A Novel Approach of Polyethylene Glycol-4000 Hydrogels as Controlled Drug Carriers

IF 1.5 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Micro & Nano Letters Pub Date : 2023-06-01 DOI:10.3390/micro3020039

M. Suhail, Iain H Chiu, I-Ling Lin, M. Tsai, Pao-chu Wu

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引用次数: 0

Abstract

In this study, we developed polyethylene glycol-4000-based hydrogels for ketorolac tromethamine-controlled delivery systems through a free radical polymerization method. The developed hydrogels were subjected to FTIR, TGA, DSC, XRD, SEM, porosity analysis, dynamic swelling analysis, release studies, etc. The successful crosslinking and stability of the prepared hydrogels were confirmed by FTIR, DSC, and TGA analysis. The surface morphology and the reduction in the crystallinity of the polymer after grafting were shown by SEM and XRD analysis. Similarly, the soluble part of the developed hydrogels was eliminated from their insoluble part by the Soxhlet extraction process. Higher dynamic swelling and drug release were observed at high pH values compared to low pH values. High porosity was perceived with high concentrations of the monomers and polymer and decreased with the high incorporation of a crosslinker. The release mechanism of all formulations followed non-Fickian diffusion. The results demonstrate that the developed polyethylene glycol-4000 hydrogels could serve as promising controlled drug delivery carriers.

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聚乙二醇-4000水凝胶作为受控药物载体的新方法

在这项研究中，我们通过自由基聚合的方法开发了基于聚乙二醇-4000的水凝胶，用于酮咯酸甲基三胺控制的递送系统。对制备的水凝胶进行了FTIR、TGA、DSC、XRD、SEM、孔隙度分析、动态溶胀分析、释放研究等。通过红外光谱(FTIR)、DSC和热重分析(TGA)证实了所制备的水凝胶的交联成功和稳定性。用SEM和XRD分析了接枝后聚合物的表面形貌和结晶度的降低。同样，开发的水凝胶的可溶部分通过索氏萃取法从其不溶部分中去除。与低pH值相比，高pH值下观察到更高的动态肿胀和药物释放。当单体和聚合物浓度较高时，孔隙率较高，而交联剂的掺入越多，孔隙率就越低。各制剂的释放机制均为非菲克扩散。结果表明，所制备的聚乙二醇-4000水凝胶是一种很有前途的药物控制载体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Micro & Nano Letters 工程技术-材料科学：综合

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.8 months

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