Microbes and Infection最新文献_第8页

Microneedle-based arrays - Breakthrough strategy for the treatment of bacterial and fungal skin infections. 微针阵列--治疗细菌和真菌皮肤感染的突破性策略。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-24 DOI: 10.1016/j.micinf.2024.105426

Oliwia Kordyl, Zuzanna Styrna, Monika Wojtyłko, Bozena Michniak-Kohn, Tomasz Osmałek

{"title":"Microneedle-based arrays - Breakthrough strategy for the treatment of bacterial and fungal skin infections.","authors":"Oliwia Kordyl, Zuzanna Styrna, Monika Wojtyłko, Bozena Michniak-Kohn, Tomasz Osmałek","doi":"10.1016/j.micinf.2024.105426","DOIUrl":"https://doi.org/10.1016/j.micinf.2024.105426","url":null,"abstract":"Currently, fungal and bacterial skin infections rank among the most challenging public health problems due to the increasing prevalence of microorganisms and the development of resistance to available drugs. A major issue in treating these infections with conventional topical medications is the poor penetration through the stratum corneum, the outermost layer of the skin. The concept of microneedles seems to be a future-proof approach for delivering drugs directly into deeper tissues. By bypassing the skin barrier, microneedle systems allow therapeutic substances to reach deeper layers more efficiently, significantly improving treatment outcomes. Nonetheless, the primary challenges regarding the effectiveness of microneedles involve selecting the appropriate size and shape, along with polymer composition and fabrication technology, to enable controlled and efficient drug release. This review offers a comprehensive overview of the latest knowledge on microneedle types and manufacturing techniques, highlighting their potential effectiveness in treating bacterial and fungal skin infections. It includes updated statistics on infection prevalence and provides a detailed examination of common bacterial and fungal diseases, focusing on their symptoms, causative species, and treatment methods. Additionally, the review addresses safety considerations, regulatory aspects, and future perspectives for microneedle-based therapeutic systems. It also underscores the importance of industrialization and clinical translation efforts, emphasizing the significant potential of microneedle technology for advancing medical applications.","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":" ","pages":"105426"},"PeriodicalIF":2.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of various DNA and RNA viruses in bats in Yamaguchi Prefecture, Japan. 日本山口县蝙蝠体内各种 DNA 和 RNA 病毒的检测。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-24 DOI: 10.1016/j.micinf.2024.105425

Miyuka Nishizato, Urara Imai, Chisato Shigenaga, Miho Obata, Saki Mitsunaga, Marla Anggita, Samuel Nyampong, Shelly Wulandari, Weiyin Hu, Kazuki Kiuno, Lydia Mali Langata, Hiroyuki Imai, Masashi Sakurai, Tetsuya Yanagida, Ai Takano, Takashi Murakami, Chang-Gi Jeong, Jae-Ku Oem, Daisuke Hayasaka, Hiroshi Shimoda

{"title":"Detection of various DNA and RNA viruses in bats in Yamaguchi Prefecture, Japan.","authors":"Miyuka Nishizato, Urara Imai, Chisato Shigenaga, Miho Obata, Saki Mitsunaga, Marla Anggita, Samuel Nyampong, Shelly Wulandari, Weiyin Hu, Kazuki Kiuno, Lydia Mali Langata, Hiroyuki Imai, Masashi Sakurai, Tetsuya Yanagida, Ai Takano, Takashi Murakami, Chang-Gi Jeong, Jae-Ku Oem, Daisuke Hayasaka, Hiroshi Shimoda","doi":"10.1016/j.micinf.2024.105425","DOIUrl":"10.1016/j.micinf.2024.105425","url":null,"abstract":"Bats are important natural hosts of various zoonotic viruses, including Ebola virus, Lyssa virus, and severe acute respiratory syndrome coronavirus (SARS-CoV). Although investigation of bats is valuable for predicting emerging infectious diseases from these animals, few surveys of bat-derived viruses have been conducted in Japan. In the present study, samples were collected from a total of 132 bats of 4 different species from 4 different locations within Yamaguchi Prefecture; these sample were employed for comprehensive detection of bat-derived viruses by polymerase chain reaction (PCR) and reverse transcription (RT)-PCR using primers universal for each of 4 different viral classes. As a result of PCR and RT-PCR, various herpesviruses, astroviruses, coronaviruses, and adenoviruses were identified from a total of 80 bats. The detected herpesviruses belong to the Betaherpesvirinae or Gammaherpesvirinae subfamily, the detected adenoviruses to the genus Mastadenovirus, the detected astroviruses to the genus Mamastrovirus; and the detected coronaviruses belong to the genus Alphacoronavirus. The detected sequences of 12 strains of 4 families showed 100 % amino acid identity with viruses previously detected either in China or South Korea. These findings expand our understanding of viruses carried by bats, and provide insights into the nature of bat-derived viruses in Japan.","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":" ","pages":"105425"},"PeriodicalIF":2.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice. 包柔氏菌感染小鼠淋巴结早期免疫反应的单细胞转录组分析。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-19 DOI: 10.1016/j.micinf.2024.105424

Varpu Rinne, Kirsi Gröndahl-Yli-Hannuksela, Ruth Fair-Mäkelä, Marko Salmi, Pia Rantakari, Tapio Lönnberg, Jukka Alinikula, Annukka Pietikäinen, Jukka Hytönen

{"title":"Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice.","authors":"Varpu Rinne, Kirsi Gröndahl-Yli-Hannuksela, Ruth Fair-Mäkelä, Marko Salmi, Pia Rantakari, Tapio Lönnberg, Jukka Alinikula, Annukka Pietikäinen, Jukka Hytönen","doi":"10.1016/j.micinf.2024.105424","DOIUrl":"https://doi.org/10.1016/j.micinf.2024.105424","url":null,"abstract":"Lyme borreliosis is a disease caused by Borrelia burgdorferi sensu lato bacteria. Borrelia burgdorferi is known to induce prolonged extrafollicular immune responses and abnormal germinal centre formation. The infection fails to generate a neutralizing type of immunity, eventually establishing a persistent infection. Here, we performed single-cell RNA sequencing to characterize the immune landscape of lymph node lymphocytes during the early Borrelia burgdorferi infection in a murine model. Our results indicate key features of an extrafollicular immune response four days after Borrelia burgdorferi infection, including notable B cell proliferation, immunoglobulin class switching to IgG3 and IgG2b isotypes, plasmablast differentiation, and the presence of extrafollicular B cells identified through immunohistochemistry. Additionally, we found infection-derived upregulation of suppressor of cytokine signalling genes Socs1 and Socs3, along with downregulation of genes associated with MHC II antigen presentation in B cells. Our results support the central role of B cells in the immune response of a Borrelia burgdorferi infection, and provide cues of mechanisms behind the determination between extrafollicular and germinal centre responses during Borrelia burgdorferi infection.","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":" ","pages":"105424"},"PeriodicalIF":2.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-resolution kinetics and cellular determinants of SARS-CoV-2 antibody response over two years after COVID-19 vaccination. 接种 COVID-19 疫苗两年后，SARS-CoV-2 抗体反应的高分辨率动力学和细胞决定因素。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-17 DOI: 10.1016/j.micinf.2024.105423

Rocío Rubio, Dídac Macià, Diana Barrios, Marta Vidal, Alfons Jiménez, Luis M Molinos-Albert, Natalia Díaz, Mar Canyelles, Maria Lara-Escandell, Cyril Planchais, Pere Santamaria, Carlo Carolis, Luis Izquierdo, Ruth Aguilar, Gemma Moncunill, Carlota Dobaño

{"title":"High-resolution kinetics and cellular determinants of SARS-CoV-2 antibody response over two years after COVID-19 vaccination.","authors":"Rocío Rubio, Dídac Macià, Diana Barrios, Marta Vidal, Alfons Jiménez, Luis M Molinos-Albert, Natalia Díaz, Mar Canyelles, Maria Lara-Escandell, Cyril Planchais, Pere Santamaria, Carlo Carolis, Luis Izquierdo, Ruth Aguilar, Gemma Moncunill, Carlota Dobaño","doi":"10.1016/j.micinf.2024.105423","DOIUrl":"https://doi.org/10.1016/j.micinf.2024.105423","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) studies usually rely on cross-sectional data of large cohorts but limited repeated samples, overlooking significant inter-individual antibody kinetic differences. By combining Luminex, activation-induced marker (AIM) and IFN-γ/IL-2 Fluorospot assays, we characterized the IgM, IgA, and IgG antibody kinetics using 610 samples from 31 healthy adults over two years after COVID-19 vaccination, and the T-cell responses six months post-booster. Antibody trajectories varied among isotypes: IgG decayed slowly, IgA exhibited an initial sharp decline, which gradually slowed down and stabilized above the seropositivity threshold. Contrarily, IgM rapidly dropped to undetectable levels after primary vaccination. Importantly, three vaccine doses induced higher and more durable anti-spike IgG and IgA levels compared to two doses, whereas infection led to the highest antibody peak and slowest antibody decay rate compared to vaccination. Comparing with ancestral virus, antibody levels recognizing Omicron subvariants had a faster antibody decay. Finally, polyfunctional T cells were positively associated with subsequent IgA responses. These results revealed distinctive antibody patterns by isotype and highlight the benefits of booster doses in enhancing and sustaining antibody responses.","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":" ","pages":"105423"},"PeriodicalIF":2.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Murine C3 of the complement system affects infection by Leptospira interrogans. 小鼠补体系统 C3 对钩端螺旋体感染的影响

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-14 DOI: 10.1016/j.micinf.2024.105413

Julia Avian Vassalakis, Denise Harumi Silva Yamashita, Leonardo Moura Midon, Bruno Cogliati, Marcos Bryan Heinemann, Thaís Akemi Amamura, Lourdes Isaac

{"title":"Murine C3 of the complement system affects infection by Leptospira interrogans.","authors":"Julia Avian Vassalakis, Denise Harumi Silva Yamashita, Leonardo Moura Midon, Bruno Cogliati, Marcos Bryan Heinemann, Thaís Akemi Amamura, Lourdes Isaac","doi":"10.1016/j.micinf.2024.105413","DOIUrl":"https://doi.org/10.1016/j.micinf.2024.105413","url":null,"abstract":"Leptospirosis is an infectious neglected disease estimated to affect more than one million people worldwide each year. The Complement System plays a vital role in eliminating infectious agents. However, its precise role in leptospirosis remains to be fully understood. We investigated the importance of C3 in L. interrogans serovar Kennewicki strain Pomona Fromm (LPF) infection. Lack of C3 leads to decreased leukocyte number, impaired inflammatory response and failure to eliminate bacteria during the early stages of infection, which may cause interstitial nephritis later. These findings could be explained, at least in part, by the lower presence of local opsonins. Furthermore, antibody production against Leptospira was compromised in the absence of C3, highlighting the importance of CR2 in B lymphocyte proliferation and the adjuvant role of C3d in humoral immunity. Leptospires can be eliminated through the urine, and according to our study, the lack of C3 delays the elimination of LPF through urine during the early stages of the infection. These results strongly suggest the crucial role of C3 protein in orchestrating an appropriate inflammatory response against LPF infection and in effectively eliminating the bacteria from the body during the acute phase of leptospirosis.","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":" ","pages":"105413"},"PeriodicalIF":2.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intragenomic diversity of the small subunit rDNA gene shows limited impact on the pathogenicity of Blastocystis infection in clinical patients 小亚基 rDNA 基因的基因组内多样性对临床患者感染大疱菌的致病性影响有限

IF 5.8 4区医学

Microbes and Infection Pub Date : 2024-09-11 DOI: 10.1016/j.micinf.2024.105422

Laura Seijas-Pereda, Pamela C. Köster, Alejandro Dashti, Begoña Bailo, Isabel Guadano-Procesi, Carlos Rescalvo-Casas, Marcos Hernando-Gozalo, Juan Cuadros-González, David Carmena, Ramón Pérez-Tanoira

{"title":"Intragenomic diversity of the small subunit rDNA gene shows limited impact on the pathogenicity of Blastocystis infection in clinical patients","authors":"Laura Seijas-Pereda, Pamela C. Köster, Alejandro Dashti, Begoña Bailo, Isabel Guadano-Procesi, Carlos Rescalvo-Casas, Marcos Hernando-Gozalo, Juan Cuadros-González, David Carmena, Ramón Pérez-Tanoira","doi":"10.1016/j.micinf.2024.105422","DOIUrl":"https://doi.org/10.1016/j.micinf.2024.105422","url":null,"abstract":"The clinical significance of <ce:italic>Blastocystis</ce:italic> sp. remains to be fully elucidated. This study assesses whether <ce:italic>Blastocystis</ce:italic> subtype diversity can affect the outcome of the infection and the occurrence of clinical manifestations in infected individuals. Stool samples from 219 <ce:italic>Blastocystis</ce:italic>-positive patients by PCR targeting the <ce:italic>ssu</ce:italic> rDNA gene were fully genotyped by Sanger sequencing analyses. Co-infections by other parasitic, viral, and bacterial enteropathogens were identified by molecular and culture methods. Sequence analyses revealed the presence of six <ce:italic>Blastocystis</ce:italic> subtypes including ST1 (21.5 %), ST2 (17.8 %), ST3 (29.7 %), ST4 (22.8 %), ST6 (5.5 %), and ST7 (2.3 %), with a single sample harbouring a ST1+ST3 co-infection (0.5 %). Multivariate risk factor analyses using logistic regression models indicated that neither <ce:italic>Blastocystis</ce:italic> subtypes nor patient-associated variables including sex, country of origin, travelling history, and presence of nonspecific symptoms were positively associated with a higher likelihood of developing gastrointestinal symptoms (abdominal pain and diarrhoea). However, being of a young age (p-value: 0.003) and experiencing skin pruritus (p-value < 0.001) and eosinophilia (p-value: 0.016) were found to increase the odds of presenting gastrointestinal symptoms. <ce:italic>Blastocystis</ce:italic> subtypes based on variability within the <ce:italic>ssu</ce:italic> rDNA gene do not seem to be the main drivers of clinical manifestations in the surveyed clinical population.","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"2 1","pages":"105422"},"PeriodicalIF":5.8,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutibacterium acnes as an overseen autoimmunity trigger: Unearthing heat-shock driven molecular mimicry. 痤疮分枝杆菌是一种被忽视的自身免疫诱因：揭示热冲击驱动的分子拟态

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-07 DOI: 10.1016/j.micinf.2024.105420

Jelena Repac, Bojan Božić, Biljana Božić Nedeljković

{"title":"Cutibacterium acnes as an overseen autoimmunity trigger: Unearthing heat-shock driven molecular mimicry.","authors":"Jelena Repac, Bojan Božić, Biljana Božić Nedeljković","doi":"10.1016/j.micinf.2024.105420","DOIUrl":"10.1016/j.micinf.2024.105420","url":null,"abstract":"Cutibacterium acnes, common resident of the human skin, can establish both commensal and pathogenic relations with the human host; however, long-term consequences of C. acnes-induced inflammation remained un(der)explored. To infer the capacity of triggering autoimmunity in humans via molecular mimicry, a comprehensive immunoinformatics analysis of the experimentally characterized C. acnes proteome was performed. The protocol included homology screening between the C. acnes and the human proteome, and validation of shared specificity regions against the collection of experimentally characterized T-cell epitopes, related to autoimmunity. To obtain highly reliable predictions, the results were subjected to additional cross-validation by a dedicated MHC-restriction analysis, including a docking study of C. acnes mimotopes and human counterparts with the highest degree of sequence similarity to MHCII molecules representing the highest risk for detected autoimmune pathologies. Due to mimicking of highly immunogenic, but also evolutionary conserved autoantigens from the Heat Shock protein family, association between C. acnes and the pathogenesis of highly incident autoimmune diseases: Type 1 Diabetes, Rheumatoid Arthritis, and Juvenile Idiopathic Arthritis, was found. To the best of our knowledge, this study is the first one to provide preliminary information and a mechanistic link on the putative involvement of C. acnes in the pathogenesis of autoimmunity in humans.","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":" ","pages":"105420"},"PeriodicalIF":2.6,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

S100A12 inhibits Streptococcus pneumoniae and aids in wound healing of corneal epithelial cells both in vitro and in vivo. S100A12 可抑制肺炎链球菌，并有助于角膜上皮细胞的体外和体内伤口愈合。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-07 DOI: 10.1016/j.micinf.2024.105421

Priyasha Mishra, Sanjay Ch, Abhijit Ghosh, Srijita Kundu, Riddhi Agarwal, Bharathi Bhogapurapu, Swati Biswas, Sanhita Roy

引用次数: 0

Replication-deficient Sendai virus expressing human norovirus capsid protein elicits robust NoV-specific antibody and T-cell responses in mice. 表达人类诺瓦克病毒壳蛋白的复制缺陷型 sentai 病毒可在小鼠体内引起强大的诺瓦克病毒特异性抗体和 T 细胞反应。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-03 DOI: 10.1016/j.micinf.2024.105412

Yazdan Samieipour, Marian Wiegand, Elena M Willner, Dieter Hoffmann, Kamyar Shameli, Ulrike Protzer, Hassan Moeini

{"title":"Replication-deficient Sendai virus expressing human norovirus capsid protein elicits robust NoV-specific antibody and T-cell responses in mice.","authors":"Yazdan Samieipour, Marian Wiegand, Elena M Willner, Dieter Hoffmann, Kamyar Shameli, Ulrike Protzer, Hassan Moeini","doi":"10.1016/j.micinf.2024.105412","DOIUrl":"10.1016/j.micinf.2024.105412","url":null,"abstract":"Human norovirus (HuNoV) is a major global cause of acute gastroenteritis, with vaccine development facing several challenges. Despite years of research, there are currently no licensed vaccines available for controlling HuNoVs. Here, we describe the construction and testing of a replication-deficient Sendai virus (SeV) vector as a potential vaccine candidate against the HuNoV GII.4 genotype. SeV was chosen as the vaccine backbone due to its non-pathogenic nature in humans, its capability for long-term antigen expression in mammalian cells, and its suitability for mucosal administration. By inserting the HuNoV GII.4 capsid gene, VP1, into the SeV genome, we generated a replication-deficient SeV (SeV/dP.VP1) vector. The resultant SeV/dP.VP1 virus were observed to successfully express the inserted NoV VP1 gene upon infection. Inoculating the vaccine into wild-type mice elicited NoV-specific IgG antibodies, along with INF-γ and IL-2-producing T cells, through both intranasal (i.n.) and intramuscular (i.m.) immunization. Furthermore, a significant level of NoV-specific IgA was detected in lung homogenates after i.n. immunization, particularly using a high dose of the viral vector. Additionally, a synergistic effect was observed with heterologous prime-boost regimens using SeV/dP.VP1 and MVA.VP1 vectors, indicating the potential for more robust immune responses when the vaccine design is optimized. Our study demonstrates the potential of a SeV vaccine candidate in eliciting a broad immune response and lays the foundation for further exploration of the SeV vector platform's potential as a HuNoV vaccine. Additionally, the results emphasize the importance of vaccine dosage and administration route, highlighting the need for tailored immunization strategies.","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":" ","pages":"105412"},"PeriodicalIF":2.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copyright page Elsevier 版权页

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-01 DOI: 10.1016/S1286-4579(24)00159-X

引用次数: 0