Medical Gas Research最新文献

{"title":"Comprehensive strategy of sonodynamic therapy and gas therapy on tumor treatment.","authors":"Lilin Zhao, Yaqi Zhang, Qian Huang, Ting Zhang","doi":"10.4103/mgr.MEDGASRES-D-24-00152","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00152","url":null,"abstract":"<p><p>Sonodynamic therapy has emerged as a novel non-invasive treatment for cancer with limited single effects. To achieve optimal therapeutic efficacy, sonodynamic therapy frequently needs to be combined with other therapeutic strategies. By exploiting the biological properties of specific gas molecules, gas therapy is an emerging tumor treatment that exerts direct or indirect inhibitory effects on tumor cells. This review systematically examines the rationales, methodologies, and outcomes of sonodynamic therapy and gas therapy combinatorial strategies for malignant tumors. There is a synergistic effect between sonodynamic therapy and gas therapy in tumor treatment. The ultrasound-induced cavitation enhances tissue permeability for improved gas delivery, while gas molecules concurrently sensitize sonodynamic reactions and ameliorate tumor hypoxia. The interaction significantly enhances the therapeutic effect of tumors. Moreover, the combination of sonodynamic therapy with other therapeutic modalities can significantly enhance the anti-tumor efficacy, improve the therapeutic precision and safety, while improve the tumor microenvironment. This combined treatment strategy can also reduce side effects and has a broad clinical application perspective.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"16 3","pages":"269-276"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical applications of artificial intelligence-driven nitric oxide: a bibliometric and scientific mapping analysis.","authors":"Zhen Liu, Ainikaer Abulaiti, Yan Zhao, Junting Zang, Guohua Li, Li Shu, Paerhati Wahafu, Maihemuti Yakufu","doi":"10.4103/mgr.MEDGASRES-D-25-00096","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00096","url":null,"abstract":"<p><p>JOURNAL/mgres/04.03/01612956-202609000-00002/figure1/v/2026-01-06T135433Z/r/image-tiff Nitric oxide, a pivotal endogenous signaling molecule, plays crucial roles in cardiovascular regulation, immune response, and neuromodulation. The rapid advancement of artificial intelligence technologies offers novel approaches to optimize real-time nitric oxide monitoring, dosing regimens, and toxicity prediction. Current interdisciplinary research on the artificial intelligence-driven nitric oxide intersection remains fragmented, with a lack of systematic investigations into knowledge architecture, technological evolution, and translational barriers. This study addressed this critical gap by presenting the knowledge graph-based analysis of artificial intelligence-driven nitric oxide system. A total of 384 relevant articles (2005-2024) were retrieved in the Web of Science Core Collection and analyzed using CiteSpace, VOSviewer, and Bibliometrix R package. Annual publications demonstrated a biphasic growth, accelerating after 2017 in tandem with breakthroughs in artificial intelligence architectures. Although China and the United States were dominated in this field, international collaborations exhibited a core-periphery structure. Research themes predominantly focused on cardiovascular and respiratory diseases, with underdeveloped applications in neuroimmunology and infectious diseases. Highly cited literature that emphasized photodynamic therapy and disease risk assessment revealed insufficient integration between artificial intelligence algorithms and fundamental nitric oxide mechanisms. Keyword evolution analysis identified a paradigm shift from traditional mechanisms (e.g., \"blood pressure,\" \"inflammation\") to technology-driven approaches (e.g., \"machine learning, \" \"deep learning\"). Clinical translation has faced challenges, including data heterogeneity, algorithm interpretability, and deficiencies in multicenter validation. This pioneering study systematically delineates the knowledge framework and translational bottlenecks in artificial intelligence-driven nitric oxide convergence. Future research should prioritize artificial intelligence modeling of nitric oxide dynamic metabolism, the development of explainable algorithms, and prospective clinical trials to bridge the laboratory-to-clinic gap.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"16 3","pages":"194-204"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging electronic deodorization technologies for human odor management.","authors":"Solpa Lee, Pratiksha Diwe, Tae Ho Lim, Yongwoo Jang","doi":"10.4103/mgr.MEDGASRES-D-25-00127","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00127","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"16 3","pages":"311-312"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research and application of gas therapy in preventing biofilm associated infections.","authors":"Pan Yang, Yadi Wang, Xueling Li, Junhong Lü","doi":"10.4103/mgr.MEDGASRES-D-25-00075","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00075","url":null,"abstract":"<p><p>Conventional antibiotic therapies often fail to eradicate biofilms, which can lead to persistent infections and significant clinical challenges. Gas therapy, which utilizes the unique properties of gas molecules such as nitric oxide, carbon monoxide, hydrogen, and hydrogen sulfide, is emerging as a promising and innovative strategy to address these challenges. This review first highlights gas signaling in bacterial biofilms. It then goes on to list four types of gas therapy in detail: photothermal-enhanced gas therapy, photodynamic-activated gas therapy, micro/nanobubble-mediated gas therapy, and gas-based synergistic therapy. Their potential applications and future directions are also fully discussed. Due to its unique bioactivity, low resistance, and synergy with existing treatments, gas therapy has demonstrated significant potential in the prevention and treatment of biofilm-associated infections. However, overcoming delivery challenges, validating efficacy in large-scale trials, and developing standardized protocols are essential for its clinical translation. Future efforts should prioritize the integration of nanotechnology and mechanistic studies to unlock broader therapeutic utility.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"16 3","pages":"263-268"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein-bound nitrosyl iron complexes: long-lived physiological form of nitric oxide.","authors":"Olga V Kosmachevskaya, Alexey F Topunov","doi":"10.4103/mgr.MEDGASRES-D-25-00094","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00094","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"16 3","pages":"307-308"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of nitric oxide and its donors in hemorrhagic and ischemic stroke: a systematic review.","authors":"Shijun Wang, Sicen Wan, Xu Zhang, Ming Sun, Hongru Li, Gang Chen, Jiahe Wang, Xiang Li","doi":"10.4103/mgr.MEDGASRES-D-25-00161","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00161","url":null,"abstract":"&lt;p&gt;&lt;p&gt;FactsNitric oxide (NO) exhibits dual roles in stroke pathophysiology, serving as both a neuroprotective agent through vasodilation and anti-thrombotic effects, and a neurotoxic mediator via oxidative stress and glutamate excitotoxicity, depending on its concentration, timing, and source.NO has been shown to play a critical role in improving outcomes after stroke in experimental studies.The efficacy of NO-based interventions varies depending on stroke type and timing. The administration of NO and its donors in stroke therapy should be flexibly integrated based on the temporal dynamics of endogenous NO following stroke onset. Inappropriate timing of medication may exacerbate the patient's condition post-stroke.Open questionsWhat are the precise molecular mechanisms underlying the concentration-dependent dual effects of NO in different stroke subtypes, and how can we selectively enhance its beneficial while suppressing its detrimental actions?How can we optimize the timing and dosing of NO donors across heterogeneous stroke populations, especially in intracerebral hemorrhage where clinical evidence is notably scarce?Can NO-based interventions be safely translated from animal models to human patients? The limited number of clinical studies necessitates larger-scale trials to confirm efficacy and safety in diverse patient populations.What are the long-term neurological consequences of NO administration? While short-term benefits have been observed, the potential for delayed adverse effects or unintended impacts on brain function remains underexplored. Nitric oxide is a gas molecule that serves as a signaling molecule in mammals, regulating the relaxation and contraction of vascular, thereby modulating local blood flow. Stroke encompasses both hemorrhagic and ischemic subtypes, with hemorrhagic strokes further classified into subarachnoid and intracerebral hemorrhages. The vasodilatory effects of nitric oxide and its derivatives have been confirmed in both peripheral and central vascular diseases. Additionally, animal studies have demonstrated that exogenous supplementation of nitric oxide or its donors has beneficial effects on stroke. We systematically reviewed the existing research on the relationship between nitric oxide donors and stroke, and elaborated on the pathophysiological processes in which nitric oxide is involved in different types of strokes. Given the significant differences in the concentration and temporal effects of nitric oxide in various types of strokes and their pathophysiological processes, the optimal timing for exogenous nitric oxide intervention under different conditions was analyzed to enhance clinical awareness regarding the treatment with nitric oxide and its donors. Future research can place greater emphasis on the development of novel nitric oxide donors and their diverse administration routes to further optimize treatment outcomes for stroke. This review underscores the limited progress in the clinical translatio","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"16 3","pages":"241-257"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Permissive hypercapnia in acute respiratory distress syndrome: physiological mechanisms and clinical implications.","authors":"Giacoma Teri, Patricia Rm Rocco, Sergio Lassola, Denise Battaglini","doi":"10.4103/mgr.MEDGASRES-D-25-00113","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00113","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"16 3","pages":"305-306"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone injections reduce pain in knee osteoarthritis: a systematic review and meta-analysis.","authors":"Pedro Iván Arias-Vázquez, Rosa Giannina Castillo-Avila, Karen Hernández-Gil, Mauro Nicolás Guzzardo, Duilio Román Guzzardo","doi":"10.4103/mgr.MEDGASRES-D-25-00088","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00088","url":null,"abstract":"<p><p>The only intra-articular injections recommended by international guidelines for the treatment of knee osteoarthritis are injections of corticosteroids and hyaluronic acid; nonetheless, other substances including ozone, dextrose and platelet-rich plasma are also used in clinical. Intra-articular injections of ozone have been reported to have anti-inflammatory mechanisms and clinical benefits similar to intra-articular injections of corticosteroids in patients with knee osteoarthritis; however, this treatment has not been evaluated in a meta-analysis. The objective of this review is to evaluate the effectiveness of intra-articular injections of ozone for reducing pain and improving function in individuals with knee osteoarthritis when compared with intra-articular injections of corticosteroids. An online search was performed using the electronic databases PubMed, EMBASE, Central Cochrane and Web of Science, for controlled clinical trials that compared intra-articular injections of ozone and intra-articular injections of corticosteroid in the treatment of knee osteoarthritis. Seven clinical trials were included in this review, gathering 409 individuals with knee osteoarthritis. In the pooled analysis, ozone injections were found to be more effective in reducing pain in the short and medium terms than corticosteroids injections. Similarly, function improvement in the medium term was observed in favor of ozone injections. Our results suggest that ozone injections represent a good alternative to corticosteroids injections for reducing pain in the short and medium terms in individuals with knee osteoarthritis. Nonetheless, definitive conclusions could not be drawn due to the limited quality of the included studies. Better quality clinical trials are needed to strengthen the evidence and confirm these results.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"16 3","pages":"286-292"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decompression sickness type II and patent foramen ovale: when a common congenital anomaly becomes a life-threatening risk.","authors":"Alejandro Fernandez-Cisneros","doi":"10.4103/mgr.MEDGASRES-D-25-00065","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00065","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"16 2","pages":"184-185"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Old theory, new evidence: inhalational anesthetics disrupt a collective quantum state of intraneuronal microtubules to cause unconsciousness.","authors":"Michael C Wiest","doi":"10.4103/mgr.MEDGASRES-D-25-00111","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00111","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"16 2","pages":"182-183"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}