David A Winkler, Ira Katz, Andrew Warden, Aaron W Thornton, Géraldine Farjot
{"title":"Identifying medically relevant xenon protein targets by <i>in silico</i> screening of the structural proteome.","authors":"David A Winkler, Ira Katz, Andrew Warden, Aaron W Thornton, Géraldine Farjot","doi":"10.4103/2045-9912.333858","DOIUrl":"https://doi.org/10.4103/2045-9912.333858","url":null,"abstract":"<p><p>In a previous study, in silico screening of the binding of almost all proteins in the Protein Data Bank to each of the five noble gases xenon, krypton, argon, neon, and helium was reported. This massive and rich data set requires analysis to identify the gas-protein interactions that have the best binding strengths, those where the binding of the noble gas occurs at a site that can modulate the function of the protein, and where this modulation might generate clinically relevant effects. Here, we report a preliminary analysis of this data set using a rational, heuristic score based on binding strength and location. We report a partial prioritized list of xenon protein targets and describe how these data can be analyzed, using arginase and carbonic anhydrase as examples. Our aim is to make the scientific community aware of this massive, rich data set and how it can be analyzed to accelerate future discoveries of xenon-induced biological activity and, ultimately, the development of new \"atomic\" drugs.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a0/44/MGR-13-33.PMC9480358.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40682258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison between Air Q and intubating laryngeal mask airway as intubation conduits in patients with simulated fixed cervical spine: a prospective observational study.","authors":"Renu Bala, Jasmine Basumatary, Priyanka Bansal","doi":"10.4103/2045-9912.350920","DOIUrl":"https://doi.org/10.4103/2045-9912.350920","url":null,"abstract":"<p><p>The intubating laryngeal mask airway (ILMA) can be used for ventilation and oxygenation between intubation attempts, but there is a varied success rate ranging from 33% to 96%. Air Q is a relatively new entrant. Parker flex tube aids in atraumatic intubation. The primary aim of this study was to compare Air Q intubating laryngeal airway with ILMA as intubation conduits in patients with simulated fixed cervical spine using a Parker flex tube. It was a single-blinded, randomized, prospective, and comparative study conducted on 91 patients aged between 18 to 60 years of either sex, scheduled to undergo elective surgery under general anesthesia belonging to the American Society of Anesthesiologists physical status I and II. Out of 45 patients in each group, Air Q was successfully placed in 43 patients and ILMA was successfully placed in 44 patients. 35.56% of the patients required maneuvers for placing the Air Q, whereas, for placing the ILMA, only 15.56% of the patients required maneuvers. Intubation through the AIR Q was successful in 39 patients and through the ILMA in 44 patients, but there was no significant difference between the two groups. The number of attempts and the time of device insertion were comparable. There were a similar number of attempts, maneuvers required, and time is taken for endotracheal intubation. The incidence of cough and sore throat was comparable in both groups. We conclude that ILMA has a higher success rate than Air Q for tracheal intubation with Parker Flex tube in patients with simulated fixed cervical spine. More optimized maneuvers were required for the placement of Air Q.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/f9/MGR-13-10.PMC9480356.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40695479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haitao Shen, Gang Cui, Xiaoliang Wen, Yang Ye, Zhengquan Yu, Gang Chen
{"title":"The role of nitric oxide and hydrogen sulfide in spinal cord injury: an updated review","authors":"Haitao Shen, Gang Cui, Xiaoliang Wen, Yang Ye, Zhengquan Yu, Gang Chen","doi":"10.4103/2045-9912.385946","DOIUrl":"https://doi.org/10.4103/2045-9912.385946","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haitao Shen, Zhengquan Yu, Yang Ye, Jinhui Xu, Gang Chen
{"title":"Neuroprotective effects of hydrogen sulfide in Parkinson's disease","authors":"Haitao Shen, Zhengquan Yu, Yang Ye, Jinhui Xu, Gang Chen","doi":"10.4103/2045-9912.385945","DOIUrl":"https://doi.org/10.4103/2045-9912.385945","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of hyperbaric oxygen on Notch signaling pathway after severe carbon monoxide poisoning in mice.","authors":"Hui-Jun Hu, Dan-Feng Fan, Zhou-Heng Ye, Qiang Sun","doi":"10.4103/2045-9912.344971","DOIUrl":"https://doi.org/10.4103/2045-9912.344971","url":null,"abstract":"<p><p>Demyelination of the cerebral white matter is the most common pathological change after carbon monoxide (CO) poisoning. Notch signaling, the mechanism underlying the differentiation of astrocytes and oligodendrocytes, is critical to remyelination of the white matter after brain lesion. The purpose of this work was to determine the effects of hyperbaric oxygen (HBO) on Notch signaling pathway after CO poisoning for the explanation of the protective effects of HBO on CO-poisoning-related cerebral white matter demyelination. The male C57 BL/6 mice with severe CO poisoning were treated by HBO. And HBO therapy shortened the escape latency and improved the body mass after CO poisoning. HBO therapy also significantly suppressed protein and mRNA levels of Notch1 and Hes5 after CO poisoning. Our findings suggested that HBO could suppress the activation of Notch signaling pathway after CO poisoning, which is the mechanism underlying the neuroprotection of HBO on demyelination after severe CO poisoning.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3c/f2/MGR-13-23.PMC9480357.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10639798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alireza Kamali, Hesameddin Modir, Negar Hafez-Alsehe, Amir Almasi-Hashiani
{"title":"Effects of dexmedetomidine, fentanyl and magnesium sulfate added to ropivacaine on sensory and motor blocks in lower abdominal surgery: a randomized clinical trial","authors":"Alireza Kamali, Hesameddin Modir, Negar Hafez-Alsehe, Amir Almasi-Hashiani","doi":"10.4103/2045-9912.385947","DOIUrl":"https://doi.org/10.4103/2045-9912.385947","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wanchun You, Jianguo Xu, Hang Li, Siyuan Yang, Jiahe Wang, Gang Chen
{"title":"The potential role of nitrogen dioxide inhalation in Parkinson’s disease","authors":"Wanchun You, Jianguo Xu, Hang Li, Siyuan Yang, Jiahe Wang, Gang Chen","doi":"10.4103/2045-9912.385940","DOIUrl":"https://doi.org/10.4103/2045-9912.385940","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of hyperbaric oxygen in idiopathic sudden sensorineural hearing loss","authors":"Jiang Wu, Yukun Hu, Yang Ye, Xiaoyu Ji","doi":"10.4103/2045-9912.385943","DOIUrl":"https://doi.org/10.4103/2045-9912.385943","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HabibM R Karim, MaheshS Kurwe, SubrataK Singha, PraveenK Neema, ChinmayaK Panda
{"title":"Effect of real-time oxygen consumption versus fixed flow-based low flow anesthesia on oxygenation and perfusion: a randomized, single-blind study","authors":"HabibM R Karim, MaheshS Kurwe, SubrataK Singha, PraveenK Neema, ChinmayaK Panda","doi":"10.4103/2045-9912.385938","DOIUrl":"https://doi.org/10.4103/2045-9912.385938","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}