Medical Gas Research最新文献_第9页

Identifying medically relevant xenon protein targets by in silico screening of the structural proteome. 通过结构蛋白质组的硅筛选鉴定医学上相关的氙蛋白靶点。

IF 2.9

Medical Gas Research Pub Date : 2023-01-01 DOI: 10.4103/2045-9912.333858

David A Winkler, Ira Katz, Andrew Warden, Aaron W Thornton, Géraldine Farjot

{"title":"Identifying medically relevant xenon protein targets by in silico screening of the structural proteome.","authors":"David A Winkler, Ira Katz, Andrew Warden, Aaron W Thornton, Géraldine Farjot","doi":"10.4103/2045-9912.333858","DOIUrl":"https://doi.org/10.4103/2045-9912.333858","url":null,"abstract":"In a previous study, in silico screening of the binding of almost all proteins in the Protein Data Bank to each of the five noble gases xenon, krypton, argon, neon, and helium was reported. This massive and rich data set requires analysis to identify the gas-protein interactions that have the best binding strengths, those where the binding of the noble gas occurs at a site that can modulate the function of the protein, and where this modulation might generate clinically relevant effects. Here, we report a preliminary analysis of this data set using a rational, heuristic score based on binding strength and location. We report a partial prioritized list of xenon protein targets and describe how these data can be analyzed, using arginase and carbonic anhydrase as examples. Our aim is to make the scientific community aware of this massive, rich data set and how it can be analyzed to accelerate future discoveries of xenon-induced biological activity and, ultimately, the development of new \"atomic\" drugs.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a0/44/MGR-13-33.PMC9480358.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40682258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparison between Air Q and intubating laryngeal mask airway as intubation conduits in patients with simulated fixed cervical spine: a prospective observational study. Air Q与插管式喉罩气道在模拟颈椎固定患者插管中的比较:一项前瞻性观察研究。

IF 2.9

Medical Gas Research Pub Date : 2023-01-01 DOI: 10.4103/2045-9912.350920

Renu Bala, Jasmine Basumatary, Priyanka Bansal

{"title":"Comparison between Air Q and intubating laryngeal mask airway as intubation conduits in patients with simulated fixed cervical spine: a prospective observational study.","authors":"Renu Bala, Jasmine Basumatary, Priyanka Bansal","doi":"10.4103/2045-9912.350920","DOIUrl":"https://doi.org/10.4103/2045-9912.350920","url":null,"abstract":"The intubating laryngeal mask airway (ILMA) can be used for ventilation and oxygenation between intubation attempts, but there is a varied success rate ranging from 33% to 96%. Air Q is a relatively new entrant. Parker flex tube aids in atraumatic intubation. The primary aim of this study was to compare Air Q intubating laryngeal airway with ILMA as intubation conduits in patients with simulated fixed cervical spine using a Parker flex tube. It was a single-blinded, randomized, prospective, and comparative study conducted on 91 patients aged between 18 to 60 years of either sex, scheduled to undergo elective surgery under general anesthesia belonging to the American Society of Anesthesiologists physical status I and II. Out of 45 patients in each group, Air Q was successfully placed in 43 patients and ILMA was successfully placed in 44 patients. 35.56% of the patients required maneuvers for placing the Air Q, whereas, for placing the ILMA, only 15.56% of the patients required maneuvers. Intubation through the AIR Q was successful in 39 patients and through the ILMA in 44 patients, but there was no significant difference between the two groups. The number of attempts and the time of device insertion were comparable. There were a similar number of attempts, maneuvers required, and time is taken for endotracheal intubation. The incidence of cough and sore throat was comparable in both groups. We conclude that ILMA has a higher success rate than Air Q for tracheal intubation with Parker Flex tube in patients with simulated fixed cervical spine. More optimized maneuvers were required for the placement of Air Q.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/f9/MGR-13-10.PMC9480356.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40695479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of nitric oxide and hydrogen sulfide in spinal cord injury: an updated review 一氧化氮和硫化氢在脊髓损伤中的作用:最新综述

Medical Gas Research Pub Date : 2023-01-01 DOI: 10.4103/2045-9912.385946

Haitao Shen, Gang Cui, Xiaoliang Wen, Yang Ye, Zhengquan Yu, Gang Chen