Mayo Clinic proceedings最新文献

{"title":"45-Year-Old Woman With Transient Loss of Consciousness and Fall.","authors":"Ryan T D Nguyen, Daniel Sykora, Benjamin R Stultz","doi":"10.1016/j.mayocp.2024.08.030","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.08.030","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"26-Year-Old Woman With Headache and Left Foot Drop.","authors":"Rachel J Anderson, Rafid Mustafa","doi":"10.1016/j.mayocp.2024.08.031","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.08.031","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"55-Year-Old Man With Fever and Left Lower Extremity Pain.","authors":"Nathaniel P Rogers, Nadia Toumeh, Nirosha D Perera","doi":"10.1016/j.mayocp.2024.09.025","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.09.025","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Hyperparathyroidism Complicated With Skeletal Muscle Metastatic Calcification.","authors":"Zhifeng Jiang, Tao Li, Ming Yang","doi":"10.1016/j.mayocp.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.mayocp.2025.04.005","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Obesity and Obesity Severity With Primary Care Use.","authors":"Zhiqi Yao, Michael J Blaha","doi":"10.1016/j.mayocp.2025.05.008","DOIUrl":"https://doi.org/10.1016/j.mayocp.2025.05.008","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly Pathogenic Avian Influenza A (H5N1): Recent Trends, Human Infections, Prevention and Control, and Health Care Preparedness in 2025.","authors":"Myeongji Kim, Nischal Ranganath, Matthew J Binnicker, Rebecca C Faller, Pritish K Tosh, Kristina M Sokol, Colin M Bucks, Aditya Shah","doi":"10.1016/j.mayocp.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.mayocp.2025.06.007","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of Triptans in Treating Migraines in Pregnant Women: A Target Trial Emulation.","authors":"Zhen Wang, Juliana H VanderPluym, Rashmi B Halker Singh, Reem A Alsibai, Daniel L Roellinger, Mohammad Hassan Murad","doi":"10.1016/j.mayocp.2025.01.023","DOIUrl":"https://doi.org/10.1016/j.mayocp.2025.01.023","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the safety of triptans in pregnant women with migraine.</p><p><strong>Patients and methods: </strong>We emulated a randomized clinical trial that hypothetically assigned patients to triptans or no triptan treatments. Data were retrieved from a multistate US-based health system from 2000 to 2022 on pregnant women with a diagnosis of migraine. We compared the effect of triptans to no-triptan treatments on patient-important pregnancy outcomes.</p><p><strong>Results: </strong>One hundred eighty-three patients in the triptan group and 3674 patients in the no-triptan group were included in the analysis. Of the patients in the triptan group, 43.74% reported full-term delivery, compared with 53.09% in the no-triptan group. There was no statistically significant difference between the groups on full-term delivery (relative risk [RR], 0.84; 95% CI, 0.71 to 1.01; absolute risk difference [RD], -0.08; 95% CI, -0.16 to 0.00), pre-term delivery (RR, 1.35; 95% CI, 0.96 to 1.91; RD, 0.05; 95% CI, -0.01 to 0.11), and cesarean delivery (RR, 1.15; 95% CI, 0.91 to 1.44; RD, 0.04; 95% CI: -0.03 to 0.12). We found no significant differences in intrauterine growth restriction, fetal death/stillbirth, and major fetal malformations. Patients in the triptan group had no events of miscarriage and spontaneous abortions, eclampsia/pre-eclampsia, or tubal or ectopic pregnancy.</p><p><strong>Conclusion: </strong>This target trial emulation shows that after balancing patients' characteristics and potential confounders, triptan use during pregnancy was not associated with major birth defects or other adverse birth outcomes. These data add to the accumulating body of evidence suggesting that triptans can be offered to well-informed pregnant women in need of pharmacologic therapy to abort acute attacks.</p><p><strong>Trial registration: </strong>clinicaltrials.gov Identifier: NCT05854992. (https://clinicaltrials.gov/ct2/show/NCT05854992?id=NCT05854992&cntry=US&draw=2&rank=1).</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value - and the Values - of Listening.","authors":"Leonard L Berry, Maureen Bisognano, Nana A Y Twum-Danso, Rana L A Awdish","doi":"10.1016/j.mayocp.2025.06.002","DOIUrl":"https://doi.org/10.1016/j.mayocp.2025.06.002","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorespiratory Fitness and Colorectal Cancer Incidence in US Veterans: A Cohort Study.","authors":"Aamir Ali, Dominique E Howard, Immanuel Babu Henry Samuel, Rayelynn Murphy, Andreas Pittaras, Sara Campbell, Olivia M Becker, Nikola Mrkoci, Jonathan Myers, Carl Lavie, Alexandos Ladas, Charles Faselis, Peter Kokkinos","doi":"10.1016/j.mayocp.2025.03.015","DOIUrl":"https://doi.org/10.1016/j.mayocp.2025.03.015","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the association between cardiorespiratory fitness (CRF), objectively measured by standardized exercise treadmill test (ETT), and colorectal cancer incidence.</p><p><strong>Methods: </strong>The study involved 643,583 US veterans nationwide (41,968 women) from the Exercise Testing and Health Outcomes Study (ETHOS) cohort. None had cancer diagnosis before ETT or had cancer other than colorectal after ETT. Participants completed an ETT (Bruce) with no evidence of ischemia and were stratified into CRF categories (quintiles) based on peak metabolic equivalents (METs) achieved: least fit (n=119,673; METs: 4.8±1.5), low fit (n=157,059; METs: 7.3±1.4), moderate fit (n=122,194; METs: 8.6±1.4), fit (n=170,324; METs: 10.5±1.0), and high fit (n= 74,333; METs: 13.6±1.8).</p><p><strong>Results: </strong>During a median follow-up period of 10.0 years, totaling 6,632,561 person-years, 8190 participants had colorectal cancer (12.4 events per 10,000 person-years). Cardiorespiratory fitness was inversely associated to colorectal cancer risk, independent of comorbidities, with a 9% risk reduction per 1-MET higher in CRF (hazard ratio [HR], 0.91; 95% CI, 0.90 to 0.92), for men and women and across all races. Compared with least fit, the risk of those in the next CRF category (low fit) was 14% lower (HR, 0.86; 95% CI, 0.81 to 0.91). The risk declined progressively with increased CRF and was 57% lower (HR, 0.43; 95% CI, 0.29 to 0.48) for those in the high-fit group.</p><p><strong>Conclusion: </strong>We observed an inverse and graded association between CRF and colorectal cancer incidence, across races and sexes, independent of comorbidities. The lower risk was evident in those with a peak CRF of approximately 8.5 to 10.5 METs, a relatively moderate CRF status attainable by most middle-aged and older individuals.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Group Concept Mapping Study to Define Humanizing Health Care.","authors":"Sean Tackett, Gayle Adams, Belinda Chen, Scott M Wright","doi":"10.1016/j.mayocp.2025.04.016","DOIUrl":"https://doi.org/10.1016/j.mayocp.2025.04.016","url":null,"abstract":"<p><strong>Objective: </strong>To systematically define humanizing health care to guide systems improvements that better meet patient and health care workers' needs.</p><p><strong>Participants and methods: </strong>We conducted group concept mapping at Johns Hopkins Medicine, a large academic health system with five hospitals in Maryland and Washington, DC, outpatient practices, telemedicine, and homecare services. From October 2023 to May 2024, we recruited participants who brainstormed to the focus prompt: \"One thing that can be done to more fully humanize healthcare experiences is:\" The study team synthesized ideas for participants to sort them. Group concept mapping software generated cluster maps, which were interpreted by the study team to generate the concept map.</p><p><strong>Results: </strong>In brainstorming, 63 individuals participated, including those with the perspectives of patients (n=40, 63%), caregivers (n=25, 40%), physicians (n=23, 37%), other types of health care professionals (n=14, 22%), health professions educators (n=28, 44%), and health care researchers (n=25, 40%). The 395 statements from brainstorming were synthesized into 207 ideas for sorting, which was completed by 13 participants. The final concept map included eight domains and 32 subdomains. Domains addressed: (1) effective communication, (2) health care worker attitudes, (3) health care culture, (4) health care worker community, (5) institutional policies and health care value, (6) physical and digital systems and access to care, (7) time and attention for patients, and (8) embedding patient perspectives throughout health care.</p><p><strong>Conclusion: </strong>Health care is fundamentally about human experiences. This concept map, generated by individuals representing the perspectives of a variety of individuals involved in health care, offers guidance for interventions and measures to make health care more humanizing.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}