Microbes and Infection最新文献_第9页

Lung infection with classical Klebsiella pneumoniae strains establishes robust macrophage-dependent protection against heterologous reinfection 经典肺炎克雷伯氏菌菌株的肺部感染可建立对异源再感染的强大巨噬细胞依赖性保护。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-11-01 DOI: 10.1016/j.micinf.2024.105369

Joseph J. Mackel , Casey L.G. Mick , Emily Guo , David A. Rosen

{"title":"Lung infection with classical Klebsiella pneumoniae strains establishes robust macrophage-dependent protection against heterologous reinfection","authors":"Joseph J. Mackel , Casey L.G. Mick , Emily Guo , David A. Rosen","doi":"10.1016/j.micinf.2024.105369","DOIUrl":"10.1016/j.micinf.2024.105369","url":null,"abstract":"<div><div>At present, there is no approved vaccine for prevention of infection by the opportunistic bacterium <em>Klebsiella pneumoniae</em> (Kp); success in treating these infections is increasingly challenged by the spread of antibiotic resistance. Preclinical investigation of adaptive immunity elicited by lung infection with live classical Kp may reveal host mechanisms of protection against this pathogen. Here, we utilize multiple virulent classical Kp strains to demonstrate that following lung infection, surviving wild-type mice develop protective immunity against both homologous and heterologous (heterotypic) reinfection. For Kp strains with low capacity to disseminate from the lung, this immunity is B-cell-independent. We further demonstrate that this immune protection is also effective against subsequent challenge with hypervirulent Kp if the strains share the same capsule type. Systemic inoculation fails to elicit the same protective effect as lung inoculation, revealing a lung-specific immune effector function is responsible for this protection. We therefore utilized clodronate-loaded liposomes to substantially deplete both alveolar macrophages and lung interstitial macrophages, finding that simultaneous depletion of both subsets entirely ablates protection. These findings indicate that following initial lung infection with Kp, lung macrophages mediate protection against ensuing Kp challenge.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"26 8","pages":"Article 105369"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of macozinone in mice with genetically diverse susceptibility to Mycobacterium tuberculosis infection 麦考嗪酮对不同基因的结核分枝杆菌感染小鼠的疗效

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-11-01 DOI: 10.1016/j.micinf.2024.105376

Boris Nikonenko , Nadezhda Logunova , Anna Egorova , Marina Kapina , Natalia Sterzhanova , Irina Bocharova , Elena Kondratieva , Olga Riabova , Lyudmila Semyonova , Vadim Makarov , Dedicated to the 10th anniversary of the iM4TB Foundation

{"title":"Efficacy of macozinone in mice with genetically diverse susceptibility to Mycobacterium tuberculosis infection","authors":"Boris Nikonenko , Nadezhda Logunova , Anna Egorova , Marina Kapina , Natalia Sterzhanova , Irina Bocharova , Elena Kondratieva , Olga Riabova , Lyudmila Semyonova , Vadim Makarov , Dedicated to the 10th anniversary of the iM4TB Foundation","doi":"10.1016/j.micinf.2024.105376","DOIUrl":"10.1016/j.micinf.2024.105376","url":null,"abstract":"<div><div><span>Host heterogeneity in pulmonary tuberculosis<span> leads to varied responses to infection and drug treatment. The present portfolio of anti-TB drugs needs to be boosted with new drugs and drug regimens. Macozinone, a clinical-stage molecule targeting the essential enzyme, DprE1, represents an attractive option. Mice (I/St, B6, (AKRxI/St)F1, B6.I-100 and B6.I-139) genetically diverse susceptibility to </span></span><span><em>Mycobacterium tuberculosis</em></span> (<em>Mtb</em>) H37Rv infection were subjected to aerosol- or intravenous infection to determine the efficacy of macozinone (MCZ). They were treated with macozinone or reference drugs (isoniazid, rifampicin). Lung and spleen bacterial burdens were measured at four and eight weeks post-infection. Lung histology was evaluated at four weeks of treatment. Treatment with macozinone resulted in a statistically significant reduction in the bacterial load in the lungs and spleen as early as four weeks after treatment initiation in mice susceptible or resistant to <em>Mtb</em><span> infection. In the TB hypoxic granuloma<span> model, macozinone was more potent than rifampicin in reducing the CFU counts. However, histopathological analysis revealed significant lung changes in I/St mice after eight weeks of treatment initiation. Macozinone demonstrated efficacy to varying degrees across all mouse models of </span></span><em>Mtb</em> infection used. These results should facilitate its further development and potential introduction into clinical practice.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"26 8","pages":"Article 105376"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Staphylococcus pseudintermedius and Pseudomonas aeruginosa Lubbock Chronic Wound Biofilm (LCWB): a suitable dual-species model for in vitro studies 假中间葡萄球菌和铜绿假单胞菌卢伯克慢性伤口生物膜（LCWB）：体外研究的合适双菌种模型。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-11-01 DOI: 10.1016/j.micinf.2024.105384

Silvia Di Lodovico , Morena Petrini , Paola Di Fermo , Valeria De Pasquale , Luisa De Martino , Simonetta D'Ercole , Francesca Paola Nocera , Mara Di Giulio

{"title":"Staphylococcus pseudintermedius and Pseudomonas aeruginosa Lubbock Chronic Wound Biofilm (LCWB): a suitable dual-species model for in vitro studies","authors":"Silvia Di Lodovico , Morena Petrini , Paola Di Fermo , Valeria De Pasquale , Luisa De Martino , Simonetta D'Ercole , Francesca Paola Nocera , Mara Di Giulio","doi":"10.1016/j.micinf.2024.105384","DOIUrl":"10.1016/j.micinf.2024.105384","url":null,"abstract":"<div><div>Antimicrobial treatment of methicillin-resistant <em>Staphylococcus pseudintermedius</em> associated with canine wounds represents an important challenge. The aim of this study was to create a canine wound infection model, Lubbock Chronic Wound Biofilm (LCWB), with a focus on <em>S. pseudintermedius,</em> drawing inspiration from the established human model involving <em>Staphylococcus aureus</em>. Methicillin-resistant <em>S. pseudintermedius</em> 115 (MRSP) and <em>Pseudomonas aeruginosa</em> 700 strains, isolated from dog wounds, were used to set up the LCWB at 24, 48 and 72 h. The LCWBs were evaluated in terms of volume, weight, and microbial CFU/mg. The microbial spatial distribution in the LCWBs was assessed by SEM and CLSM imaging. The best incubation time for the LCWB production in terms of volume (3.38 cm<sup>3</sup> ± 0.13), weight (0.86 gr ± 0.02) and CFU/mg (up to 7.05 × 10<sup>6</sup> CFU/mg ± 2.89 × 10<sup>5</sup>) was 48 h. The SEM and CLSM images showed a major viable microbial colonization at 48 h with non-mixed bacteria with a prevalence of MRSP on the surface and <em>P. aeruginosa</em> 700 in the depth of the wound. The obtained findings demonstrate the capability of <em>S. pseudintermedius</em> to grow together <em>P. aeruginosa</em> in the LCWB model, representing the suitable model to reproduce the animal chronic wound <em>in vitro</em>.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"26 8","pages":"Article 105384"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Host-specific SRSF7 regulates polymerase activity and replication of influenza A virus 宿主特异性 SRSF7 可调节甲型流感病毒的聚合酶活性和复制。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-11-01 DOI: 10.1016/j.micinf.2024.105401

Lingcai Zhao , Shengmin Li , Lulu Deng , Yijia Zhang , Chenfeng Jiang , Yurong Wei , Jun Xia , Jihui Ping

{"title":"Host-specific SRSF7 regulates polymerase activity and replication of influenza A virus","authors":"Lingcai Zhao , Shengmin Li , Lulu Deng , Yijia Zhang , Chenfeng Jiang , Yurong Wei , Jun Xia , Jihui Ping","doi":"10.1016/j.micinf.2024.105401","DOIUrl":"10.1016/j.micinf.2024.105401","url":null,"abstract":"<div><div>Avian influenza viruses crossing the host barrier to infect humans have caused great panic in human society and seriously threatened public health. Herein, we revealed that knockdown of SRSF7 significantly down-regulated influenza virus titers and viral protein expression. We further observed for the first time that human SRSF7, but not avian SRSF7, significantly inhibited polymerase activity (PB2<sub>627</sub>E). Molecular mapping demonstrated that amino acids 206 to 228 of human SRSF7 play a decisive role in regulating the polymerase activity, which contains the amino acid motif absent in avian SRSF7. Importantly, our results illustrated that the PB2<sub>627</sub>K-encoding influenza virus induces SRSF7 protein degradation more strongly via the lysosome pathway and not via the proteasome pathway. Functional enrichment analysis of SRSF7-related KEGG pathways indicated that SRSF7 is closely related to cell growth and death. Lastly, our results showed that knocking down SRSF7 interferes with normal polymerase activity. Taken together, our results advance our understanding of interspecies transmission and our findings point out new targets for the development of drugs preventing or treating influenza virus infection.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"26 8","pages":"Article 105401"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles in the pathogenesis of Campylobacter jejuni 空肠弯曲杆菌致病过程中的胞外囊泡。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-11-01 DOI: 10.1016/j.micinf.2024.105377

Jeanne Malet-Villemagne, Jasmina Vidic

引用次数: 0

The PDZ domain of the E protein in SARS-CoV induces carcinogenesis and poor prognosis in LUAD SARS-CoV中E蛋白的PDZ域诱导LUAD的癌变和不良预后

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-11-01 DOI: 10.1016/j.micinf.2024.105381

Shun Li , Jinxuan Wang , Xiaozhen Dai , Churong Li , Tao Li , Long Chen

{"title":"The PDZ domain of the E protein in SARS-CoV induces carcinogenesis and poor prognosis in LUAD","authors":"Shun Li , Jinxuan Wang , Xiaozhen Dai , Churong Li , Tao Li , Long Chen","doi":"10.1016/j.micinf.2024.105381","DOIUrl":"10.1016/j.micinf.2024.105381","url":null,"abstract":"<div><h3>Background</h3><div><span>In both lung adenocarcinoma (LUAD) and </span>severe acute respiratory syndrome<span><span> (SARS), uncontrolled inflammation can be detected in lung tissue. The PDZ-binding motif (PBM) in the SARS-CoV-1 E protein has been demonstrated to be a virulence factor that induces a </span>cytokine storm.</span></div></div><div><h3>Methods</h3><div><span>To identify gene expression fluctuations induced by PBM, microarray sequencing data of lung tissue infected with wild-type (SARS-CoV-1-E-wt) or </span>recombinant virus<span> (SARS-CoV-1-E-mutPBM) were analyzed, followed by functional enrichment analysis. To understand the role of the screened genes in LUAD, overall survival and immune correlation were calculated.</span></div></div><div><h3>Results</h3><div><span>A total of 12 genes might participate in the initial and developmental stages of LUAD through expression variation and mutation. Moreover, dysregulation of a total of 12 genes could lead to a poorer prognosis. In addition, the downregulation<span> of MAMDC2 and ITGA8 by PBM could also affect patient prognosis. Although the conserved PBM (-D-L-L-V-) can be found at the end of the carboxyl terminus in multiple E proteins of </span></span>coronaviruses<span>, the specific function of each protein depends on the entire amino acid sequence.</span></div></div><div><h3>Conclusions</h3><div>In summary, PBM containing the SARS-CoV-1 E protein promoted the carcinogenesis of LUAD by dysregulating important gene expression profiles and subsequently influencing the immune response and overall prognosis.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"26 8","pages":"Article 105381"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NLRP1B allele 2 does not respond to Val-boro-Pro (VbP) in intestinal epithelial cells 肠上皮细胞中表达的 NLRP1B 对 Val-boro-Pro 的激活具有耐受性。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-11-01 DOI: 10.1016/j.micinf.2024.105398

Ryan J. Mazzone , Nathaniel J. Winsor , Lu Yi Li , Kristian T. Barry , Adrienne Ranger , Shawn Goyal , Justin J. Meade , Jessica Bruce , Dana J. Philpott , Jeremy Mogridge , Stephen E. Girardin

{"title":"NLRP1B allele 2 does not respond to Val-boro-Pro (VbP) in intestinal epithelial cells","authors":"Ryan J. Mazzone , Nathaniel J. Winsor , Lu Yi Li , Kristian T. Barry , Adrienne Ranger , Shawn Goyal , Justin J. Meade , Jessica Bruce , Dana J. Philpott , Jeremy Mogridge , Stephen E. Girardin","doi":"10.1016/j.micinf.2024.105398","DOIUrl":"10.1016/j.micinf.2024.105398","url":null,"abstract":"<div><div>The intestinal mucosa must balance tolerance to commensal microbes and luminal antigens with rapid detection of enteric pathogens in order to maintain homeostasis. This balance is facilitated through the regulation of epithelial layer integrity by innate immune receptors. Certain NOD-like receptors (NLRs) expressed in intestinal epithelial cells, including NLRC4 and NLRP9B, form inflammasomes that protect against pathogens by activating caspase-1 to cause extrusion of infected cells. NLRP1B is a murine NLR encoded by five alleles of a highly polymorphic gene homologous to human NLRP1. NLRP1B forms inflammasomes in response to a variety of pathogens that cause intestinal infections, but it has almost exclusively been studied in immune cells and has not been characterized in cells of the intestinal epithelium. Here, we show that <em>Nlrp1b</em> allele 2 is expressed in ileal and colonic organoids derived for C57BL/6J mice, while the related gene <em>Nlrp1a</em> was not expressed. <em>Nlrp1b</em> was upregulated by interleukin-13 in organoids and by the protozoan <em>Tritrichomonas muris</em> in vivo, suggesting that NLRP1B may be involved in defense against enteric parasites. Surprisingly, while Val-boro-Pro (VbP) activated C57BL/6J-derived bone marrow-derived macrophages, which expressed both <em>Nlrp1a</em> and <em>Nlrp1b</em>, it did not activate intestinal organoids of the same genotype. We furthermore did not detect <em>Nlrp1b</em> in organoids derived from Balb/cJ mice, which express a different allele than the one expressed in C57BL/6J mice. Together, our results suggest that NLRP1B may have an allele-dependent function in murine IECs whose regulation is distinct from that of macrophages, and that the response to VbP might be exclusively driven by NLRP1A in C57BL/6J mice.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"26 8","pages":"Article 105398"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors underlying the long-term efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome 粪便微生物群移植对肠易激综合征患者的长期疗效的基础因素。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-11-01 DOI: 10.1016/j.micinf.2024.105372

Magdy El-Salhy , Odd Helge Gilja , Jan Gunnar Hatlebakk

{"title":"Factors underlying the long-term efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome","authors":"Magdy El-Salhy , Odd Helge Gilja , Jan Gunnar Hatlebakk","doi":"10.1016/j.micinf.2024.105372","DOIUrl":"10.1016/j.micinf.2024.105372","url":null,"abstract":"<div><div>The long-term effects of the transplant dose, its administration route and repeated faecal microbiota transplantation (FMT) on the outcomes of FMT for patients with irritable bowel syndrome (IBS) are unknown. This study included 171 patients (125 females and 46 males): 90 g of donor feces was administered into the large intestine (LI) in 58, into the small intestine (SI) in 57, and into the SI twice (repeated SI) in 56. The patients provided a fecal sample and completed five questionnaires at the baseline and at 2 years after FMT. Fecal bacteria and the dysbiosis index were analyzed using 16S rRNA gene PCR DNA amplification/probe. The response rates at 2 years after FMT were 47.2%, 80.9%, and 76.6% in the LI, SI, and repeated-SI groups, respectively. The response rate was significantly higher in the SI and repeated SI groups than in the LI group. IBS symptoms at 2 years after FMT were less severe in the SI and repeated-SI groups than in the LI group. Fluorescent signals of several bacteria were significantly correlated with IBS symptoms and fatigue after FMT. No long-term adverse events were observed. In conclusion, administering the transplant to the SI increased the long-term response rate and reduced IBS symptom severity compared with administering it to the LI, and led to the long-term colonization of beneficial bacteria. There was no long-term difference between one and two FMT procedures (<span><span>www.clinicaltrials.gov</span><svg><path></path></svg></span>: NCT04236843).</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"26 8","pages":"Article 105372"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “N-acetyl-cysteine mediates protection against Mycobacterium avium through induction of human β-defensin-2” [Microb Infect 22 (10) (2020) 567–575] N-乙酰-半胱氨酸通过诱导人β-防御素-2介导对分枝杆菌的保护"[Microb Infect 22 (10) (2020) 567-575] 的更正。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-11-01 DOI: 10.1016/j.micinf.2024.105388

Ayako Shiozawa, Chiaki Kajiwara, Yoshikazu Ishii, Kazuhiro Tateda

引用次数: 0

Leishmania donovani modulates host miRNAs regulating cholesterol biosynthesis for its survival 唐氏利什曼原虫调节宿主的 miRNA，调控胆固醇的生物合成，以促进其生存

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-11-01 DOI: 10.1016/j.micinf.2024.105379

Shams Tabrez , Sajjadul Kadir Akand , Rahat Ali , Irshad Husain Naqvi , Neha Soleja , Mohd Mohsin , Mohammad Z. Ahmed , Mohammed Saleem , Suhel Parvez , Yusuf Akhter , Abdur Rub

{"title":"Leishmania donovani modulates host miRNAs regulating cholesterol biosynthesis for its survival","authors":"Shams Tabrez , Sajjadul Kadir Akand , Rahat Ali , Irshad Husain Naqvi , Neha Soleja , Mohd Mohsin , Mohammad Z. Ahmed , Mohammed Saleem , Suhel Parvez , Yusuf Akhter , Abdur Rub","doi":"10.1016/j.micinf.2024.105379","DOIUrl":"10.1016/j.micinf.2024.105379","url":null,"abstract":"<div><div><span>Cholesterol reduction by intracellular protozoan parasite </span><span><span>Leishmania donovani</span></span> (<em>L. donovani</em>)<em>,</em><span><span> causative agent of leishmaniasis, impairs </span>antigen presentation<span>, pro-inflammatory cytokine secretion<span> and host-protective membrane-receptor signaling in macrophages. Here, we studied the miRNA mediated regulation of cholesterol biosynthetic genes to understand the possible mechanism of </span></span></span><em>L. donovani-</em><span><span>induced cholesterol reduction and therapeutic importance of miRNAs in leishmaniasis. System-scale genome-wide microtranscriptome screening was performed to identify the miRNAs involved in the regulation of expression of key </span>cholesterol biosynthesis regulatory genes through miRanda3.0. 11 miRNAs out of 2823, showing complementarity with cholesterol biosynthetic genes were finally selected for expression analysis. These selected miRNAs were differentially regulated in THP-1 derived macrophages and in primary human macrophages by </span><em>L. donovani</em><span>. Correlation of expression and target validation through luciferase assay suggested two key miRNAs, hsa-miR-1303 and hsa-miR-874-3p regulating the key genes </span><span><span>hmgcr</span></span> and <em>hmgcs1</em> respectively. Inhibition of hsa-mir-1303 and hsa-miR-874-3p augmented the expression of targets and reduced the parasitemia in macrophages. This study will also provide the platform for the development of miRNA-based therapy against leishmaniasis.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"26 8","pages":"Article 105379"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141398578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0