MOJ proteomics & bioinformatics最新文献

{"title":"Conception–why there is no rejection? – the lesson learned will revolutionize organ transplantation","authors":"M. Kuman","doi":"10.15406/MOJPB.2020.09.00289","DOIUrl":"https://doi.org/10.15406/MOJPB.2020.09.00289","url":null,"abstract":"","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88556858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How common is homosexuality and what is causing it?","authors":"M. Kuman","doi":"10.15406/mojpb.2020.09.00285","DOIUrl":"https://doi.org/10.15406/mojpb.2020.09.00285","url":null,"abstract":"","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86857084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resurrection–myth or reality?","authors":"M. Kuman","doi":"10.15406/mojpb.2020.09.00284","DOIUrl":"https://doi.org/10.15406/mojpb.2020.09.00284","url":null,"abstract":"","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86679414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why should our science accept the fact that we have a quantum computer in our subconscious","authors":"M. Kuman","doi":"10.15406/mojpb.2020.09.00281","DOIUrl":"https://doi.org/10.15406/mojpb.2020.09.00281","url":null,"abstract":"","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76650061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Core Pseudomonas genome from 10 pseudomonas species ","authors":"M. Ling","doi":"10.15406/mojpb.2020.09.00282","DOIUrl":"https://doi.org/10.15406/mojpb.2020.09.00282","url":null,"abstract":"Core genome of a set of organisms represents the set of homologous genes shared between the set of organisms with many applications. The Pseudomonas genus is highly diverse with both plant and animal pathogens. Hence, the core genome of Pseudomonas genus can be useful. Current studies presented contradictory results with the core genome of Pseudomonas genus marginally larger than that of Pseudomonas aeruginosa . In this study, we attempt to identify a core Pseudomonas genome from 10 publicly available annotated genomes by intersecting homologous coding sequences using BLAST. Our results suggest a 218-gene core genome, which is 3.46% of the coding sequences of P. aeruginosa . 136 of 218 genes were mapped to official gene symbols and were enriched in 8 clusters in Gene Ontology biological processes related to central metabolism.","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83137205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homologs of the Tumor Suppressor Protein p53: A Bioinformatics Study for Drug Design.","authors":"Kelly M Thayer,&nbsp;Claudia Carcamo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sequence and structure of proteins related to the tumor suppressor protein p53 were studied from the perspective of gaining insight for the development of therapeutic drugs. Our study addresses two major issues encumber bringing novel drugs to market: side effects and artifacts from animal models. In the first phase of our study, we performed a genome-wide search to identify potentially similar proteins to p53 that may be susceptible to off target effects. In the second phase, we chose a selection of common model organisms that could potentially be available to undergraduate researchers in the university setting to assess which ones utilize p53 most similar to humans on the basis of sequence homology and structural similarity from predicted structures. Our results confirm the proteins in the humans significantly similar to p53 are known paralogs within the p53 family. In considering model organisms, murine p53 bore great similarity to human p53 in terms of both sequence and structure, but others performed similarly well. We discuss the findings against the background of other structural benchmarks and point out potential benefits and drawbacks of various alternatives for use in future drug design pilot studies.</p>","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"9 1","pages":"5-14"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442938/pdf/nihms-1597888.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39424371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The analysis for alteration in starch biosynthesis metabolism in a japonica rice grain mutant which does not accumulate starch","authors":"C. Shi, Z. Cao, F. Cheng, Weidong Xu, Jianguo G. Wu","doi":"10.15406/mojpb.2018.07.00252","DOIUrl":"https://doi.org/10.15406/mojpb.2018.07.00252","url":null,"abstract":"Rice (Oryza sativa. L) is one of the most important staple foods worldwide and the development of rice grain is abundantly related to growth of the endosperm. The endosperm is initiated by the fusion between a sperm nucleus and two polar nuclei during the double fertilization process and undergoes a series of coordinated cellular and metabolic events, including starch accumulation, cell death and starch granule packaging during the storage phase.1 Starch generally accounts for about 70% of the total dry weight in cereal grains and serves as a primary source of food with a wide range of industrial applications.2 In previous reports, many efforts have been made to elucidate the metabolic mechanisms underlying the starch biosynthesis pathway in developing endosperms, and some key enzymes, involving ADP‒ glucose pyrophosphorylase (AGP), sucrose synthase (Susy), soluble starch synthase (SSS), granule‒bound starch synthase (GBSS), starch branching enzyme (SBE) and starch debranching enzyme (DBE) have been considered as necessities for the starch biosynthesis in cereal endosperm. In recent decades, a series of mutants related to deficient starch biosynthesis have been generated and provided new insights into the complex mechanism of starch biosynthesis in cereal endosperms. Several isoforms including SS I, SS II, SS III, SS IV and GBSS had specific functions in initiation, elongation, branching and debranching of transient or storage starch synthesis in source and sink tissues, respectively.3 Among all of these SS isoforms, SS I was highly and specifically expressed in rice endosperm and performs about 70% of total SS activities, and its activity was also higher than that in other isoforms.4 Two related forms of SBE (SBE I and SBE II) exist in cereal endosperm. Loss of SBE I isoform activity could limit the synthesis of starch in a way that cannot be compensated by SBE II isoform; thus, the activity of SBE I was essential for normal regular organization of the starch granule whether SBE II existed or not.5 Two DBE families occurred, such as ISA and PUL in plants.6 reported that sugary‒1 phenotype was caused by the loss of the activity of the PUL enzyme, suggesting that the DBE was also involved in starch biosynthesis apart from its function in starch degradation in conjunction with other hydrolytic activities Rice, barley and maize sugary mutants were generally caused by the lack of ISA genes and low DBE activity, accompanied with a decreased starch accumulation in the endosperm and alterations in the fine structure and numbers of starch granule.7 At least three ISA genes were present in plants. Among them, ISA 1 was highly expressed in the cereal endosperm and the reduced levels of ISA 1 could be found in the synthesis of phytoglycogen in the antisense‒expression of transgenic rice plants,8","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73628459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full intuitive creativity is a collective work of the quantum computer of our subconscious and the digital computer of our conscious","authors":"M. Kuman","doi":"10.15406/MOJPB.2018.07.00251","DOIUrl":"https://doi.org/10.15406/MOJPB.2018.07.00251","url":null,"abstract":"Poincare called the full intuitive creativity a state of “overexcited conscious”.1 The Russian Shakespeare–the dramas writer Alexander Pushkin‒ describes his state of creative ecstasy as: “when conscious and subconscious are mixed”, when “the conscious cannot succeed to process all that is offered by the subconscious”.2 According to Alexander Pushkin, “creativity is excitement plus inspiration. Inspiration is as necessary in poetry as it is in geometry”.2 The famous Russian Academic Migdal, who studied creativity, claims that in most cases achieving state of creative ecstasy requires some efforts: “avoiding all the obstacles and rejecting all side thoughts, with consistent and constant efforts, with different side approaches, one have to reach the state of ecstasy, when conscious and subconscious are mixed, when the conscious thinking continue during the sleep and subconscious work is done during the day”.3 Indeed, for most creative people there is an element of unpredictability when the state of enlightenment will be reached. Also, the creative periods are not everlasting and once they disappear, it is not known when they will come back. However, Alexander Pushkin was not one of them. The writing of Alexander Pushkin seemed to be effortless. He wrought about his political captivity in Borodin:“All days were full with dense and constant full illumination that made the grief and care go away dispersing all the doubts, and one can work 20 out of 24 hours without feeling tired. My Conscious could barely succeed to process all that was offered by my Subconscious, but this created a fabulous feeling of full life and full happiness”.2‒6","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85771152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The journey to death; asian swamp eel fate in a non‒native habitat","authors":"A. Hilles, S. Mahmood, M. Kaderi, R. Hashim","doi":"10.15406/mojpb.2018.07.00250","DOIUrl":"https://doi.org/10.15406/mojpb.2018.07.00250","url":null,"abstract":"The Asian swamp eel was first introduced into the Hawaiian Islands in 1900,5 and in 1990, it was introduced to different ponds near Atlanta and Georgia, within the Chattahoochee River drainage basin.6 In 1993, there are two more populations of the eel have been discovered; one outside of Tampa, Florida, and one in southern Georgia near the Chattahoochee River.7 In 1997, eel was collected in the southeast and in west‒ central of Florida.8 It has been reported that the introduction of Asian swamp eel into Georgia as an aquarium release, and to Florida it might be because aquarium release, escape from fish farm or release of from the life fish market.9","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83785860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review about the importance of skin mucus from asian swamp eel (Monopterus albus)","authors":"A. Hilles, S. Mahmood, M. Kaderi, R. Hashim","doi":"10.15406/mojpb.2018.07.00249","DOIUrl":"https://doi.org/10.15406/mojpb.2018.07.00249","url":null,"abstract":"Asian swamp eel mucus is secreted by the epidermal goblet cells in the epidermis which composed from inorganic salts, immunoglobulins, lipids and gel forming macromolecules such as mucins, and other glycoproteins suspended in water,7 which giving the mucus lubricating properties.8 The mucus layer is continuously replaced which protect the eel from stable colonization by bacteria, parasites and fungi.9 The functional properties of the mucus depend on its ability to form a gel on the epithelial surface,10 which produce antimicrobial molecules serve as the first line of a host’s defense against microbial invasion.11 The mucopolysaccharides in the mucus has a high value for immunoprotection and defense mechanism.12,13 It has been proven that mucin has potential of antimicrobial and noxious properties,14 as it plays an important role to protect the eel from pathogens.15 Overall mucus layer on the surface of eel functions as a physical and biochemical barrier between eel and its environment.16","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90368072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}