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Effects of hyperbaric oxygen on Notch signaling pathway after severe carbon monoxide poisoning in mice. 高压氧对小鼠重度一氧化碳中毒后Notch信号通路的影响。
IF 2.9
Medical Gas Research Pub Date : 2023-01-01 DOI: 10.4103/2045-9912.344971
Hui-Jun Hu, Dan-Feng Fan, Zhou-Heng Ye, Qiang Sun
{"title":"Effects of hyperbaric oxygen on Notch signaling pathway after severe carbon monoxide poisoning in mice.","authors":"Hui-Jun Hu,&nbsp;Dan-Feng Fan,&nbsp;Zhou-Heng Ye,&nbsp;Qiang Sun","doi":"10.4103/2045-9912.344971","DOIUrl":"https://doi.org/10.4103/2045-9912.344971","url":null,"abstract":"<p><p>Demyelination of the cerebral white matter is the most common pathological change after carbon monoxide (CO) poisoning. Notch signaling, the mechanism underlying the differentiation of astrocytes and oligodendrocytes, is critical to remyelination of the white matter after brain lesion. The purpose of this work was to determine the effects of hyperbaric oxygen (HBO) on Notch signaling pathway after CO poisoning for the explanation of the protective effects of HBO on CO-poisoning-related cerebral white matter demyelination. The male C57 BL/6 mice with severe CO poisoning were treated by HBO. And HBO therapy shortened the escape latency and improved the body mass after CO poisoning. HBO therapy also significantly suppressed protein and mRNA levels of Notch1 and Hes5 after CO poisoning. Our findings suggested that HBO could suppress the activation of Notch signaling pathway after CO poisoning, which is the mechanism underlying the neuroprotection of HBO on demyelination after severe CO poisoning.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"13 1","pages":"23-28"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3c/f2/MGR-13-23.PMC9480357.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10639798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nitrous oxide induces subacute combined degeneration by affecting vitamin B12 metabolism 氧化亚氮通过影响维生素B12代谢诱导亚急性合并变性
Medical Gas Research Pub Date : 2023-01-01 DOI: 10.4103/2045-9912.385941
Zhifeng Wang, Weiliang Hu, Wenjie Wang, Yang Chen, Xuejian Wang, Zhao Wang, Jinjie Tian, Yi Zhang
{"title":"Nitrous oxide induces subacute combined degeneration by affecting vitamin B12 metabolism","authors":"Zhifeng Wang, Weiliang Hu, Wenjie Wang, Yang Chen, Xuejian Wang, Zhao Wang, Jinjie Tian, Yi Zhang","doi":"10.4103/2045-9912.385941","DOIUrl":"https://doi.org/10.4103/2045-9912.385941","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The potential role of nitrogen dioxide inhalation in Parkinson’s disease 吸入二氧化氮在帕金森病中的潜在作用
Medical Gas Research Pub Date : 2023-01-01 DOI: 10.4103/2045-9912.385940
Wanchun You, Jianguo Xu, Hang Li, Siyuan Yang, Jiahe Wang, Gang Chen
{"title":"The potential role of nitrogen dioxide inhalation in Parkinson’s disease","authors":"Wanchun You, Jianguo Xu, Hang Li, Siyuan Yang, Jiahe Wang, Gang Chen","doi":"10.4103/2045-9912.385940","DOIUrl":"https://doi.org/10.4103/2045-9912.385940","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of hyperbaric oxygen in idiopathic sudden sensorineural hearing loss 高压氧在特发性突发性感音神经性听力损失中的作用
Medical Gas Research Pub Date : 2023-01-01 DOI: 10.4103/2045-9912.385943
Jiang Wu, Yukun Hu, Yang Ye, Xiaoyu Ji
{"title":"The role of hyperbaric oxygen in idiopathic sudden sensorineural hearing loss","authors":"Jiang Wu, Yukun Hu, Yang Ye, Xiaoyu Ji","doi":"10.4103/2045-9912.385943","DOIUrl":"https://doi.org/10.4103/2045-9912.385943","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of real-time oxygen consumption versus fixed flow-based low flow anesthesia on oxygenation and perfusion: a randomized, single-blind study 实时耗氧量与基于固定流量的低流量麻醉对氧合和灌注的影响:一项随机、单盲研究
Medical Gas Research Pub Date : 2023-01-01 DOI: 10.4103/2045-9912.385938
HabibM R Karim, MaheshS Kurwe, SubrataK Singha, PraveenK Neema, ChinmayaK Panda
{"title":"Effect of real-time oxygen consumption versus fixed flow-based low flow anesthesia on oxygenation and perfusion: a randomized, single-blind study","authors":"HabibM R Karim, MaheshS Kurwe, SubrataK Singha, PraveenK Neema, ChinmayaK Panda","doi":"10.4103/2045-9912.385938","DOIUrl":"https://doi.org/10.4103/2045-9912.385938","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible role of high calcium concentrations in rat neocortical neurons in inducing hyper excitatory behavior during emergence from sevoflurane: a proposed pathophysiology 高钙浓度的大鼠新皮质神经元在七氟醚苏醒过程中诱导过度兴奋行为的可能作用:一种提出的病理生理学
Medical Gas Research Pub Date : 2023-01-01 DOI: 10.4103/2045-9912.385942
AndiAde Wijaya Ramlan, AmirS Madjid, Elizeus Hanindito, Irawan Mangunatmaja, Nurhadi Ibrahim
{"title":"Possible role of high calcium concentrations in rat neocortical neurons in inducing hyper excitatory behavior during emergence from sevoflurane: a proposed pathophysiology","authors":"AndiAde Wijaya Ramlan, AmirS Madjid, Elizeus Hanindito, Irawan Mangunatmaja, Nurhadi Ibrahim","doi":"10.4103/2045-9912.385942","DOIUrl":"https://doi.org/10.4103/2045-9912.385942","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of nitric oxide in Alzheimer's disease 一氧化氮对阿尔茨海默病的影响
Medical Gas Research Pub Date : 2023-01-01 DOI: 10.4103/2045-9912.385939
Zongqi Wang, Wen Li, Lingling Wang, Dengfeng Lu, Xiaodong Wang, Gang Chen
{"title":"The effects of nitric oxide in Alzheimer's disease","authors":"Zongqi Wang, Wen Li, Lingling Wang, Dengfeng Lu, Xiaodong Wang, Gang Chen","doi":"10.4103/2045-9912.385939","DOIUrl":"https://doi.org/10.4103/2045-9912.385939","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current research progress of isoflurane in cerebral ischemia/reperfusion injury: a narrative review. 异氟醚在脑缺血再灌注损伤中的研究进展
IF 2.9
Medical Gas Research Pub Date : 2022-07-01 DOI: 10.4103/2045-9912.330689
Shu-Jun Chen, Xia-Qing Yuan, Qun Xue, Hai-Feng Lu, Gang Chen
{"title":"Current research progress of isoflurane in cerebral ischemia/reperfusion injury: a narrative review.","authors":"Shu-Jun Chen,&nbsp;Xia-Qing Yuan,&nbsp;Qun Xue,&nbsp;Hai-Feng Lu,&nbsp;Gang Chen","doi":"10.4103/2045-9912.330689","DOIUrl":"https://doi.org/10.4103/2045-9912.330689","url":null,"abstract":"<p><p>Cerebral ischemia/reperfusion injury is an important factor leading to poor prognosis in ischemic stroke patients. Therefore, it is particularly important to find effective remedial measures to promote the health of patients to return to society. Isoflurane is a safe and reliable anesthetic gas with a long history of clinical application. In recent years, its protection function to human body has been widely recognized, and nowadays isoflurane for cerebral protection has been widely studied, and the stable effect of isoflurane has satisfied many researchers. Basic studies have shown that isoflurane's protection of brain tissue after ischemia/reperfusion involves a variety of signaling pathways and effector molecules. Even though many signaling pathways have been described, more and more studies focus on exploring their mechanisms of action, in order to provide strong evidence for clinical application. This could prompt the introduction of isoflurane therapy to clinical patients as soon as possible. In this paper, several confirmed signaling pathways will be reviewed to find possible strategies for clinical treatment.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"12 3","pages":"73-76"},"PeriodicalIF":2.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/69/43/MGR-12-73.PMC8690858.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39683868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Comparative analgesic, hemodynamic, pain and duration of sensory and motor block effects of dexmedetomidine, granisetron, and nitroglycerin added to ropivacaine in intravenous anesthesia for forearm surgeries: a randomized clinical study. 右美托咪定、格拉司琼和硝酸甘油加入罗哌卡因静脉麻醉用于前臂手术的镇痛、血流动力学、疼痛和感觉和运动阻滞效应持续时间的比较:一项随机临床研究。
IF 2.9
Medical Gas Research Pub Date : 2022-07-01 DOI: 10.4103/2045-9912.330690
Esmail Moshiri, Hesameddin Modir, Alireza Kamali, Mehran Azami, Morteza Molouk
{"title":"Comparative analgesic, hemodynamic, pain and duration of sensory and motor block effects of dexmedetomidine, granisetron, and nitroglycerin added to ropivacaine in intravenous anesthesia for forearm surgeries: a randomized clinical study.","authors":"Esmail Moshiri,&nbsp;Hesameddin Modir,&nbsp;Alireza Kamali,&nbsp;Mehran Azami,&nbsp;Morteza Molouk","doi":"10.4103/2045-9912.330690","DOIUrl":"https://doi.org/10.4103/2045-9912.330690","url":null,"abstract":"<p><p>This trial-based paper strives to address the comparative efficacy of some ropivacaine adjuvant options, comprising dexmedetomidine, granisetron, and nitroglycerin, on pain and hemodynamic changes in intravenous anesthesia for forearm surgeries. This double-blind, placebo-controlled study enrolled four block-randomized eligible groups with patients (overall, n=128) undergoing orthopedic forearm surgeries in the dexmedetomidine, nitroglycerin, granisetron, and placebo groups. Intra- and post-operative vital signs (mean arterial pressure/heart rate/ oxygen saturation) were monitored at baseline and captured every 10 minutes until the end of the surgery, as well as the onset of sensory and motor block and length and duration of the block and mean opioid use within 24 hours. Lastly, pain was noted after tourniquet inflation (at 15, 30, and 45 minutes every 15 minutes until the end of surgery) and after deflation (every 30 minutes to 2 hours at 30, 60, 90, and 120 minutes), as well as 6, 12, and 24 hours after the tourniquet was deflated. The dexmedetomidine-sedated subjects appeared to demonstrate quicker onset and longer length and duration of sensory and motor block, plus less pain and opioid use at all scheduled times (both P = 0.0001). Dexmedetomidine is recommended as an adjuvant to regional anesthesia (Bier's block), while being coupled with the rapid onset and prolonged length and duration of sensory and motor blocks, in addition to soothed pain and diminished opioid use within postoperative 24 hours. The study was approved by Ethics Committee of Arak University of Medical Sciences (approval No. IR.ARAKMU.REC.1398.112) on July 21, 2019, and registered at Iranian Registry of Clinical Trials (registration number IRCT20141209020258N123) on November 2, 2019.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"12 3","pages":"77-82"},"PeriodicalIF":2.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/96/ca/MGR-12-77.PMC8690857.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39684772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Spuriously low end tidal carbon dioxide in capnometry: Nafion tube malfunction in end tidal carbon dioxide module blamed for near mishap! 在二氧化碳测量中出现了虚假的低端潮汐二氧化碳:国家石油公司在终端潮汐二氧化碳模块中出现了故障,导致了近乎不幸的事故!
IF 2.9
Medical Gas Research Pub Date : 2022-07-01 DOI: 10.4103/2045-9912.330695
Suma Rabab Ahmad, Chitta Ranjan Mohanty, Snigdha Bellapukonda, Bishu Prasad Patro
{"title":"Spuriously low end tidal carbon dioxide in capnometry: Nafion tube malfunction in end tidal carbon dioxide module blamed for near mishap!","authors":"Suma Rabab Ahmad,&nbsp;Chitta Ranjan Mohanty,&nbsp;Snigdha Bellapukonda,&nbsp;Bishu Prasad Patro","doi":"10.4103/2045-9912.330695","DOIUrl":"https://doi.org/10.4103/2045-9912.330695","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"12 3","pages":"113-114"},"PeriodicalIF":2.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/33/90/MGR-12-113.PMC8690852.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39685227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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