Medical Gas Research最新文献

{"title":"Effects of Iranian Polyherbal Syrup (Zufa syrup) on oxygen saturation and clinical symptoms in suspected patients with COVID-19: a triple-blinded, randomized, placebo-controlled trial.","authors":"Razieh Borujerdi,&nbsp;Seyed Hasan Adeli,&nbsp;Abolfazl Mohammadbeigi,&nbsp;Fatemeh Aliasl,&nbsp;Akram Asghari,&nbsp;Ahmad Hormati,&nbsp;Hosein Moradi Dehnavi,&nbsp;Farhad Hoseini,&nbsp;Majid Asghari","doi":"10.4103/2045-9912.325991","DOIUrl":"https://doi.org/10.4103/2045-9912.325991","url":null,"abstract":"<p><p>Coronavirus disease 2019 (COVID-19) pandemic has caused an urgent need for investigating potential treatments. Traditional medicine offers many potential remedies that have been historically used and have the advantage of bypassing the cultural obstacles in the practice of medicine. We aimed to investigate the efficacy of Zufa syrup in the treatment of suspected patients with mild to moderate symptoms of COVID-19. This triple-blind randomized controlled trial recruited patients with evidence of COVID-19 on chest computed tomography without an indication of hospital admission from March 2020 until April 2020. Participants were assessed by a physician and completed a pre-specified form to assess the duration and severity of symptoms. Patients were randomized to receive Zufa syrup (a combination of herbal medicines: Nepetabracteata, Ziziphus jujube, Glycyrrhizaglabra, Ficuscarica, Cordia myxa, Papaver somniferum, Fennel, Adiantumcapillus-veneris, Viola, Viper's-buglosses, Lavender, Iris, and sugar) or identical-looking placebo syrup at a dose of 7.5 mL (one tablespoon) every 4 hours for 10 days. After applying the eligibility criteria, 116 patients (49.1% male) were randomized to trial arms with a mean age of 44.3. During the follow-up, Cough, dyspnea, headache, myalgia, anorexia, anxiety, and insomnia improved gradually in both groups, and showed no difference between Zufa syrup and placebo. Oxygen saturation and pulse rate had stable trends throughout the follow-up and were similar between study arms. No patient required hospital admission or supplemental oxygen therapy during the study period. To conclude, in patients with mild to moderate symptoms of COVID-19, Zufa syrup did not show any difference in symptomatology over a 10 days' period when compared with placebo. Due to potential effects of medicinal plants in the treatment of respiratory infections, further studies are warranted to clarify their role in COVID-19. The study was approved by the Ethics Committee of the Qom University of Medical Science (Ethics committee reference number IR.MUQ.REC.1398.165) on March 10, 2020 and was registered in Iranian Clinical Trial Center (approval ID: IRCT20200404046934N1) on April 13, 2020.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"12 2","pages":"44-50"},"PeriodicalIF":2.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/cb/MGR-12-44.PMC8562395.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39542730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can united airway disease be the cause of variable severity experience of COVID-19 in health care workers?","authors":"Merih Onal,&nbsp;Ozkan Onal,&nbsp;Alparslan Turan","doi":"10.4103/2045-9912.326004","DOIUrl":"https://doi.org/10.4103/2045-9912.326004","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"12 2","pages":"69-71"},"PeriodicalIF":2.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/20/MGR-12-69.PMC8562400.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39542734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone gas applied through nebulization as adjuvant treatment for lung respiratory diseases due to COVID-19 infections: a prospective randomized trial.","authors":"Erhan Dengiz,&nbsp;Çağrı Özcan,&nbsp;Yusuf İzzettin Güven,&nbsp;Selcen Uçar,&nbsp;Behçet Kemal Ener,&nbsp;Semih Sözen,&nbsp;Buket Yağcı,&nbsp;İnal Albek Güzel,&nbsp;Betül Yiğit,&nbsp;Aslınur Andaç,&nbsp;Beyza Güneş,&nbsp;Emire Bor,&nbsp;Uğur Karabudak,&nbsp;Ali Kaya","doi":"10.4103/2045-9912.326001","DOIUrl":"https://doi.org/10.4103/2045-9912.326001","url":null,"abstract":"<p><p>The objective of this study was to provide lung disinfection by nebulizing ozone gas with distilled water and olive oil for patients who have clinical symptoms due to coronavirus disease 2019 (COVID-19). The study attempted to reduce the viral load of COVID-19 in the lungs of patients, to provide a faster response to medical treatment. Between August 2020 and September 2020, 30 patients who met the study criteria were prospectively evaluated. There were 2 groups with 15 patients in each group: patients in control group were not treated with ozone and only received standard COVID-19 treatment; patients in ozone group received lung disinfection technique with ozone and standard COVID-19 treatment. A statistically significant difference was found in the length of stay in hospital, change in C-reactive protein, polymerase chain reaction results after 5 days, and computed tomography scores between two groups. There was no statistically significant difference in D-dimer, urea, lactate dehydrogenase, lymphocyte, leukocyte, and platelet between two groups. According to the data, we think that the lung disinfection technique applied with ozone inhalation reduces the rate of pneumonia in COVID-19 patients and makes the patients respond faster to the treatment and become negative according to the polymerase chain reaction tests. The study was approved by the Ethical Committee of the Istanbul Medipol University Clinical Trials (approval No. 0011) on July 2, 2020.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"12 2","pages":"55-59"},"PeriodicalIF":2.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bb/51/MGR-12-55.PMC8562398.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39542731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute asthma exacerbation after SARS-CoV-2 vaccine (Sinovac®): a case report.","authors":"Fatih Uzer,&nbsp;Aykut Cilli","doi":"10.4103/2045-9912.326003","DOIUrl":"https://doi.org/10.4103/2045-9912.326003","url":null,"abstract":"<p><p>A 76-year-old female received a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (CoronaVac, Sinovac^®, Beijing, China) and subsequently experienced chest discomfort. A computed tomography performed 1 day after vaccination showed multiple infiltrations in both lungs and ground-glass shadows in both lung fields. Her fingertip oxygen saturation was 81% and there was widespread wheezing on physical examination. Based on these findings, the patient was hospitalized with a preliminary diagnosis of drug-induced pneumonitis and acute asthma exacerbation due to a SARS-CoV-2 vaccine. During her hospitalization, 40 mg/d systemic steroid, 4 times a day salbutamol nebulized, 2 L/min inhaled oxygen therapy and 400 mg/d moxifloxacin intravenous were administered for 5 days. One month later, the thorax computed tomography scan revealed that the previous findings were almost completely regressed.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"12 2","pages":"67-68"},"PeriodicalIF":2.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8a/f1/MGR-12-67.PMC8562397.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39542733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 is more dangerous for older people and its severity is increasing: a case-control study.","authors":"Cuma Mertoglu,&nbsp;Mehmet Tahir Huyut,&nbsp;Hasan Olmez,&nbsp;Mustafa Tosun,&nbsp;Mecit Kantarci,&nbsp;Taha Abdulkadir Coban","doi":"10.4103/2045-9912.325992","DOIUrl":"10.4103/2045-9912.325992","url":null,"abstract":"<p><p>Coronavirus disease 2019 (COVID-19) triggers important changes in routine blood tests. In this retrospective case-control study, biochemical, hematological and inflammatory biomarkers between March 10, 2020, and November 30, 2020 from 3969 COVID-19 patients (3746 in the non-intensive care unit (non-ICU) group and 223 in the ICU group) were analyzed by dividing into three groups as spring, summer and autumn. In the non-ICU group, lymphocyte to monocyte ratio was lower in autumn than the other two seasons and neutrophil to lymphocyte ratio was higher in autumn than the other two seasons. Also, monocyte and platelet were higher in spring than autumn; and eosinophil, hematocrit, hemoglobin, lymphocyte, and red blood cells decreased from spring to autumn. In the non-ICU group, alanine aminotransferase and gamma-glutamyltransferase gradually increased from spring to autumn, while albumin, alkaline phosphatase, calcium, total bilirubin and total protein gradually decreased. Additionally, C-reactive protein was higher in autumn than the other seasons, erythrocyte sedimentation rate was higher in autumn than summer. The changes in routine blood biomarkers in COVID-19 varied from the emergence of the disease until now. Also, the timely changes of blood biomarkers were mostly more negative, indicating that the disease progresses severely. The study was approved by the Erzincan Binali Yildirim University Non-interventional Clinical Trials Ethic Committee (approval No. 86041) on June 21, 2021.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"12 2","pages":"51-54"},"PeriodicalIF":2.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/d1/MGR-12-51.PMC8562399.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39565735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 incidence and local ozone level: is there any association?","authors":"Beuy Joob,&nbsp;Viroj Wiwanitkit","doi":"10.4103/2045-9912.326005","DOIUrl":"https://doi.org/10.4103/2045-9912.326005","url":null,"abstract":"Dear Editor, Coronavirus disease 2019 (COVID-19) is a new coronavirus respiratory infection. This new emerging infection disease has already caused more than 30,000,000 infected cases worldwide since its first appearance in late 2019. The effect of underlying metrological background on the incidence of the COVID-19 is an interesting issue but little is known on this issue.1 In fact, the effect of environmental gas on the respiratory infection is an important issue in public health.2 Focusing on local environmental gas in atmosphere, the association with local COVID-19 incidence has never been assessed. We analyzed the data to assess the relationship between COVID-19 incidence and local ozone level in a tropical country which is the second country of the world getting affected by the new emerging COVID-19. The primary data on incidence of COVID-19 was derived from local Public Health Ministry and the primary data of local ozone was derived from Department of Pollution Control of Thailand. The studied area in the present study is the area covering 13 provinces (Payao, Phare, Uttaradit, Pitsanuloke, Pichit, Nongbualumpu, Chaiyaphum, Mahasarakham, Roiet, Yasothorn, Sakonnakorn, Beungkarn and Kalaasin) in rural northern and northeastern region areas of Thailand which is not a destination for international tourists. In the present study, only data on non-local transmission COVID-19 cases were used for further analysis. The data were collected between March and June 2020, when the COVID-19 outbreak started in the studied area following its first appearance in China. According to the study, the scatterplot shows the relationship between COVID-19 incidence and ozone level (Figure 1). There was no significant correlation (r = 0.076, P = 0.805) between COVID-19 incidence and local ozone level in the studied area. The association between ozone and COVID-19 is still poorly understood. The positive effect of ozone therapy on the COVID-19 infection has been reported.3 The cytoprotection of ozone may attribute to the therapeutic effect of ozone on COVID-19 infection.3,4 In the present report, we assessed the interrelationship between environmental ozone level and COVID-19 incidence. Interestingly, there was no association between them. In some areas with high ozone level still have high incidence (number) of COVID-19 cases. This might not support that environmental ozone background can have protective effect against severe acute respiratory syndrome coronavirus 2 infection. This preliminary observation may provide evidence for further investigations on this issue.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"12 2","pages":"72"},"PeriodicalIF":2.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/fa/MGR-12-72.PMC8562401.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39542735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of an ionic antineoplastic agent Cytoreg on blood chemistry in a Wistar rat model.","authors":"Katiusca Villasana,&nbsp;William Quintero,&nbsp;Yepsys Montero,&nbsp;Cristian Pino,&nbsp;Oscar Uzcategui,&nbsp;Geizon Torres,&nbsp;Mariangel Prada,&nbsp;Lewis Pozo,&nbsp;William Bauta,&nbsp;William Jimenez","doi":"10.4103/2045-9912.324592","DOIUrl":"https://doi.org/10.4103/2045-9912.324592","url":null,"abstract":"<p><p>Cytoreg is an ionic therapeutic agent comprising a mixture of hydrochloric, sulfuric, phosphoric, hydrofluoric, oxalic, and citric acids. In diluted form, it has demonstrated efficacy against human cancers in vitro and in vivo. Although Cytoreg is well tolerated in mice, rats, rabbits, and dogs by oral and intravenous administration, its mechanism of action is not documented. The acidic nature of Cytoreg could potentially disrupt the pH and levels of ions and dissolved gases in the blood. Here, we report the effects of the intravenous administration of Cytoreg on the arterial pH, oxygen and carbon dioxide pressures, and bicarbonate, sodium, potassium, and chloride concentrations. Our results demonstrate that Cytoreg does not disturb the normal blood pH, ion levels, or carbon dioxide content, but increases oxygen levels in rats. These data are consistent with the excellent tolerability of intravenous Cytoreg observed in rabbits, and dogs. The study was approved by the Bioethics Committee of the University of the Andes, Venezuela (CEBIOULA) (approval No. 125) on November 3, 2019.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"12 1","pages":"18-23"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/51/MGR-12-18.PMC8447950.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39393219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A special oropharyngeal oxygenation device to facilitate apneic oxygenation in comparison to high flow oxygenation devices.","authors":"Wolfgang A Wetsch,&nbsp;Daniel C Schroeder,&nbsp;Simon-Richard Finke,&nbsp;David Sander,&nbsp;Hannes Ecker,&nbsp;Bernd W Böttiger,&nbsp;Holger Herff","doi":"10.4103/2045-9912.323536","DOIUrl":"https://doi.org/10.4103/2045-9912.323536","url":null,"abstract":"<p><p>Oxygen application and apneic oxygenation may reduce the risk of hypoxemia due to apnea during awake fiberoptic intubation or failed endotracheal intubation. High flow devices are recommended, but their effect compared to moderate deep oropharyngeal oxygen application is unknown. Designed as an experimental manikin trial, we made a comparison between oxygen application via nasal prongs at 10 L/min (control group), applying oxygen via oropharyngeal oxygenation device (at 10 L/min), oxygen application via high flow nasal oxygen with 20 L/min and 90% oxygen (20 L/90% group), oxygen application via high flow nasal oxygen with 60 L/min and 45% oxygen (60 L/45% group), and oxygen application via sealed face mask with a special adapter to allow for fiberoptic entering of the airway. We preoxygenated the lung of a manikin and measured the decrease in oxygen level during the following 20 minutes for each way of oxygen application. Oxygen levels fell from 97 ± 1% at baseline to 75 ± 1% in control group, and to 86 ± 1% in oropharyngeal oxygenation device group. In the high flow nasal oxygen group, oxygen level dropped to 72 ± 1% in the 20 L/90% group and to 44 ± 1% in the 60 L/45% group. Oxygen level remained at 98 ± 0% in the face mask group. In conclusion, in this manikin simulation study of apneic oxygenation, oxygen insufflation using a sealed face mask kept oxygen levels in the test lung at 98% over 20 minutes, oral oxygenation device led to oxygen levels at 86%, whereas all other methods resulted in the decrease of oxygen levels below 75%.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"12 1","pages":"28-31"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/ee/MGR-12-28.PMC8447949.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39393222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of hyperbaric oxygen in glioma: a narrative review.","authors":"Wen-Jie Wang,&nbsp;Jia-Sheng Ding,&nbsp;Qing Sun,&nbsp;Xiang Xu,&nbsp;Gang Chen","doi":"10.4103/2045-9912.324589","DOIUrl":"https://doi.org/10.4103/2045-9912.324589","url":null,"abstract":"<p><p>Gliomas are common brain mass with a high mortality rate. Patients with gliomas have a severely bad outcome, with an average survive duration less 15 months because of high recurrent rate and being resistant to radio-therapy and chemistry drugs therapy. Hyperbaric oxygen is extensively taken as an adjuvant treatment for various disease conditions. To know the characteristics of hyperbaric oxygen as a remedy for gliomas, we find that, in general, hyperbaric oxygen shows an obviously positive effect on the treatment of gliomas, and it can also relieve the complications caused by postoperative radiotherapy and chemotherapy of gliomas. Whereas, several researches have shown that hyperbaric oxygen promotes glioma progression.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"12 1","pages":"1-5"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/34/83/MGR-12-1.PMC8447952.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39377175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the effect of xenon and sevoflurane anesthesia on postoperative neural injury biomarkers: a randomized controlled trial.","authors":"Steven McGuigan,&nbsp;Lisbeth Evered,&nbsp;David A Scott,&nbsp;Brendan Silbert,&nbsp;Henrik Zetterberg,&nbsp;Kaj Blennow","doi":"10.4103/2045-9912.324591","DOIUrl":"https://doi.org/10.4103/2045-9912.324591","url":null,"abstract":"<p><p>General anesthesia and surgery are associated with an increase in neural injury biomarkers. Elevations of these neural injury biomarkers in the perioperative period are associated with postoperative delirium. Xenon has been shown to be protective against a range of neurological insults in animal models. It remains to be seen if xenon anesthesia is neuroprotective in the perioperative setting in humans. Twenty-four participants scheduled for lithotripsy were randomized to receive either xenon or sevoflurane general anesthesia. There was no statistically significant difference in the concentrations of postoperative neural injury biomarkers between the xenon and sevoflurane group. Following the procedure there was a significant increase in the concentration from baseline of all three biomarkers at 1 hour post-induction with a return to baseline at 5 hours. General anesthesia for lithotripsy was associated with a significant increase at 1 hour post-induction in the neural injury biomarkers total tau, neurofilament light and tau phosphorylated at threonine 181, a marker of tau phosphorylation. The protocol was approved by the St. Vincent's Hospital Melbourne Ethics Committee (approval No. HREC/18/SVHM/221) on July 20, 2018 and was registered with the Australia New Zealand Clinical Trials Registry (registration No. ACTRN12618000916246) on May 31, 2018.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"12 1","pages":"10-17"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/e9/MGR-12-10.PMC8447955.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39393218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}