Mayo Clinic proceedings最新文献

{"title":"Parity and Risk of Pancreatic Cancer Among Premenopausal Women","authors":"Joo-Hyun Park MD, PhD,&nbsp;Jung Yong Hong MD, PhD,&nbsp;Jay J. Shen PhD,&nbsp;Kyungdo Han PhD,&nbsp;Joon Oh Park MD, PhD,&nbsp;Young Suk Park MD, PhD,&nbsp;Ho Yeong Lim MD, PhD","doi":"10.1016/j.mayocp.2026.05.020","DOIUrl":"10.1016/j.mayocp.2026.05.020","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the association between parity and pancreatic cancer risk, along with other reproductive factors, in premenopausal women, amid the rising incidence of pancreatic cancer among younger women and concurrent decline in fertility rates.</div></div><div><h3>Patients and Methods</h3><div>In this nationwide cohort study, 935,345 premenopausal women from 40 to 55 years of age without prior cancer who participated in the 2009 Korean National Cancer Screening Program were followed from January 1, 2009, through December 31, 2019, until pancreatic cancer diagnosis, death, or end of follow-up, whichever came first. Multivariable-adjusted HRs and 95% CIs were estimated using Cox proportional hazards regression models.</div></div><div><h3>Results</h3><div>Over a median follow-up of 9.3 years, 2065 women developed pancreatic cancer (mean age at baseline, 45.0±3.9 years). The incidence rate was 30.2 per 100,000 person-years in nulliparous women, compared with 23.6 and 23.4 per 100,000 person-years in women with one and two or more births, respectively. Parity was inversely associated with pancreatic cancer risk, with adjusted HRs of 0.72 (95% CI, 0.57 to 0.91) for one birth and 0.70 (95% CI, 0.57 to 0.86) for two or more births, compared with nulliparity. The associations were consistent across most subgroups, except those stratified by alcohol consumption and hypertension (<em>P</em> for interaction =.001 and 0.02, respectively). Other reproductive factors were not significantly associated with risk.</div></div><div><h3>Conclusion</h3><div>Parity was associated with a reduced risk of pancreatic cancer in premenopausal women after adjustment for multiple potential confounders, suggesting that targeted prevention strategies for nulliparous women may help mitigate the growing burden of this malignancy among younger women.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1712-1723"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148330913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Neurologic Signal: Restless Legs Syndrome Associated With Androgen Receptor Signaling Inhibitor Therapy for Prostate Cancer","authors":"Shubhang K. Bhatt MD, MS,&nbsp;Nayla Ahmed MD,&nbsp;Berty M. Baskaran MD,&nbsp;Melissa C. Lipford MD","doi":"10.1016/j.mayocp.2026.08.001","DOIUrl":"10.1016/j.mayocp.2026.08.001","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1879-1880"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sinonasal Rosai-Dorfman Disease","authors":"Jorge Torres-Mora MD,&nbsp;Sounak Gupta MBBS, PhD,&nbsp;Lori A. Erickson MD","doi":"10.1016/j.mayocp.2026.06.021","DOIUrl":"10.1016/j.mayocp.2026.06.021","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1887-1889"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Necrolytic Migratory Erythema With Glucagonoma.","authors":"Elise J Lehman, Nicholas E Bohrer, Burak Tekin","doi":"10.1016/j.mayocp.2026.08.003","DOIUrl":"https://doi.org/10.1016/j.mayocp.2026.08.003","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple β-Catenin–Mutated Hepatic Adenomas in a Male Patient: A Case Report and Discussion of a Potential Role for Liver Transplant","authors":"Mohammed Y. Youssef MD,&nbsp;Mohamad Elgozair MB, ChB,&nbsp;Lewis Roberts MB, BCh, PhD","doi":"10.1016/j.mayocp.2026.06.010","DOIUrl":"10.1016/j.mayocp.2026.06.010","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1884-1886"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bladder ATTRwt Amyloidosis Preceding Cardiac Transthyretin Amyloidosis by a Decade: Implications for Early Detection","authors":"Adrianna Wierzbicka MD,&nbsp;Radhika K. Neicheril MD,&nbsp;Pablo Bejarano MD,&nbsp;David Snipelisky MD","doi":"10.1016/j.mayocp.2026.07.003","DOIUrl":"10.1016/j.mayocp.2026.07.003","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1881-1883"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic Risk Improvement in Endoscopic Sleeve Gastroplasty: A 1-Year Real-World Study","authors":"Wissam Ghusn MD,&nbsp;Yara Salameh MD,&nbsp;Maria Antonia Espinosa MD,&nbsp;Jose Villamarin MD,&nbsp;Karim Al Annan MD,&nbsp;Lea Sayegh MD,&nbsp;Kamal Abi Mosleh MD,&nbsp;Serena J. Rahme MD,&nbsp;Khushboo Gala MBBS,&nbsp;Eric J. Vargas MD,&nbsp;Andrew C. Storm MD","doi":"10.1016/j.mayocp.2026.07.005","DOIUrl":"10.1016/j.mayocp.2026.07.005","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1868-1870"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148447950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Next-Generation Sequencing in Renal Neoplasia, Including Tumors With Clear Cytoplasm and Rare Phenotypes (ELOC/MITF Alterations and Mismatch Repair Deficiency)","authors":"Michael McCarthy MD,&nbsp;Antonina A. Wojcik MS, CGC,&nbsp;Emily G. Barr Fritcher CT (ASCP), MB (ASCP),&nbsp;Burak Tekin MD,&nbsp;Wei Shen PhD,&nbsp;Hussam Al-Kateb PhD,&nbsp;Surendra Dasari PhD,&nbsp;Peter C. Lucas MD, PhD,&nbsp;Kingsley Ebare MD,&nbsp;Jordan P. Reynolds MD,&nbsp;Melissa L. Stanton MD,&nbsp;Aditya Raghunathan MD,&nbsp;Rumeal D. Whaley MD,&nbsp;Lori A. Erickson MD,&nbsp;Loren Herrera Hernandez MD,&nbsp;Rafael E. Jimenez MD,&nbsp;Brian A. Costello MD,&nbsp;Aaron Potretzke MD,&nbsp;Stephen A. Boorjian MD,&nbsp;Vidit Sharma MD,&nbsp;Sounak Gupta MBBS, PhD","doi":"10.1016/j.mayocp.2025.11.003","DOIUrl":"10.1016/j.mayocp.2025.11.003","url":null,"abstract":"<div><h3>Objective</h3><div>To define the clinical utility of next-generation sequencing (NGS) of renal tumors, including carbonic anhydrase 9–positive renal neoplasia with clear cell features (ccRCN) that include <em>ELOC</em> (for expansion of gene symbols, use search tool at <span><span>www.genenames.org</span><svg><path></path></svg></span>) and <em>MTOR</em>/<em>TSC1/TSC2</em>-mutated renal cell carcinoma (RCC) with fibromyomatous stroma (<em>ELOC</em>-RCCfms and <em>M/TSC</em>-RCCfms, respectively), as these tumors often have overlapping features.</div></div><div><h3>Patients and Methods</h3><div>Renal tumors (n=234) diagnosed between August 1, 2021, and June 15, 2025, were submitted for genomic profiling using Clinical Laboratory Improvement Amendments–validated 515-gene (n=30), 30-gene (n=175), and smaller (&lt;5 gene, n=29) next-generation sequencing panels. Available histologic and NGS data was reviewed to render a final integrated diagnosis and determine clinical utility.</div></div><div><h3>Results</h3><div>Next-generation sequencing was requested solely for diagnostic indications in most cases (209 of 234 [89%]), with 66% of cases (154 of 234) showing a clinically impactful genomic profile. The highest utility was among ccRCN and high-grade RCC/RCC, type not otherwise specified (NOS) in which only 8 of 79 (10%) and 17 of 57 (30%) remained unclassifiable, respectively. Some rare phenotypes included variants associated with hereditary disease, uncommon presentations, multiple driver alterations, mismatch repair deficiency (n=3), and rare <em>MITF</em> p.E318K alterations (n=3). The cohort of ccRCN included 12 <em>ELOC</em>-RCCfms (p.Y79C/S: 9 of 12; p.A100E, 2 of 12; p.L104Q: 1 of 12). GPNMB was expressed in <em>M/TSC</em>-RCCfms (10 of 10, 100%) and lacked appreciable expression in most ccRCN tested (n=25), including <em>ELOC</em>-RCCfms.</div></div><div><h3>Conclusion</h3><div>Next-generation sequencing–based molecular profiling had clinical utility in two-thirds of patients, and the greatest benefit was within the broad category of ccRCN. Our results suggest that GPNMB expression was helpful in separating <em>ELOC</em>-RCCfms from <em>M/TSC</em>-RCCfms. Other benefits of NGS include subtyping high-grade RCC/RCC type not otherwise specified and identification of rare phenotypes.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1751-1777"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146180975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Obesity With Mortality and Bleeding in Cancer-Associated Venous Thromboembolism","authors":"Álvaro Dubois-Silva MD,&nbsp;Cristina Barbagelata-López MD,&nbsp;Behnood Bikdeli MD, MS,&nbsp;María Luisa Peris MD, PhD,&nbsp;Raquel Barba MD, PhD,&nbsp;Luciano López-Jiménez MD,&nbsp;Son Truong Nguyen MD, PhD,&nbsp;Marijan Bosevski MD, PhD,&nbsp;Antonio López-Ruiz MD,&nbsp;Manuel Monreal MD, PhD","doi":"10.1016/j.mayocp.2026.05.018","DOIUrl":"10.1016/j.mayocp.2026.05.018","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the prognostic significance of obesity in patients with cancer-associated venous thromboembolism (VTE).</div></div><div><h3>Methods</h3><div>This cohort study used data from the Registro Informatizado de Enfermedad TromboEmbólica (RIETE) registry (2001-2025), a prospective, multicenter registry including patients with objectively confirmed acute VTE. Adults with active cancer and VTE were included if they had normal weight (body mass index 18.5-24.9 kg/m²) or obesity (body mass index ≥30.0 kg/m²). Primary outcome was 90-day all-cause mortality. Secondary outcomes included 1-year all-cause mortality, pulmonary embolism–related mortality, VTE recurrence, and major bleeding. Multivariable logistic regression (for 90-day outcomes), adjusted hazard models (for 1-year outcomes), and time-to-event analyses accounting for competing risks were used.</div></div><div><h3>Results</h3><div>Among 10,059 patients with cancer-associated VTE, 3748 (37.3%) had obesity. Compared with patients with normal weight, those with obesity were more likely to be female (59.2% vs 45.2%), present with pulmonary embolism (60.5% vs 55.3%), and have hormone-dependent cancers (38.7% vs 23.0%). Obesity was associated with lower 90-day (14.8% vs 26.9%; adjusted odds ratio, 0.68; 95% CI, 0.61 to 0.77) and 1-year all-cause mortality (26.4% vs 42.6%; adjusted hazard ratio, 0.73; 95% CI, 0.67 to 0.79) but higher risk of major bleeding at both time points (90-day adjusted odds ratio, 1.38; 95% CI, 1.11 to 1.73; 1-year adjusted hazard ratio, 1.36; 95% CI, 1.12 to 1.64). VTE recurrence rates were similar between groups.</div></div><div><h3>Conclusion</h3><div>In this large cohort of patients with cancer-associated VTE, obesity was associated with a lower risk of mortality but a higher risk of major bleeding. These findings support the obesity paradox in this population and highlight the need for personalized approaches to anticoagulation.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1687-1699"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"57-Year-Old Man With Hematochezia","authors":"Darine Daher MD,&nbsp;Eva E. Schaible MD,&nbsp;Xiao Jing (Iris) Wang MD","doi":"10.1016/j.mayocp.2025.09.023","DOIUrl":"10.1016/j.mayocp.2025.09.023","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1855-1859"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}