Acta Medico-Biotechnica最新文献

{"title":"Razvoj znanstvenoraziskovalnega dela študentov MF UM v zadnji 20 letih / The development of the scientific research work of MF UM students in the last 20 years","authors":"Dušica Pahor","doi":"10.18690/actabiomed.245","DOIUrl":"https://doi.org/10.18690/actabiomed.245","url":null,"abstract":"Glavno vodilo Univerze v Mariboru je zavezanost k raziskovalni odličnosti in mednarodni primerljivosti v širšem raziskovalnem prostoru, kar je zapisano v strategiji Univerze v Mariboru. Medicinska fakulteta je ena izmed 17 članic Univerze in zato zavezana k izpolnjevanju vseh sprejetih strateških ciljev in usmeritvam za obdobje 2021–2030. Da bi te cilje lahko uresničili, je treba omogočiti optimalne raziskovalne pogoje kot predpogoj za doseganje odličnosti pri raziskovanju. Pri tem je pomembno povezovanje na znanstvenoraziskovalnem področju med posameznimi fakultetami znotraj Univerze v Mariboru, kakor tudi v širšem slovenskem prostoru. Izjemno pomembno je povezovanje z mednarodnimi raziskovalnimi organizacijami pri različnih projektih, prenosu znanosti kot prispevek k razvoju družbe in napredku regije. Izjemno pomembno je vključevanje študentov v raziskovalno delo že na začetku študija.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132380044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopy versus laparotomy for the management of early-stage endometrial cancer: Effect on oncological outcomes","authors":"M. Pakiz, I. Šibli, A. Cokan, R. Šumak, I. But","doi":"10.18690/actabiomed.247","DOIUrl":"https://doi.org/10.18690/actabiomed.247","url":null,"abstract":"Background and aim: Endometrial cancer is the most common gynecologic malignancy diagnosed in an early stage in 80% of patients. The standard treatment for this includes hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection. The advancement of laparoscopy has facilitated the use of minimally invasive techniques also in the field of oncologic surgery. Every new approach should be evaluated in terms of oncological outcomes. This study aimed to compare the oncological outcomes among women with early-stage endometrial cancer treated using laparotomy and a laparoscopic approach. \u0000Methods: We conducted a retrospective analysis of patients with early-stage endometrial cancer treated in the Department of Gynecologic Oncology and Breast Oncology, University Medical Center Maribor. All consecutive patients who underwent laparotomy (from 2001 to 2006) or laparoscopy (from 2008 to 2016) were included. All patients had a standard surgical treatment: hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection. We analyzed the prognostic factors in each group of patients, which could affect our primary and secondary goals. The primary goal (the recurrence rate) and secondary goal (the disease-free survival) were determined during a follow-up of at least 5 years. \u0000Results: A total of 73 consecutive patients who underwent laparotomy from 2001 to 2006 and 60 consecutive patients who underwent laparoscopy from 2008 to 2016 were included in the analysis. No statistically significant between-group difference was found in the prognostic factors, except the adjuvant radiotherapy being more frequent in the laparotomy group (change in clinical practice). No statistically significant between-group difference was found in the disease recurrence rate [6/73 (8.2%) laparotomy group vs. 2/60 (3.3%) laparoscopy group (P = 0.238)] or in the disease-free survival during at least 5-year follow-up (P = 0.180).  \u0000Conclusion: No statistically significant difference was found in oncological outcomes during a 5-year follow-up of women with early-stage endometrial cancer treated using laparotomy or laparoscopy. This finding was an important retrospective overview, but future prospective randomized trials should validate this. ","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121136717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyneuritis cranialis related to SARS-CoV-2 infection: a case report","authors":"P. Gradišnik, Andreja Osterc Koprivšek, M. Rus, T. Golli, H. Damjan","doi":"10.18690/actabiomed.251","DOIUrl":"https://doi.org/10.18690/actabiomed.251","url":null,"abstract":"Purpose: Polyneuritis cranialis (PNC) is a less known regional variant of Guillain-Barré syndrome and has rarely been described in children. Here, we report a case of an adolescent, who became perilously ill following severe acute respiratory syndrome-coronavirus 2 infection. \u0000Case report: A 15-year-old boy presented with acute multiple cranial nerve palsies. The presence of GQ1b antibodies and nerve conduction studies confirmed the diagnosis of PNC. The patient was treated with plasmapheresis and intravenous immunoglobulins, but clinical improvement was gradual and very slow. \u0000Conclusion: PNC is a rare and severe neurologic condition that can be triggered by coronavirus infection.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123458101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of the 2019 pandemic of severe acute respiratory syndrome–coronavirus 2 on the quality of life of patients with inflammatory rheumatic diseases","authors":"Domen Lah, I. Holc","doi":"10.18690/actabiomed.248","DOIUrl":"https://doi.org/10.18690/actabiomed.248","url":null,"abstract":"Purpose: The aim of this study was to assess the impact of the SARS-CoV-2 pandemic and protective measures on the QoL of patients with inflammatory rheumatic diseases (IRDs) who received treatment at the Department of Rheumatology at the University Medical Centre Maribor (UCM-MB). \u0000Methods: A questionnaire was sent to IRD patients who visited a rheumatology outpatient clinic or were contacted by phone or virtually at least once between February 1, 2020 and May 30, 2021. The questionnaires were included if returned to UCM-MB by January 1, 2022 and were completed correctly and in full. \u0000Results: Of the 125 patients who met the inclusion criteria, 57 (45.6%) had no cancelled rheumatology appointments, 52 (41.6%) had one, 15 (12.0%) had two, and one patient (0.8%) had three. The most preferred mode of communication was in-person meetings with a rheumatologist (89%) and the least was a video call (1%). Only 2% of patients had problems obtaining medication during the pandemic, but none reported consequences with disease status. More than half (58%) of patients agreed with the restrictions during the pandemic and 5% stated the restrictions should be terminated. Most (70%) patients were vaccinated against SARS-CoV-2 and 21% reported SARS-CoV-2 infection. The mean disease activity score (DAS-28) was 3.100 ± 1.292 (rheumatoid arthritis, 3.252 ± 1.209; psoriatic arthritis, 2.927 ± 1.376; p = 0.274; t = 1.101). \u0000Conclusion: The pandemic and associated protective measures had deleterious effects on the QoL of IRD patients.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128420738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital transformation of healthcare through the prism of trends, challenges and principles","authors":"Muhamed Turkanović","doi":"10.18690/actabiomed.252","DOIUrl":"https://doi.org/10.18690/actabiomed.252","url":null,"abstract":"Based on the theoretical research method perspective, we present the complex topic of digitalizing the healthcare domain. We start withthe elaboration of the keywords connected to digitalization and continue with a slight overview of principles, trends, and challenges. Thepaper is limited only to the digital transformation processes and thus excludes insights into technology-related topics like nanomedicine,bioengineering, etc. While presenting the trends, we try to emphasize the key novel technologies currently being used to supporthealthcare digitalization endeavors. We conclude by highlighting the most important actions and initiatives (focusing on the EU market),which are and will be of high importance for the healthcare domain in the future.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127255977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient Neonatal Myasthenia Gravis: Case Report","authors":"Sara Sitar, M. Treiber","doi":"10.18690/actabiomed.249","DOIUrl":"https://doi.org/10.18690/actabiomed.249","url":null,"abstract":"Purpose: Transient neonatal myasthenia gravis (NMG) results from the transplacental transfer of antibodies of mothers with an autoimmune form of myasthenia gravis. The clinical presentation develops in 10%–20% of their children. This study aimed to present a case of a newborn with transient myasthenia gravis (MG) born to a mother diagnosed with MG. \u0000Case presentation: The disease manifested itself as generalized hypotonia, weak cry, respiratory distress, poor sucking, and facial diplegia. The symptoms were usually self-limiting, and transient supportive treatment was required. A diagnostic test was a good clinical response of the child to the administration of an acetylcholinesterase inhibitor. After the clearance of antibodies from the child's blood, long-term therapy was not necessary and the disease resolved. Treatment was supportive and included the administration of smaller and more frequent meals via a tube, noninvasive or invasive support of respiratory function, and use of acetylcholinesterase inhibitors (neostigmine and pyridostigmine). \u0000Conclusion: Pediatric patients diagnosed with transient NMG are extremely rare in everyday clinical practice, and hence it is important to be familiar with it.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123217264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha Cell Stimulus-Secretion Coupling and Intercellular Interactions in Health and Type 2 Diabetes","authors":"V. Pohorec, Nika Zadravec, Marko Turk, J. Dolenšek, A. Stožer","doi":"10.18690/actabiomed.246","DOIUrl":"https://doi.org/10.18690/actabiomed.246","url":null,"abstract":"Beta cell dysfunction has long been thought to be at the root of type 2 diabetes pathogenesis; however, a bi-hormonal model of the disease appears to be more realistic. Alpha cells play a significant role in glucose homeostasis due to their communication with other cells within the islets of Langerhans and tissues like the liver through glucagon action. Although a concise model of their physiology is still lacking, new approaches provide more insight into the pathways of glucagon secretion and processes regulating it, which gives insight into alpha cell function in health and disease, with potential implications for type 2 diabetes management.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125001381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transaxillary transcutaneous aortic valve implantation (TAVI)—our first case reports","authors":"Nina Glavnik Poznic, I. Balevski, B. Robič, Jure Fluher, Jože Kučič, V. Kanič","doi":"10.18690/actabiomed.250","DOIUrl":"https://doi.org/10.18690/actabiomed.250","url":null,"abstract":"In the past decade, the incidence of severe aortic stenosis has been high because of population aging. Guidelines have recommended transfemoral transcutaneous aortic valve implantation (TAVI) for a wider patient population, because of technical improvements and increased experience among physicians. Peripheral artery disease often accompanies aortic stenosis and is an important contraindication for transfemoral TAVI. Currently, new access sites for TAVI are used in cases with high surgical risk. We performed the first two axillary TAVI procedures at our institution. The two patients are described in this case report.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126578523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"15 let od podelitve prvih 'Dekanovih nagrad' za znanstvenoraziskovalno delo študentov na Medicinski fakulteti Univerze v Mariboru","authors":"Dušica Pahor","doi":"10.18690/actabiomed.236","DOIUrl":"https://doi.org/10.18690/actabiomed.236","url":null,"abstract":"Leta 2007 je vodstvo Medicinske fakultete Univerze v Mariboru (MF UM) na predlog prodekanje za raziskovalno delo sklenilo, da je treba spodbujati znanstvenoraziskovalno delo študentov, in uvedlo 'Dekanove nagrade' za najboljše študente na področju raziskovalnega dela na MF UM. S tem smo želeli, da študentje pridobijo izkušnje na področju raziskovanja, hkrati pa možnosti za vrednotenje raziskovalnega dela v času študija. Tako so študentje pridobili možnost, da kandidirajo s svojo raziskovalno nalogo za Perlachovo nagrado UM, ki se podeljuje za najboljše raziskovalne naloge študentom na UM vsako leto na različnih področjih študija. \u0000Prve 'Dekanove nagrade' so bile podeljene pred 15 leti, in sicer 1. decembra 2008 na dan MF UM. Od takrat se nagrade podeljujejo vsako leto. Od leta 2010 se poleg teh nagrad podeljujejo še 'Dekanova priznanja' za vsa raziskovalna dela, ki so pokazala visoko kakovost, a se za nagrade niso uvrstila v najožji izbor. Nagrade in priznanja slovesno podeli vsako leto dekan in prodekan za raziskovalno dejavnost MF UM ob dnevu fakultete. Ob podelitvi nagrad se predstavi življenjepis nagrajenca in raziskovalno delo.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116711820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of the correct choice of Franz diffusion cell volume for in vitro drug release testing of wound dressings","authors":"U. Maver, T. Maver","doi":"10.18690/actabiomed.241","DOIUrl":"https://doi.org/10.18690/actabiomed.241","url":null,"abstract":"Purpose: Wound dressings are one of the most commonly used products in wound care. Nowadays, various wound dressings are developed containing different active ingredients, often drugs from different pharmacodynamic groups. Considering the variable and changing environment in each wound type, it is important that the experimental design for evaluating the in vitro drug release of such materials takes into account these different conditions. \u0000Methods: For this purpose, Franz diffusion cells for in vitro drug release testing are the method of choice, as they are not only able to simulate different conditions during wound healing but also allow for a certain degree of possible changes in the experimental design (e.g., diffusion cell size). \u0000Results: In this study, we aimed to compare two Franz diffusion cells with different volumes of receptor medium to evaluate naproxen release from an alginate-based model wound dressing. We confirmed that the volume of the receptor medium not only affects the amount of drug released in the selected time but also significantly influences the release mechanism. \u0000Conclusion: The different volumes of the Franz diffusion cell receptor compartments allow the simulation of wounds with a higher and a lower degree of exudation. The experimental design for in vitro drug release testing based on Franz diffusion cells must be based on a thorough consideration of the targeted wound type for which the dressings are being developed.","PeriodicalId":186880,"journal":{"name":"Acta Medico-Biotechnica","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126272540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}