Medical Gas Research最新文献

{"title":"Various gases for the treatment of neuropathic pain: mechanisms, current status, and future perspectives.","authors":"Yan Liu, Tianhao Shen, Qiuying Li, Xue Yu, Yu Liu, Cheng Zhou, Ji Han, Yongqiang Zhu","doi":"10.4103/mgr.MEDGASRES-D-24-00161","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00161","url":null,"abstract":"<p><p>In recent years, medical gas therapy has emerged as a promising approach for treating neuropathic pain. This review article aimed to investigate the therapeutic effects of medical gas therapy on neuropathic pain and its underlying mechanisms, thereby providing a theoretical foundation for clinical practice. A literature search was conducted using the Web of Science Core Collection database. Co-occurrence analysis of keywords revealed that terms including \"neuropathic pain,\" \"nitric oxide,\" \"nitric oxide synthase,\" \"pain,\" and \"ozone\" frequently appeared. Cluster analysis grouped these keywords into four primary categories: intervertebral disc disease and gas therapy, mechanisms of neuropathic pain and gas interventions, the role of nitric oxide in modulating neuropathic pain and gas therapy, and the effects of gas therapy on mental disorders in the context of neuropathic pain treatment. The analysis of highly cited literature in the field of medical gas therapy for neuropathic pain emphasizes the crucial roles of nitric oxide and nitric oxide synthase in nerve injury and pain. Various types of gas therapy, including oxygen-ozone therapy and nitric oxide-related therapies, show promise in treating pain following peripheral nerve injury. Oxidative stress and nitric oxide are crucial regulatory factors in the pain signaling associated with trigeminal neuralgia. Ozone therapy alleviates trigeminal pain by inhibiting inflammatory responses, reducing oxidative stress, and modulating neurotransmitter release. Novel nanomaterials, such as manganese oxide nanoparticles, have also demonstrated potential in scavenging free radicals and alleviating sciatic nerve pain. Ozone therapy has shown good clinical efficacy in treating lumbar disc herniation and sciatica, whereas both ozone therapy and hyperbaric oxygen therapy have demonstrated effectiveness and safety in managing postherpetic neuralgia. In conclusion, medical gas therapy for neuropathic pain primarily includes oxygen-ozone therapy, nitric oxide-related therapies, hydrogen sulfide-related therapies, and hyperbaric oxygen therapy. While these therapies exhibit efficacy in managing neuropathic pain, further research is necessary to elucidate their mechanisms of action and safety profiles. Although hyperbaric oxygen therapy and ozone therapy have already been implemented in clinical research, other types of gas therapy are still in the animal testing phase. Therefore, future studies should focus on conducting more multicenter, large-sample randomized controlled trials to accelerate clinical translation and provide more effective treatment options for patients suffering from neuropathic pain.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 4","pages":"488-495"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of hepatic gluconeogenesis in type 2 diabetes by metformin: complementary role of nitric oxide.","authors":"Arman Farahani, Aryan Farahani, Khosrow Kashfi, Asghar Ghasemi","doi":"10.4103/mgr.MEDGASRES-D-24-00100","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00100","url":null,"abstract":"<p><p>Metformin is the first-line treatment for type 2 diabetes mellitus. Type 2 diabetes mellitus is associated with decreased nitric oxide bioavailability, which has significant metabolic implications, including enhanced insulin secretion and peripheral glucose utilization. Similar to metformin, nitric oxide also inhibits hepatic glucose production, mainly by suppressing gluconeogenesis. This review explores the combined effects of metformin and nitric oxide on hepatic gluconeogenesis and proposes the potential of a hybrid metformin-nitric oxide drug for managing type 2 diabetes mellitus. Both metformin and nitric oxide inhibit gluconeogenesis through overlapping and distinct mechanisms. In hepatic gluconeogenesis, mitochondrial oxaloacetate is exported to the cytoplasm via various pathways, including the malate, direct, aspartate, and fumarate pathways. The effects of nitric oxide and metformin on the exportation of oxaloacetate are complementary; nitric oxide primarily inhibits the malate pathway, while metformin strongly inhibits the fumarate and aspartate pathways. Furthermore, metformin effectively blocks gluconeogenesis from lactate, glycerol, and glutamine, whereas nitric oxide mainly inhibits alanine-induced gluconeogenesis. Additionally, nitric oxide contributes to the adenosine monophosphate-activated protein kinase-dependent inhibition of gluconeogenesis induced by metformin. The combined use of metformin and nitric oxide offers the potential to mitigate common side effects. For example, lactic acidosis, a known side effect of metformin, is linked to nitric oxide deficiency, while the oxidative and nitrosative stress caused by nitric oxide could be counterbalanced by metformin's enhancement of glutathione. Metformin also amplifies nitric oxide -induced activation of adenosine monophosphate-activated protein kinase. In conclusion, a metformin-nitric oxide hybrid drug can benefit patients with type 2 diabetes mellitus by enhancing the inhibition of hepatic gluconeogenesis, decreasing the required dose of metformin for maintaining optimal glycemia, and lowering the incidence of metformin-associated lactic acidosis.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 4","pages":"507-519"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of non-intubated spontaneous breathing on cerebral oxygen saturation and postoperative cognition in elderly patients with lung cancer undergoing video-assisted thoracoscopic surgery.","authors":"Lei Zhang, Yuwen Lao, Yufan Zhang","doi":"10.4103/mgr.MEDGASRES-D-25-00181","DOIUrl":"https://doi.org/10.4103/mgr.MEDGASRES-D-25-00181","url":null,"abstract":"<p><p>JOURNAL/mgres/04.03/01612956-990000000-00064/figure1/v/2025-10-02T154314Z/r/image-tiff Video-assisted thoracoscopic surgery during one-lung ventilation may impair cerebral oxygen balance and increase the risk of postoperative cognitive impairment. This perspective study aimed to analyze the effect of non-intubated anesthesia with preserved spontaneous breathing on cerebral oxygen saturation and postoperative cognitive dysfunction in elderly patients with lung cancer during video-assisted thoracoscopic surgery. A total of 104 elderly patients with lung cancer who underwent video-assisted thoracoscopic surgery in Jinhua Municipal Central Hospital from January 2023 to October 2024 were selected, and they were randomly divided into non-intubated group (n = 52) and intubated group (n = 52). The cerebral oxygen saturation, postoperative cognitive dysfunction incidence and laboratory indicators were compared between the two groups. At last, the influencing factors to postoperative cognitive dysfunction were analyzed by multivariate Logistic regression. The cerebral oxygen saturation was higher at 15, 30 and 60 minutes after operation than at the beginning of anesthesia, and moreover, it in the non-intubation group were significantly higher than that in the intubated group (P < 0.05). At 72 hours after operation, the levels of tumor necrosis factor-α, interleukin-6 and S100β in serum were lower than those before operation, and the levels in the non-intubated group were significantly lower than those in the intubated group; the levels of epinephrine, atrial natriuretic peptide and cortisol in serum were higher than those before operation, and they in the non-intubated group were significantly more than those in the intubated group (P < 0.05). The total incidence of postoperative cognitive dysfunction in intubation group was higher than that in the non-intubated group within 2 months after operation (P < 0.05). Multivariate Logistic regression analysis showed that age (odds ratio = 1.729), cerebral oxygen saturation at 30 minutes after operation (odds ratio = 0.727) and cerebral oxygen saturation at 60 minutes after operation (odds ratio = 0.734) were independent influencing factors for postoperative cognitive dysfunction (all P < 0.05). Non-tracheal intubation anesthesia with preserved spontaneous breathing can increase cerebral oxygen saturation, reduce systemic inflammatory response and stress response, and decrease the incidence of postoperative cognitive dysfunction in elderly patients with lung cancer undergoing video-assisted thoracoscopic surgery, which is conducive to promoting postoperative recovery in such patients.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ammonia as a critical metabolic modulator of anti-tumor immunity.","authors":"Liang Zhao, Zheng Hong Lee, Yatrik M Shah","doi":"10.4103/mgr.MEDGASRES-D-24-00147","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00147","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 3","pages":"446-447"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen targets in critically ill patients: from pathophysiology to population enrichment strategies.","authors":"Claudio Ripa, Laveena Munshi, Wolfgang M Kuebler, Aurora Magliocca, Fabio S Taccone, Lorraine B Ware, Giuseppe Citerio, John G Laffey, Emanuele Rezoagli","doi":"10.4103/mgr.MEDGASRES-D-24-00120","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00120","url":null,"abstract":"<p><p>Oxygen supplementation is widely used to enhance oxygen delivery and to treat or prevent hypoxia; however, it requires careful management to avoid the harmful effects of excessive oxygen exposure. Both hyperoxia (inspiratory oxygen fraction exceeding 0.21) and hyperoxemia (arterial oxygen tension oxygen partial pressure [PaO2] > 100 mmHg) can contribute to lung injury, promote systemic vasoconstriction, and increase the production of reactive oxygen species, which can impair macromolecular and cellular functions. Conversely, in certain situations, hyperoxemia may provide benefits, such as hemodynamic stabilization in hyperdynamic shock, immunomodulation, and bactericidal effects. The literature presents conflicting evidence regarding the impact of different oxygen targets (i.e., PaO2 and/or peripheral saturation of oxygen [SpO2]) on both short- and long-term outcomes in patients with acute critical conditions, such as acute respiratory distress syndrome, sepsis, cardiac arrest, and acute central nervous system injuries. These discrepancies may stem from the small differences between the oxygenation targets used in randomized trials, the physiological limitations of PaO2 and SpO2 targets, which reflect blood oxygen content rather than oxygen delivery, the lack of measurements of microvascular function or oxygen delivery, and the heterogeneity in treatment response. Furthermore, advanced analytical methods (e.g., machine learning) are emerging as promising tools to implement population enrichment strategies. By refining patient sub-group identification, these approaches can significantly optimize precision medicine, enabling more personalized oxygen therapy tailored to individual patient characteristics.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 3","pages":"409-419"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary addition of magnesium hydride nanoparticles: a breakthrough in combating high-fat diet-induced chronic kidney disease.","authors":"Hongtao Lu, Wanqiu Chen, Yajing Ying, Deqian Gu, Rui Li, Xiangtong Li, Jin Cheng, Xuejun Sun, Yinyin Zhang, Wenrui Liu, Hui Shen","doi":"10.4103/mgr.MEDGASRES-D-24-00090","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00090","url":null,"abstract":"<p><p>A substantial body of evidence indicates a positive correlation between dyslipidemia and an elevated risk of chronic kidney disease, with renal interstitial fibrosis frequently serving as a common pathway in the advanced stages of chronic kidney disease progression. Hydrogen has anti-inflammatory and antioxidant properties, and magnesium hydride nanoparticle is a material with high hydrogen storage capacity. Magnesium hydride -fortified feed is capable of releasing hydrogen gas steadily and continuously within the digestive tract. A 12-week high-fat diet significantly elevated the serum urea and creatinine levels in mice. In contrast, dietary addition of magnesium hydride demonstrated a notable protective effect against pathological conditions. Additionally, magnesium hydride -fortified feed was found to reduce renal fibrosis and thereby improve renal function. In support of these findings, an in vitro study utilizing human kidney cortical proximal tubule epithelial cells (HK-2 cells) exposed to palmitic acid under conditions mimicking a high-fat diet confirmed the renoprotective effects of magnesium hydride. Furthermore, the primary target phosphatase and tensin homologue deleted on chromosome 10 and the molecular mechanisms underlying the effects of magnesium hydride, specifically its ability to inhibit the transforming growth factor-beta -Smad family member 2 and 3 (Smad2/3) axis through downregulating the expression of phosphatase and tensin homologue deleted on chromosome 10, were elucidated. Additionally, overexpression of Hes family BHLH transcription factor 1 can negate the beneficial effects of magnesium hydride, suggesting that Hes family BHLH transcription factor 1 may serve as an upstream regulatory target in the context of the effects of magnesium hydride. In conclusion, this study demonstrated that magnesium hydride functions as a safe and effective hydrogen source capable of inhibiting the activation of the transforming growth factor-beta/Smad2/3 and protein kinase B/mechanistic target of rapamycin pathways by increasing the expression of phosphatase and tensin homologue deleted on chromosome 10. This mechanism counteracts the progression of high-fat diet-induced chronic renal damage.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 3","pages":"374-382"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application and progress of hyperbaric oxygen therapy in cardiovascular diseases.","authors":"Menglin Tian, Wenyin Du, Sen Yang, Qiwei Liao, Fuding Guo, Shaolong Li","doi":"10.4103/mgr.MEDGASRES-D-24-00107","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00107","url":null,"abstract":"<p><p>Cardiovascular diseases remain the leading cause of death worldwide, underscoring the urgent need for additional therapeutic strategies to reduce their mortality rates. This review systematically outlines the historical development and recent advances of hyperbaric oxygen therapy in cardiovascular diseases, with a focus on its therapeutic mechanisms and clinical outcomes. Hyperbaric oxygen therapy enhances oxygen delivery to ischemic and reperfused tissues, promotes angiogenesis, and significantly suppresses oxidative stress, inflammatory cascades, and cardiomyocyte apoptosis, demonstrating multifaceted therapeutic potential in cardiovascular conditions. Specifically, hyperbaric oxygen therapy combined with reperfusion strategies has been shown to markedly improve left ventricular ejection fraction in acute myocardial infarction. In heart failure, it facilitates myocardial repair and enhances cardiac function. For arrhythmias, hyperbaric oxygen therapy effectively reduces the frequency and duration of premature ventricular contractions and paroxysmal tachycardia, while mitigating the risk of neurological complications following atrial fibrillation ablation. Furthermore, hyperbaric oxygen therapy preconditioning in cardiac surgery has demonstrated improvements in left ventricular stroke work, reductions in postoperative myocardial injury, and a decrease in related complications. Despite its promising applications, the widespread adoption of hyperbaric oxygen therapy remains hindered by the lack of standardized treatment protocols and high-quality evidence from rigorous clinical trials. In conclusion, this review underscores the potential value of hyperbaric oxygen therapy in the cardiovascular domain while highlighting the need for further optimization of therapeutic parameters and exploration of its synergistic effects with conventional therapies to provide clearer guidance for clinical implementation.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 3","pages":"427-434"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials as medicinal gas sensors described by density functional theory: a comprehensive review.","authors":"Handriela Hoff de Oliveira Sobrinho, Renato Eising, Ernesto Osvaldo Wrasse","doi":"10.4103/mgr.MEDGASRES-D-24-00121","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00121","url":null,"abstract":"<p><p>Using medical gas detectors offers a promising and non-invasive approach for the early identification of diseases. This technique provides a less painful and more accessible alternative to traditional diagnostic methods. In the development of these new detection methods, the use of nanomaterials as gas sensors has proven advantageous due to their large surface areas, which enhance reactivity and sensitivity in identifying volatile compounds. To evaluate the behavior of nanomaterials when in contact with medical gases, ab initio computational simulations based on density functional theory have shown to be effective. This literature review presents studies that have applied density functional theory to investigate intermolecular interactions between specific nanosystems and gases, such as toluene, hydrogen sulfide, ammonia, and nitric oxide. These studies have yielded promising results related to adsorption and dissociation energies, electronic properties, energy gaps, bond lengths, and charge transfer, suggesting the potential of nanomaterials as effective sensors for medical gas detection.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"435-441"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone therapy addresses neuropathic pain in ulcerous wounds.","authors":"Giuseppe Masiello, Marianno Franzini, Tommaso Richelmi, Umberto Tirelli, Luigi Valdenassi, Salvatore Chirumbolo","doi":"10.4103/mgr.MEDGASRES-D-24-00145","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00145","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"15 3","pages":"448-449"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability in flow-induced vasodilation mechanisms in cerebral arteries: the impact of different hyperbaric oxygen protocols.","authors":"Ines Drenjančević, Ivana Jukić, Vedran Đambić, Ana Stupin, Nataša Kozina, Anita Matić, Petar Šušnjara, Aleksandar Kibel, Darko Biljan, Zrinka Mihaljević","doi":"10.4103/mgr.MEDGASRES-D-24-00091","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00091","url":null,"abstract":"<p><p>The present study aimed to assess the mechanisms of flow-induced dilation (FID) altered by acute/intermittent hyperbaric oxygenation (HBO 2 ) in isolated middle cerebral arteries of healthy male Sprague‒Dawley rats ( n = 96) and randomized to the Ac-HBO 2 group (exposed to a single HBO 2 session, 120 minutes of 100% O 2 at 2.0 bars), the 4Dys-HBO 2 group (4 consecutive days of single HBO 2 sessions, analyzed on the fifth day), and the CTRL (untreated) group. Results demonstrated increased vascular oxidative stress and decreased vascular nitric oxide bioavailability, as measured by direct fluorescence microscopy, leading to attenuated FID in the Ac-HBO 2 group compared with the CTRL and 4Dys-HBO 2 groups. Superoxide scavenging restored FID. Moreover, the increased expression of antioxidative enzymes in the cerebral vasculature in the 4Dys-HBO 2 group indicates the ability of intermittent HBO 2 to activate antioxidative mechanisms. Importantly, the results suggest a switch or at least activation of the compensatory mechanism of FID after HBO 2 from nitric oxide-dependent to epoxygenase metabolite-mediated via TRPV4 (transient receptor potential cation channel subfamily V member 4) and potassium channels, as demonstrated by increased protein expression of KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1), TRPV4, and Kir2 (a component of the inward rectifier-type potassium channel Kir2) in the vasculature. Overall, acute HBO 2 modulates FID in cerebral vessels by increasing oxidative stress and altering the subsequent mechanisms of FID, which are mainly mediated by nitric oxide, while suppressing potassium and TRPV4 channel function/expression due to increased oxidative stress. Moreover, intermittent HBO 2 activates antioxidative mechanisms and the compensatory mechanism of FID from nitric oxide-dependent to epoxygenase metabolite-mediated mechanisms via TRPV4, KCNMB1 and Kir2.1.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"383-390"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}