In Tae Moon, Yung Ki Park, Hyeong-Joong Yi, Hyoung-Joon Chun, Kyu-Sun Choi, Young-Jun Lee, Hyun Young Kim
{"title":"Long-term Outcomes of Hypertension and Antihypertensive Drugs in Healthy Young Adults: A Nationwide Population-Based Prospective Cohort Study in Korea.","authors":"In Tae Moon, Yung Ki Park, Hyeong-Joong Yi, Hyoung-Joon Chun, Kyu-Sun Choi, Young-Jun Lee, Hyun Young Kim","doi":"10.1016/j.mayocp.2025.03.016","DOIUrl":"10.1016/j.mayocp.2025.03.016","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effect of hypertension (HTN) and antihypertensive medications on the incidence of cardiovascular disease in healthy young adults (approximately 20 to 45 years).</p><p><strong>Patients and methods: </strong>In total, 4,590,597 young Korean adults without comorbidities who underwent regular health examinations were included in this study. They were stratified into 4 groups according to their blood pressure (BP) (optimal BP, normal BP, high normal BP, and HTN). The primary outcome was a composite of the incidence of myocardial infarction and ischemic and hemorrhagic stroke, obtained by tracking the medical use data of the first-ever International Classification of Diseases, Tenth Revision codes. Subgroup analysis was conducted by categorizing the HTN group into 2 subgroups according to the prescription ratios of the antihypertensive drugs during the follow-up period.</p><p><strong>Results: </strong>The average age was 33.8 years, and the median follow-up duration was 15.9 years. Hypertension elevated the incidence risk of major cardiovascular disease by 2.16 times compared with that of the optimal BP group. Dyslipidemia and HTN were the most dominant risk factors for myocardial infarction and stroke, respectively. In the subgroup analysis, antihypertensive medications decreased the incidence of cardiovascular disease by 70% in all diseases.</p><p><strong>Conclusion: </strong>Cardiovascular risk factors, including HTN, contribute to major cardiovascular disease incidence in young adults. Antihypertensive medications decreased the major cardiovascular disease incidence estimates.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Early Career Phase: Fostering Physician Well-being Over the Career Life Cycle.","authors":"Lisa Rotenstein, Elizabeth Harry, Tait Shanafelt","doi":"10.1016/j.mayocp.2025.05.025","DOIUrl":"10.1016/j.mayocp.2025.05.025","url":null,"abstract":"<p><p>This article is the second chapter in a series of 5 articles considering the different stages of physicians' career life cycle. The present article focuses on exploring the early career phase. The early career phase represents an exciting time when physicians establish themselves in independent practice and develop their professional identity. Despite the excitement and opportunity of this phase, it is marked by several challenges, including those related to navigating new practice settings, defining and integrating one's personal and professional priorities, and developing a long-term approach to a physician career. Organizations can support physicians' effective navigation of the early career phase in multiple ways, ranging from the provision of individual supports such as mentorship and coaching to enhancing care processes and provision of standard supports for supporting work-life integration. Ultimately, organizations have a unique opportunity to bring early career physicians into the fold as satisfied colleagues and ensure they are set on the path to long and fulfilling careers.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa Suppah, Humam Abo Abdullah, Amro Badr, Kaitlin Roehl, Reza Arsanjani, Dan Sorajja, Jeffrey B Geske, Said Alsidawi
{"title":"Electrophysiologic and Anatomic Changes in Patients With oHCM on Mavacamten: 1-Year Insights From AI-ECG and Echocardiography Data.","authors":"Mustafa Suppah, Humam Abo Abdullah, Amro Badr, Kaitlin Roehl, Reza Arsanjani, Dan Sorajja, Jeffrey B Geske, Said Alsidawi","doi":"10.1016/j.mayocp.2025.07.006","DOIUrl":"10.1016/j.mayocp.2025.07.006","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Camilleri MD, DSc, Nicholas J. Talley AC, MD, PhD
{"title":"Mayo Clinic Proceedings in the Last Century: Seminal Contributions by Mayo Clinic Physicians and Researchers to the Field of Neurogastroenterology","authors":"Michael Camilleri MD, DSc, Nicholas J. Talley AC, MD, PhD","doi":"10.1016/j.mayocp.2025.07.012","DOIUrl":"10.1016/j.mayocp.2025.07.012","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1458-1462"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Older Populations: The Impact of Smoking and Diet and the Prevalence of Polypharmacy—Limelight, September 2025","authors":"Karl A. Nath MBChB (Editor-in-Chief)","doi":"10.1016/j.mayocp.2025.07.026","DOIUrl":"10.1016/j.mayocp.2025.07.026","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1455-1457"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryan T.D. Nguyen MD, MEng , Daniel Sykora MD , Benjamin R. Stultz MD
{"title":"45-Year-Old Woman With Transient Loss of Consciousness and Fall","authors":"Ryan T.D. Nguyen MD, MEng , Daniel Sykora MD , Benjamin R. Stultz MD","doi":"10.1016/j.mayocp.2024.08.030","DOIUrl":"10.1016/j.mayocp.2024.08.030","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1643-1648"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed Abdelfattah MB, BCh, BAO, Burak Tekin MD, Lori A. Erickson MD
{"title":"Primary Ewing Sarcoma of the Kidney","authors":"Ahmed Abdelfattah MB, BCh, BAO, Burak Tekin MD, Lori A. Erickson MD","doi":"10.1016/j.mayocp.2025.06.015","DOIUrl":"10.1016/j.mayocp.2025.06.015","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1673-1674"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}