Mayo Clinic proceedings最新文献

{"title":"37-Year-Old Man With Chest Pain.","authors":"Naba Farooqui, Sara S Inglis, Francisco Lopez-Jimenez","doi":"10.1016/j.mayocp.2024.01.004","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.01.004","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pemphigus Foliaceus.","authors":"Alexandra L McLennan, Clay J Cockerell, Vicky Z Ren","doi":"10.1016/j.mayocp.2024.07.019","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.07.019","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Work on Personal Relationships and Physician Well-being","authors":"Mickey T. Trockel MD, PhD ,&nbsp;Liselotte N. Dyrbye MD, MHPE, FACP ,&nbsp;Colin P. West MD, PhD ,&nbsp;Christine A. Sinsky MD ,&nbsp;Hanhan Wang MPS ,&nbsp;Lindsey E. Carlasare MBA ,&nbsp;Michael Tutty PhD, MHA ,&nbsp;Tait D. Shanafelt MD","doi":"10.1016/j.mayocp.2024.03.010","DOIUrl":"10.1016/j.mayocp.2024.03.010","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the impact of work on personal relationships (IWPR) by specialty and demographic variables in a national sample of physicians, to assess the association between the IWPR and burnout, and to determine the effect of adjusting for IWPR on the risk of burnout associated with being a physician.</div></div><div><h3>Methods</h3><div>Analysis was conducted of data from a representative sample of US physicians surveyed between November 20, 2020, and March 23, 2021, and from a probability-based sample of other US workers. IWPR and burnout were measured with published assessments.</div></div><div><h3>Results</h3><div>Of the 7360 physicians who responded to the survey, 6271 (85.2%) completed the IWPR assessment. In multivariable analysis, moderate or higher IWPR was associated with female sex (odds ratio [OR], 1.26; 95% CI, 1.11 to 1.43), married vs single (OR, 0.59; 95% CI, 0.48 to 0.71), and emergency medicine (OR, 1.93; 95% CI, 1.43 to 2.60) or physical and rehabilitative medicine (OR, 1.67; 95% CI, 1.12 to 2.50) vs internal medicine subspecialty. Physicians were more likely than workers in other fields (OR, 2.65; 95% CI, 2.33 to 3.02) to endorse the statement “In the past year, my job contributed to me feeling more isolated or detached from the people who are important to me” as at least moderately true. After adjustment for responses to this statement, work hours, and demographic characteristics, being a physician was not associated with the risk of burnout.</div></div><div><h3>Conclusion</h3><div>IWPR is associated with burnout. Adjustment for IWPR eliminated the observed difference in burnout between physicians and workers in other fields. Interventions that identify and mitigate work practices that have a negative impact on physicians’ personal relationships and interventions that support affected individual physicians are warranted.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 10","pages":"Pages 1567-1576"},"PeriodicalIF":6.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bariatric and Metabolic Surgery in the Adult Population","authors":"Betemariam Sharew BA ,&nbsp;Nandan Kodur BS ,&nbsp;Ricard Corcelles MD ,&nbsp;Yael Mauer MD, MPH","doi":"10.1016/j.mayocp.2024.05.022","DOIUrl":"10.1016/j.mayocp.2024.05.022","url":null,"abstract":"<div><div>Obesity is a significant public health concern worldwide and a leading cause of preventable death and morbidity, but the management of this condition remains a challenge. Metabolic and bariatric surgery (MBS) is safe and currently has the most consistent and robust data among anti-obesity interventions for ameliorating obesity and its associated complications. Despite the benefits and safety of MBS, it is significantly underused. There are several proposed reasons for this underuse, one of which is a knowledge gap among primary care physicians, contributing to low referral rates. The purpose of this review is to summarize key points of the 2022 American Society for Metabolic and Bariatric Surgery/International Federation for the Surgery of Obesity and Metabolic Disorders guidelines regarding MBS, as well as to discuss indications, benefits and risks, most common types of MBS, and barriers to access, thereby increasing awareness of MBS among primary care physicians. This narrative review was based on articles found by searching PubMed from its inception until April 2024 for the terms sleeve gastrectomy, gastric bypass, and metabolic and bariatric surgery. Our search was confined to English-language publications, with emphasis placed on evidence derived from systematic literature reviews, meta-analyses, and randomized clinical trials whenever available.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 10","pages":"Pages 1631-1645"},"PeriodicalIF":6.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventional Radiology Partial Splenic Embolization for Refractory Thrombocytopenia in Still Disease","authors":"Frank G. Lee MD,&nbsp;Maxwell J. Jabaay DO, MS,&nbsp;John M. Zietlow MD,&nbsp;Chris J. Reisenauer MD","doi":"10.1016/j.mayocp.2024.07.018","DOIUrl":"10.1016/j.mayocp.2024.07.018","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 10","pages":"Pages 1674-1675"},"PeriodicalIF":6.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trimethylamine-N-Oxide and Related Metabolites: Assessing Cardiovascular Risk in the Dallas Heart Study","authors":"","doi":"10.1016/j.mayocp.2023.12.021","DOIUrl":"10.1016/j.mayocp.2023.12.021","url":null,"abstract":"<div><h3>Objective</h3><div><span>To evaluate the association between trimethylamine </span><em>N</em>-oxide (TMAO) and related metabolites with adverse cardiovascular events in a multiethnic urban primary prevention population.</div></div><div><h3>Methods</h3><div><span>We performed a case-control study of 361 participants of the Dallas Heart Study, including 88 participants with an incident atherosclerotic cardiovascular disease (ASCVD) event and 273 controls matched for age, sex, and </span>body mass index<span><span><span><span> without an ASCVD event during 12 years of follow-up (January 1, 2000, through December 31, 2015). Plasma levels of TMAO, choline, </span>carnitine, </span>betaine, and </span>butyrobetaine<span> were measured by mass spectrometry. The differential odds for incident ASCVD by metabolite levels between cases and controls were compared by a conditional logistic regression model adjusted for cardiovascular risk factors.</span></span></div></div><div><h3>Results</h3><div>Participants with incident ASCVD had higher levels of TMAO and related metabolites compared with those without ASCVD (<em>P</em>&lt;.05 for all). Those with plasma TMAO concentrations in quartile 4 had a more than 2-fold higher odds of ASCVD compared with those in quartile 1 (odds ratio, 2.77 [95% CI, 1.05 to 7.7; <em>P</em>=.04] for hard ASCVD and 2.41 [95% CI, 1.049 to 5.709; <em>P</em><span><span>=.04]). Similar trends were seen with the related metabolites choline, </span>betaine<span><span>, carnitine, and </span>butyrobetaine.</span></span></div></div><div><h3>Conclusion</h3><div>Our results suggest that TMAO and related metabolites are independently associated with ASCVD events. Although further studies are needed, measurement of TMAO and related metabolites may have a role in ASCVD risk stratification for primary prevention.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 10","pages":"Pages 1606-1614"},"PeriodicalIF":6.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Vaccination–Related Pericarditis","authors":"Nuri Lee MD ,&nbsp;Kye Hun Kim MD, PhD ,&nbsp;Jae-Hyeong Park MD, PhD ,&nbsp;Jae Yeong Cho MD, PhD ,&nbsp;Soo Hyeon Cho MPH ,&nbsp;Dong Keun Kim MD ,&nbsp;Seung Yun Kim MD ,&nbsp;Eun Kyoung Kim MS ,&nbsp;Eui-Young Choi MD, PhD ,&nbsp;Jin-Oh Choi MD, PhD ,&nbsp;Suji Cho MD ,&nbsp;Ga Hui Choi MD ,&nbsp;Hyukjin Park MD, PhD ,&nbsp;Hyung Yoon Kim MD, PhD ,&nbsp;Hyun Ju Yoon MD, PhD ,&nbsp;Youngkeun Ahn MD, PhD ,&nbsp;Myung Ho Jeong MD, PhD","doi":"10.1016/j.mayocp.2024.03.026","DOIUrl":"10.1016/j.mayocp.2024.03.026","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the incidence, characteristics, and outcomes of COVID-19 vaccine–related pericarditis (VRP) without myocarditis, we analyzed nationwide Korean data.</div></div><div><h3>Patients and Methods</h3><div>This is a retrospective nationwide report including all vaccinated Koreans with COVID-19 vaccine of any platform (BNT162b2, mRNA-1273, ChAdOx1, or Ad26.COV2.S) from February 26 to December 31, 2021. We analyzed the confirmed cases of COVID-19 VRP by the Expert Adjudication Committee. The incidence, clinical characteristics, and outcomes of COVID-19 VRP were analyzed.</div></div><div><h3>Results</h3><div>Among 44,322,068 Koreans with least one dose of COVID-19 vaccination, COVID-19 VRP was confirmed in 179 cases, with 1.73 per million shots (95% CI, 1.48 to 2.00 per million shots). The incidence of VRP was significantly higher in males than females (2.01 per 1 million doses vs 1.45 per 1 million doses, respectively; <em>P</em>=.029), in mRNA vaccines than in other vaccines (2.09 per 1 million doses vs 0.36 per 1 million doses, respectively; <em>P</em>&lt;.001), and in those younger than 40 years of age than those older than 40 years of age (3.52 per 1 million doses vs 0.89 per 1 million doses, respectively; <em>P</em>&lt;.001). The incidence of VRP was highest in males between the ages of 12 and 17 years (7.38 per 1 million doses; 95% CI, 2.01 to 16.07). Although there was no case of mortality, hemodynamically significant pericardial effusion requiring pericardial drainage was noted in 10 cases (5.6%).</div></div><div><h3>Conclusion</h3><div>COVID-19 VRP was very rare and developed mainly in association with mRNA vaccines, especially in males younger than 40 years of age. The clinical course of VRP was excellent, and there were no cases of mortality. However, the development of hemodynamically significant pericardial effusion should be carefully monitored.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 10","pages":"Pages 1577-1588"},"PeriodicalIF":6.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudoendocrine Sarcoma","authors":"Jorge Torres-Mora MD,&nbsp;Jorge Trejo-Lopez MD,&nbsp;Lori A. Erickson MD","doi":"10.1016/j.mayocp.2024.08.004","DOIUrl":"10.1016/j.mayocp.2024.08.004","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 10","pages":"Pages 1676-1677"},"PeriodicalIF":6.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General Information","authors":"","doi":"10.1016/S0025-6196(24)00444-0","DOIUrl":"10.1016/S0025-6196(24)00444-0","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 10","pages":"Page A7"},"PeriodicalIF":6.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox (Monkeypox) or Money-Pox? Unjust Global Responses Toward Infectious Diseases","authors":"Zhaohui Su PhD,&nbsp;Dean McDonnell PhD,&nbsp;Barry L. Bentley PhD,&nbsp;Ali Cheshmehzangi PhD,&nbsp;Sabina Šegalo PhD,&nbsp;Claudimar Pereira da Veiga PhD,&nbsp;Yu-Tao Xiang PhD, MD","doi":"10.1016/j.mayocp.2024.06.008","DOIUrl":"10.1016/j.mayocp.2024.06.008","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 10","pages":"Pages 1672-1673"},"PeriodicalIF":6.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}