Medical Gas Research最新文献

{"title":"Retraction: Carbon monoxide inhibits Fas activating antibody-induced apoptosis in endothelial cells.","authors":"","doi":"10.4103/2045-9912.374045","DOIUrl":"10.4103/2045-9912.374045","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1186/2045-9912-1-8].</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"13 4","pages":"180"},"PeriodicalIF":2.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/89/55/MGR-13-180.PMC10226690.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9898417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The overlooked benefits of hydrogen-producing bacteria.","authors":"Yusuke Ichikawa,&nbsp;Haru Yamamoto,&nbsp;Shin-Ichi Hirano,&nbsp;Bunpei Sato,&nbsp;Yoshiyasu Takefuji,&nbsp;Fumitake Satoh","doi":"10.4103/2045-9912.344977","DOIUrl":"https://doi.org/10.4103/2045-9912.344977","url":null,"abstract":"<p><p>Intestinal bacteria can be classified into \"beneficial bacteria\" and \"harmful bacteria.\" However, it is difficult to explain the mechanisms that make \"beneficial bacteria\" truly beneficial to human health. This issue can be addressed by focusing on hydrogen-producing bacteria in the intestines. Although it is widely known that molecular hydrogen can react with hydroxyl radicals, generated in the mitochondria, to protect cells from oxidative stress, the beneficial effects of hydrogen are not fully pervasive because it is not generally thought to be metabolized in vivo. In recent years, it has become clear that there is a close relationship between the amount of hydrogen produced by intestinal bacteria and various diseases, and this report discusses this relationship.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"13 3","pages":"108-111"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/25/MGR-13-108.PMC9979208.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9076376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A major leak from the condenser assembly of the anesthesia workstation.","authors":"Amit Rai,&nbsp;Krithika Ramamoorthy,&nbsp;Sachin Kulkarni,&nbsp;Sameer Taneja","doi":"10.4103/2045-9912.345173","DOIUrl":"https://doi.org/10.4103/2045-9912.345173","url":null,"abstract":"Dear Editor, From a simple pneumatic device of the early 20th century, the anesthesia machine has evolved to incorporate various mechanical, electrical and electronic components to be more appropriately called anesthesia workstation.1 Despite advanced technology, a remote but life-threatening possibility of intraoperative machine malfunction exists. The leakage in the anesthesia circuit may result in hypoventilation, hypoxia, awareness, pollution of operating room and ventilatory failure even leading to death.2 Various causes of leaks in the breathing system have been reported in the literature that includes failure of an adjustable pressure limiting valve to close, mis-installation of a canister,3 weak connections in between different parts of the breathing circuit. We reported a case of gas leak from an unconventional site in the Datex Ohmeda Aespire View (GE Healthcare Pvt. Ltd. (India), Bangalore, India) workstation after anesthesia machine checks. As a routine, the complete pre-use anesthesia machine check was performed through the electronic self-check. A complete pre-use check of the machine included cylinders, pipelines, low-pressure system, vaporizers, breathing circuits, monitors and integrated ventilator. The circle system was also checked for any leaks and the ventilator systems were checked by setting the oxygen flow meter at minimum flows. However, after preliminary checks, soda lime in the carbon dioxide (CO2) absorber canister was changed. The canister was then reattached firmly. The water trap was also drained at this time. The patient was induced with propofol but bag mask ventilation was not adequate. There was a chest rise along with an end tidal CO2 trace but the reservoir bag was not filled adequately at a usual flow of 5 L/min. An oropharyngeal airway was inserted, and the flow increased to 10 L/min and the bag was filled better. The trachea was intubated with an 8.5 mm internal diameter cuffed endotracheal polyvinyl chloride tube using succinylcholine. However, the bag still required higher flows to fill up and when turned to the ventilation mode, the bellows required more than 8 L/min to fill up. We checked all the connections in the external circuit but found no loose connections or leaks. However, there was a large audible leak heard from the soda lime canister assembly. The CO2 absorber canister was removed and put back again to ensure that it is secured appropriately and locked. However, the audible leak still persisted. We decided to go ahead with the surgery as it was an emergency and ventilate the patient manually using Bains circuit. After the surgery got over, a detailed inspection of the CO2 canister assembly was done, and the leak seemed to originate from the EZchange and condenser part of the machine (Figure 1). Further evaluation revealed no issue in the EZchange part. The drain button of the condenser, however, was stuck in a semiopen position due to a soda lime granule trapped under the flap valve, leading ","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"13 3","pages":"159-160"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c2/12/MGR-13-159.PMC9979204.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9076378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular hydrogen therapy for neurological diseases: a review of current evidence.","authors":"Dinesh Ramanathan,&nbsp;Lei Huang,&nbsp;Taylor Wilson,&nbsp;Warren Boling","doi":"10.4103/2045-9912.359677","DOIUrl":"https://doi.org/10.4103/2045-9912.359677","url":null,"abstract":"<p><p>Reactive oxygen species and other free radicals cause oxidative stress which is the underlying pathogenesis of cellular injury in various neurological diseases. Molecular hydrogen therapy with its unique biological property of selectively scavenging pathological free radicals has demonstrated therapeutic potential in innumerable animal studies and some clinical trials. These studies have implicated several cellular pathways affected by hydrogen therapy in explaining its anti-inflammatory and antioxidative effects. This article reviews relevant animal and clinical studies that demonstrate neuroprotective effects of hydrogen therapy in stroke, neurodegenerative diseases, neurotrauma, and global brain injury.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"13 3","pages":"94-98"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c8/95/MGR-13-94.PMC9979207.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9076373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"H₂-induced transient upregulation of phospholipids with suppression of energy metabolism.","authors":"Masumi Iketani,&nbsp;Iwao Sakane,&nbsp;Yasunori Fujita,&nbsp;Masafumi Ito,&nbsp;Ikuroh Ohsawa","doi":"10.4103/2045-9912.344973","DOIUrl":"https://doi.org/10.4103/2045-9912.344973","url":null,"abstract":"<p><p>Molecular hydrogen (H₂) is an antioxidant and anti-inflammatory agent; however, the molecular mechanisms underlying its biological effects are largely unknown. Similar to other gaseous molecules such as inhalation anesthetics, H₂ is more soluble in lipids than in water. A recent study demonstrated that H₂ reduces radical polymerization-induced cellular damage by suppressing fatty acid peroxidation and membrane permeability. Thus, we sought to examine the effects of short exposure to H₂ on lipid composition and associated physiological changes in SH-SY5Y neuroblastoma cells. We analyzed cells by liquid chromatography-high-resolution mass spectrometry to define changes in lipid components. Lipid class analysis of cells exposed to H₂ for 1 hour revealed transient increases in glycerophospholipids including phosphatidylethanolamine, phosphatidylinositol, and cardiolipin. Metabolomic analysis also showed that H₂ exposure for 1 hour transiently suppressed overall energy metabolism accompanied by a decrease in glutathione. We further observed alterations to endosomal morphology by staining with specific antibodies. Endosomal transport of cholera toxin B to recycling endosomes localized around the Golgi body was delayed in H₂-exposed cells. We speculate that H₂-induced modification of lipid composition depresses energy production and endosomal transport concomitant with enhancement of oxidative stress, which transiently stimulates stress response pathways to protect cells.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"13 3","pages":"133-141"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e9/48/MGR-13-133.PMC9979205.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9076377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New scientific definitions: hyperbaric therapy and hyperbaric oxygen therapy.","authors":"Paul G Harch","doi":"10.4103/2045-9912.356475","DOIUrl":"https://doi.org/10.4103/2045-9912.356475","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"13 2","pages":"92-93"},"PeriodicalIF":2.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/4e/MGR-13-92.PMC9555024.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9848654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain globins in physiology and pathology.","authors":"Luo-Kun Xie,&nbsp;Shao-Hua Yang","doi":"10.4103/2045-9912.191361","DOIUrl":"https://doi.org/10.4103/2045-9912.191361","url":null,"abstract":"<p><p>Globins are globular proteins for either transport or storage of oxygen which are critical for cellular metabolism. Four globins have been identified in rodent and human brains. Among them, neuroglobin, cytoglobin and hemoglobin chains are constitutively expressed in normal brain, while myoglobin is only expressed in some neurological disorders. Studies on the molecular structure, expression and functional features of these brain globins indicated that they may play crucial roles in maintenance of neural cell survival and activity, including neurons and astrocytes. Their regulation in neurological disorders may help thoroughly understand initiation and progression of ischemia, Alzheimer's disease and glioma, <i>etc</i>. Elucidation of the brain globin functions might remarkably improve medical strategies that sustain neurological homeostasis and treat neurological diseases. Here the expression pattern and functions of brain globins and their involvement in neurological disorders are reviewed.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"6 3","pages":"154-163"},"PeriodicalIF":2.9,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a1/43/MGR-6-154.PMC5110136.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9874346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective.","authors":"Shu-Hai Shi,&nbsp;Zhi-Feng Qi,&nbsp;Yu-Min Luo,&nbsp;Xun-Ming Ji,&nbsp;Ke Jian Liu","doi":"10.4103/2045-9912.191360","DOIUrl":"https://doi.org/10.4103/2045-9912.191360","url":null,"abstract":"<p><p>Acute ischemic stroke is a common and serious neurological disease. Oxygen therapy has been shown to increase oxygen supply to ischemic tissues and improve outcomes after cerebral ischemia/reperfusion. Normobaric hyperoxia (NBO), an easily applicable and non-invasive method, shows protective effects on acute ischemic stroke animals and patients in pilot studies. However, many critical scientific questions are still unclear, such as the therapeutic time window of NBO, the long-term effects and the benefits of NBO in large clinic trials. In this article, we review the current literatures on NBO treatment of acute ischemic stroke in preclinical and clinical studies and try to analyze and identify the key gaps or unknowns in our understanding about NBO. Based on these analyses, we provide suggestions for future studies.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"6 3","pages":"147-153"},"PeriodicalIF":2.9,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/e1/MGR-6-147.PMC5110139.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon monoxide inhibits Fas activating antibody-induced apoptosis in endothelial cells.","authors":"Xue Wang,&nbsp;Yong Wang,&nbsp;Seon-Jin Lee,&nbsp;Hong Pyo Kim,&nbsp;Augustine Mk Choi,&nbsp;Stefan W Ryter","doi":"10.1186/2045-9912-1-8","DOIUrl":"https://doi.org/10.1186/2045-9912-1-8","url":null,"abstract":"<p><strong>Background: </strong>The extrinsic apoptotic pathway initiates when a death ligand, such as the Fas ligand, interacts with its cell surface receptor (ie., Fas/CD95), forming a death-inducing signaling complex (DISC). The Fas-dependent apoptotic pathway has been implicated in several models of lung or vascular injury. Carbon monoxide, an enzymatic product of heme oxygenase-1, exerts antiapoptotic effects at low concentration in vitro and in vivo.</p><p><strong>Methods: </strong>Using mouse lung endothelial cells (MLEC), we examined the antiapoptotic potential of carbon monoxide against apoptosis induced by the Fas/CD95-activating antibody (Jo2). Carbon monoxide was applied to cell cultures in vitro. The expression and/or activation of apoptosis-related proteins and signaling intermediates were determined using Western Immunoblot and co-immunoprecipitation assays. Cell death was monitored by lactate dehydrogenase (LDH) release assays. Statistical significance was determined by student T-test and a value of P < 0.05 was considered significant.</p><p><strong>Results: </strong>Treatment of MLEC with Fas-activating antibody (Jo2) induced cell death associated with the formation of the DISC, and activation of caspases (-8, -9, and -3), as well as the pro-apoptotic Bcl-2 family protein Bax. Exposure of MLEC to carbon monoxide inhibited Jo2-induced cell death, which correlated with the inhibition of DISC formation, cleavage of caspases-8, -9, and -3, and Bax activation. Carbon monoxide inhibited the phosphorylation of the Fas-associated death domain-containing protein, as well as its association with the DISC. Furthermore, carbon monoxide induced the expression of the antiapoptotic protein FLIP and increased its association with the DISC.CO-dependent cytoprotection against Fas mediated apoptosis in MLEC depended in part on activation of ERK1/2-dependent signaling.</p><p><strong>Conclusions: </strong>Carbon monoxide has been proposed as a potential therapy for lung and other diseases based in part on its antiapoptotic effects in endothelial cells. In vitro, carbon monoxide may inhibit both Fas/caspase-8 and Bax-dependent apoptotic signaling pathways induced by Fas-activating antibody in endothelial cells. Strategies to block Fas-dependent apoptotic pathways may be useful in development of therapies for lung or vascular disorders.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"1 1","pages":"8"},"PeriodicalIF":2.9,"publicationDate":"2011-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2045-9912-1-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9323873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}