Medical Gas Research最新文献

{"title":"Evaluation of the potential efficacy of the nitric oxide donor molsidomine for the treatment of schizophrenia.","authors":"Nikolaos Pitsikas","doi":"10.4103/mgr.MEDGASRES-D-24-00070","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00070","url":null,"abstract":"<p><p>Schizophrenia is a chronic devastating psychiatric disease characterized by a high recurrence rate. Pharmacological management of this disorder appears disappointing since it is associated with a lack of efficacy for negative symptoms and cognitive deficits, typical features of schizophrenia, and the presence of severe undesired side effects. Thus, novel molecules with high efficacy and low toxicity for the treatment of schizophrenia are urgently needed. The involvement of the gaseous molecule nitric oxide in the pathogenesis of schizophrenia is well documented since low concentrations of nitric oxide are associated with this psychiatric disease. Therefore, chemicals able to normalize nitric oxide levels, such as nitric oxide donors, might be useful for the management of this type of schizophrenia. Molsidomine is a nitric oxide donor and is under investigation as a novel antischizophrenia agent. The aim of this review is to critically evaluate the potential efficacy of this molecule for the treatment of schizophrenia.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"228-233"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ozone treatment on chemotherapy-induced peripheral neuropathy: a promising research area.","authors":"Bernardino Clavo, Angeles Cánovas-Molina, Carla García-Lourve, Sara Cazorla-Rivero, Mario Federico, Francisco Rodríguez-Esparragón","doi":"10.4103/mgr.MEDGASRES-D-24-00074","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00074","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 2","pages":"195-197"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive detection of early-stage lung cancer through exhaled breath volatile organic compound analysis.","authors":"V A Binson, Sania Thomas, M Subramoniam","doi":"10.4103/mgr.MEDGASRES-D-24-00101","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00101","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 2","pages":"198-199"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ethylene oxide exposure and osteoarthritis risk mediated by oxidative stress: evidence from NHANES 2013-2020.","authors":"Xinyue Yang, Jianwen Wang, Chengcheng Wei, Jia Tian, Lizhao Yan, Qishun Huang","doi":"10.4103/mgr.MEDGASRES-D-24-00054","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00054","url":null,"abstract":"<p><p>Ethylene oxide is extensively used for sterilizing medical equipment, and its carcinogenicity has been well documented. Furthermore, the onset of multiple diseases, including diabetes and hypertension, has been demonstrated to be associated with exposure to this compound. However, its association with osteoarthritis risk remains elusive. The study analyzed data from the National Health and Nutrition Examination Survey from 2013-2020, which included 6088 American adults, among whom 763 (12.5%) were diagnosed with osteoarthritis. We utilized a weighted generalized linear model to assess the correlation between ethylene oxide exposure levels and osteoarthritis risk. This study used mediation analysis to assess the functions of indicators of oxidative stress (γ-glutamyl transferase) and inflammation (alkaline phosphatase, white blood cell count, neutrophil count, and lymphocyte count) as mediators of how ethylene oxide affects osteoarthritis. The analysis revealed that elevated levels of ethylene oxide were correlated with a higher risk of osteoarthritis, even when controlling for other variables. The odds of developing osteoarthritis were 1.86 times higher in the fourth quartile than in the first quartile (95% confidence interval: 1.20-2.88, P = 0.0097, P for trend = 0.0087). Subgroup analyses indicated consistency across different cohorts. Mediation analysis revealed that oxidative stress (γ-glutamyl transferase), not inflammation, was the mediator linking ethylene oxide levels to the risk of osteoarthritis. This finding in a sample of American adults revealed a direct relationship between exposure to ethylene oxide and increased osteoarthritis risk. Oxidative stress has been suggested as a possible biological explanation for osteoarthritis caused by ethylene oxide.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"348-355"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical evaluation of the biological activity of hydrogen.","authors":"Grace Russell","doi":"10.4103/mgr.MEDGASRES-D-24-00083","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00083","url":null,"abstract":"<p><p>Hydrogen (H2), the simplest and most ubiquitous molecule in the universe, has garnered significant scientific interest over the past two decades because of its potential as an effective antioxidant and anti-inflammatory agent. Traditionally considered inert, H2 is now being re-evaluated for its unique bioactive properties. H2 selectively neutralizes reactive oxygen and nitrogen species, mitigating oxidative stress without disrupting essential cellular functions. This review therefore aims to provide a theoretical evaluation of the biological activity of H2, focusing on its pharmacokinetics, including absorption, distribution, and retention within biological systems. The pharmacokinetic profile of H2 is crucial for understanding its potential therapeutic applications. The interaction of H2 with protein pockets is of particular interest, as these sites may serve as reservoirs or active sites for H2, influencing its biological activity and retention time. Additionally, the impact of H2 on cellular signaling pathways, including those regulating glucose metabolism and oxidative stress responses, will be explored, offering insights into its potential as a modulator of metabolic and redox homeostasis. Finally, interactions with ferromagnetic molecules within biological environments, as well as effects on cellular signaling mechanisms, add another layer of complexity to the biological role of H2. By synthesizing the current research, this review seeks to elucidate the underlying mechanisms by which H2 may exert therapeutic effects while also identifying critical areas for further investigation. Understanding these aspects is essential for fully characterizing the pharmacodynamic profile of H2 and assessing its clinical potential in the treatment of oxidative stress-related disorders.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 2","pages":"266-275"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone therapy for knee osteoarthritis: a literature visualization analysis of research hotspots and prospects.","authors":"Qing Liu, Jian Liu, Guanglei Cao, Yuan Liu, Ye Huang, Xieyuan Jiang","doi":"10.4103/mgr.MEDGASRES-D-24-00099","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00099","url":null,"abstract":"<p><p>Medical ozone is a molecule composed of three oxygen atoms with anti-inflammatory, analgesic, and antioxidant functions. Ozone therapy (O 3 or O 2 - O 3 ) for knee osteoarthritis has gradually received increasing attention from researchers in recent years. Here, we discuss the research hotspots and development trends of ozone therapy for knee osteoarthritis through literature visualization and analysis. (1) From 2012 to the present, the overall trend of publications on ozone treatment for knee osteoarthritis has been increasing annually, and it has received widespread attention, especially in Iran and China. (2) Keyword analysis revealed that the keywords with the greatest number of citations for ozone treatment of knee osteoarthritis are \"osteoarthritis,\" \"ozone,\" \"knee osteoarthritis,\" \"ozone therapy,\" and \"hyaluronic acid.\" (3) The results of the cocitation analysis revealed that the themes of the cocited literature are concentrated in 11 directions: intra-articular injections, intra-articular oxygen ozone, treatment of knee osteoarthritis, rehabilitation studies, time effects, pain function, comprehensive review, growth factors, rheumatic diseases, ultrasound-guided corticosteroid injections, and placebo. (4) The hotspots of the available highly cited literature have focused mainly on the efficacy and safety of ozone or growth factors alone in the treatment of knee osteoarthritis. Most of the literature suggests that intra-articular injections are the most common form of ozone therapy, and the accuracy and safety of ozone injections can be ensured using ultrasound-guided techniques. Ozone therapy has a positive short-term effect on pain control and functional recovery within 6 months after injection, but how to maintain the long-term efficacy of ozone therapy has rarely been described. It is hypothesized that the combination of ozone and growth factors may be beneficial for prolonging the efficacy of ozone therapy. (5) Ozone therapy has no advantages over other therapies in terms of therapeutic efficacy. Compared with ozone therapy, platelet-rich plasma and growth factor-rich plasma have better long-term outcomes in the treatment of knee osteoarthritis, whereas stromal vascular components have the best effects on pain relief and functional improvement. Few studies address the combination of ozone and growth factors for the treatment of knee osteoarthritis, and a few clinical studies registered have explored other treatments (e.g., corticosteroids). (6) Future studies could further explore the specific mechanisms and optimal dosing regimens of ozone combined with different growth factors in the treatment of knee osteoarthritis to compensate for the short-term efficacy of ozone therapy and to validate the long-term efficacy and safety of this combination therapy. It is also imperative to develop international guidelines for ozone therapy for osteoarthritis of the knee as soon as possible.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"356-365"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen: an advanced and safest gas option for cancer treatment.","authors":"Nishant Gupta, N S Abd El-Gawaad, L O Mallasiy, Saad Alghamdi, Virendra Kumar Yadav","doi":"10.4103/mgr.MEDGASRES-D-24-00082","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00082","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 2","pages":"191-192"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latanoprostene bunod: the first nitric oxide-donating antiglaucoma medication.","authors":"Ghazaleh Soltani, Wesam Shamseldin Shalaby, Reza Razeghinejad","doi":"10.4103/mgr.MEDGASRES-D-24-00023","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00023","url":null,"abstract":"<p><p>Glaucoma is a chronic optic neuropathy that causes characteristic visual field defects and is considered one of the leading causes of irreversible vision loss worldwide. Lowering intraocular pressure is the only proven treatment for glaucoma. Medical therapy is usually the first-line treatment for open-angle glaucoma and ocular hypertension. Latanoprostene bunod ophthalmic drop 0.024% is a nitric oxide-donating prostaglandin F2α analog. It lowers the intraocular pressure via a dual mechanism of enhancing aqueous humor outflow through both the trabecular meshwork and uveoscleral pathways. Additionally, the nitric oxide component has shown promise in regulating ocular blood flow and promoting the survival of retinal ganglionic cells. Herein, the mechanism of action, efficacy, safety, and tolerability of the latanoprostene bunod and its effects on ocular blood flow are reviewed. Latanoprostene bunod has demonstrated strong efficacy and a favorable safety profile in both clinical trials and real-world studies. Given the promising results of latanoprostene bunod and advancements in drug delivery, topical fixed-combination and sustained-release formulations containing latanoprostene bunod and other agents targeting different intraocular pressure-lowering mechanisms may become available in the future.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 2","pages":"220-227"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risks of perturbed oxygen homeostasis: responses and adaptations to hyperoxia and hypoxia.","authors":"Johannes Burtscher, Tobias Dünnwald, Martin Faulhaber, Wolfgang Schobersberger, Michele Samaja, Martin Burtscher, Martin Kopp","doi":"10.4103/mgr.MEDGASRES-D-24-00075","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00075","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 2","pages":"189-190"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heme oxygenase/carbon monoxide system affects the placenta and preeclampsia.","authors":"Vicki L Mahan","doi":"10.4103/mgr.MEDGASRES-D-24-00081","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00081","url":null,"abstract":"<p><p>Preeclampsia affects 2% to 8% of pregnancies worldwide and results in significantly high maternal and perinatal morbidity and mortality, with delivery being the only definitive treatment. It is not a single disorder, but rather a manifestation of an insult(s) to the uteroplacental unit -whether maternal, fetal, and/or placental. Multiple etiologies have been implicated, including uteroplacental ischemia, maternal infection and/or inflammation, maternal obesity, sleep disorders, hydatidiform mole, maternal intestinal dysbiosis, autoimmune disorders, fetal diseases, breakdown of maternal-fetal immune tolerance, placental aging, and endocrine disorders. Early- and late-onset preeclampsia are associated with different etiologies: early-onset preeclampsia develops because of poor placentation, while late-onset preeclampsia occurs in women with latent maternal endothelial dysfunction. In preeclamptic placentas, acquired, genetic, and immune risk factors may result in impaired trophoblast invasion and spiral artery remodeling, which affects uteroplacental perfusion. The resulting placental hypoxia affects the heme oxygenase system-a known stress response pathway affected by hypoxia that is important during normal pregnancy and may offer a therapeutic approach in preeclampsia. This review will address the effect of the heme oxygenase/carbon monoxide system on the placenta and preeclampsia.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 2","pages":"276-287"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}