Medical Gas Research最新文献_第7页

Medical gas therapy in human diabetic wound healing. 医用气体疗法在糖尿病患者伤口愈合中的应用。

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Medical Gas Research Pub Date : 2025-06-01 Epub Date: 2025-01-18 DOI: 10.4103/mgr.MEDGASRES-D-24-00125

Xin Yee Foo, Lai Kuan Lee

引用次数: 0

Exploring the nexus between medical gases and ion channel function: implications for therapeutic innovation. 探索医用气体与离子通道功能之间的联系：对治疗创新的影响。

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Medical Gas Research Pub Date : 2025-06-01 Epub Date: 2024-12-07 DOI: 10.4103/mgr.MEDGASRES-D-24-00076

Chitaranjan Mahapatra

引用次数: 0

Restoring nitric oxide production using dietary inorganic nitrate: recent advances on cardiovascular and physical performance in middle-aged and older adults. 使用膳食无机硝酸盐恢复一氧化氮的产生：中老年人心血管和身体表现的最新进展

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Medical Gas Research Pub Date : 2025-06-01 Epub Date: 2025-01-18 DOI: 10.4103/mgr.MEDGASRES-D-24-00104

Cicero Jonas R Benjamim, Leonardo da Silva Gonçalves, Leonardo Santos Lopes da Silva, Carlos Roberto Bueno Júnior

引用次数: 0

Phototherapy for carbon monoxide poisoning: origins, innovations, and future directions. 一氧化碳中毒的光疗：起源、创新和未来方向。

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Medical Gas Research Pub Date : 2025-06-01 Epub Date: 2025-01-18 DOI: 10.4103/mgr.MEDGASRES-D-24-00103

Luca Zazzeron

引用次数: 0

Mechanisms by which sevoflurane affects cognitive function in aged marmosets and mice: up-regulation of FKBP5 expression in brain microglia. 七氟醚影响老年狨猴和小鼠认知功能的机制：上调脑小胶质细胞中FKBP5的表达。

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Medical Gas Research Pub Date : 2025-04-17 DOI: 10.4103/mgr.MEDGASRES-D-24-00155

Lei Zhang, Jiao Zhu, Zhengjie Miao, Haoli Mao, Hong Jiang

{"title":"Mechanisms by which sevoflurane affects cognitive function in aged marmosets and mice: up-regulation of FKBP5 expression in brain microglia.","authors":"Lei Zhang, Jiao Zhu, Zhengjie Miao, Haoli Mao, Hong Jiang","doi":"10.4103/mgr.MEDGASRES-D-24-00155","DOIUrl":"https://doi.org/10.4103/mgr.MEDGASRES-D-24-00155","url":null,"abstract":"JOURNAL/mgres/04.03/01612956-990000000-00062/figure1/v/2025-04-22T045710Z/r/image-tiff Inhalation anesthetics may trigger the hypothalamic-pituitary-adrenal axis. FK-506 binding protein (FKBP5) is a critical regulator of the hypothalamic- pituitary-adrenal axis and has been implicated in postoperative cognitive dysfunction. However, how inhalation anesthetics affect the expression and function of FKBP5 in the brain is unclear. We employed single-nucleus RNA sequencing to delineate the hippocampal transcriptomic profiles of the brains of aged marmosets and mice after sevoflurane anesthesia. The results of single-nucleus RNA sequencing revealed that long-term exposure (6 hours) to sevoflurane significantly increased FKBP5 expression in the hippocampus of aged marmosets and mice, especially in microglia. Western blot assay also verified the above results. The Barnes maze test showed that, compared with heterozygous control mice, microglia-specific FKBP5 conditional knockout mice exhibited improved neurocognitive function after sevoflurane/surgery. Transcriptome sequencing analysis was performed on the brains of microglia-specific FKBP5 conditional knockout mice and heterozygous mice after sevoflurane/surgery and further revealed that FKBP5 was related mainly to inflammatory signaling pathways. Therefore, these findings indicate that long-term exposure to sevoflurane increases FKBP5 expression in the hippocampus of aged marmosets and mice, which thereby affects inflammatory signaling pathways and leads to postoperative cognitive dysfunction.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxygen-ozone therapy for myocardial ischemic stroke and cardiovascular disorders. 氧-臭氧疗法治疗心肌缺血中风和心血管疾病。

IF 3

Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-08-31 DOI: 10.4103/mgr.MEDGASRES-D-23-00013

Sergio Pandolfi, Salvatore Chirumbolo, Marianno Franzini, Umberto Tirelli, Luigi Valdenassi

{"title":"Oxygen-ozone therapy for myocardial ischemic stroke and cardiovascular disorders.","authors":"Sergio Pandolfi, Salvatore Chirumbolo, Marianno Franzini, Umberto Tirelli, Luigi Valdenassi","doi":"10.4103/mgr.MEDGASRES-D-23-00013","DOIUrl":"10.4103/mgr.MEDGASRES-D-23-00013","url":null,"abstract":"Cardiovascular diseases (CVDs) represent a major concern for human health worldwide. Emergencies in this field include wide repertories of studies dealing primarily with CVD prevention. In addition to dietary habits and lifestyles, medical knowledge is fully needed to improve public educational programs toward cardiovascular risk factors and to enrich the endowment of pharmaceutical options and therapies to address CVDs, particularly for ischemic damage due to an impairment in the endothelial-myocardial relationship. Because ozone is a stimulator of the endothelial nitric oxide synthase/nitric oxide pathway, ozone therapy has been widely demonstrated to have the ability to counteract endothelial-cardiac disorders, providing a novel straightforward opportunity to reduce the impact of CVDs, including atrial fibrillation. In this review, we attempt to establish a state-of-the-art method for the use of ozone in CVD, suggesting that future remarks be addressed to provide fundamental insights into this issue. The purpose of this study was to highlight the role of ozone in the adjunctive medical treatment of cardiovascular pathologies such as acute myocardial infarction due to ischemic disorders.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"36-43"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heme oxygenase/carbon monoxide system and development of the heart. 血红素含氧酶/一氧化碳系统与心脏的发育

IF 3

Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-09-25 DOI: 10.4103/mgr.MEDGASRES-D-24-00031

Vicki L Mahan

{"title":"Heme oxygenase/carbon monoxide system and development of the heart.","authors":"Vicki L Mahan","doi":"10.4103/mgr.MEDGASRES-D-24-00031","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00031","url":null,"abstract":"Progressive differentiation controlled by intercellular signaling between pharyngeal mesoderm, foregut endoderm, and neural crest-derived mesenchyme is required for normal embryonic and fetal development. Gasotransmitters (criteria: 1) a small gas molecule; 2) freely permeable across membranes; 3) endogenously and enzymatically produced and its production regulated; 4) well-defined and specific functions at physiologically relevant concentrations; 5) functions can be mimicked by exogenously applied counterpart; and 6) cellular effects may or may not be second messenger-mediated, but should have specific cellular and molecular targets) are integral to gametogenesis and subsequent embryogenesis, fetal development, and normal heart maturation. Important for in utero development, the heme oxygenase/carbon monoxide system is expressed during gametogenesis, by the placenta, during embryonic development, and by the fetus. Complex sequences of biochemical pathways result in the progressive maturation of the human heart in utero . The resulting myocardial architecture, consisting of working myocardium, coronary arteries and veins, epicardium, valves and cardiac skeleton, endocardial lining, and cardiac conduction system, determines function. Oxygen metabolism in normal and maldeveloping hearts, which develop under reduced and fluctuating oxygen concentrations, is poorly understood. \"Normal\" hypoxia is critical for heart formation, but \"abnormal\" hypoxia in utero affects cardiogenesis. The heme oxygenase/carbon monoxide system is important for in utero cardiac development, and other factors also result in alterations of the heme oxygenase/carbon monoxide system during in utero cardiac development. This review will address the role of the heme oxygenase/carbon monoxide system during cardiac development in embryo and fetal development.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"10-22"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disrupting the activity of endogenous gas neurotransmitters: a therapeutic strategy using engineered metal-organic frameworks for cancer. 干扰内源性气体神经递质的活性：利用工程金属有机框架治疗癌症的策略。

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Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-09-25 DOI: 10.4103/mgr.MEDGASRES-D-24-00046

Nan Wang, Yichao Tao, Yang Yang, Yuqin Jin, Hui Zhang, Cheng Li, Huanlong Qin, Qian Chen

引用次数: 0

Hyperbaric oxygen treatment promotes tendon-bone interface healing in a rabbit model of rotator cuff tears. 高压氧治疗可促进肩袖撕裂兔模型中肌腱与骨骼界面的愈合。

IF 3

Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-08-31 DOI: 10.4103/mgr.MEDGASRES-D-24-00034

Hongqiu Li, Meiling Xiao, Feng Yang, Zhonghai Zhao, A Liang

{"title":"Hyperbaric oxygen treatment promotes tendon-bone interface healing in a rabbit model of rotator cuff tears.","authors":"Hongqiu Li, Meiling Xiao, Feng Yang, Zhonghai Zhao, A Liang","doi":"10.4103/mgr.MEDGASRES-D-24-00034","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00034","url":null,"abstract":"Due to the high-intensity pressure that the shoulder cuff endures, it is prone to traumas and tears. The main critical function of the shoulder cuff muscles is to effectively facilitate shoulder movement and securely maintain the humeral head in the precise center of the joint cavity to prevent superior migration during abduction processes. Shoulder cuff injuries typically involve the muscle-tendon-bone interface, but existing repair techniques do not always guarantee complete and secure healing, leading to retears. Hyperbaric oxygen therapy, as an auxiliary treatment, can significantly promote the muscle-tendon-bone healing process. To explore the impact of hyperbaric oxygen therapy on the bone-tendon interface healing process in a rabbit model specifically designed for shoulder cuff tears, an experiment was conducted on New Zealand white rabbits by performing a full-thickness tear of the supraspinatus tendon in the left shoulder, followed by 2 hours per day of 100% oxygen treatment at 2 absolute atmospheres for 5 days. The results indicate that hyperbaric oxygen therapy significantly enhances vascularization at the interface between the shoulder cuff and tendon-bone, promotes collagen fiber regeneration in the tendon, improves the tensile strength of the tendon-bone complex, and does not have a significant effect on biomechanical stability. This suggests that hyperbaric oxygen therapy has a significant positive impact on the histological and biomechanical healing of shoulder cuff tears in rabbits, expediting the healing process of the tendon-bone interface.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"164-170"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of lung function with brachial artery function and cardiac function in divers after hyperbaric exposure. 高压氧暴露后潜水员肺功能与肱动脉功能和心脏功能的相关性。

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Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-07-25 DOI: 10.4103/mgr.MEDGASRES-D-24-00037

Lijun Yin, Tingting Zhang, Yukun Wen, Xuhua Yu, Jiajun Xu, Shifeng Wang, Wenwu Liu

引用次数: 0