Microbes and Infection最新文献_第3页

Replication-deficient Sendai virus expressing human norovirus capsid protein elicits robust NoV-specific antibody and T-cell responses in mice 表达人类诺瓦克病毒壳蛋白的复制缺陷型 sentai 病毒可在小鼠体内引起强大的诺瓦克病毒特异性抗体和 T 细胞反应。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/j.micinf.2024.105412

Yazdan Samieipour , Marian Wiegand , Elena M. Willner , Dieter Hoffmann , Kamyar Shameli , Ulrike Protzer , Hassan Moeini

{"title":"Replication-deficient Sendai virus expressing human norovirus capsid protein elicits robust NoV-specific antibody and T-cell responses in mice","authors":"Yazdan Samieipour , Marian Wiegand , Elena M. Willner , Dieter Hoffmann , Kamyar Shameli , Ulrike Protzer , Hassan Moeini","doi":"10.1016/j.micinf.2024.105412","DOIUrl":"10.1016/j.micinf.2024.105412","url":null,"abstract":"<div><div>Human norovirus (HuNoV) is a major global cause of acute gastroenteritis, with vaccine development facing several challenges. Despite years of research, there are currently no licensed vaccines available for controlling HuNoVs. Here, we describe the construction and testing of a replication-deficient Sendai virus (SeV) vector as a potential vaccine candidate against the HuNoV GII.4 genotype. SeV was chosen as the vaccine backbone due to its non-pathogenic nature in humans, its capability for long-term antigen expression in mammalian cells, and its suitability for mucosal administration. By inserting the HuNoV GII.4 capsid gene, VP1, into the SeV genome, we generated a replication-deficient SeV (SeV/dP.VP1) vector. The resultant SeV/dP.VP1 virus were observed to successfully express the inserted NoV VP1 gene upon infection. Inoculating the vaccine into wild-type mice elicited NoV-specific IgG antibodies, along with INF-γ and IL-2-producing T cells, through both intranasal (i.n.) and intramuscular (i.m.) immunization. Furthermore, a significant level of NoV-specific IgA was detected in lung homogenates after i.n. immunization, particularly using a high dose of the viral vector. Additionally, a synergistic effect was observed with heterologous prime-boost regimens using SeV/dP.VP1 and MVA.VP1 vectors, indicating the potential for more robust immune responses when the vaccine design is optimized. Our study demonstrates the potential of a SeV vaccine candidate in eliciting a broad immune response and lays the foundation for further exploration of the SeV vector platform's potential as a HuNoV vaccine. Additionally, the results emphasize the importance of vaccine dosage and administration route, highlighting the need for tailored immunization strategies.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"27 2","pages":"Article 105412"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Copyright page Elsevier 版权页

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/S1286-4579(25)00019-X

引用次数: 0

Murine C3 of the complement system affects infection by Leptospira interrogans 小鼠补体系统 C3 对钩端螺旋体感染的影响

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/j.micinf.2024.105413

Julia Avian Vassalakis , Denise Harumi Silva Yamashita , Leonardo Moura Midon , Bruno Cogliati , Marcos Bryan Heinemann , Thaís Akemi Amamura , Lourdes Isaac

{"title":"Murine C3 of the complement system affects infection by Leptospira interrogans","authors":"Julia Avian Vassalakis , Denise Harumi Silva Yamashita , Leonardo Moura Midon , Bruno Cogliati , Marcos Bryan Heinemann , Thaís Akemi Amamura , Lourdes Isaac","doi":"10.1016/j.micinf.2024.105413","DOIUrl":"10.1016/j.micinf.2024.105413","url":null,"abstract":"<div><div>Leptospirosis is an infectious neglected disease estimated to affect more than one million people worldwide each year. The Complement System plays a vital role in eliminating infectious agents. However, its precise role in leptospirosis remains to be fully understood. We investigated the importance of C3 in <em>L. interrogans</em> serovar Kennewicki strain Pomona Fromm (LPF) infection. Lack of C3 leads to decreased leukocyte number, impaired inflammatory response and failure to eliminate bacteria during the early stages of infection, which may cause interstitial nephritis later. These findings could be explained, at least in part, by the lower presence of local opsonins. Furthermore, antibody production against <em>Leptospira</em> was compromised in the absence of C3, highlighting the importance of CR2 in B lymphocyte proliferation and the adjuvant role of C3d in humoral immunity. Leptospires can be eliminated through the urine, and according to our study, the lack of C3 delays the elimination of LPF through urine during the early stages of the infection. These results strongly suggest the crucial role of C3 protein in orchestrating an appropriate inflammatory response against LPF infection and in effectively eliminating the bacteria from the body during the acute phase of leptospirosis.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"27 2","pages":"Article 105413"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of various DNA and RNA viruses in bats in Yamaguchi Prefecture, Japan 日本山口县蝙蝠体内各种 DNA 和 RNA 病毒的检测。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-02-01 DOI: 10.1016/j.micinf.2024.105425

Miyuka Nishizato , Urara Imai , Chisato Shigenaga , Miho Obata , Saki Mitsunaga , Marla Anggita , Samuel Nyampong , Shelly Wulandari , Weiyin Hu , Kazuki Kiuno , Lydia Mali Langata , Hiroyuki Imai , Masashi Sakurai , Tetsuya Yanagida , Ai Takano , Takashi Murakami , Chang-Gi Jeong , Jae-Ku Oem , Daisuke Hayasaka , Hiroshi Shimoda

{"title":"Detection of various DNA and RNA viruses in bats in Yamaguchi Prefecture, Japan","authors":"Miyuka Nishizato , Urara Imai , Chisato Shigenaga , Miho Obata , Saki Mitsunaga , Marla Anggita , Samuel Nyampong , Shelly Wulandari , Weiyin Hu , Kazuki Kiuno , Lydia Mali Langata , Hiroyuki Imai , Masashi Sakurai , Tetsuya Yanagida , Ai Takano , Takashi Murakami , Chang-Gi Jeong , Jae-Ku Oem , Daisuke Hayasaka , Hiroshi Shimoda","doi":"10.1016/j.micinf.2024.105425","DOIUrl":"10.1016/j.micinf.2024.105425","url":null,"abstract":"<div><div>Bats are important natural hosts of various zoonotic viruses, including Ebola virus, Lyssa virus, and severe acute respiratory syndrome coronavirus (SARS-CoV). Although investigation of bats is valuable for predicting emerging infectious diseases from these animals, few surveys of bat-derived viruses have been conducted in Japan. In the present study, samples were collected from a total of 132 bats of 4 different species from 4 different locations within Yamaguchi Prefecture; these sample were employed for comprehensive detection of bat-derived viruses by polymerase chain reaction (PCR) and reverse transcription (RT)-PCR using primers universal for each of 4 different viral classes. As a result of PCR and RT-PCR, various herpesviruses, astroviruses, coronaviruses, and adenoviruses were identified from a total of 80 bats. The detected herpesviruses belong to the <em>Betaherpesvirinae</em> or <em>Gammaherpesvirinae</em> subfamily, the detected adenoviruses to the genus <em>Mastadenovirus</em>, the detected astroviruses to the genus <em>Mamastrovirus</em>; and the detected coronaviruses belong to the genus <em>Alphacoronavirus</em>. The detected sequences of 12 strains of 4 families showed 100 % amino acid identity with viruses previously detected either in China or South Korea. These findings expand our understanding of viruses carried by bats, and provide insights into the nature of bat-derived viruses in Japan.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"27 2","pages":"Article 105425"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The transactivation of human endogenous retroviruses is associated with HIV-1 reservoir, lymphocyte activation and low CD4 count in virologically suppressed PLWH.

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-01-31 DOI: 10.1016/j.micinf.2025.105478

Vita Petrone, Rossana Scutari, Vincenzo Malagnino, Lorenzo Piermatteo, Mirko Compagno, Romina Salpini, Martina Giudice, Marialaura Fanelli, Elisabetta Teti, Marco Iannetta, Antonella Minutolo, Maria Mercedes Santoro, Valentina Svicher, Paola Sinibaldi Vallebona, Massimo Andreoni, Emanuela Balestrieri, Loredana Sarmati, Francesca Ceccherini-Silberstein, Sandro Grelli, Claudia Matteucci

{"title":"The transactivation of human endogenous retroviruses is associated with HIV-1 reservoir, lymphocyte activation and low CD4 count in virologically suppressed PLWH.","authors":"Vita Petrone, Rossana Scutari, Vincenzo Malagnino, Lorenzo Piermatteo, Mirko Compagno, Romina Salpini, Martina Giudice, Marialaura Fanelli, Elisabetta Teti, Marco Iannetta, Antonella Minutolo, Maria Mercedes Santoro, Valentina Svicher, Paola Sinibaldi Vallebona, Massimo Andreoni, Emanuela Balestrieri, Loredana Sarmati, Francesca Ceccherini-Silberstein, Sandro Grelli, Claudia Matteucci","doi":"10.1016/j.micinf.2025.105478","DOIUrl":"10.1016/j.micinf.2025.105478","url":null,"abstract":"<p><p>In the context of long-term therapy in virologically suppressed people living with HIV-1 (PLWH), the identification of new biomarkers associated with immuno-virological discordance, and the risk of disease progression is needed. Herein we investigated HERVs expression in association with immuno-virological discordance parameters for the identification of novel markers for the clinical monitoring of virologically suppressed PLWH. It is known the human endogenous retroviruses (HERVs), relics of ancestral exogenous retroviral infections comprising 8 % of human genome, could be reactivated by exogenous viruses including HIV-1. The study included 31 virologically suppressed PLWH and 10 healthy donors; blood HIV-DNA levels and residual plasma viremia were quantified by droplet digital-PCR, the expression of HERVs by RT-Real time PCR, and immunophenotyping by flow cytometry. The results revealed a dynamic association of HERVs with several virological and immunological parameters such as the HIV-1 reservoir, CD4 cell count, CD4 nadir and with CD8 and CD19 lymphocyte activation. In an era of searching innovative biomarkers for people living with HIV-1, the interconnection of HERVs with the HIV-1 reservoir and lymphocyte activation opens to further investigation on HERVs role in persistent immune activation in virologically suppressed PLWH, proposing them as potential new markers for clinical monitoring.</p>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":" ","pages":"105478"},"PeriodicalIF":2.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of the bacteriocinogenic Enterococcus faecalis 14 in the control of induced necrotic enteritis in broilers.

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-01-31 DOI: 10.1016/j.micinf.2025.105477

Rabia Ladjouzi, Bernard Taminiau, Georges Daube, Anca Lucau-Danila, Djamel Drider

{"title":"The efficacy of the bacteriocinogenic Enterococcus faecalis 14 in the control of induced necrotic enteritis in broilers.","authors":"Rabia Ladjouzi, Bernard Taminiau, Georges Daube, Anca Lucau-Danila, Djamel Drider","doi":"10.1016/j.micinf.2025.105477","DOIUrl":"10.1016/j.micinf.2025.105477","url":null,"abstract":"<p><strong>Purpose: </strong>To demonstrate the efficacy of the bacteriocinogenic Enterococcus faecalis 14 (E. faecalis 14) in the control of induced necrotic enteritis (NE) in broilers.</p><p><strong>Methods: </strong>Six groups of 504 broilers consisting of an infected untreated control (IUC) group, an infected and amoxicillin treated control (ITC) group, and groups receiving prophylactically (2 groups) or therapeutically (2 groups) E. faecalis 14 or its Δbac mutant were used. All groups were challenged with Clostridium perfringens 56 to induce NE. To predispose the boilers to develop subclinical NE, a high protein grower diet containing 15 % fishmeal and a coccidial inoculum were administered.</p><p><strong>Results: </strong>NE lesions were observed on D26 in all groups except ITC and those receiving prophylactically and therapeutically E. faecalis 14. On D27, only ITC and the group prophylactically treated with E. faecalis 14 (T03) were without lesions. Average body weight and daily weight gain remained lower in the treated groups compared to the ITC group, but there was a clear improvement in the period between D21 to D27, especially in the group prophylactically treated with E. faecalis 14. Specifically, the daily weight gain (DWG) in this period for group T03, was second highest after the group ITC. Metataxonomic analyses showed a positive effect of E. faecalis 14 in maintaining the diversity and richness of the intestinal microbiota, in contrast to ITC group and other conditions.</p><p><strong>Conclusions: </strong>The results of this in vivo study demonstrated the efficacy of the prophylactic administration of the bacteriocinogenic E. faecalis 14 in preventing of the NE lesions caused by C. perfringens.</p>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":" ","pages":"105477"},"PeriodicalIF":2.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteolytic activity of secreted proteases from pathogenic leptospires and effects on phagocytosis by murine macrophages. 致病性钩端螺旋体分泌蛋白酶的蛋白水解活性及其对小鼠巨噬细胞吞噬的影响。

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-01-04 DOI: 10.1016/j.micinf.2025.105469

Thais A Amamura, Daniella Dos S Courrol, Angela S Barbosa, Ildefonso A Silva-Junior, Tiago F da Silva, Leonardo M Midon, Mario C Cruz, Marcos B Heinemann, Rosa M Chura-Chambi, Ligia Morganti, Lourdes Isaac

{"title":"Proteolytic activity of secreted proteases from pathogenic leptospires and effects on phagocytosis by murine macrophages.","authors":"Thais A Amamura, Daniella Dos S Courrol, Angela S Barbosa, Ildefonso A Silva-Junior, Tiago F da Silva, Leonardo M Midon, Mario C Cruz, Marcos B Heinemann, Rosa M Chura-Chambi, Ligia Morganti, Lourdes Isaac","doi":"10.1016/j.micinf.2025.105469","DOIUrl":"https://doi.org/10.1016/j.micinf.2025.105469","url":null,"abstract":"<p><p>Leptospirosis is a zoonosis caused by spirochete Leptospira. Pathogenic leptospires evade the Complement System, enabling their survival upon contact with normal human serum in vitro. In a previous study, we demonstrated that proteases secreted by pathogenic leptospires cleave several Complement proteins, including C3 and the opsonins C3b and iC3b. We hypothesize that these Leptospira proteases, such as thermolysin and leptolysin, may decrease the phagocytic activity of murine peritoneal macrophages. We observed decreased amounts of CR3 and CR4 using flow cytometry when these cells were treated with supernatant from the culture of pathogenic leptospires (SPL) for 24 h. Through confocal microscopy, we observed a reduction in TLR2, CD11b, and CD206 (mannose receptor) levels when these cells were treated with SPL or recombinant thermolysin for 24 h. Furthermore, opsonins such as C3b/iC3b deposited on the surface of pathogenic leptospires were clearly degraded in the presence of recombinant thermolysin or recombinant leptolysin. Consequently, when opsonized bacteria and macrophages were previously incubated with these proteases, phagocytic activity was diminished. These observations lead us to suggest that proteases secreted by pathogenic leptospires could degrade opsonins present in normal serum or deposited on the bacterial membrane, as well as cleave or inhibit macrophage surface molecules. Therefore, these proteases could interfere with the recognition and internalization by murine macrophages, favoring the spread of leptospires in the host.</p>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":" ","pages":"105469"},"PeriodicalIF":2.6,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial and host factors involved in zoonotic Streptococcal meningitis 人畜共患链球菌脑膜炎涉及的细菌和宿主因素

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-01-01 DOI: 10.1016/j.micinf.2024.105335

Jiale Ma , Huizhen Wu , Zhe Ma , Zongfu Wu

{"title":"Bacterial and host factors involved in zoonotic Streptococcal meningitis","authors":"Jiale Ma , Huizhen Wu , Zhe Ma , Zongfu Wu","doi":"10.1016/j.micinf.2024.105335","DOIUrl":"10.1016/j.micinf.2024.105335","url":null,"abstract":"<div><div>Zoonotic streptococci cause several invasive diseases with high mortality rates, especially meningitis. Numerous studies elucidated the meningitis pathogenesis of zoonotic streptococci, some specific to certain bacterial species. In contrast, others are shared among different bacterial species, involving colonization and invasion of mucosal barriers, survival in the bloodstream, breaching the blood–brain and/or blood–cerebrospinal fluid barrier to access the central nervous system, and triggering inflammation of the meninges. This review focuses on the recent advancements in comprehending the molecular and cellular events of five major zoonotic streptococci responsible for causing meningitis in humans or animals, including <em>Streptococcus agalactiae</em>, <em>Streptococcus equi</em> subspecies <em>zooepidemicus</em>, <em>Streptococcus suis</em>, <em>Streptococcus dysgalactiae</em>, and <em>Streptococcus iniae</em>. The underlying mechanism was summarized into four themes, including 1) bacterial survival in blood, 2) brain microvascular endothelial cell adhesion and invasion, 3) penetration of the blood–brain barrier, and 4) activation of the immune system and inflammatory reaction within the brain. This review may contribute to developing therapeutics to prevent or mitigate injury of streptococcal meningitis and improve risk stratification.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"27 1","pages":"Article 105335"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140566419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copyright page Elsevier

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-01-01 DOI: 10.1016/S1286-4579(25)00006-1

引用次数: 0

Comparative genome analysis of Streptococcus suis serotype 5 strains from humans and pigs revealed pathogenic potential of virulent, antimicrobial resistance, and genetic relationship 来自人和猪的猪链球菌血清型 5 菌株的基因组比较分析揭示了毒力、抗菌药耐药性和遗传关系的致病潜力

IF 2.6 4区医学

Microbes and Infection Pub Date : 2025-01-01 DOI: 10.1016/j.micinf.2023.105273

Anusak Kerdsin , Rujirat Hatrongjit , Thidathip Wongsurawat , Piroon Jenjaroenpun , Han Zheng , Peechanika Chopjitt , Parichart Boueroy , Nahuel Fittipaldi , Mariela Segura , Marcelo Gottschalk

{"title":"Comparative genome analysis of Streptococcus suis serotype 5 strains from humans and pigs revealed pathogenic potential of virulent, antimicrobial resistance, and genetic relationship","authors":"Anusak Kerdsin , Rujirat Hatrongjit , Thidathip Wongsurawat , Piroon Jenjaroenpun , Han Zheng , Peechanika Chopjitt , Parichart Boueroy , Nahuel Fittipaldi , Mariela Segura , Marcelo Gottschalk","doi":"10.1016/j.micinf.2023.105273","DOIUrl":"10.1016/j.micinf.2023.105273","url":null,"abstract":"<div><div><em>Streptococcus suis</em> is a causative agent of swine and human infections. Genomic analysis indicated that eight <em>S. suis</em> serotype 5 strains recovered from human patients and pigs carried many virulence-associated genes and markers defining pathogenic pathotypes. The strains were sequence types diverse and clustered within either minimum core genome group 3 (MCG-3) or MCG-7-3. Almost all the serotype 5 strains were non-susceptible to penicillin, ceftriaxone, erythromycin, and levofloxacin. Resistance to tetracycline and clindamycin was observed in all strains. The antimicrobial resistance genes <em>tet(O), tet(O/W/32/O), tet(W)</em>, <em>tet(44)</em>, <em>erm(B), ant(6)-Ia, lsaE</em>, and <em>lnuB</em> were found in these strains. Moderate-to-large numbers of substitutions were observed in three penicillin-binding proteins (PBP)—PBP1A, PBP2B, and PBP2X—in the penicillin-non-susceptible serotype 5 isolates that were involved in β-lactam-non-susceptibility. Comparative genomics between the serotype 5 and 2 strains revealed that only 15 genes absent from the serotype 2 strains were shared by all the serotype 5 strains. However, some additional genes were present only in some of the serotype 5 strains. This study highlighted the pathogenic potential of virulent serotype 5 strains in humans and pigs and the need for increased monitoring of penicillin-non-susceptibility in <em>S. suis</em> serotypes other than for serotype 2.</div></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":"27 1","pages":"Article 105273"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138558348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0