MOJ proteomics & bioinformatics最新文献

{"title":"Relative influence of natural selection and mutational pressure on the genes of primary and secondary chromosome of multichromosomal bacteria","authors":"Sushanta Deb, Surajit Basak","doi":"10.15406/mojpb.2017.06.00197","DOIUrl":"https://doi.org/10.15406/mojpb.2017.06.00197","url":null,"abstract":"Rhodobacter sphaeroides is the first reported multiple chromosomal bacteria, a rod-shaped, Gram-negative bacterium [1]. The researchers provide a complete physical map of the Rhodobacter sphaeroides genome by obtaining chromosomal DNA fragments through restriction digestion with endonuclease from the genomic DNA, which support in establishing the existence of more than one chromosome [1]. Chromosomes may produce by three different mechanisms: by the separation of a single chromosome, by chromosome copying, or by integration of a large plasmid with essential genes [2]. Of these processes, the theory of plasmid derived chromosome is more widely acceptable and has the greatest support because origins of replication of some secondary chromosomes have similarity with the plasmids oriC [2]. The emerging picture is that Multichromosomal bacteria have one primary chromosome (chromosome1) carrying most housekeeping genes, and generally one or two secondary chromosomes having some plasmid features which is recognisable and also contains some essential genes [3]. Under a certain environmental (external) conditions specified amplification of one chromosome can alter gene pool and thereby the levels of gene expression [3].","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81819482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selecting molecular markers for a specific phylogenetic problem","authors":"C. Russo, Barbara O. Aguiar, Alex, re P Selvatti","doi":"10.15406/MOJPB.2017.06.00196","DOIUrl":"https://doi.org/10.15406/MOJPB.2017.06.00196","url":null,"abstract":"Submit Manuscript | http://medcraveonline.com of new technologies and the subsequent accessibility of refined methods due to cost reduction contributed to an immeasurable expansion of molecular facilities worldwide [1]. The rate of sequence submission has recently intensified for three primary reasons: the numerous and successful DNA barcoding projects [2,3], the advent of Next Generation Sequencing [4] and the subsequent decrease in prices for molecular sequencing services [5].","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76809105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of insulin-like growth factor I and its receptor of an Indian major carp labeo rohita: an in silico approach","authors":"Samik Acharjee, A. D. Upadhyay, A. Roy, R. Ghosh","doi":"10.15406/mojpb.2017.06.00195","DOIUrl":"https://doi.org/10.15406/mojpb.2017.06.00195","url":null,"abstract":"Insulin-like growth factor (IGF) remains in the different classes of vertebrates including birds [1,2], reptiles, amphibians [3], fishes [4-6] and mammals [7]. Insulin-like growth factor I (IGF-I) is a protein comprising two major forms, IGF-I and IGF-II [8,9] . The IGF-I is produced from the liver Sjogren et al. [10] by the influence of growth hormone involving the axis of pituitary/hepatic system-GH/IGF-I system [11,12]. Further, the IGF-I [13] and its receptors (IGF-IR) are also expressed in various extrahepatic regions [14]. The circulatory IGF-I promotes the systemic body growth by effecting cells of muscle, cartilage, bones etc. [15]. The transmembrane receptor insulin-like growth factor I (IGF-IR) is involved in exerting the functional role of IGF-I for the promotion of growth by effecting the anabolic reactions of the physiological system [16]. The binding of IGF-IR to IGF-I or IGF-II, leads to activation of either RAS/RAF/MEK/ERK or PI3K/ AKT signaling pathways for promoting the cell proliferation and anti-apoptotic activities [17]. A crosstalk of insulin/IGF-I and GPCR signaling mechanism can create suppression of apoptosis in certain physiological conditions [18].","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75145151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of population specific sequence variants as control to investigate the causality of rare sequence variants in human diseases in Jordans","authors":"T. Froukh, Saja Q Froukh","doi":"10.15406/mojpb.2017.06.00194","DOIUrl":"https://doi.org/10.15406/mojpb.2017.06.00194","url":null,"abstract":"Human diseases are caused by environmental factors (infections, malnutrition, poisons, or injuries), or genetic factors including single gene/Mendelian diseases, complex diseases (defects in multiple genes), and genomic diseases (chromosomal abnormalities). The focus is on Mendelian diseases which are characterized by: (1) rare alleles (<0.5% MAF, minor allele frequency) or very rare alleles (<0.1%MAF), and (2) high effect size (OR>3; Odds Ratio of genetic variant per disease expression) [1]. Much of what is known about the relationship between gene function and phenotype is based on the identification of rare variants causing Mendelian diseases. Such identifications have developed new diagnostic, therapeutic, and preventative strategies [2].","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74296770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A personal narrative of 6 pre-university research projects over 7years (2009-2015) yielding 19 manuscripts","authors":"M. Ling","doi":"10.15406/MOJPB.2017.06.00193","DOIUrl":"https://doi.org/10.15406/MOJPB.2017.06.00193","url":null,"abstract":"Scientific enquiry is important in scientific education,1 in addition to acquiring a body of knowledge. Upon acquiring a body of knowledge, the student is expected to be able to apply the knowledge in new settings. A common tool for teaching scientific enquiry is to engage students in project work or problem-based learning;2 which had been carried out at all levels of scientific education, from high school3–6 to undergraduate studies.7–13 Such research skills are exceptionally crucial in bioinformatics as bioinformatics is primarily a hands-on, minds-on endeavour.1 This emphasis on bioinformatics research and problem-solving skills are supported by significant number of bioinformaticists.14–16","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76318158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observation and Forecast of NO2 Emissions Using Satellite Data for Ghana","authors":"I. Yeboah, P. Obeng, G. Akrofi","doi":"10.15406/MOJPB.2017.06.00192","DOIUrl":"https://doi.org/10.15406/MOJPB.2017.06.00192","url":null,"abstract":"","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80471271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of prednisone on urinary proteome and disease biomarkers in a rat model","authors":"Jianqiang Wu, Xundou Li, Youhe Gao","doi":"10.15406/MOJPB.2017.06.00191","DOIUrl":"https://doi.org/10.15406/MOJPB.2017.06.00191","url":null,"abstract":"Disease biomarkers are measurable changes associated with specific pathophysiological conditions that can be used to diagnose and monitor diseases, to predict prognoses and to reflect treatment efficiency. As a non-invasively accessible and relatively stable liquid, urine is a promising clinical sample source for biomarker discovery via proteomics approaches [1]. Recently, urinary proteomics has received increasing attention in disease biomarker research.","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78757968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microarray as high throughput tool for tyrosinase gene expression analysis","authors":"Naima Parveen, Kamal Uddin Zaidi, Sharique A. Ali, Ayesha S Ali","doi":"10.15406/mojpb.2017.06.00190","DOIUrl":"https://doi.org/10.15406/mojpb.2017.06.00190","url":null,"abstract":"Since ancient times, a face with fair skin is considered as a sign of beauty and the demand for young, healthy, bright and fair skin has created a whitening cosmetics market. The color of human skin and hair established through a number of factors. Melanogenesis i.e. the biosynthesis of melanin is the major factor. It is a multistage process involving melanin synthesis in special organelles called melanosomes of melanocytes and melanin transport to keratinocytes. The actual color of the skin is determined by the distribution pattern of the melanin by the melanocytes. Tyrosinase is considered as key enzyme of melanogenesis as it plays a central role in biosynthetic pathway of melanin and catalyzes the first two steps: the hydroxylation of monophenol to diphenol and the oxidation of diphenol to quinine [1-4]. Abnormal deposition or irregular distribution of melanin causes hyper pigmentary disorders such as melasma, freckles and age spots. One of the major causes of hyper pigmentation is probably UV light. However, the skin darkening can be restrained, at least to some extent, by deactivating the enzyme tyrosinase [5]. So, in order to treat hyper pigmentation and the quest for skin whitening move forward the scientists of all over the world to search inhibitors of enzyme tyrosinase. Although a number of ingredients from natural sources with an inhibitory effect on melanogenesis have been studied in order to treat hyper pigmentation as well as developed as cosmetic agents to make skin white. But many of them find associated with several side effects Hence research is going on for the elucidation of tyrosinase inhibitors with less or no side effects [6,7]. Traditionally, the molecules having antityrosinase activity have been elucidated by using different time consuming and labour intensive experiments. But, with the advancement in technology and the introduction of high throughput techniques make it easier for the biotechnologists to screen many compounds at a time for its inhibitory activity against tyrosinase. One of the techniques of high throughput screening of a molecule is microarray It is a powerful tool used for profiling gene expression, proteinprotein and protein-ligand interaction in high throughput [8]. So it is possible with microarray to screen various compounds as tyrosinase inhibitors. Besides traditional and manual approaches of elucidation and development of tyrosinase inhibitors, here in this review we will focus the importance of the use of high throughput techniques with special emphasis on microarray.","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"166 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88114729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on global prevalence and recent advancements in the genetics of psoriasis","authors":"Harishch, er An, Aram","doi":"10.15406/MOJPB.2017.06.00189","DOIUrl":"https://doi.org/10.15406/MOJPB.2017.06.00189","url":null,"abstract":"","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"39 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81513815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroma liquid biopsy™-a proteomic model of the systemic response to cancer","authors":"Haiyan Zheng, S. Roy, Amenah Soherwardy, S. Rahman, M. Kuruc","doi":"10.15406/mojpb.2017.06.00188","DOIUrl":"https://doi.org/10.15406/mojpb.2017.06.00188","url":null,"abstract":"The advancements in “nextgen” and rapid genome sequencing have spawned new companies for liquid biopsy products and services that are quick, minimally invasive and that allow clinicians to monitor the course of therapy and to forecast recurrent disease. While these are certainly exciting prospects, challenges remain as genomic instability is a fundamental hallmark of cancer cells [1]. So in many respects, genomic driven approaches will always suffer the problem of shooting after a moving target.","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87200540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}