Micro & Nano Letters最新文献

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Simulation of the Dynamics of Supersonic N-Crowdions in fcc Lead and Nickel 超声速氮离子在fcc铅镍中的动力学模拟
IF 1.3 4区 材料科学
Micro & Nano Letters Pub Date : 2023-07-04 DOI: 10.3390/micro3030044
A. Bayazitov, A. Semenov, S. V. Dmitriev
{"title":"Simulation of the Dynamics of Supersonic N-Crowdions in fcc Lead and Nickel","authors":"A. Bayazitov, A. Semenov, S. V. Dmitriev","doi":"10.3390/micro3030044","DOIUrl":"https://doi.org/10.3390/micro3030044","url":null,"abstract":"In the case where an interstitial atom is located in a close-packed atomic row of the crystal lattice, it is called a crowdion. Crowdions play an important role in the processes of mass and energy transfer resulting from irradiation, severe plastic deformation, ion implantation, plasma and laser processing, etc. In this work, supersonic N-crowdions (N=1, 2) in fcc lattices of lead and nickel are studied by the method of molecular dynamics. Modeling shows that the propagation distance of a supersonic 2-crowdion in lead at a high initial velocity is less than that of a supersonic 1-crowdion. In other fcc metals studied, including nickel, supersonic 2-crowdions have a longer propagation distance than 1-crowdions. The relatively short propagation distance of supersonic 2-crowdions in lead is due to their instability and rapid transformation into supersonic 1-crowdions. This feature of the dynamics of supersonic N-crowdions in lead explains its high radiation-shielding properties.","PeriodicalId":18398,"journal":{"name":"Micro & Nano Letters","volume":"8 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74305274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation of chitosan-embedded recombinant human epidermal growth factor nanoparticles as accelerating compounds for skin remodelling in chronic lesions 壳聚糖包埋重组人表皮生长因子纳米颗粒作为慢性病变皮肤重塑促进剂的制备
IF 1.3 4区 材料科学
Micro & Nano Letters Pub Date : 2023-07-03 DOI: 10.1049/mna2.12171
Saadeh Hashemi, Elnaz Mihandoost, Sepideh Khaleghi
{"title":"Preparation of chitosan-embedded recombinant human epidermal growth factor nanoparticles as accelerating compounds for skin remodelling in chronic lesions","authors":"Saadeh Hashemi,&nbsp;Elnaz Mihandoost,&nbsp;Sepideh Khaleghi","doi":"10.1049/mna2.12171","DOIUrl":"https://doi.org/10.1049/mna2.12171","url":null,"abstract":"<p>The chronic lesion has become a major biological difficulty. Using nanoparticles as drug delivery systems is remarkable nowadays. The unique properties of chitosan in combination with epidermal growth factor (EGF) can accelerate the wound-healing process.</p><p>In this study, Chitosan-EGF (CS-EGF) nanoparticles were manipulated and characterized by Transmission Electron Microscopy (TEM) microscopy, dynamic light scattering (DLS) method, and Fourier Transform Infrared Spectroscopy (FTIR) radiation. The antibacterial effect was estimated by minimum inhibitory concentration (MIC)/minimum bactericidal concentration (MBC) methods and the proliferation assay was measured on the HFF-1 (human fibroblast cell line). Then, migration assay was accomplished and the gene expression analysis for transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), and platelets-derived growth factor (PDGF) was manipulated by the real-time-PCR method. The obtained results were considered statistically significant with <i>P</i> &lt; 0.05.</p><p>Obtained results illustrated no toxic effect on the HFF-1 cell line treated with CS-EGF. In cellular proliferation and migration assays, CS-EGF nanoparticles demonstrated 2-folds higher than the control. In the duration of 72 h of the experiment, and concentration of 10 µM, 90 ±10% of cells were migrated and the whole scratch was covered by fibroblasts. The real-time-PCR analysis also showed 7.5, 4.5-, and 7-fold upregulation of all TGF-β, VEGF, and PDGF genes in comparison with the control group.</p><p>This study confirmed that using chitosan nanoparticles as a carrier for EGF can accelerate cellular remodelling and annihilate bacterial infection in the process of treatment. As CS-EGF nanoparticles in the acceleration of the skin remodelling process showed promising results, subsequent studies might be useful.</p>","PeriodicalId":18398,"journal":{"name":"Micro & Nano Letters","volume":"18 7","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/mna2.12171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50119139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication of Circular Cross-Section Microchannels with 3-D Lattice Arrangement and Their Use as On-Off Valves 三维点阵布置圆形截面微通道的制备及其开关阀的应用
IF 1.3 4区 材料科学
Micro & Nano Letters Pub Date : 2023-06-30 DOI: 10.3390/micro3030043
Kaori Uehara, Yutaka Hori, T. Ishigure
{"title":"Fabrication of Circular Cross-Section Microchannels with 3-D Lattice Arrangement and Their Use as On-Off Valves","authors":"Kaori Uehara, Yutaka Hori, T. Ishigure","doi":"10.3390/micro3030043","DOIUrl":"https://doi.org/10.3390/micro3030043","url":null,"abstract":"In this paper, circular cross-section microchannels with 3-D lattice arrangements are designed and fabricated using the Mosquito method in order to construct on-off valves. The 3-D microchannels with on-off valves consist of two types of lines: the flow lines for chemical liquid flow and the control lines to activate the valves. We confirmed that both a circular cross-section and a PDMS with low elastic modulus used as the microchannel material contribute to a valve that can be closed with a lower pressure. Then, we demonstrated liquid flow to evaluate the functionality of the valve. Fluorescein solution was flown into a flow line. We found that the fluorescence intensity decreases at the intersection between the flow and control lines when the flow line is closed by the inflation of the control line, experimentally confirming the functionality of the valve microchannels fabricated via the Mosquito method.","PeriodicalId":18398,"journal":{"name":"Micro & Nano Letters","volume":"25 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80058445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosynthesis of ZnO.Ag2O3 using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells 利用钝叶单叶藻水提取物生物合成ZnO.Ag2O3:特性和对肝癌细胞的细胞毒性
IF 1.3 4区 材料科学
Micro & Nano Letters Pub Date : 2023-06-25 DOI: 10.1049/mna2.12170
Majid Halimi Khalil Abad, Mohabat Nadaf, Mohammad Ehsan Taghavizadeh Yazdi
{"title":"Biosynthesis of ZnO.Ag2O3 using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells","authors":"Majid Halimi Khalil Abad,&nbsp;Mohabat Nadaf,&nbsp;Mohammad Ehsan Taghavizadeh Yazdi","doi":"10.1049/mna2.12170","DOIUrl":"https://doi.org/10.1049/mna2.12170","url":null,"abstract":"<p>The zinc oxide-silver oxide nanocomposite (ZnO.Ag<sub>2</sub>O<sub>3</sub> particles) was prepared by using an aqueous plant extract of <i>Haplophyllum obtusifolium</i> for the first time. Powder X-ray diffraction (PXRD), Fourier transforms spectroscopy (FTIR), field emission microscopy (FESEM), energy dispersive X-ray analysis (EDX), and transmission electron microscopy (TEM) were applied to analyze the structure, functional groups, morphology, and purity of the prepared nanocomposite. PXRD revealed the formulation of ZnO.Ag<sub>2</sub>O<sub>3</sub> for the particles. The investigation of functional groups has demonstrated the presence of some carbonated impurities along with absorbed water in the composition of the ZnO.Ag<sub>2</sub>O<sub>3</sub> nanocomposite. Morphologically, particles have formed a petal-like shape with different sizes. The EDX analysis also confirmed the composition of the prepared sample and the presence of 4.78% silver in the formula. Additionally, the TEM analysis revealed spherical and rectangular shapes with a particle size of 80.43 ± 46.73 nm. Moreover, the ZnO.Ag<sub>2</sub>O<sub>3</sub> particles were used against cancer cells, which has shown synthesized NCs have a toxic effect against liver cancer cells in a concentration and time-dependent manner.</p>","PeriodicalId":18398,"journal":{"name":"Micro & Nano Letters","volume":"18 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/mna2.12170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50143600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Selective Hydrodeoxygenation of Guaiacol to Cyclohexane over Ru-Catalysts Based on MFI Nanosheets 基于MFI纳米片的钌催化剂上愈创木酚选择性加氢脱氧制环己烷
IF 1.3 4区 材料科学
Micro & Nano Letters Pub Date : 2023-06-20 DOI: 10.3390/micro3020042
Dmitry E. Tsaplin, A. Sadovnikov, D. Ramazanov, D. Gorbunov, Valeriya Ryleeva, A. Maximov, Kaige Wang, E. Naranov
{"title":"Selective Hydrodeoxygenation of Guaiacol to Cyclohexane over Ru-Catalysts Based on MFI Nanosheets","authors":"Dmitry E. Tsaplin, A. Sadovnikov, D. Ramazanov, D. Gorbunov, Valeriya Ryleeva, A. Maximov, Kaige Wang, E. Naranov","doi":"10.3390/micro3020042","DOIUrl":"https://doi.org/10.3390/micro3020042","url":null,"abstract":"Bio-oils derived from the pyrolysis of lignin-based biomass often contain a variety of oxygenated compounds, which can compromise their usefulness as a fuel. To improve the quality of bio-oil, catalytic hydrodeoxygenation (HDO) is a crucial step that removes oxygen from the oil in the form of water. In this study, we showed that MFI nanosheets are excellent supports for Ru-catalysts. We synthesized highly crystalline MFI nanosheets using a simple hydrothermal seeding procedure; the final material was obtained in 56 h of crystallization. We investigated the activity of Ru supported on different materials. Our findings indicated that Ru supported on hierarchical MFI demonstrated excellent activity in HDO of guaiacol. Our results demonstrated that Ru/ZNS-56 achieved nearly 100% selectivity towards cyclohexane under mild conditions (200 °C, 50 bar H2, 1 h).","PeriodicalId":18398,"journal":{"name":"Micro & Nano Letters","volume":"33 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88733794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
F2 Laser-Induced Micro-Reticulated Structural Changes of Amorphous Carbon Thin Films 激光诱导非晶碳薄膜微网状结构的变化
IF 1.3 4区 材料科学
Micro & Nano Letters Pub Date : 2023-06-16 DOI: 10.3390/micro3020041
M. Okoshi
{"title":"F2 Laser-Induced Micro-Reticulated Structural Changes of Amorphous Carbon Thin Films","authors":"M. Okoshi","doi":"10.3390/micro3020041","DOIUrl":"https://doi.org/10.3390/micro3020041","url":null,"abstract":"Micro/nanoprocessing of materials using lasers is currently an active research topic. In that research, the choice of the laser to be used is critical, but the F2 laser, which has the shortest wavelength (157 nm) among commercially available lasers, has few research compared to its potential. In this paper, we discovered a new photochemical processing by using an F2 laser to irradiate an amorphous carbon thin film. The short wavelength and high photon energy of the F2 laser can photoexcite the surface of the thin film at high density and generate active oxygen atoms O(1D) by photodecomposition of atmospheric oxygen molecules. As a result, the optical change of the amorphous carbon thin film was induced without thickness reduction, and a micron-sized network-like, reticulated structural change was formed in the thin film surface after one month at the latest. The formed micron-sized reticulated structure was relatively swollen, and a graphitization occurred in the structure, observed by Raman spectroscopy. However, the structure was not observed when the laser irradiated area became smaller. This work has made it possible to form a micron-sized reticulated structure including carbon nanocrystals in an amorphous carbon, which is expected to further expand the applications of carbon materials.","PeriodicalId":18398,"journal":{"name":"Micro & Nano Letters","volume":"57 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77699023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three novel iridium (III) complexes containing double chiral atoms for organic light-emitting diodes 三种用于有机发光二极管的新型双手性铱(III)配合物
IF 1.3 4区 材料科学
Micro & Nano Letters Pub Date : 2023-06-12 DOI: 10.1049/mna2.12169
Gan Cheng, Jun-jian Lu, Li-Ya Zhu, Guangzhao Lu
{"title":"Three novel iridium (III) complexes containing double chiral atoms for organic light-emitting diodes","authors":"Gan Cheng,&nbsp;Jun-jian Lu,&nbsp;Li-Ya Zhu,&nbsp;Guangzhao Lu","doi":"10.1049/mna2.12169","DOIUrl":"https://doi.org/10.1049/mna2.12169","url":null,"abstract":"<p>Chiral iridium (III) complexes are very important for the preparation of circularly polarized organic diodes light-emitting diodes (CP-OLEDs). Three novel iridium (III) complexes, Ir(dnfppy)<sub>2</sub>(Cl/pyrrole), Ir(dfppy)<sub>2</sub>(dpp), and Ir(tfmqz)<sub>2</sub>(sdpp), have been synthesized and characterized, respectively. These iridium (III) complexes emitted deep-blue, blue, and red photoluminescence with high quantum yields (Ir(dnfppy)<sub>2</sub>(Cl/Pyrrole): λ<sub>max</sub> = 447 nm, F = 62.4%; Ir(dfppy)<sub>2</sub>(dpp): λ<sub>max</sub> = 467 nm, F = 25%; Ir(tfmqz)<sub>2</sub>(sdpp): λ<sub>max</sub> = 609 nm, F = 73.7%). Compared with Ir(dnfppy)<sub>2</sub>(Cl/pyrrole), the HOMO energy levels of Ir(dfppy)<sub>2</sub>(dpp) and Ir(tfmqz)<sub>2</sub>(sdpp) were calculated to be −5.71/−5.73 eV, and the LUMO energy levels were increased to be −2.75/−3.36 eV, respectively. The circular dichroism spectra of two pairs of the enantiomers for Ir(dfppy)<sub>2</sub>(dpp) or Ir(tfmqz)<sub>2</sub>(sdpp) displayed symmetry with opposite polarization between 300 and 600 nm. The maximum external quantum efficiency (EQE<sub>max</sub>) of OLEDs based on Ir(tfmpqz)<sub>2</sub>(sddp) was 13.8%, showing a relatively low efficiency roll-off with the EQE of 10.7% at 5000 cd/m<sup>2</sup>.</p>","PeriodicalId":18398,"journal":{"name":"Micro & Nano Letters","volume":"18 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/mna2.12169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50130105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sacrificial Doping as an Approach to Controlling the Energy Properties of Adsorption Sites in Gas-Sensitive ZnO Nanowires 牺牲掺杂作为控制气敏ZnO纳米线中吸附位点能量特性的方法
IF 1.3 4区 材料科学
Micro & Nano Letters Pub Date : 2023-06-01 DOI: 10.3390/micro3020040
S. Nalimova, Z. Shomakhov, A. Bobkov, V. Moshnikov
{"title":"Sacrificial Doping as an Approach to Controlling the Energy Properties of Adsorption Sites in Gas-Sensitive ZnO Nanowires","authors":"S. Nalimova, Z. Shomakhov, A. Bobkov, V. Moshnikov","doi":"10.3390/micro3020040","DOIUrl":"https://doi.org/10.3390/micro3020040","url":null,"abstract":"Currently, devices for environmental gas analyses are required in many areas of application. Among such devices, semiconductor-resistive gas sensors differ advantageously. However, their characteristics need further improvement. The development of methods for controlling the surface properties of nanostructured metal oxides for their use as gas sensors is of great interest. In this paper, a method involving the sacrificial doping of ZnO nanowires to control the content of their surface defects (oxygen vacancies) was proposed. Zinc oxide nanowires were synthesized using the hydrothermal method with sodium iodide or bromide as an additional precursor. The surface composition was studied using X-ray photoelectron spectroscopy. The sensor properties of the isopropyl alcohol vapors at 150 °C were studied. It was shown that a higher concentration of oxygen vacancies/hydroxyl groups was observed on the surfaces of the samples synthesized with the addition of iodine and bromine precursors compared to the pure zinc oxide nanowires. It was also found out that these samples were more sensitive to isopropyl alcohol vapors. A model was proposed to explain the appearance of additional oxygen vacancies in the subsurface layer of the zinc oxide nanowires when sodium iodide or sodium bromide was added to the initial solution. The roles of oxygen vacancies and surface hydroxyl groups in providing the samples with an increased sensitivity were explained. Thus, a method involving the sacrificial doping of zinc oxide nanowires has been developed, which led to an improvement in their gas sensor characteristics due to an increase in the concentration of oxygen vacancies on their surface. The results are promising for percolation gas sensors equipped with additional water vapor traps that work stably in a high humidity.","PeriodicalId":18398,"journal":{"name":"Micro & Nano Letters","volume":"1 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82105071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Novel Approach of Polyethylene Glycol-4000 Hydrogels as Controlled Drug Carriers 聚乙二醇-4000水凝胶作为受控药物载体的新方法
IF 1.3 4区 材料科学
Micro & Nano Letters Pub Date : 2023-06-01 DOI: 10.3390/micro3020039
M. Suhail, Iain H Chiu, I-Ling Lin, M. Tsai, Pao-chu Wu
{"title":"A Novel Approach of Polyethylene Glycol-4000 Hydrogels as Controlled Drug Carriers","authors":"M. Suhail, Iain H Chiu, I-Ling Lin, M. Tsai, Pao-chu Wu","doi":"10.3390/micro3020039","DOIUrl":"https://doi.org/10.3390/micro3020039","url":null,"abstract":"In this study, we developed polyethylene glycol-4000-based hydrogels for ketorolac tromethamine-controlled delivery systems through a free radical polymerization method. The developed hydrogels were subjected to FTIR, TGA, DSC, XRD, SEM, porosity analysis, dynamic swelling analysis, release studies, etc. The successful crosslinking and stability of the prepared hydrogels were confirmed by FTIR, DSC, and TGA analysis. The surface morphology and the reduction in the crystallinity of the polymer after grafting were shown by SEM and XRD analysis. Similarly, the soluble part of the developed hydrogels was eliminated from their insoluble part by the Soxhlet extraction process. Higher dynamic swelling and drug release were observed at high pH values compared to low pH values. High porosity was perceived with high concentrations of the monomers and polymer and decreased with the high incorporation of a crosslinker. The release mechanism of all formulations followed non-Fickian diffusion. The results demonstrate that the developed polyethylene glycol-4000 hydrogels could serve as promising controlled drug delivery carriers.","PeriodicalId":18398,"journal":{"name":"Micro & Nano Letters","volume":"38 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81817280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pressure-Driven Sample Flow through an Electrospun Membrane Increases the Analyte Adsorption 压力驱动的样品流通过静电纺丝膜增加了分析物的吸附
IF 1.3 4区 材料科学
Micro & Nano Letters Pub Date : 2023-05-26 DOI: 10.3390/micro3020038
A. Maslakova, K. Prusakov, Anastasia Sidorova, E. Pavlova, A. Ramonova, D. Bagrov
{"title":"Pressure-Driven Sample Flow through an Electrospun Membrane Increases the Analyte Adsorption","authors":"A. Maslakova, K. Prusakov, Anastasia Sidorova, E. Pavlova, A. Ramonova, D. Bagrov","doi":"10.3390/micro3020038","DOIUrl":"https://doi.org/10.3390/micro3020038","url":null,"abstract":"Electrospun polymer membranes are regarded as prospective biosensor components due to their large specific surface area and diverse opportunities for chemical modifications. However, their intricate porous structure can impede diffusion and render some analyte-binding sites inaccessible. To overcome these diffusion limitations and improve analyte adsorption onto the polymer, a pressure-driven sample flow through the membrane can be employed. To date, the efficiency of pressure-driven analyte delivery into these membranes has not been quantified. Here, we compare forced flow and passive sample diffusion through poly(dioxanone) electrospun membranes. We examine two model analytes, BSA and interleukin-1 beta (IL1b), to address both non-specific and specific binding. Following exposure of the membranes to the test solutions, we measured the residual concentrations of the analytes using fluorometry and enzyme-linked immunosorbent assay (ELISA) techniques. The pressure-driven sample loading was superior to passive diffusion, with a 2.8–11.5-fold change for physical adsorption and a 2.4–3.4-fold difference for specific binding. Our data can be useful for the development of immunoassays and microfluidic devices.","PeriodicalId":18398,"journal":{"name":"Micro & Nano Letters","volume":"2 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72820232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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