Medical Gas Research最新文献

{"title":"Retraction: Carbon monoxide inhibits Fas activating antibody-induced apoptosis in endothelial cells.","authors":"","doi":"10.4103/2045-9912.374045","DOIUrl":"10.4103/2045-9912.374045","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1186/2045-9912-1-8].</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/89/55/MGR-13-180.PMC10226690.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9898417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The overlooked benefits of hydrogen-producing bacteria.","authors":"Yusuke Ichikawa,&nbsp;Haru Yamamoto,&nbsp;Shin-Ichi Hirano,&nbsp;Bunpei Sato,&nbsp;Yoshiyasu Takefuji,&nbsp;Fumitake Satoh","doi":"10.4103/2045-9912.344977","DOIUrl":"https://doi.org/10.4103/2045-9912.344977","url":null,"abstract":"<p><p>Intestinal bacteria can be classified into \"beneficial bacteria\" and \"harmful bacteria.\" However, it is difficult to explain the mechanisms that make \"beneficial bacteria\" truly beneficial to human health. This issue can be addressed by focusing on hydrogen-producing bacteria in the intestines. Although it is widely known that molecular hydrogen can react with hydroxyl radicals, generated in the mitochondria, to protect cells from oxidative stress, the beneficial effects of hydrogen are not fully pervasive because it is not generally thought to be metabolized in vivo. In recent years, it has become clear that there is a close relationship between the amount of hydrogen produced by intestinal bacteria and various diseases, and this report discusses this relationship.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/25/MGR-13-108.PMC9979208.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9076376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone for the treatment of temporomandibular joint disorders: a systematic review and meta-analysis.","authors":"Rafael Torres-Rosas,&nbsp;María Eugenia Marcela Castro-Gutiérrez,&nbsp;Luis Angel Flores-Mejía,&nbsp;Eduardo Ulises Torres-Rosas,&nbsp;Roberto Miguel Nieto-García,&nbsp;Liliana Argueta-Figueroa","doi":"10.4103/2045-9912.345174","DOIUrl":"https://doi.org/10.4103/2045-9912.345174","url":null,"abstract":"<p><p>Temporomandibular joint disorders (TMD) generate pain and difficulties for mouth opening affecting the patients' quality of life. Ozone is an emerging therapy that has been proposed as a potential treatment, due to that, the evidence about its efficacy should be reviewed. Therefore, this work aimed to conduct a comprehensive systematic review to address the efficacy of ozone therapy for the treatment of pain and limited mouth opening in patients with TMD. The design of the included studies was clinical trials and observational studies, whereas, a series of cases, in vivo, and in vitro studies were excluded. The search was performed in PubMed, ClinicalTrials, Web of Science, and Scopus. Gray literature was searched at Google Scholar. Relevant data of all included studies were recorded. The risk of bias (using RoB 2) and the quality (using Grading of Recommendations Assessment, Development, and Evaluation) assessments were carried out. Meta-analyses using random-effects models of pain and maximal mouth opening data were performed. This review included 8 studies with 404 participants suffering limited function and pain related to TMD. At the overall bias of the studies, 25% exhibited some concerns and 75% had high risk; and the quality of the studies was low. The analysis of the included studies suggests that ozone therapy can diminish pain and improve the maximal mouth opening in TMD patients. However, there is no conclusive evidence of ozone therapy as a superior treatment for TMD compared with occlusal splint and pharmacotherapy.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7b/d2/MGR-13-149.PMC9979202.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10825629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isobaric forms of ropivacaine <i>vs</i>. bupivacaine in lower abdominal surgeries: a hospital-based, prospective, comparative study.","authors":"Pavitra Patil,&nbsp;Pavan Vithal Dhulkhed,&nbsp;Vithal K Dhulkhed","doi":"10.4103/2045-9912.359678","DOIUrl":"https://doi.org/10.4103/2045-9912.359678","url":null,"abstract":"<p><p>We aimed to assess whether ropivacaine (0.75%; 22.5 mg) can replace bupivacaine (0.5%; 15 mg) as a better intrathecal anesthetic in lower abdominal surgery. In this hospital-based, single-blind, randomized, prospective, comparative study, 100 patients of either sex, aged between 18 and 70 years, weighing 40-80 kg, with American Society of Anesthesiologists physical status 1 and 2, and undergoing lower abdominal surgery were randomly allocated into two groups to receive intrathecal isobaric bupivacaine 0.5% 3 mL (15 mg) or ropivacaine 0.75% 3 mL (22.5 mg). In the intraoperative period, the onset, efficacy, duration, and regression of sensory and motor blockade and the quality of anesthesia and hemodynamic effects were observed at regular intervals. The ropivacaine and bupivacaine groups were comparable for demographic parameters. The duration of onset of sensory and motor blocks was significantly shorter in the bupivacaine group (P < 0.01). In the ropivacaine group, a faster recovery from sensory block (P = 0.02) and higher segmental height [thoracic (T)10 and T8] were achieved (P < 0.01). Bradycardia and hypotension were insignificant in the ropivacaine group (P > 0.05). Isobaric ropivacaine is a better spinal anesthetic in lower abdominal surgeries as it provides faster recovery from sensory block and a higher level of segmental sensory block with fewer side-effects.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b0/5d/MGR-13-123.PMC9979211.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10825630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled study to compare analgesic efficacy of sublingual buprenorphine and intravenous tramadol in patients undergoing mastectomy.","authors":"Krishna Sumanth Dokku, Abhijit Sukumaran Nair, Srinivasa Shyam Prasad Mantha, Vibhavari Milind Naik, Mohammed Salman Saifuddin, Basanth Kumar Rayani","doi":"10.4103/2045-9912.345170","DOIUrl":"10.4103/2045-9912.345170","url":null,"abstract":"<p><p>Sublingual (SL) buprenorphine is approved for managing acute postoperative pain, characterized by easy administration, good pain relief and good patient compliance. We hypothesized that SL buprenorphine would be a better perioperative analgesic compared to intravenous (IV) opioids like tramadol in patients undergoing mastectomy surgery for breast cancer. After institutional ethics committee approval, we randomized 60 patients with breast cancer into 2 groups. In buprenorphine group, patients received 200 μg of SL buprenorphine thrice daily and in tramadol group patients received 100 mg of IV tramadol thrice daily. The analgesic efficacy of SL buprenorphine was comparable to that of IV tramadol. Visual Analogue Scale scores had no significant difference between the two groups at various time frames (0, 1, 3, 6, 12, 18 and 24 hours) at rest and movement except at 0 and 3 hours during movement when the score was lower in the tramadol group than the buprenorphine group. Four patients in the buprenorphine group received rescue analgesic (IV morphine 3 mg). Analgesic efficacy of SL buprenorphine appears comparable to IV tramadol for managing postoperative pain after mastectomy. SL buprenorphine can be administered sublingually, which is an advantage.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ac/c2/MGR-13-118.PMC9979200.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10825635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of ozonized saline solution in the treatment of <i>Proteus</i> spp. bacterial cystitis.","authors":"Ana Martiele Engelmann,&nbsp;Andressa Bueno,&nbsp;Nathalia Viana Barbosa,&nbsp;Carolina Machado,&nbsp;Diego Correa,&nbsp;Juliana Felipetto Cargnelutti,&nbsp;Cinthia Melazzo de Andrade","doi":"10.4103/2045-9912.350861","DOIUrl":"https://doi.org/10.4103/2045-9912.350861","url":null,"abstract":"<p><p>Bacterial cystitis is a common clinical problem among cats and dogs and is one of the main reasons for the administration of antimicrobials. This can cause serious damage to public and animal health, as this practice facilitates the selection of bacteria that are multidrug-resistant to antibiotics. In this context, it is urgent to understand and validate therapeutic modalities that complement antimicrobial treatment in cystitis cases. Ozone therapy has been proposed by scientists owing to the various mechanisms of action in a range of pathologies, both in human and animal medicine. This paper describes the bactericidal action of two different protocols of bladder irrigation with ozonized saline solution (59 μg/mL) in a paraplegic canine with recurrent bacterial cystitis caused by Proteus spp. In the first protocol, the bladder instillations were applied once a day for three consecutive days while in the second, successive lavages were performed throughout the day until a significant reduction in the presence of bacteria in the urine sediment. In this study, we were able to demonstrate that repeated bladder instillation within 24 hours was the most effective treatment for Proteus compared to a single instillation on successive days.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/1c/MGR-13-155.PMC9979206.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10825633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A major leak from the condenser assembly of the anesthesia workstation.","authors":"Amit Rai,&nbsp;Krithika Ramamoorthy,&nbsp;Sachin Kulkarni,&nbsp;Sameer Taneja","doi":"10.4103/2045-9912.345173","DOIUrl":"https://doi.org/10.4103/2045-9912.345173","url":null,"abstract":"Dear Editor, From a simple pneumatic device of the early 20th century, the anesthesia machine has evolved to incorporate various mechanical, electrical and electronic components to be more appropriately called anesthesia workstation.1 Despite advanced technology, a remote but life-threatening possibility of intraoperative machine malfunction exists. The leakage in the anesthesia circuit may result in hypoventilation, hypoxia, awareness, pollution of operating room and ventilatory failure even leading to death.2 Various causes of leaks in the breathing system have been reported in the literature that includes failure of an adjustable pressure limiting valve to close, mis-installation of a canister,3 weak connections in between different parts of the breathing circuit. We reported a case of gas leak from an unconventional site in the Datex Ohmeda Aespire View (GE Healthcare Pvt. Ltd. (India), Bangalore, India) workstation after anesthesia machine checks. As a routine, the complete pre-use anesthesia machine check was performed through the electronic self-check. A complete pre-use check of the machine included cylinders, pipelines, low-pressure system, vaporizers, breathing circuits, monitors and integrated ventilator. The circle system was also checked for any leaks and the ventilator systems were checked by setting the oxygen flow meter at minimum flows. However, after preliminary checks, soda lime in the carbon dioxide (CO2) absorber canister was changed. The canister was then reattached firmly. The water trap was also drained at this time. The patient was induced with propofol but bag mask ventilation was not adequate. There was a chest rise along with an end tidal CO2 trace but the reservoir bag was not filled adequately at a usual flow of 5 L/min. An oropharyngeal airway was inserted, and the flow increased to 10 L/min and the bag was filled better. The trachea was intubated with an 8.5 mm internal diameter cuffed endotracheal polyvinyl chloride tube using succinylcholine. However, the bag still required higher flows to fill up and when turned to the ventilation mode, the bellows required more than 8 L/min to fill up. We checked all the connections in the external circuit but found no loose connections or leaks. However, there was a large audible leak heard from the soda lime canister assembly. The CO2 absorber canister was removed and put back again to ensure that it is secured appropriately and locked. However, the audible leak still persisted. We decided to go ahead with the surgery as it was an emergency and ventilate the patient manually using Bains circuit. After the surgery got over, a detailed inspection of the CO2 canister assembly was done, and the leak seemed to originate from the EZchange and condenser part of the machine (Figure 1). Further evaluation revealed no issue in the EZchange part. The drain button of the condenser, however, was stuck in a semiopen position due to a soda lime granule trapped under the flap valve, leading ","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c2/12/MGR-13-159.PMC9979204.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9076378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen applications: advances in the field of medical therapy.","authors":"Tao Yuan,&nbsp;Jian-Ning Zhao,&nbsp;Ni-Rong Bao","doi":"10.4103/2045-9912.344978","DOIUrl":"https://doi.org/10.4103/2045-9912.344978","url":null,"abstract":"<p><p>Hydrogen (H₂) has been widely used in the chemical industry as a reducing agent. As the researches move along, increasing attention has been paid to its biological functions. The selective antioxidant effect of hydrogen is considered to be the main reason for medical applications. So far, many studies have confirmed its potential protective effects on ischemia/reperfusion injury of multiple organs, neurodegenerative diseases, bone and joint diseases, and respiratory diseases, opening a new era in the medical research and application of H₂. Increasing studies have focused on its biological effects and molecular mechanisms in the treatment of different diseases. In this paper, we review the biological effects, molecular mechanisms and methods of H₂ supply. We do hope that the advances in materials science can be better translated into medical applications and solve clinical problems. The medical application of H₂ is promising, and how to prepare an H₂ sustained-release system to achieve a sustained and stable H₂ supply in the body and ultimately improve the therapeutic effect of H₂ is a problem worthy of further investigation.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/2a/MGR-13-99.PMC9979201.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10825636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of ketamine, propofol, and dexmedetomidine for anesthesia in electroconvulsive therapy in treatment-resistant major depressive disorder patients: a double-blind randomized clinical trial.","authors":"Hesameddin Modir, Behnam Mahmoodiyeh, Mehran Shayganfard, Ayda Abdus, Amir Almasi-Hashiani","doi":"10.4103/2045-9912.350860","DOIUrl":"10.4103/2045-9912.350860","url":null,"abstract":"<p><p>Electroconvulsive therapy (ECT) is one of the therapeutic opportunities for patients with psychological disorders when they may decline to take medication. We sought to systematically compare the anesthetic efficacy of ketamine, propofol, and dexmedetomidine for electroconvulsive therapy in treatment-resistant major depressive disorder patients. This double-blind trial enrolled treatment-resistant major depressive disorder patients (n = 85) who had been hospitalized for ECT in the Amir Kabir Hospital's psychiatric ward (Arak, Iran). The ketamine, propofol, and dexmedetomidine groups received a dose of 0.2 μg/kg ketamine, 1.5 mg/kg propofol, and 0.8 mg/kg dexmedetomidine, respectively. In all intervention groups, 10 mL of interventional drugs was injected intravenously for 10 minutes, and in the placebo group, 10 mL of normal saline was given over the same period. The dexmedetomidine group's blood pressure was revealed comparatively lower at all times. Dexmedetomidine-treated patients showed their marked satisfaction, while those treated with propofol had shorter recovery time, shorter seizure duration, and shorter time to achieve an Aldrete score of 9-10 and increased relaxation, and next dexmedetomidine produced deeper relaxation. Propofol could shorten recovery time and seizure duration, and enhance relaxation, while dexmedetomidine was associated with higher patient satisfaction. Considering that any anesthetic which does not shorten seizure duration may serve efficiently for ECT and that ketamine-treated patients had more prolonged seizure duration, the preferred drug can hence be considered from various angles, thereby offering anesthetic agents with highly favorable efficacy in treatment-resistant major depressive disorder patients needing ECT. The drug choice thus depends on physical conditions, underlying diseases, and psychiatrist consultation.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/85/ec/MGR-13-112.PMC9979203.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10825634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular hydrogen therapy for neurological diseases: a review of current evidence.","authors":"Dinesh Ramanathan,&nbsp;Lei Huang,&nbsp;Taylor Wilson,&nbsp;Warren Boling","doi":"10.4103/2045-9912.359677","DOIUrl":"https://doi.org/10.4103/2045-9912.359677","url":null,"abstract":"<p><p>Reactive oxygen species and other free radicals cause oxidative stress which is the underlying pathogenesis of cellular injury in various neurological diseases. Molecular hydrogen therapy with its unique biological property of selectively scavenging pathological free radicals has demonstrated therapeutic potential in innumerable animal studies and some clinical trials. These studies have implicated several cellular pathways affected by hydrogen therapy in explaining its anti-inflammatory and antioxidative effects. This article reviews relevant animal and clinical studies that demonstrate neuroprotective effects of hydrogen therapy in stroke, neurodegenerative diseases, neurotrauma, and global brain injury.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c8/95/MGR-13-94.PMC9979207.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9076373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}