Microorganisms最新文献

{"title":"Rhizosphere Soil Fungal Community Patterns and Drivers in Chinese Fir Plantations Across Developmental Stages.","authors":"Hui Zhang, Chunmei Xie, Hui Wang, Daoqiang Lu, Lin Qiu, Guannan Ma, Yuefeng Li, Lisha Fang, Yun Zhang","doi":"10.3390/microorganisms14092078","DOIUrl":"10.3390/microorganisms14092078","url":null,"abstract":"<p><p>The composition, richness, and diversity of rhizosphere fungal communities play significant roles in plant development in Chinese fir plantations. Understanding their structure and assembly, along with their relationship to soil physicochemical properties and root traits, is essential for maximizing the benefits of fungal symbionts for Chinese fir trees. Hence, fungal communities in two soil layers (0-20 cm and 20-40 cm) at four plantation developmental stages were analyzed using internal transcribed spacer rRNA gene sequencing. Soil physicochemical properties and root traits were examined to determine the main fungal community drivers. Our results revealed that fungal communities were significantly influenced by stand developmental stage, rhizosphere, and soil depth. Fungal biomass was highest at the young stand stage, whereas the α-diversity and evenness of the surface rhizosphere soil fungi remained stable across stages. With increasing stand age, the fungal community structure shifted from aggregated to dispersed. Co-occurrence network analysis demonstrated that stand development promoted network connectivity and modularity, with tighter local associations and distinct core functional consortia formed in the mature and over-mature stages. The proportion of positive links and positive cohesion increased along the stand developmental gradient, indicating a shift from competitive to cooperative interspecific interactions. Ascomycota and Basidiomycota consistently dominated soil fungal communities regardless of stand age, whereas Mortierellomycota and Chytridiomycota displayed sensitivity to stand development despite their low relative abundance. Soil physicochemical properties (total carbon, potassium, dissolved organic carbon, and phosphorus) were the primary drivers of rhizosphere fungal community dynamics and regulated fungal assembly by controlling soil resource availability. Additionally, the structural configuration of the fungal community was found to be intricately linked to root biomass and morphological traits.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13609283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted Lipidomics Reveals Lipid Alterations in Colonic Contents of C57BL/6J Mice with Acute <i>Toxoplasma gondii</i> Infection.","authors":"Wen-Jie Cheng, Bo-Fang Duan, Cai-Qin Deng, Peng-Hao Wei, Min-Min Sui, Yi-Dan Wang, Xing-Quan Zhu, Feng-Cai Zou, Zhao Li","doi":"10.3390/microorganisms14092077","DOIUrl":"10.3390/microorganisms14092077","url":null,"abstract":"<p><strong>Background: </strong>Although <i>Toxoplasma gondii</i> has been recognized as an obligate intracellular parasite, the lipid metabolic alterations it induces in colonic contents during acute infection remain poorly characterized.</p><p><strong>Methods: </strong>An acute infection model was established using C57BL/6J mice by oral inoculation with the <i>T. gondii</i> ME49 strain. Untargeted lipidomics analysis was performed on the colonic contents collected at day 10 post-infection.</p><p><strong>Results: </strong>Acute infection significantly elevated glycerophospholipids (GPs) and reduced glycerolipids (GLs), and prenol lipids (PRs), leading to 136 differentially abundant lipids. Pathway enrichment analysis identified the two most significantly affected pathways: choline metabolism in cancer and glycerophospholipid metabolism, with lysophosphatidic acid (LPA(16:0)) and lysophosphatidylcholine (LPC(18:1)) functioning as core hub nodes. Receiver operating characteristic (ROC) analysis identified phosphatidylethanolamine (PE(20:1e_22:4)), PE(16:0_22:6), hexosylceramide (Hex1Cer(m18:0_20:4)), and Hex1Cer(t17:0_22:6) as exploratory candidate biomarkers with high discriminatory performance (AUC > 0.94).</p><p><strong>Conclusions: </strong>Acute <i>T. gondii</i> infection induces lipid metabolic reprogramming in colonic contents of C57BL/6J mice. The findings provide a novel metabolic perspective on the intestinal pathogenesis of toxoplasmosis and offer exploratory candidate lipid markers for diagnosing acute infection.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Conventional Yeasts with Probiotic Potential: Diversity, Functional Role, Sustainable Bioprocessing and Local Relevance.","authors":"Izlia J Arroyo-Maya, Itzel Gaytán, Arlette Santacruz, Sylvie Le Borgne","doi":"10.3390/microorganisms14092075","DOIUrl":"10.3390/microorganisms14092075","url":null,"abstract":"<p><p><i>Saccharomyces boulardii</i> is the most clinically established probiotic yeast, but non-<i>Saccharomyces</i> strains also exhibit probiotic potential. These non-conventional yeasts can survive gastrointestinal conditions, adhere to intestinal mucosa, and modulate host physiology in human and veterinary contexts. This review examines their diversity, probiotic traits, safety requirements, and applications, emphasizing strain recovery from fermented foods, environmental niches, and local biotopes. <i>Kluyveromyces marxianus</i>, <i>Debaryomyces hansenii</i>, and <i>Pichia kudriavzevii</i> illustrate this potential, showing promising in vitro and animal evidence, technological versatility, and strain-level safety constraints. Finally, we discuss the path to application and commercialization, including sustainable biomass production, encapsulation, and incorporation into food matrices. The transition from promising isolates to commercial products will require standardized strain-level assessments and clinical studies.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13609542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycosynthesized Silver Nanoparticles (AgNPs) for the Control of Foodborne Pathogenic Bacteria: <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>.","authors":"Mayra Eleonora Beltrán Pineda, Daniela Fernanda Valencia, José Castellanos-Rozo, Alida Marcela Gomez Rodriguez, Ingrid Rocio Fonseca-Guerra","doi":"10.3390/microorganisms14092083","DOIUrl":"10.3390/microorganisms14092083","url":null,"abstract":"<p><p>This study evaluated the ability of filamentous fungi to biosynthesize silver nanoparticles (AgNPs). The nitrate reductase activity of the selected fungi, considered a key enzyme involved in AgNP biosynthesis, was assessed as a selection criterion. AgNPs were mycosynthesized using <i>Fusarium equiseti</i> AM-0197, <i>F. cerealis</i> AM-0206, <i>F. oxysporum</i> AM-0192, <i>Alternaria scrophulariae</i> AM-0187, and <i>Aspergillus</i> sp. (1-HSF-08 and 3-HSF-02) isolates. The synthesized AgNPs were characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and Zeta potential analysis. In all cases, spherical AgNPs were obtained, with maximum absorption peaks ranging from 400 to 420 nm. XRD analysis demonstrated a face-centered cubic crystalline structure, whereas Zeta potential measurements revealed a negative surface charge. FTIR analysis indicated the presence of organic functional groups on the nanoparticle surface acting as capping agents. The antibacterial activity of the synthesized nanomaterials was evaluated against reference strains of <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, two major foodborne pathogens, using the disk diffusion method. Inhibition zones ranged from 11.3 to 13.6 mm for <i>E. coli</i> ATCC 25922 and from 9.3 to 15.0 mm for <i>S. aureus</i> ATCC 43300. The minimum inhibitory concentration (MIC) determined by microdilution was 37.5 ppm for all AgNPs tested against <i>E. coli</i>, whereas MIC values against <i>S. aureus</i> ranged from 18.7 to 75 ppm depending on the nanoparticle evaluated. These findings demonstrate the effectiveness of mycosynthesized AgNPs as next-generation antibacterial agents for the in vitro control of foodborne bacterial pathogens.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13609474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Stability of the Gut Microbiota in Relapsing-Remitting Multiple Sclerosis: A Prospective Observational Study.","authors":"Cristiana Vacaras, Vitalie Vacaras, Cristina Nistor, Cristina Jucan, Ioana Monica Furdui, Stefan Cristian Vesa, Stefan Strilciuc, Emanuel Ștefănescu, Diana Chira, Alexandru Rafila, Dafin F Muresanu","doi":"10.3390/microorganisms14092080","DOIUrl":"10.3390/microorganisms14092080","url":null,"abstract":"<p><p>The gut microbiota plays a key role in immune regulation in multiple sclerosis (MS), yet longitudinal data on microbiome dynamics and their relationships with disability and biomarkers remain limited. This study aimed to identify longitudinal gut microbiome changes in patients with relapsing-remitting multiple sclerosis (RRMS) and their association with disability and specific serum biomarkers, including predicted metabolic pathways. In this prospective longitudinal study, 29 treatment-naïve RRMS patients were evaluated at baseline and after one year of disease-modifying therapy. Clinical assessments included the Expanded Disability Status Scale (EDSS) and disability tests. Serum glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and S100B protein concentrations were measured at both visits. Gut microbiota composition was characterized by shotgun metagenomic sequencing, including taxonomic composition, diversity measures, functional pathways, gut metabolic modules, and gut-brain modules. In the 29 patients, overall gut microbiota composition and diversity remained stable during follow-up. Although EDSS progression was associated with a trend toward greater microbiome instability, this association did not reach statistical significance. Several bacterial taxa and predicted metabolic pathways showed nominal associations with disability, but were not significant after correction. GFAP levels increased significantly over time, whereas NfL levels decreased and S100B levels remained unchanged. Early RRMS is characterized by a stable gut microbiome during the first year of treatment. Exploratory taxonomic and functional associations did not remain significant after correction for multiple testing, highlighting the need for larger longitudinal cohorts.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Tol-Pal System Promotes Pseudoiodinine Production by Enhancing Bacterial Growth in <i>Pseudomonas mosselii</i>.","authors":"Ruihuan Yang, Xiangning Du, Heng Zhang, Jiacan Yang, Zhuoyi Huang, Ning Xu, Lifang Zou, Gongyou Chen","doi":"10.3390/microorganisms14092079","DOIUrl":"10.3390/microorganisms14092079","url":null,"abstract":"<p><p>Pseudoiodinine is an antimicrobial compound produced by <i>Pseudomonas mosselii</i> that exhibits strong inhibitory activity against bacterial and fungal pathogens of rice, highlighting its potential as a green biopesticide. However, the regulatory mechanisms underlying pseudoiodinine production remain poorly understood. In this study, genome-wide random mutagenesis identified two insertion mutants of 277-3 and 277-23 that completely abolished antagonistic activity against <i>Xanthomonas oryzae</i> pv. <i>oryzicola</i> (<i>Xoc</i>) RS105, with transposon insertions mapped to <i>tolB</i> and <i>tolR</i>, respectively. Further analysis showed that mutations in <i>tolB</i> and <i>tolR</i> significantly impaired bacterial growth during the exponential phase, suggesting that the Tol-Pal system is required for the optimal growth of <i>P. mosselii</i>. Consistently, overexpression of the <i>tol-pal</i> operon resulted in a 3.2-fold increase in pseudoiodinine production compared with the original strain. These findings indicate that the Tol-Pal system contributes to pseudoiodinine production primarily by maintaining efficient bacterial growth. Collectively, this study provides the first insight into the Tol-Pal system in promoting pseudoiodinine production and suggests its potential application in engineering <i>P. mosselii</i> strains.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13609540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vector Competence for West Nile Virus Lineage 1 and 2: Temperature Dependency in Temperate <i>Culex pipiens</i> Mosquitoes.","authors":"Estela Gonzalez, Insiyah Parekh, Sanam Thakkar, Henry F Ashpitel, Mohammed Salman, Stuart Ackroyd, Alejandro Nunez, Audra-Lynn Schlachter, Nicholas Johnson, Karen L Mansfield","doi":"10.3390/microorganisms14092084","DOIUrl":"10.3390/microorganisms14092084","url":null,"abstract":"<p><p>West Nile virus (WNV) is a mosquito-borne pathogen predominantly transmitted by <i>Culex</i> mosquitoes. Although birds are the primary hosts, other vertebrates, such as humans and horses, can also be affected. WNV incidence is increasing globally, expanding to northerly latitudes. This study investigated the vector competence of UK <i>Culex pipiens</i> exposed to WNV lineage 1 (Lin1) and lineage 2 (Lin2) at temperatures frequently experienced during northern European summers. Colonised <i>Cx. pipiens</i> exposed to blood meals containing WNV Lin1 and Lin2 were maintained at 20 °C or 25 °C and sampled at 7, 14, and 21 days post-infection (DPI) to assess infection, dissemination, and transmission potential. Differences between lineages were observed; at 20 °C, dissemination and transmission potential were greater for Lin1, whereas at 25 °C both lineages disseminated and showed transmission potential, with consistently higher rates for Lin2. These findings indicate that <i>Cx. pipiens</i> demonstrate transmission potential for both WNV Lin1 and Lin2 at temperatures representative of current northern European summers, with Lin2 showing greater transmission efficiency, particularly at 25 °C, while Lin1 was less efficient but remained active across a broader temperature range. These data highlight the potential risk of this virus in temperate areas currently free of this mosquito-borne virus.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13609240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specificity Analysis of Alternative Splicing During <i>Botrytis cinerea</i> Infection of Different Hosts.","authors":"Siyuan Wang, Panpan Huang, Ping Lu","doi":"10.3390/microorganisms14092086","DOIUrl":"10.3390/microorganisms14092086","url":null,"abstract":"<p><p>Alternative splicing (AS) is a significant post-transcriptional regulatory mechanism that facilitates environmental adaptation in fungi. However, the conservation of this mechanism and its host specificity during the infection of various hosts by <i>B. cinerea</i> remain ambiguous. This study utilized strand-specific RNA sequencing to perform a comparative analysis of genome-wide AS patterns during the infection of tomato and strawberry by <i>B. cinerea</i>. A comparative analysis identified a total of 1714 AS events and 1130 associated genes across the two hosts, alongside a significant number of host-specific events. Common alternatively spliced genes were predominantly enriched in processes related to gene expression regulation and signal transduction, whereas host-specific genes displayed distinct functional enrichment characteristics and temporal dynamics in their Percent Spliced In (PSI) patterns. Notably, introns linked to AS were generally longer than those associated with constitutive splicing and predominantly featured canonical GT-AG splice boundaries. Furthermore, the magnitude of PSI changes in host-specific events was greater than that observed in common events. This study reveals that <i>B. cinerea</i> exhibits both conserved and host-dependent AS regulatory programs, providing new insights into its post-transcriptional regulatory plasticity during the infection of various plant hosts.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13609290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wnt/Notch Crosstalk Promotes Epithelial-Mesenchymal Transition During <i>Chlamydia trachomatis</i> Infection Under IFN-γ Treatment.","authors":"Yewei Yang, Chunxia Fang, Hongrong Wu, Lili Chen, Yating Wen, Zhongyu Li","doi":"10.3390/microorganisms14092074","DOIUrl":"10.3390/microorganisms14092074","url":null,"abstract":"<p><p><i>Chlamydia trachomatis</i> (Ct) infection is a major cause of infertility, primarily through inducing tubal fibrosis. Epithelial-mesenchymal transition (EMT) plays a central role in this fibrotic process. However, the molecular mechanisms by which Ct infection triggers EMT are not fully understood. IFN-γ is a major component of the host immune pressure acting on infected epithelial cells during Ct infection. To mimic this immune environment in vitro and investigate how host signaling responses to Ct infection influence EMT, we maintained Ct-infected HeLa cells under continuous IFN-γ treatment and examined Wnt/β-catenin and Notch signaling. Under this condition, both pathways were activated and exhibited functional crosstalk potentially involving JAG1. Inhibition of either pathway attenuated EMT-associated phenotypes and was associated with reduced infectious progeny production. These findings support a role for Wnt/β-catenin-Notch crosstalk in promoting EMT in Ct-infected cells under continuous IFN-γ treatment.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the Production of D-Tagatose Using L-Arabinose Isomerase.","authors":"Bingyi Tao, Wei Liu, Ziheng Li, Ren He, Tingting Huang, Shaoxiong Liang, Hongkun Chen, Xiaoping Rao, Xuchong Tang, Jianchun Jiang","doi":"10.3390/microorganisms14092085","DOIUrl":"10.3390/microorganisms14092085","url":null,"abstract":"<p><p>D-tagatose is a rare sugar that occurs naturally and combines high sweetness with a low caloric value. It has several beneficial effects, including anticariogenic activity, modulation of the intestinal microbiota, and potential benefits for diabetes management. It is used as a novel sweetener and pharmaceutical excipient in the food and pharmaceutical industries. Currently, D-tagatose is produced mainly through chemical synthesis and biocatalysis. The chemical preparation of D-tagatose requires complex product purification and entails high waste-treatment costs, while biological preparation of D-tagatose offers high catalytic efficiency, mild reaction conditions, and fewer by-products. Therefore, in recent years, the biocatalytic conversion of D-galactose into D-tagatose using L-arabinose isomerase (L-AI) has attracted considerable attention, prompting extensive efforts to develop more economical and environmentally friendly production methods. To date, L-AI from various microbial sources has been identified and characterized, and researchers have engineered L-AI into a more effective biocatalyst through mutagenesis to improve process feasibility. This paper comprehensively reviews the current status and the latest advancements in the synthesis of D-tagatose from the perspective of biocatalysis.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13609448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}