MOJ proteomics & bioinformatics最新文献_第6页

In silico-mediated virtual screening and molecular docking platforms for discovery of non β-lactam inhibitors of y-49 β-lactamase from Mycobacterium tuberculosis 在硅介导的虚拟筛选和分子对接平台中发现结核分枝杆菌y-49 β-内酰胺酶非β-内酰胺抑制剂

MOJ proteomics & bioinformatics Pub Date : 2018-01-30 DOI: 10.15406/mojpb.2018.07.00207

J. González, Elainie Lendebol, A. Shen, M. Philipp, Cristina C. Clement

{"title":"In silico-mediated virtual screening and molecular docking platforms for discovery of non β-lactam inhibitors of y-49 β-lactamase from Mycobacterium tuberculosis","authors":"J. González, Elainie Lendebol, A. Shen, M. Philipp, Cristina C. Clement","doi":"10.15406/mojpb.2018.07.00207","DOIUrl":"https://doi.org/10.15406/mojpb.2018.07.00207","url":null,"abstract":"Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a worldwide health concern. The world health organization in its 2017 tuberculosis report states, “TB is the ninth leading cause of death worldwide and the leading cause from a single infectious agent, ranking above HIV/AIDS” [1-3]. The failure to control TB is due to the emergence of Mtb strains that are resistant to first line beta lactam antibiotics, because of overuse. One of the most effective resistance mechanisms to β-lactam antibiotics involves the production of β-lactamases which cleave the amide bond in the target β-lactam ring hydrolyzing the drug before it reaches its target. The beta-lactamases are classified into four classes: A, B, C and D. These classes are based on conserved and distinguishing amino acid motifs [1-3]. Classes A, C, and D include enzymes that hydrolyze their substrates by forming an acyl enzyme through an active site serine. Class B β-lactamases are metalloenzymes that utilize at least one active-site zinc ion to facilitate β-lactam hydrolysis. One of the most efficient and prevalent mechanisms of resistance to β-lactam antibiotics is the production of β-lactamases in both Gram-negative and Gram-positive bacteria that hydrolyze the drugs before they can reach their target and exert the desired effect. These resistance mechanisms are important, and each bacterium can create a combination of defenses depending on the selective pressures placed on it [1-4]. The intrinsic resistance to β-lactam antibiotics was demonstrated to be mainly due to the presence of a chromosomally-encoded gene (blaC) in M. tuberculosis for a Class A, Ambler β-lactamase (BlaC). The BlaC enzyme has already been validated as one of the leading targets of tuberculosis therapy. This enzyme is extremely active against Volume 7 Issue 1 2018","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86274991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

DNA - The Phantom Effect, Quantum Hologram and the Etheric Body DNA -幽灵效应，量子全息图和以太体

MOJ proteomics & bioinformatics Pub Date : 2018-01-29 DOI: 10.15406/mojpb.2018.07.00206

L. Gadbois

引用次数: 0

Ebola virus: an updated review on immunity and vaccine 埃博拉病毒:关于免疫和疫苗的最新审查

MOJ proteomics & bioinformatics Pub Date : 2018-01-19 DOI: 10.15406/MOJPB.2018.07.00205

Nazmin Sultana Runa, Asmaul Husna, S. Yesmin, Nurjahan Yasmin Runa, A. Badruzzaman, Md Mahfujur Rahman, F. Hossain, Md Masudur, Rahman, A. Bari

{"title":"Ebola virus: an updated review on immunity and vaccine","authors":"Nazmin Sultana Runa, Asmaul Husna, S. Yesmin, Nurjahan Yasmin Runa, A. Badruzzaman, Md Mahfujur Rahman, F. Hossain, Md Masudur, Rahman, A. Bari","doi":"10.15406/MOJPB.2018.07.00205","DOIUrl":"https://doi.org/10.15406/MOJPB.2018.07.00205","url":null,"abstract":"Ebola virus (EBOV) derived its name from the Ebola River in Democratic Republic of Congo (DRC) (formerly Zaire) where the first Ebola virus disease (EVD) outbreak was observed in 1976 [1]. EBOV is enveloped, non-segmented, negative-stranded RNA virus containing filamentous virion which belongs to the family Filoviridae. EVD is caused by filamentous EBOV associated with mortality rates between 25 and 90 % [2]. The clinical symptoms of this disease are non-specific and flu-like, such as high fever, headache and myalgia at the early stage [3]. The symptoms also included diarrhea and vomiting when the large outbreak occurs in West Africa (2014 to present) [4]. Immune cell disorders are associated at the late stage of this disease such as, diffuse intravascular coagulopathy caused by coagulation and neutrophilia disorders [5-7]. Humans may acquire the disease by close contact with biological fluids of the infected animals or patients. During the acute phase of illness, EBOV has been detected in different body fluids including breast milk, saliva, semen, stool, sweat, tears and urine [8-12]. EBOV has been isolated from urine (9 days) and from aqueous humor (9 weeks) after the virus was cleared from plasma [13].","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85463617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Selected concepts on ethics in biopharmaceutical innovation 生物制药创新中的伦理概念选择

MOJ proteomics & bioinformatics Pub Date : 2017-12-29 DOI: 10.15406/mojpb.2017.06.00204

Kadour Ghanemi, Shuangsheng Yan

{"title":"Selected concepts on ethics in biopharmaceutical innovation","authors":"Kadour Ghanemi, Shuangsheng Yan","doi":"10.15406/mojpb.2017.06.00204","DOIUrl":"https://doi.org/10.15406/mojpb.2017.06.00204","url":null,"abstract":"Responsible research and innovation (RRI) is among the most important issues that have generated a huge debate within the political and social milieu, which became an overall case for the biggest EU Research and innovation program ever Horizon [1]. Responsible research and innovation is among the important doctrines for the sustainability of the company [2]. Ethics and the biopharmaceutical responsible innovation is a paradigm of a sector where the ethics and responsibility of health professionals is inevitably linked to public and private life. The biopharmaceutical research, development and marketing responsibilities are taken by the pharmacists, directors and managers of the biopharmaceutical company, all are a combined healthcare team which work together and have a lot of combined bio drugs innovation’s issues [3]. Now we are in age where the bio pharmacy improves with a high rapidity, a new generation of several bio drugs is discovered for improving survival rates, a lot of chronic and even fatal maladies are promised now with a new series of bio drugs to enhance the patient health [4-7]. The role of this staff (bio pharmacists, directors, and managers) is to minimize the risks and the harm of the new developed bio drugs during the clinical trials process and during the patient’s consumption of this new treatment, also to secure the efficacy of the new bio drug and guarantee that the novel discovered bio drugs can be used safely. Moreover, to facilitate its access and also to strengthen the country’s economy in order to serve the humanity interests and boosting the healthcare progress in general [8]. However, the biopharmaceutical innovation can be seen as a junction between business and health, this gives rise to a several series of ethical and responsibility issues and a dire need to make some rules, standards and principles for the bio drug innovation’s process built on rational and virtues.","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73705448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A review on the impact of genetics and genome wide association studies in autoimmunity 遗传学和全基因组关联研究对自身免疫的影响综述

MOJ proteomics & bioinformatics Pub Date : 2017-12-11 DOI: 10.15406/mojpb.2017.06.00203

Harishch, er An, Aram

{"title":"A review on the impact of genetics and genome wide association studies in autoimmunity","authors":"Harishch, er An, Aram","doi":"10.15406/mojpb.2017.06.00203","DOIUrl":"https://doi.org/10.15406/mojpb.2017.06.00203","url":null,"abstract":"Autoimmune diseases (AIDs) in humans are considered as major issues in public health. AIDs affect almost 10% of human population [1]. AIDs in human are disorders with complexity and they develop from the interactions between polygenic risk and environmental factors [2]. Investigations of genetics in AIDs contain the potential to have an unbiased view of etiologies in common conditions to identify novel targets for therapy. In the era of pre genomics, the understanding of heritability in disease were derived based on the high prevalence rate of autoimmune disease in twins [3] or family members [4] compared with nonbiological relatives in a shared environment [5]. Apart from the recognition of risk factors influenced by genetics in autoimmune disease, there exists a challenge to identify the causal nucleotide variants and correlate their functional effects. The sequencing of human genome and rapidly emerging technologies in genomics helps us to retrieve the genetic variants that contribute to the risk factors of autoimmune disease. Understandings of genetics in human AIDs were expanded with a high rate of prevalence in the last 15 years. In this review, we analyze the biological lessons learnt from the genetic studies of AIDs in humans.","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83418014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary protein changes in a rat starvation model 大鼠饥饿模型尿蛋白的变化

MOJ proteomics & bioinformatics Pub Date : 2017-11-24 DOI: 10.15406/MOJPB.2017.06.00202

Yuan Yuan, Fanshuang Zhang, Yanying Ni, Youhe Gao

{"title":"Urinary protein changes in a rat starvation model","authors":"Yuan Yuan, Fanshuang Zhang, Yanying Ni, Youhe Gao","doi":"10.15406/MOJPB.2017.06.00202","DOIUrl":"https://doi.org/10.15406/MOJPB.2017.06.00202","url":null,"abstract":"Protein has been found in urine in all relevant studies. Why are there proteins in urine? If the protein in urine acts as a nutrient, should all proteins be reabsorbed into the blood during starvation to maintain the homeostasis of the internal environment? Are they toxic? Is there any protein in urine when the animal is starved? If the protein in urine is toxic or is discarded for the regulation of body’s own cellular functions, it still must be released into the urine even when the animal is starved. Does the kidney need protein to maintain urine flow? If the protein is necessary to maintain urine flow, at least some of it should remain in the urine even after starvation. Starvation can lead to different disorders of the body. During the process of starvation, a series of energy metabolism changes leads to a decrease of body weight and changes in the body’s components and the metabolic gene expression profile [1,2]. A short duration of starvation can cause the acceleration of protein metabolism [3] and increases in nitrogen excretion, leucine flux and oxidation [4]. All of the above observations illustrate that the effect of starvation on the body may possibly reflect urinary protein changes.","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"63 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86074286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Antifungal activity of dihydrobenzofuran neolignans 二氢苯并呋喃新木质素的抗真菌活性

MOJ proteomics & bioinformatics Pub Date : 2017-11-24 DOI: 10.15406/MOJPB.2017.06.00201

Herbert J Dias, Nayara As Aquaroni, R. C. Pietro, A. Crotti

引用次数: 3

Correct Use of Percent Coefficient of Variation (%CV) Formula for Log-Transformed Data 对数转换数据的百分比变异系数(%CV)公式的正确使用

MOJ proteomics & bioinformatics Pub Date : 2017-11-16 DOI: 10.15406/MOJPB.2017.06.00200

Jesse A. Canchola, Shaowu Tang, P. Hemyari, E. Paxinos, E. Marins

引用次数: 50

The impact of genomics evolution and genomic island in Burkholderia pseudomallei 伪马利氏伯克氏菌基因组进化与基因组岛的影响

MOJ proteomics & bioinformatics Pub Date : 2017-11-16 DOI: 10.15406/MOJPB.2017.06.00199

Alaa A Elnour

引用次数: 1

DNA testing applied to fibromyalgia syndrome analysis and management DNA检测在纤维肌痛综合征分析和治疗中的应用

MOJ proteomics & bioinformatics Pub Date : 2017-11-13 DOI: 10.15406/mojpb.2017.06.00198

J. I. Lao

引用次数: 0