Microbes and Infection最新文献_第2页

The replacement of ergosterol with alternative sterols affects the physiological function of the yeast plasma membrane, including its H+-ATPase activity and resistance to antifungal drugs 用替代固醇取代麦角甾醇会影响酵母质膜的生理功能，包括其 H+-ATP 酶活性和对抗真菌药物的抗性。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/j.micinf.2024.105409

Marie Kodedová , Martin Valachovič , Hana Sychrová

{"title":"The replacement of ergosterol with alternative sterols affects the physiological function of the yeast plasma membrane, including its H+-ATPase activity and resistance to antifungal drugs","authors":"Marie Kodedová , Martin Valachovič , Hana Sychrová","doi":"10.1016/j.micinf.2024.105409","DOIUrl":"10.1016/j.micinf.2024.105409","url":null,"abstract":"<div><div>Sterols perform essential structural and signalling functions in living organisms. Ergosterol contributes to the fluidity, permeability, microdomain formation and functionality of proteins in the yeast membrane. In our study, desmosterol was the most successful at compensating for the lack of ergosterol in <em>Saccharomyces cerevisiae</em>, besides stigmasterol and sitosterol. These three sterols supported cell growth without causing severe morphological defects, unlike cholesterol, 7-dehydrocholesterol, lathosterol, cholestanol or lanosterol. Together with ergosterol, they were also able to bring the plasma membrane potential of <em>hem1</em>Δ cells closer to the level of the wild type. In addition, desmosterol conferred even higher thermotolerance to yeast than ergosterol. Some sterols counteracted the antifungal toxicity of polyenes, azoles and terbinafine to <em>hem1</em>Δ cells. Plant sterols (stigmasterol, sitosterol) and desmosterol ensured the glucose-induced activation of H<sup>+</sup>-ATPase in <em>hem1</em>Δ cells analogously to ergosterol, whereas cholesterol and 7-dehydrocholesterol were less effective. Exogenous ergosterol, stigmasterol, sitosterol, desmosterol and cholesterol also improved the growth of <em>Candida glabrata</em> and <em>Candida albicans</em> in the presence of inhibitory concentration of fluconazole. The proper incorporation of exogenous sterols into the membrane with minimal adverse side effects on membrane functions was mainly influenced by the structure of the sterol acyl chain, and less by their ring structures.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"27 2","pages":"Article 105409"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-resolution kinetics and cellular determinants of SARS-CoV-2 antibody response over two years after COVID-19 vaccination 接种 COVID-19 疫苗两年后，SARS-CoV-2 抗体反应的高分辨率动力学和细胞决定因素。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/j.micinf.2024.105423

Rocío Rubio , Dídac Macià , Diana Barrios , Marta Vidal , Alfons Jiménez , Luis M. Molinos-Albert , Natalia Díaz , Mar Canyelles , Maria Lara-Escandell , Cyril Planchais , Pere Santamaria , Carlo Carolis , Luis Izquierdo , Ruth Aguilar , Gemma Moncunill , Carlota Dobaño

{"title":"High-resolution kinetics and cellular determinants of SARS-CoV-2 antibody response over two years after COVID-19 vaccination","authors":"Rocío Rubio , Dídac Macià , Diana Barrios , Marta Vidal , Alfons Jiménez , Luis M. Molinos-Albert , Natalia Díaz , Mar Canyelles , Maria Lara-Escandell , Cyril Planchais , Pere Santamaria , Carlo Carolis , Luis Izquierdo , Ruth Aguilar , Gemma Moncunill , Carlota Dobaño","doi":"10.1016/j.micinf.2024.105423","DOIUrl":"10.1016/j.micinf.2024.105423","url":null,"abstract":"<div><div>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) studies usually rely on cross-sectional data of large cohorts but limited repeated samples, overlooking significant inter-individual antibody kinetic differences. By combining Luminex, activation-induced marker (AIM) and IFN-γ/IL-2 Fluorospot assays, we characterized the IgM, IgA, and IgG antibody kinetics using 610 samples from 31 healthy adults over two years after COVID-19 vaccination, and the T-cell responses six months post-booster. Antibody trajectories varied among isotypes: IgG decayed slowly, IgA exhibited an initial sharp decline, which gradually slowed down and stabilized above the seropositivity threshold. Contrarily, IgM rapidly dropped to undetectable levels after primary vaccination. Importantly, three vaccine doses induced higher and more durable anti-spike IgG and IgA levels compared to two doses, whereas infection led to the highest antibody peak and slowest antibody decay rate compared to vaccination. Comparing with ancestral virus, antibody levels recognizing Omicron subvariants had a faster antibody decay. Finally, polyfunctional T cells were positively associated with subsequent IgA responses. These results revealed distinctive antibody patterns by isotype and highlight the benefits of booster doses in enhancing and sustaining antibody responses.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"27 2","pages":"Article 105423"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intragenomic diversity of the small subunit rDNA gene shows limited impact on the pathogenicity of Blastocystis infection in clinical patients 小亚基 rDNA 基因的基因组内多样性对临床患者感染大疱菌的致病性影响有限

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/j.micinf.2024.105422

Laura Seijas-Pereda , Pamela C. Köster , Alejandro Dashti , Begoña Bailo , Isabel Guadano-Procesi , Carlos Rescalvo-Casas , Marcos Hernando-Gozalo , Juan Cuadros-González , David Carmena , Ramón Pérez-Tanoira

{"title":"Intragenomic diversity of the small subunit rDNA gene shows limited impact on the pathogenicity of Blastocystis infection in clinical patients","authors":"Laura Seijas-Pereda , Pamela C. Köster , Alejandro Dashti , Begoña Bailo , Isabel Guadano-Procesi , Carlos Rescalvo-Casas , Marcos Hernando-Gozalo , Juan Cuadros-González , David Carmena , Ramón Pérez-Tanoira","doi":"10.1016/j.micinf.2024.105422","DOIUrl":"10.1016/j.micinf.2024.105422","url":null,"abstract":"<div><div>The clinical significance of <em>Blastocystis</em> sp. remains to be fully elucidated. This study assesses whether <em>Blastocystis</em> subtype diversity can affect the outcome of the infection and the occurrence of clinical manifestations in infected individuals. Stool samples from 219 <em>Blastocystis</em>-positive patients by PCR targeting the <em>ssu</em> rDNA gene were fully genotyped by Sanger sequencing analyses. Co-infections by other parasitic, viral, and bacterial enteropathogens were identified by molecular and culture methods. Sequence analyses revealed the presence of six <em>Blastocystis</em> subtypes including ST1 (21.5 %), ST2 (17.8 %), ST3 (29.7 %), ST4 (22.8 %), ST6 (5.5 %), and ST7 (2.3 %), with a single sample harbouring a ST1+ST3 co-infection (0.5 %). Multivariate risk factor analyses using logistic regression models indicated that neither <em>Blastocystis</em> subtypes nor patient-associated variables including sex, country of origin, travelling history, and presence of nonspecific symptoms were positively associated with a higher likelihood of developing gastrointestinal symptoms (abdominal pain and diarrhoea). However, being of a young age (p-value: 0.003) and experiencing skin pruritus (p-value < 0.001) and eosinophilia (p-value: 0.016) were found to increase the odds of presenting gastrointestinal symptoms. <em>Blastocystis</em> subtypes based on variability within the <em>ssu</em> rDNA gene do not seem to be the main drivers of clinical manifestations in the surveyed clinical population.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"27 2","pages":"Article 105422"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD4, but not Cxcr6, is necessary for control of Pneumocystis murina infection CD4而非 Cxcr6 是控制鼠肺孢子菌感染的必要条件

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/j.micinf.2024.105408

Lisa R. Bishop , Matthew F. Starost , Joseph A. Kovacs

{"title":"CD4, but not Cxcr6, is necessary for control of Pneumocystis murina infection","authors":"Lisa R. Bishop , Matthew F. Starost , Joseph A. Kovacs","doi":"10.1016/j.micinf.2024.105408","DOIUrl":"10.1016/j.micinf.2024.105408","url":null,"abstract":"<div><div>CD4+ T cells are critical to control of <em>Pneumocystis</em> infection, and Cxcr6 has been shown to be upregulated in these cells during infection, but the roles of CD4 and Cxcr6 in this setting are undefined. To explore this, mice deficient in CD4 or Cxcr6 expression were utilized in a co-housing mouse model that mimics the natural route of <em>Pneumocystis</em> infection. Organism load and anti-<em>Pneumocystis</em> antibodies were assayed over time, and immunohistochemistry, flow cytometry, and quantitative PCR were used to characterize host immune responses during infection. CD4 was found to be necessary for clearance of <em>Pneumocystis murina,</em> though partial control was seen in it's absence; based on ThPOK expression, double negative T cells with T helper cell characteristics may be contributing to this control. Using a Cxcr6 deficient mouse expressing <em>gfp</em>, control of infection in the absence of Cxcr6 was similar to that in heterozygous control mice. It is noteworthy that <em>gfp</em> + cells were seen in the lungs with similar frequencies between the 2 strains. Interferon-ɣ and chemokine/ligands Cxcr3, Cxcl9, and Cxcl10 increased during <em>P. murina</em> infection in all models. Thus, CD4, but not Cxcr6, is needed for clearance of <em>P. murina</em> infection.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"27 2","pages":"Article 105408"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

S100A12 inhibits Streptococcus pneumoniae and aids in wound healing of corneal epithelial cells both in vitro and in vivo S100A12 可抑制肺炎链球菌，并有助于角膜上皮细胞的体外和体内伤口愈合。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/j.micinf.2024.105421

Priyasha Mishra , Sanjay Ch , Abhijit Ghosh , Srijita Kundu , Riddhi Agarwal , Bharathi Bhogapurapu , Swati Biswas , Sanhita Roy

引用次数: 0

Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice 包柔氏菌感染小鼠淋巴结早期免疫反应的单细胞转录组分析。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/j.micinf.2024.105424

Varpu Rinne , Kirsi Gröndahl-Yli-Hannuksela , Ruth Fair-Mäkelä , Marko Salmi , Pia Rantakari , Tapio Lönnberg , Jukka Alinikula , Annukka Pietikäinen , Jukka Hytönen

{"title":"Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice","authors":"Varpu Rinne , Kirsi Gröndahl-Yli-Hannuksela , Ruth Fair-Mäkelä , Marko Salmi , Pia Rantakari , Tapio Lönnberg , Jukka Alinikula , Annukka Pietikäinen , Jukka Hytönen","doi":"10.1016/j.micinf.2024.105424","DOIUrl":"10.1016/j.micinf.2024.105424","url":null,"abstract":"<div><div>Lyme borreliosis is a disease caused by <em>Borrelia burgdorferi</em> sensu lato bacteria. <em>Borrelia burgdorferi</em> is known to induce prolonged extrafollicular immune responses and abnormal germinal centre formation. The infection fails to generate a neutralizing type of immunity, eventually establishing a persistent infection. Here, we performed single-cell RNA sequencing to characterize the immune landscape of lymph node lymphocytes during the early <em>Borrelia burgdorferi</em> infection in a murine model.</div><div>Our results indicate key features of an extrafollicular immune response four days after <em>Borrelia burgdorferi</em> infection, including notable B cell proliferation, immunoglobulin class switching to IgG3 and IgG2b isotypes, plasmablast differentiation, and the presence of extrafollicular B cells identified through immunohistochemistry. Additionally, we found infection-derived upregulation of suppressor of cytokine signalling genes <em>Socs1</em> and <em>Socs3,</em> along with downregulation of genes associated with MHC II antigen presentation in B cells.</div><div>Our results support the central role of B cells in the immune response of a <em>Borrelia burgdorferi</em> infection, and provide cues of mechanisms behind the determination between extrafollicular and germinal centre responses during <em>Borrelia burgdorferi</em> infection.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"27 2","pages":"Article 105424"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suppressive effects of toll-like receptor 2, toll-like receptor 4, and toll-like receptor 7 on protective responses to Mycobacterium bovis BCG from epithelial cells Toll-Like Receptor 2、Toll-Like Receptor 4 和 Toll-Like Receptor 7 对上皮细胞卡介苗分枝杆菌保护性反应的抑制作用。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/j.micinf.2024.105428

Aarti Singh, Akshita Singh, Shakuntala Surender Kumar Saraswati, Ankush Kumar Rana, Aayushi Singh, Chaitenya Verma, Vishal Sinha, Kanika Kalra, Krishnamurthy Natarajan

{"title":"Suppressive effects of toll-like receptor 2, toll-like receptor 4, and toll-like receptor 7 on protective responses to Mycobacterium bovis BCG from epithelial cells","authors":"Aarti Singh, Akshita Singh, Shakuntala Surender Kumar Saraswati, Ankush Kumar Rana, Aayushi Singh, Chaitenya Verma, Vishal Sinha, Kanika Kalra, Krishnamurthy Natarajan","doi":"10.1016/j.micinf.2024.105428","DOIUrl":"10.1016/j.micinf.2024.105428","url":null,"abstract":"<div><div>Mycobacteria have several mechanisms for evasion of protective responses mounted by the host. In this study, we unravel yet another mechanism that is mediated by Toll-Like Receptors TLR2, TLR4, and TLR7 in epithelial cells. We show that mycobacterial infection of epithelial cells increases the expression of TLR2, TLR4, and TLR7. Stimulation of either TLR along with mycobacterial infection results in an inhibition of oxidative burst resulting in increased survival of mycobacteria inside epithelial cells. TLR stimulation along with mycobacterial infection also inhibits activation of epithelial cells for T cell responses by differentially regulating the activation of ERK-MAPK and p38-MAPK along with inhibition of co-stimulatory molecule CD86 expression. Furthermore, stimulation of either TLR inhibits the induction of apoptosis and autophagy. Knockdown of either TLR by specific siRNAs reverses the inhibition by ROS and apoptosis by mycobacteria and results in reduced intracellular survival of mycobacteria in a MyD88-dependent manner. These results point towards a negative role for TLR2, TLR4, and TLR7 in regulating protective responses to <em>M. bovis</em> BCG infection in epithelial cells.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"27 2","pages":"Article 105428"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LPS-LBP complex induced endothelial cell pyroptosis in aortic dissection is associated with gut dysbiosis 主动脉夹层中 LPS-LBP 复合物诱导的内皮细胞脓毒症与肠道菌群失调有关

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/j.micinf.2024.105406

Gulinazi Yesitayi , Qi Wang , Mengmeng Wang , Mierxiati Ainiwan , Kaisaierjiang Kadier , Aliya Aizitiaili , Yitong Ma , Xiang Ma

{"title":"LPS-LBP complex induced endothelial cell pyroptosis in aortic dissection is associated with gut dysbiosis","authors":"Gulinazi Yesitayi , Qi Wang , Mengmeng Wang , Mierxiati Ainiwan , Kaisaierjiang Kadier , Aliya Aizitiaili , Yitong Ma , Xiang Ma","doi":"10.1016/j.micinf.2024.105406","DOIUrl":"10.1016/j.micinf.2024.105406","url":null,"abstract":"<div><div>Acute aortic dissection (AAD) is the most severe traumatic disease affecting the aorta. Pyroptosis-mediated vascular wall inflammation is a crucial trigger for AAD, and the exact mechanism requires further investigation. In this study, our proteomic analysis showed that Lipopolysaccharide (LPS)-binding protein (LBP) was significantly upregulated in the plasma and aortic tissue of patients with AAD. Further, 16S rRNA sequencing of stool samples suggested that patients with AAD exhibit gut dysbiosis, which may lead to an impaired intestinal barrier and LPS leakage. By comparing with control mice, we found that LBP, including Pyrin Domain Containing Protein3 (NLRP3), the CARD-containing adapter apoptosis-associated speck-like protein (ASC), and Cleaved caspase-1, were upregulated in the AAD aorta, whereas gut intestinal barrier-related proteins were downregulated. Moreover, treated with LBPK95A (an LBP inhibitor) attenuated the incidence of AAD, the expression levels of pyroptosis-related factors, and the extent of vascular pathological changes compared to those in AAD mice. In addition, LPS and LBP treatment of human umbilical vein endothelial cells (HUVECs) activated TLR4 signaling and intracellular reactive oxygen species (ROS) production, which stimulated NLRP3 inflammasome formation and mediated pyroptosis in endothelial cells. Our findings showed that gut dysbiosis mediates pyroptosis by the LPS-LBP complex, thus providing new insights into developing AAD.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"27 2","pages":"Article 105406"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Replication-deficient Sendai virus expressing human norovirus capsid protein elicits robust NoV-specific antibody and T-cell responses in mice 表达人类诺瓦克病毒壳蛋白的复制缺陷型 sentai 病毒可在小鼠体内引起强大的诺瓦克病毒特异性抗体和 T 细胞反应。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/j.micinf.2024.105412

Yazdan Samieipour , Marian Wiegand , Elena M. Willner , Dieter Hoffmann , Kamyar Shameli , Ulrike Protzer , Hassan Moeini

{"title":"Replication-deficient Sendai virus expressing human norovirus capsid protein elicits robust NoV-specific antibody and T-cell responses in mice","authors":"Yazdan Samieipour , Marian Wiegand , Elena M. Willner , Dieter Hoffmann , Kamyar Shameli , Ulrike Protzer , Hassan Moeini","doi":"10.1016/j.micinf.2024.105412","DOIUrl":"10.1016/j.micinf.2024.105412","url":null,"abstract":"<div><div>Human norovirus (HuNoV) is a major global cause of acute gastroenteritis, with vaccine development facing several challenges. Despite years of research, there are currently no licensed vaccines available for controlling HuNoVs. Here, we describe the construction and testing of a replication-deficient Sendai virus (SeV) vector as a potential vaccine candidate against the HuNoV GII.4 genotype. SeV was chosen as the vaccine backbone due to its non-pathogenic nature in humans, its capability for long-term antigen expression in mammalian cells, and its suitability for mucosal administration. By inserting the HuNoV GII.4 capsid gene, VP1, into the SeV genome, we generated a replication-deficient SeV (SeV/dP.VP1) vector. The resultant SeV/dP.VP1 virus were observed to successfully express the inserted NoV VP1 gene upon infection. Inoculating the vaccine into wild-type mice elicited NoV-specific IgG antibodies, along with INF-γ and IL-2-producing T cells, through both intranasal (i.n.) and intramuscular (i.m.) immunization. Furthermore, a significant level of NoV-specific IgA was detected in lung homogenates after i.n. immunization, particularly using a high dose of the viral vector. Additionally, a synergistic effect was observed with heterologous prime-boost regimens using SeV/dP.VP1 and MVA.VP1 vectors, indicating the potential for more robust immune responses when the vaccine design is optimized. Our study demonstrates the potential of a SeV vaccine candidate in eliciting a broad immune response and lays the foundation for further exploration of the SeV vector platform's potential as a HuNoV vaccine. Additionally, the results emphasize the importance of vaccine dosage and administration route, highlighting the need for tailored immunization strategies.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"27 2","pages":"Article 105412"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copyright page Elsevier 版权页

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/S1286-4579(25)00019-X

引用次数: 0