富氢水减轻运动性疲劳的机制:激活免疫应答基因1-衣康酸/核因子2-相关因子2/血红素加氧酶-1通路。

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Medical Gas Research Pub Date : 2026-03-01 Epub Date: 2025-06-28 DOI:10.4103/mgr.MEDGASRES-D-24-00148
Yinyin Zhang, Yajing Ying, Xianpeng Zu, Lingling Ding, Xuan Shi, Jing Wang, Xiangtong Li, Chujian Li, Qicheng Zhou, Hui Shen, Hongxia Li, Hongtao Lu, Jin Cheng
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引用次数: 0

摘要

运动引起的疲劳限制了运动员的表现。氢分子是一种有效的缓解疲劳的治疗方法,但确切的机制尚不清楚。本研究通过建立小鼠疲劳模型,探讨富氢水减轻运动性疲劳的分子机制。结果表明,富氢水改善了疲劳小鼠的运动功能,降低了疲劳相关生物标志物(血尿素氮、乳酸和肌酸激酶)的水平,减轻了腓肠肌损伤。此外,超高效液相色谱-质谱分析显示富氢水上调免疫应答基因1 (IRG1)的表达,增加因疲劳而异常降低的衣康酸水平,进而激活下游核因子红细胞2相关因子2 (Nrf2)/血红素加氧酶1 (HO-1)通路。最后,将暴露于IRG1抑制剂(IRG1- in)或4-辛酰衣康酸(4-OI)的C2C12细胞用富氢水处理,表明富氢水有效上调细胞中Nrf2和HO-1的表达。综上所述,富氢水通过激活irg1 -衣康酸/Nrf2/HO-1通路,抑制氧化应激,缓解运动性疲劳。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechanism by which hydrogen-rich water mitigates exercise-induced fatigue: activation of the immunoresponsive gene 1-itaconate/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway.

JOURNAL/mgres/04.03/01612956-202603000-00005/figure1/v/2025-06-28T140100Z/r/image-tiff Exercise-induced fatigue limits athletic performance. Molecular hydrogen is an effective treatment for relieving fatigue, but the exact mechanism is not clear. In our study, a mouse model of fatigue was established to explore the molecular mechanism by which hydrogen-rich water reduces exercise-induced fatigue. The results showed that hydrogen-rich water improved the motor function of fatigue mice, reduced the levels of fatigue-related biomarkers (blood urea nitrogen, lactate, and creatine kinase), and alleviated gastrocnemius muscle injury. Furthermore, ultrahigh-performance liquid chromatography-mass spectrometry revealed that hydrogen-rich water upregulated the expression of immune response gene 1 (IRG1), increased the abnormally reduced levels of itaconic acid due to fatigue, and subsequently activated the downstream nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. Finally, C2C12 cells exposed to an IRG1 inhibitor (IRG1-IN) or 4-octyl itaconic acid (4-OI) were treated with hydrogen-rich water, indicating that hydrogen-rich water effectively upregulated the expression of Nrf2 and HO-1 in cells. In summary, hydrogen-rich water alleviates exercise-induced fatigue by activating the IRG1-itaconic acid/Nrf2/HO-1 pathway and inhibiting oxidative stress.

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来源期刊
Medical Gas Research
Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
5.10
自引率
13.80%
发文量
35
期刊介绍: Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.
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