Microbes and Infection最新文献_第9页

Organoids and organ-on-chip technology for investigating host-microorganism interactions 用于研究宿主与微生物相互作用的有机体和芯片上有机体技术。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-01 DOI: 10.1016/j.micinf.2024.105319

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Microbiome and infectious disease: diagnostics to therapeutics 微生物和传染性疾病：从诊断到治疗

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-01 DOI: 10.1016/j.micinf.2024.105345

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Unraveling the intricacies of host-pathogen interaction through single-cell genomics 通过单细胞基因组学揭示宿主与病原体相互作用的复杂性。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-01 DOI: 10.1016/j.micinf.2024.105313

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Dissecting viral infections, one cell at a time, by single-cell technologies 通过单细胞技术，一次一个细胞地解剖病毒感染。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-01 DOI: 10.1016/j.micinf.2023.105268

{"title":"Dissecting viral infections, one cell at a time, by single-cell technologies","authors":"","doi":"10.1016/j.micinf.2023.105268","DOIUrl":"10.1016/j.micinf.2023.105268","url":null,"abstract":"<div><p>The meteoric rise of single-cell genomic technologies, especially of single-cell RNA-sequencing (scRNA-seq), has revolutionized several fields of cellular biology, especially immunology, oncology, neuroscience and developmental biology. While the field of virology has been relatively slow to adopt these technological advances, many works have shed new light on the fascinating interactions of viruses with their hosts using single cell technologies. One clear example is the multitude of studies dissecting viral infections by single-cell sequencing technologies during the recent COVID-19 pandemic. In this review we will detail the advantages of studying viral infections at a single-cell level, how scRNA-seq technologies can be used to achieve this goal and the associated technical limitations, challenges and solutions. We will highlight recent biological discoveries and breakthroughs in virology enabled by single-cell analyses and will end by discussing possible future directions of the field. Given the rate of publications in this exciting new frontier of virology, we have likely missed some important works and we apologize in advance to the researchers whose work we have failed to cite.</p></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"26 7","pages":"Article 105268"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11161131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138440998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Host-pathogen interactions from a metabolic perspective: methods of investigation 从代谢角度看宿主-病原体相互作用:调查方法。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-01 DOI: 10.1016/j.micinf.2023.105267

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Present and future perspectives on mass spectrometry for clinical microbiology 质谱法用于临床微生物学的现状与未来展望。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-01 DOI: 10.1016/j.micinf.2024.105296

{"title":"Present and future perspectives on mass spectrometry for clinical microbiology","authors":"","doi":"10.1016/j.micinf.2024.105296","DOIUrl":"10.1016/j.micinf.2024.105296","url":null,"abstract":"<div><p>In the last decade, MALDI-TOF Mass Spectrometry (MALDI-TOF MS) has been introduced and broadly accepted by clinical laboratory laboratories throughout the world as a powerful and efficient tool for rapid microbial identification. During the MALDI-TOF MS process, microbes are identified using either intact cells or cell extracts. The process is rapid, sensitive, and economical in terms of both labor and costs involved. Whilst MALDI-TOF MS is currently the gold-standard, it suffers from several shortcomings such as lack of direct information on antibiotic resistance, poor depth of analysis and insufficient discriminatory power for the distinction of closely related bacterial species or for reliably sub-differentiating isolates to the level of clones or strains. Thus, new approaches targeting proteins and allowing a better characterization of bacterial strains are strongly needed, if possible, on a very short time scale after sample collection in the hospital. Bottom-up proteomics (BUP) is a nice alternative to MALDI-TOF MS, offering the possibility for in-depth proteome analysis. Top-down proteomics (TDP) provides the highest molecular precision in proteomics, allowing the characterization of proteins at the proteoform level. A number of studies have already demonstrated the potential of these techniques in clinical microbiology. In this review, we will discuss the current state-of-the-art of MALDI-TOF MS for the rapid microbial identification and detection of resistance to antibiotics and describe emerging approaches, including bottom-up and top-down proteomics as well as ambient MS technologies.</p></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"26 7","pages":"Article 105296"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1286457924000169/pdfft?md5=09547e92e44af695d835bd8bcb95450e&pid=1-s2.0-S1286457924000169-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139417390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subcellular particles for characterization of host-parasite interactions 用于鉴定寄主-寄主相互作用的微粒。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-01 DOI: 10.1016/j.micinf.2024.105314

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Special issue: emerging technologies for infectious disease research 特刊：传染病研究的先进技术。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-01 DOI: 10.1016/j.micinf.2024.105386

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Systems vaccinology studies – achievements and future potential 系统疫苗学研究--成就与未来潜力。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-01 DOI: 10.1016/j.micinf.2024.105318

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NMR spectroscopy can help accelerate antiviral drug discovery programs 核磁共振波谱学有助于加快抗病毒药物的发现项目。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2024-09-01 DOI: 10.1016/j.micinf.2024.105297

引用次数: 0