重症监护或麻醉环境下的氧分压、高氧血症和高氧。

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Medical Gas Research Pub Date : 2026-03-01 Epub Date: 2025-06-28 DOI:10.4103/mgr.MEDGASRES-D-25-00028
Sylvain Diop, Roman Mounier
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引用次数: 0

摘要

在临床研究中,氧分压(PaO2)和氧脉冲饱和度是评估血液氧合的主要变量,也是确定低氧/高氧和低氧血症/高氧血症阈值的主要变量。近年来,最佳氧合目标的确定引起了人们的极大兴趣,主要是因为高氧相关的潜在不良后果风险,而低氧相关的风险已经众所周知。在这篇简短的叙述性回顾中,我们回顾了一些生理学的基本要素,包括PaO2的含义、氧气向细胞的扩散、高氧血症和高氧血症的定义以及氧毒性的机制,以更好地理解重症监护临床医生经常遇到的这些概念。PaO2仅提供有关血液携带氧浓度的有限信息,不能确定细胞是否暴露于高氧环境。这应该考虑到未来研究的设计,旨在确定最佳氧合目标和临床医生的日常实践。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Partial pressure of oxygen, hyperoxemia and hyperoxia in the intensive care or anesthesia setting.

In clinical studies, the partial pressure of oxygen (PaO2) and oxygen pulse saturation are the main variables used to assess blood oxygenation and define the threshold of hypoxia/hyperoxia and hypoxemia/hyperoxemia. Determination of the optimal oxygenation target has generated a lot of interest in recent years, mainly because of the potential risk of worse outcomes associated with hyperoxia, whereas the risk associated with hypoxia has been already well known. In this short narrative review, we recall some fundamental elements of physiology regarding the meaning of PaO2, the diffusion of oxygen to cells, the definitions of hyperoxemia and hyperoxia and the mechanisms of oxygen toxicity to provide a better understanding of these concepts, to which intensive care clinicians are frequently confronted. PaO2 provides only limited information about oxygen concentration carried by blood and does not allow to determine whether cells are exposed to hyperoxia. This should be considered for the design of future studies that aim to determine optimal oxygenation target and by clinicians for their daily practice.

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来源期刊
Medical Gas Research
Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
5.10
自引率
13.80%
发文量
35
期刊介绍: Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.
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