Acta Medico-Biotechnica Pub Date : 2021-11-29 DOI: 10.18690/actabiomed.196

Kristijan Skok, D. Vidovič, G. Gačevski, B. Veingerl, Jure Auda, A. Crnjac

{"title":"Surgical treatment in severely immunocompromised patient with invasive fungal infection","authors":"Kristijan Skok, D. Vidovič, G. Gačevski, B. Veingerl, Jure Auda, A. Crnjac","doi":"10.18690/actabiomed.196","DOIUrl":"https://doi.org/10.18690/actabiomed.196","url":null,"abstract":"Purpose: We present a case report of successful surgical treatment of a 58-year- old severely immunocompromised male patient with invasive fungal infection. \u0000Case presentation: A 58-year-old male with a smoking history of 30 years was admitted to hospital because of sudden shortness of breath. Radiographic imaging showed an extensive pneumothorax. The patient had a history of T-cell lymphoma, B-cell MALT lymphoma, and chronic obstructive pulmonary disease. He had also previously undergone chemotherapy. During hospitalization, his health state started to deteriorate. On the basis of imaging and microbiological culture results, he was diagnosed to have a fungal infection with Aspergillus fumigatus. After careful preoperative care, preparations, and several consultations, we performed video-assisted thoracic surgery. Because of poor visibility, inaccessibility, and rupture of an intercostal artery, we performed thoracotomy with excision of the right lung apex. Histopathology and microbiology results confirmed the initial diagnosis. Postoperatively, a 1-year treatment regimen with voriconazole was introduced. The follow-up CT scan showed no signs of fungal infection progression. The patient was given further instructions and discharged from the hospital in a cardiorespiratory compensated state. \u0000Conclusion: Despite poor prognostic factors, the surgical procedure was successful and the patient’s health state considerably improved.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130342518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early detection of neck lymph node metastases in breast cancer patients: the role of ultrasound and fine needle biopsy 早期发现乳腺癌患者颈部淋巴结转移:超声和细针活检的作用

Acta Medico-Biotechnica Pub Date : 2021-11-29 DOI: 10.18690/actabiomed.183

J. Rebol, Peter Balon, P. Kokol, B. Lanišnik, I. Takač, A. Dovnik, Nina Fokter Dovnik, M. Sobočan, D. Arko

{"title":"Early detection of neck lymph node metastases in breast cancer patients: the role of ultrasound and fine needle biopsy","authors":"J. Rebol, Peter Balon, P. Kokol, B. Lanišnik, I. Takač, A. Dovnik, Nina Fokter Dovnik, M. Sobočan, D. Arko","doi":"10.18690/actabiomed.183","DOIUrl":"https://doi.org/10.18690/actabiomed.183","url":null,"abstract":"Purpose: To analyze the distribution and pattern of neck metastasis in breast cancer (BC) patients. \u0000Methods: The clinicopathological characteristics of 41 patients with BC and confirmed neck metastasis (NM) treated at our institution between 2010 and 2016 were retrospectively analyzed by reviewing medical records. The diagnosis of NM was confirmed by fine needle aspiration cytology, and node localization was classified into six levels according to Robbins' classification. Statistical analysis was performed using descriptive statistics, Pearson’s correlation and multidimensional correspondence analysis. All statistical analyses were performed using SPSS. \u0000Results: At the time of neck ultrasonography, 34 (85%) patients had developed distant metastases, 38% of the patients were asymptomatic, and 17% had no palpable nodes. The average time from BC diagnosis to the development of NM was 5.8 years (range, 0–26 years). Lymph node metastasis occurred at level V in 53.7% of patients and level IV in 19.5% of patients. Two-level involvement occurred in 9.8% and one-level involvement in 75% of patients. There were significant correlations (p < 0.01) between patient age andtime from diagnosis to development of NM, age and stage of the disease, and stage and appearance of conglomerates. \u0000Conclusion: The most common site of NM from BC was next to the supraclavicular fossa, although they occurred at other levels. Ultrasonography combined with fine needle aspiration cytology is effective for the detection of early occult metastatic lymph nodes.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128770714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microvessel density and PSA level in prostatic adenocarcinoma of Gleason score 6 and 7 前列腺腺癌Gleason评分为6分和7分时微血管密度和PSA水平的变化

Acta Medico-Biotechnica Pub Date : 2021-11-29 DOI: 10.18690/actabiomed.170

B. Dariš, M. Munda

{"title":"Microvessel density and PSA level in prostatic adenocarcinoma of Gleason score 6 and 7","authors":"B. Dariš, M. Munda","doi":"10.18690/actabiomed.170","DOIUrl":"https://doi.org/10.18690/actabiomed.170","url":null,"abstract":"Purpose: The aim of this investigation was to determine the differences in microvessel density (MVD) and serum levels of prostate-specific antigen (PSA) between groups of patients with Gleason score (GS) 6 prostatic adenocarcinoma and patients with GS 7 prostatic adenocarcinoma. \u0000Methods: The study included a series of 100 patients with prostatic adenocarcinoma. Tumor specimens were divided into two groups: GS 6 (52 cases) and GS 7 (48 cases). Intratumoral microvasculature was determined by immunohistochemistry using an antibody against endoglin. Endoglin stained microvessels were observed in and around the tumor, but weak or no staining of blood vessels was seen in non-neoplastic tissue. Areas of maximal angiogenesis within the tumor were identified and microvessels were counted at ×400 magnification (0.19 mm2 field). \u0000Results: The GS 6 specimens did not significantly differ in MVD per field (24.5 vs. 29.0; P=0.46) or MVD per mm2 (109.3 vs. 129.6; P=0.78) when compared with the GS 7 specimens. No significant difference in mean serum levels of PSA between the two groups was observed (8.5 vs. 10.1 ng/mL; P=0.66). MVD per mm2 was not correlated with PSA (r=0.1; P=0.62). The age of patients at diagnosis was not significantly different between the two groups (63.0 vs. 65.0 years; P=0.84). \u0000Conclusion: Our results show no significant differences in neovascularization and PSA level between Gleason score 6 and 7 prostatic adenocarcinoma.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122829011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of Coronary Heart Disease Patient Assessments of Chronic Illness Care and Quality of Care Procedures 冠心病患者慢性疾病护理评价与护理程序质量的相关性

Acta Medico-Biotechnica Pub Date : 2021-11-29 DOI: 10.18690/actabiomed.158

Ksenija Tušek-Bunc, M. Petek-Šter, Davorina Petek

{"title":"Correlation of Coronary Heart Disease Patient Assessments of Chronic Illness Care and Quality of Care Procedures","authors":"Ksenija Tušek-Bunc, M. Petek-Šter, Davorina Petek","doi":"10.18690/actabiomed.158","DOIUrl":"https://doi.org/10.18690/actabiomed.158","url":null,"abstract":"Purpose: Patient-centered assessment of chronic illness care is replacing the assessment of satisfaction, which does not cover all dimensions of care. Patient assessments reflect both the quality of chronic illness care and provide feedback to healthcare workers about their work. The study aim was to investigate the patient-centered assessment of coronary heart disease (CHD) patients and its correlation with the care that was delivered. \u0000Methods: This cross-sectional study evaluated data obtained from the patient medical records and surveyed patients using the Patient Assessment of Chronic Illness Care (PACIC) questionnaire. A descriptive analysis of the overall and domain-specific responses to the PACIC questionnaire was conducted and the association of the results with delivery of care data in the patient records was determined by Pearson's correlation coefficient. \u0000Results: The study sample included 768 of 1080 CHD patients (71,1%) at 36 family medicine practices who completed the PACIC questionnaire. The mean age of the respondents was 68.3 ± 10.7 years and the overall PACIC score was 3.3 ± 0.9. The highest PACIC scores were delivery system design (3.7), patient activation (3.7), and problem solving (3.6). Follow-up received the lowest score (2.8). Quality of delivered care and PACIC scores were correlated (r = 0.10, p = 0.009). \u0000Conclusions: CHD patients highly rated all aspects of chronic care included in the PACIC questionnaire. They were least satisfied with the follow-up and coordination aspects of chronic care. The process indicators of care were positively correlate with patient assessment of care.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132336266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Lifestyle of medical students 医学生的生活方式

Acta Medico-Biotechnica Pub Date : 2021-11-29 DOI: 10.18690/actabiomed.194

M. Žnidarič, Iza Zavodnik, Lucijan Lučič Šrajer

{"title":"Lifestyle of medical students","authors":"M. Žnidarič, Iza Zavodnik, Lucijan Lučič Šrajer","doi":"10.18690/actabiomed.194","DOIUrl":"https://doi.org/10.18690/actabiomed.194","url":null,"abstract":"Purpose: Using the World Health Organization definition that a healthy lifestyle is a way of living that lowers the risk of serious illness or early death, our goal was to examine the lifestyle changes made by medical students over the years of study. A healthy lifestyle, which is crucial to maintain and protect health, is determined by many variables, both positive and negative. \u0000Methods: A total of first, third and fifth year medical students at the Faculty of Medicine of the University of Maribor (165 students, 57 males and 108 females) were enrolled in the study during the academic year 2017/18. Lifestyle data, including physical activity, nutrition, sleep hygiene, and drug, tobacco and alcohol use, were collected using a standardized self-assessment questionnaire, the FANTASTIC Lifestyle Assessment Instrument, which had been translated into Slovenian. The questionnaire was supplemented with further questions to explore psychological aspects of lifestyle, such as mental well-being, social inclusion, altruism and student activities. \u0000Results: Our sample of first, third and fifth year medical students revealed unhealthy changes in life habits, which were closely associated with the length of training. For the third year students, the situation had reached a crisis point, probably because the initial enthusiasm over choice of study had worn off, and stress had become less managable in the transition period between preclinical and clinical training. During their third year, the students consumed the largest amount of controlled substances and prescription and OTC drugs (p=0.003), lacked goals and purpose in life, were less connected with the faculty (p=0.000) and showed a decline in altruism (p=0.007). \u0000Conclusions: Our results show that the psychophysical stress burden among medical students increases with duration of training, reaching crisis point during the third year. We recommend that medical students should arrange self-help and support groups to maintain a healthier lifestyle during this challenging period.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114554422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cumulative pregnancy and live birth rates following intrauterine insemination and in vitro fertilization in couples with unexplained infertility 不明原因不孕症夫妇宫内授精和体外授精后的累计妊娠率和活产率

Acta Medico-Biotechnica Pub Date : 2021-11-29 DOI: 10.18690/actabiomed.186

N. Kozar, B. Kovačič, M. Reljic, V. Kovač

{"title":"Cumulative pregnancy and live birth rates following intrauterine insemination and in vitro fertilization in couples with unexplained infertility","authors":"N. Kozar, B. Kovačič, M. Reljic, V. Kovač","doi":"10.18690/actabiomed.186","DOIUrl":"https://doi.org/10.18690/actabiomed.186","url":null,"abstract":"Purpose: There are multiple options for the treatment of unexplained infertility. Two of the most commonly used treatments are intrauterine insemination (IUI) and in vitro fertilization (IVF). The aim of our research was to analyze and compare the success rates of IUI and IVF procedures in the treatment of unexplained infertility. \u0000Methods: This was a retrospective study including 914 cycles of IUI performed for 355 couples, and 302 IVF cycles performed for 161 couples. All cases involved unexplained infertility and were treated in our department between 2012 and 2014. We analyzed differences in pregnancy, live birth rate, multiple pregnancy rate, and predictive factors for IUI. \u0000Results:There was a significant difference between IUI and IVF in terms of cumulative pregnancy and live birth rates after 4 cycles (22.0% vs. 71.8%; p < 0.001 for clinical pregnancy rates and 16.1% vs. 64.8%for live birth rate). Differences between the two techniques in terms of twin live birth rates were not significant (16.5% for IUI vs. 17.6% for IVF; p=0.936). Using logistic regression, we found that the duration of infertility, total sperm count, and the type of stimulation, were significant predictive factors for IUI (p = 0.014, p = 0.036 and p = 0.046, respectively). \u0000Conclusion: As expected, according to pregnancy rate, IVF is a better option for the treatment of idiopathic infertility than IUI. However, IUI should not be underestimated since it offers reasonable success rates with significantly less invasiveness. To improve the outcome of treatment for unexplained infertility, we suggest that treatment methods should be chosen with respect to predictive factors.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127157388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0