Medical Gas Research最新文献

Heme oxygenase/carbon monoxide system and development of the heart. 血红素含氧酶/一氧化碳系统与心脏的发育

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Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-09-25 DOI: 10.4103/mgr.MEDGASRES-D-24-00031

Vicki L Mahan

{"title":"Heme oxygenase/carbon monoxide system and development of the heart.","authors":"Vicki L Mahan","doi":"10.4103/mgr.MEDGASRES-D-24-00031","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00031","url":null,"abstract":"Progressive differentiation controlled by intercellular signaling between pharyngeal mesoderm, foregut endoderm, and neural crest-derived mesenchyme is required for normal embryonic and fetal development. Gasotransmitters (criteria: 1) a small gas molecule; 2) freely permeable across membranes; 3) endogenously and enzymatically produced and its production regulated; 4) well-defined and specific functions at physiologically relevant concentrations; 5) functions can be mimicked by exogenously applied counterpart; and 6) cellular effects may or may not be second messenger-mediated, but should have specific cellular and molecular targets) are integral to gametogenesis and subsequent embryogenesis, fetal development, and normal heart maturation. Important for in utero development, the heme oxygenase/carbon monoxide system is expressed during gametogenesis, by the placenta, during embryonic development, and by the fetus. Complex sequences of biochemical pathways result in the progressive maturation of the human heart in utero . The resulting myocardial architecture, consisting of working myocardium, coronary arteries and veins, epicardium, valves and cardiac skeleton, endocardial lining, and cardiac conduction system, determines function. Oxygen metabolism in normal and maldeveloping hearts, which develop under reduced and fluctuating oxygen concentrations, is poorly understood. \"Normal\" hypoxia is critical for heart formation, but \"abnormal\" hypoxia in utero affects cardiogenesis. The heme oxygenase/carbon monoxide system is important for in utero cardiac development, and other factors also result in alterations of the heme oxygenase/carbon monoxide system during in utero cardiac development. This review will address the role of the heme oxygenase/carbon monoxide system during cardiac development in embryo and fetal development.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"10-22"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disrupting the activity of endogenous gas neurotransmitters: a therapeutic strategy using engineered metal-organic frameworks for cancer. 干扰内源性气体神经递质的活性：利用工程金属有机框架治疗癌症的策略。

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Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-09-25 DOI: 10.4103/mgr.MEDGASRES-D-24-00046

Nan Wang, Yichao Tao, Yang Yang, Yuqin Jin, Hui Zhang, Cheng Li, Huanlong Qin, Qian Chen

引用次数: 0

Oxygen-ozone therapy for myocardial ischemic stroke and cardiovascular disorders. 氧-臭氧疗法治疗心肌缺血中风和心血管疾病。

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Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-08-31 DOI: 10.4103/mgr.MEDGASRES-D-23-00013

Sergio Pandolfi, Salvatore Chirumbolo, Marianno Franzini, Umberto Tirelli, Luigi Valdenassi

{"title":"Oxygen-ozone therapy for myocardial ischemic stroke and cardiovascular disorders.","authors":"Sergio Pandolfi, Salvatore Chirumbolo, Marianno Franzini, Umberto Tirelli, Luigi Valdenassi","doi":"10.4103/mgr.MEDGASRES-D-23-00013","DOIUrl":"10.4103/mgr.MEDGASRES-D-23-00013","url":null,"abstract":"Cardiovascular diseases (CVDs) represent a major concern for human health worldwide. Emergencies in this field include wide repertories of studies dealing primarily with CVD prevention. In addition to dietary habits and lifestyles, medical knowledge is fully needed to improve public educational programs toward cardiovascular risk factors and to enrich the endowment of pharmaceutical options and therapies to address CVDs, particularly for ischemic damage due to an impairment in the endothelial-myocardial relationship. Because ozone is a stimulator of the endothelial nitric oxide synthase/nitric oxide pathway, ozone therapy has been widely demonstrated to have the ability to counteract endothelial-cardiac disorders, providing a novel straightforward opportunity to reduce the impact of CVDs, including atrial fibrillation. In this review, we attempt to establish a state-of-the-art method for the use of ozone in CVD, suggesting that future remarks be addressed to provide fundamental insights into this issue. The purpose of this study was to highlight the role of ozone in the adjunctive medical treatment of cardiovascular pathologies such as acute myocardial infarction due to ischemic disorders.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"36-43"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperbaric oxygen treatment promotes tendon-bone interface healing in a rabbit model of rotator cuff tears. 高压氧治疗可促进肩袖撕裂兔模型中肌腱与骨骼界面的愈合。

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Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-08-31 DOI: 10.4103/mgr.MEDGASRES-D-24-00034

Hongqiu Li, Meiling Xiao, Feng Yang, Zhonghai Zhao, A Liang

{"title":"Hyperbaric oxygen treatment promotes tendon-bone interface healing in a rabbit model of rotator cuff tears.","authors":"Hongqiu Li, Meiling Xiao, Feng Yang, Zhonghai Zhao, A Liang","doi":"10.4103/mgr.MEDGASRES-D-24-00034","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00034","url":null,"abstract":"Due to the high-intensity pressure that the shoulder cuff endures, it is prone to traumas and tears. The main critical function of the shoulder cuff muscles is to effectively facilitate shoulder movement and securely maintain the humeral head in the precise center of the joint cavity to prevent superior migration during abduction processes. Shoulder cuff injuries typically involve the muscle-tendon-bone interface, but existing repair techniques do not always guarantee complete and secure healing, leading to retears. Hyperbaric oxygen therapy, as an auxiliary treatment, can significantly promote the muscle-tendon-bone healing process. To explore the impact of hyperbaric oxygen therapy on the bone-tendon interface healing process in a rabbit model specifically designed for shoulder cuff tears, an experiment was conducted on New Zealand white rabbits by performing a full-thickness tear of the supraspinatus tendon in the left shoulder, followed by 2 hours per day of 100% oxygen treatment at 2 absolute atmospheres for 5 days. The results indicate that hyperbaric oxygen therapy significantly enhances vascularization at the interface between the shoulder cuff and tendon-bone, promotes collagen fiber regeneration in the tendon, improves the tensile strength of the tendon-bone complex, and does not have a significant effect on biomechanical stability. This suggests that hyperbaric oxygen therapy has a significant positive impact on the histological and biomechanical healing of shoulder cuff tears in rabbits, expediting the healing process of the tendon-bone interface.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"164-170"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of lung function with brachial artery function and cardiac function in divers after hyperbaric exposure. 高压氧暴露后潜水员肺功能与肱动脉功能和心脏功能的相关性。

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Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-07-25 DOI: 10.4103/mgr.MEDGASRES-D-24-00037

Lijun Yin, Tingting Zhang, Yukun Wen, Xuhua Yu, Jiajun Xu, Shifeng Wang, Wenwu Liu

引用次数: 0

Not a laughing matter: revisiting nitric oxide as a potential target for glaucoma therapy. 并非笑谈：重新审视一氧化氮作为青光眼治疗的潜在靶点。

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Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-06-26 DOI: 10.4103/mgr.MEDGASRES-D-24-00004

Ayobami Adebayo, Eyitayo Adebayo

引用次数: 0

Unveiling the link: exploring muscle oxygen saturation in fibromyalgia and its implications for symptomatology and therapeutic strategies. 揭示联系：探索纤维肌痛中的肌肉氧饱和度及其对症状学和治疗策略的影响。

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Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-04-21 DOI: 10.4103/mgr.MEDGASRES-D-24-00013

Alejandro Rubio-Zarapuz, Jose A Parraca, José Francisco Tornero-Aguilera, Vicente J Clemente-Suárez

{"title":"Unveiling the link: exploring muscle oxygen saturation in fibromyalgia and its implications for symptomatology and therapeutic strategies.","authors":"Alejandro Rubio-Zarapuz, Jose A Parraca, José Francisco Tornero-Aguilera, Vicente J Clemente-Suárez","doi":"10.4103/mgr.MEDGASRES-D-24-00013","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00013","url":null,"abstract":"Fibromyalgia, characterized as a complex chronic pain syndrome, presents with symptoms of pervasive musculoskeletal pain, significant fatigue, and pronounced sensitivity at specific anatomical sites. Despite extensive research efforts, the origins of fibromyalgia remain enigmatic. This narrative review explores the intricate relationship between muscle oxygen saturation and fibromyalgia, positing that disruptions in the oxygenation processes within muscle tissues markedly influence the symptom profile of this disorder. Muscle oxygen saturation, crucial for muscle function, has been meticulously investigated in fibromyalgia patients through non-invasive techniques such as near-infrared spectroscopy and magnetic resonance imaging. The body of evidence consistently indicates substantial alterations in oxygen utilization within muscle fibers, manifesting as reduced efficiency in oxygen uptake during both rest and physical activity. These anomalies play a significant role in fibromyalgia's symptomatology, especially in terms of chronic pain and severe fatigue, potentially creating conditions that heighten pain sensitivity and accumulate metabolic byproducts. Hypothesized mechanisms for these findings encompass dysfunctions in microcirculation, mitochondrial irregularities, and autonomic nervous system disturbances, all meriting further research. Understanding the dynamics of muscle oxygen saturation in fibromyalgia is of paramount clinical importance, offering the potential for tailored therapeutic approaches to alleviate symptoms and improve the quality of life for sufferers. This investigation not only opens new avenues for innovative research but also fosters hope for more effective treatment strategies and improved outcomes for individuals with fibromyalgia.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 1","pages":"58-72"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-09-25 DOI: 10.4103/mgr.MEDGASRES-D-24-00047

Gerardo Tricarico, Mauro Poggialini, Valter Travagli

引用次数: 0

New approach of modern pharmacology: from gasotransmitters to traditional mineral drugs. 现代药理学的新方法：从气体递质到传统矿物药。

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Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-06-26 DOI: 10.4103/mgr.MEDGASRES-D-24-00022

Yefan Duan, Jianfei Sun

引用次数: 0

Warm alkaline hydrogen peroxide solution as an oxygen-releasing antihypoxic drug: potential benefits and applications. 温碱性过氧化氢溶液作为一种释放氧气的抗缺氧药物：潜在的益处和应用。

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