Medical Gas Research最新文献

{"title":"New scientific definitions: hyperbaric therapy and hyperbaric oxygen therapy.","authors":"Paul G Harch","doi":"10.4103/2045-9912.356475","DOIUrl":"https://doi.org/10.4103/2045-9912.356475","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/4e/MGR-13-92.PMC9555024.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9848654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of ozone therapy on neutrophil/lymphocyte, platelet/lymphocyte ratios, and disease activity in ankylosing spondylitis: a self-controlled randomized study.","authors":"Habibe Inci,&nbsp;Fatih İnci","doi":"10.4103/2045-9912.344981","DOIUrl":"https://doi.org/10.4103/2045-9912.344981","url":null,"abstract":"<p><p>This retrospective self-controlled randomized study was carried out with the participation of 53 patients diagnosed with ankylosing spondylitis according to the modified New York criteria. The patients who did not receive medical treatment or did not change their medical treatment within the last 6 months were included in the study. There was a statistically significant decrease in the patients' neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio, C-reactive protein, Visual Analog Scale, Bath Ankylosing Spondylitis Functional Index, and Bath Ankylosing Spondylitis Disease Activity Index scores measured after ozone therapy. There was a positive correlation between neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet volume/lymphocyte ratio, monocyte/lymphocyte ratio and C-reactive protein, Visual Analog Scale, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Disease Activity Index before and after ozone therapy. Our study revealed that the changes in the decreasing tendency of the markers measured in complete blood count after ozone therapy were correlated with the disease activity, which can contribute to understand the effect of ozone therapy on biomarkers.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/69/MGR-13-53.PMC9555027.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33491657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhalation of 4% and 67% hydrogen ameliorates oxidative stress, inflammation, apoptosis, and necroptosis in a rat model of glycerol-induced acute kidney injury.","authors":"Jun-Li Xue,&nbsp;Bo-Yan Liu,&nbsp;Min Zhao,&nbsp;Meng-Yu Zhang,&nbsp;Ming-Yue Wang,&nbsp;Qian-Qian Gu,&nbsp;Xiao-Yi Zhang,&nbsp;Shu-Cun Qin","doi":"10.4103/2045-9912.345169","DOIUrl":"https://doi.org/10.4103/2045-9912.345169","url":null,"abstract":"<p><p>Acute kidney injury (AKI) is the major complication of rhabdomyolysis (RM) clinically, which is usually mimicked by glycerol injection in basic research. Oxidative stress, inflammatory response and apoptosis are recognized to play important roles in development of this disease. Recently, numerous studies have reported the therapeutic effects of molecular hydrogen (H₂) on oxidative stress and inflammation-related diseases. Here, the effects of H₂ against glycerol-induced AKI and the underlying mechanisms were explored in rats. Low (4%) and high (67%) concentrations of H₂ were prepared using a self-made device to investigate the dose-response. After 72 hours of glycerol injection (8 mL/kg), we found that glycerol triggered oxidative stress, inflammatory reactions, and apoptotic events. These caused subsequent renal damage, evidenced by a significant reduction of antioxidases and up-regulation of the relevant damaged biomarkers. H₂ inhalation reversed the above alterations and exerted renoprotective effects. Interestingly, for RM/AKI-related factors, no consistent dose-response benefits of H₂ were observed. However, higher concentration of H₂ inhalation improved histological and morphological changes better. This study suggests that H₂ is a potential alternative therapy to prevent or minimize RM induced AKI possibly via its antioxidant, anti-inflammatory, anti-apoptotic and anti-necroptotic properties.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/7e/MGR-13-78.PMC9555022.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33493381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic applications of hydrogen sulfide and novel donors for cerebral ischemic stroke: a narrative review.","authors":"Jia-Sheng Ding,&nbsp;Yan Zhang,&nbsp;Tian-Yi Wang,&nbsp;Xiang Li,&nbsp;Cheng Ma,&nbsp;Zhong-Mou Xu,&nbsp;Qing Sun,&nbsp;Xiang Xu,&nbsp;Gang Chen","doi":"10.4103/2045-9912.350863","DOIUrl":"https://doi.org/10.4103/2045-9912.350863","url":null,"abstract":"<p><p>Ischemic stroke happens when the blood supply to the brain is obstructed and it is associated with numerous complex mechanisms, such as activated apoptosis genes, oxidative stress and reaction of inflammation, which finally result in neurological deficits. Several gases have been proved to have neuroprotective roles, even the classic gases that are thought to be toxic such as hydrogen sulfide (H₂S). H₂S is the third identified endogenous gas signaling molecule following carbon monoxide and nitric oxide. H₂S plays a significant role in stroke. Inhalation of H₂S can attenuate cerebral infarct volume and promote neurological function in a rat model of middle cerebral artery occlusion to reduce ischemic stroke-induced injury in vivo and in vitro as a result. Therefore, H₂S can be clinically used to reduce ischemic stroke-induced injury. This review introduces the toxic mechanisms and effects of H₂S on cerebral ischemic stroke.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b7/ea/MGR-13-7.PMC9480360.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40695478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of vedolizumab combined with hyperbaric oxygen therapy to treat enteric fistula in Crohn's disease","authors":"EnioChaves Oliveira, Mauro Bafutto, AlexandreAugusto Ferreira Bafutto, CarlosAlberto Ximenes Filho","doi":"10.4103/2045-9912.385948","DOIUrl":"https://doi.org/10.4103/2045-9912.385948","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperbaric oxygen therapy increases the effect of 5-fluorouracil chemotherapy on experimental colorectal cancer in mice","authors":"VanessaForesto Machado, JoséJoaquim Ribeiro da Rocha, RogérioSerafim Parra, MarleyRibeiro Feitosa, CaioAbner Leite, StefâniaBovo Minto, SérgioBritto Garcia, ThiagoMattar Cunha, Omar Feres","doi":"10.4103/2045-9912.385944","DOIUrl":"https://doi.org/10.4103/2045-9912.385944","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Realizing brain therapy with “smart medicine”: Mechanism and case report of molecular hydrogen inhalation for Parkinson's disease","authors":"Yusuke Ichikawa, Bunpei Sato, Shin-ichi Hirano, Yoshiyasu Takefuji, Fumitake Satoh","doi":"10.4103/2045-9912.385949","DOIUrl":"https://doi.org/10.4103/2045-9912.385949","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light-cured calcium hydroxide cements release of calcium ions using argon based induction coupled mass spectroscopy - an <i>in vitro</i> study.","authors":"Sidharth S Menon,&nbsp;Zarana Sanghvi,&nbsp;Shraddha Chokshi,&nbsp;Pruthvi Patel,&nbsp;Pooja Trivedi,&nbsp;Nishit Patel","doi":"10.4103/2045-9912.344976","DOIUrl":"https://doi.org/10.4103/2045-9912.344976","url":null,"abstract":"<p><p>Calcium ion-releasing ability of different calcium hydroxide-based pulp capping materials was comparatively evaluated in this study. Different brands of cements were taken from different manufacturers and categorized into three groups. Three different brands of Ca(OH)₂ cements (Dycal, TheraCal, and Cal LC) were taken prepared by mixing and curing the cements as per the manufacturer's instructions. Consequently, ion release was measured after 7, 14, and 21 days by argon-based induction coupled plasma mass spectroscopy test. Within the limitations of this study, light-cured Ca(OH)₂ cements released a higher amount of calcium ions compared with self-cured Ca(OH)₂ cements. Theracal was found to be the highest light-cured calcium ion releasing materials throughout the period of 21 days. In conclusion, further clinical studies are warranted to substantiate the findings of this study.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e2/06/MGR-13-29.PMC9480359.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40682257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation of an oxygen policy to ensure adequate supply of oxygen reserves during the second wave of COVID-19 pandemic.","authors":"Tanmay Tiwari,&nbsp;Divya Narain Upadhyaya,&nbsp;Yadvendra Dheer,&nbsp;Gyan Prakash Singh,&nbsp;Sandeep Tiwari","doi":"10.4103/2045-9912.344975","DOIUrl":"https://doi.org/10.4103/2045-9912.344975","url":null,"abstract":"The second wave of the coronavirus disease 2019 (COVID-19) pandemic has wreaked havoc with healthcare systems in India as well as in other parts of the world. The health care systems across the world were suddenly overburdened, due to the rapidly increasing oxygen demand for supporting COVID-19 patients who could not maintain their blood oxygen saturation on their own. Majority of the institutions, states, and countries could not keep up with this sudden surge in oxygen demand and found themselves face to face with an oxygen crisis of epic proportions. Oxygen is critically important for saving lives in emergencies, resuscitation of critical patients, trauma settings, and diseases that primarily affect the respiratory system, like pneumonia. Despite being in the list of essential medicines by World Health Organization,1 the importance of oxygen is usually forgotten due to it being easily available naturally in the environment. Eighty percent of the patients admitted in the United Kingdom due to COVID-19 required supplemental oxygen at higher-than-normal doses.2 The mere thought of oxygen being in short supply, and requiring rationing is alarming, but this is exactly what several health systems had to undergo during this pandemic. The combined efforts of the union government, local administration, and health institutions to maintain adequate supplies of medical grade oxygen during this pandemic proved fruitful, but the demand supply ratio was always under pressure.3 These strenuous circumstances have taught us that even with our best efforts the supply of oxygen would always be precarious, if healthcare providers, individually and collectively, do not find solutions to our increasing demands by implementing protocols for the judicious usage of oxygen. Being a large public sector hospital in the most populous state (Uttar Pradesh) of India, with a bed capacity of more than 3000 beds, and a dedicated COVID-19 facility of more than 900 beds, managing oxygen supplies was not easy during the recently crested second wave of the COVID-19 pandemic. The primary supply of oxygen in our institution is through a vacuum insulated evaporator liquid medical oxygen (LMO) vessel system, with cylinder manifolds as the secondary and backup (reserve) supply. During the second wave of the pandemic, the increasing demands of oxygen at our institution were maintained with the collective efforts of the hospital administration and government agencies.4 Additionally, efforts were done to formulate an “oxygen policy” to check the rising demands, and ensure judicious use of the rapidly diminishing oxygen reserves that we had at our disposal. Here, we try to highlight some of our oxygen conservation strategies that helped us achieve a state of balance in terms of demand and supply of oxygen during the stressful time of the second wave of this pandemic. • Daily oxygen consumption details were traced, and analyzed for the last few months and anticipatory storage of LMO was done ","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/85/67/MGR-13-39.PMC9480355.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40682259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined high-voltage pulsed radiofrequency and ozone therapy <i>versus</i> ozone therapy alone in treating postherpetic neuralgia: a retrospective comparison.","authors":"Jian-Feng Zhang,&nbsp;John P Williams,&nbsp;Qian-Nan Zhao,&nbsp;Hui Liu,&nbsp;Jian-Xiong An","doi":"10.4103/2045-9912.352660","DOIUrl":"https://doi.org/10.4103/2045-9912.352660","url":null,"abstract":"<p><p>Postherpetic neuralgia (PHN) is a devastating disease with extraordinarily poor treatment outcomes. Both pulsed radiofrequency (PRF) and ozone have good effects on the treatment of the disease. However, whether PRF and ozone have a synergistic effect on PHN remains unclear. Therefore, this study aimed to assess the therapeutic effects of ozone alone and in combination with PRF in the treatment of PHN. Ninety-one patients with PHN were assigned into two groups: PRF combined with ozone (PRF + ozone group, n = 44) and ozone therapy alone (ozone group, n = 47). In PRF + ozone group, the high-voltage, long-duration PRF was applied to the target dorsal root ganglions. Then ozonated water (11.5 µg/mL) was injected through the inner cannula. In the ozone group, all other processes were the same as those in the PRF + ozone group apart from the electrical stimulation. The therapeutic efficacy was evaluated by visual analog scale and tactile sensation at pre-treatment and post-treatment 3, 6, and 12 months. Compared with pre-treatment data, the visual analog scale score was significantly decreased in both groups after treatment. Compared with the ozone group, the visual analog scale score was significantly decreased in the PRF + ozone group at 3, 6, and 12 months. Similarly, the tactile sensation was also significantly decreased at post-treatment when compared to pre-treatment. However, there were no statistical differences between the two groups. Regression analysis results showed that the history of diabetes mellitus and age had significant negative and positive effects, respectively, on the treatment results. To conclude, the administration of PRF + ozone and ozone therapy alone could both improve pain symptoms. Moreover, treatment effects and total efficacy rates tended to be higher for the combination of PRF and ozone than ozone alone. This conclusion was especially true for long-term therapeutic effects.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/59/18/MGR-13-15.PMC9480353.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40695480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}