Mayo Clinic proceedings最新文献

{"title":"Implementing the 2026 Cardiovascular-Kidney-Metabolic Syndrome Guideline Into Clinical Practice","authors":"Sohail Zahid MD, PhD, Bige Ozkan MD, ScM, Roger S. Blumenthal MD","doi":"10.1016/j.mayocp.2026.07.006","DOIUrl":"10.1016/j.mayocp.2026.07.006","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1678-1680"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"52-Year-Old Woman With Dyspnea on Exertion","authors":"Cyrus M. Nouraee MD, Mia Poleksic MD, Kyle W. Klarich MD","doi":"10.1016/j.mayocp.2025.12.017","DOIUrl":"10.1016/j.mayocp.2025.12.017","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1845-1849"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Congenital Absence of the Lower Lobe Pulmonary Arteries With Extensive Collaterals","authors":"Kennedy Sparling MD, Muhammad Naeem MD, Matthew T. Stib MD","doi":"10.1016/j.mayocp.2026.07.028","DOIUrl":"10.1016/j.mayocp.2026.07.028","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1866-1867"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Breast Cancer","authors":"Kathryn J. Ruddy MD,&nbsp;Damé Idossa MD,&nbsp;Dalliah M. Black MD,&nbsp;Kimberly S. Corbin MD,&nbsp;Elizabeth Cathcart-Rake MD,&nbsp;Ciara C. O’Sullivan MB, BCh, BAO","doi":"10.1016/j.mayocp.2026.07.019","DOIUrl":"10.1016/j.mayocp.2026.07.019","url":null,"abstract":"<div><div>Breast cancer (BC) is the most frequently diagnosed cancer among women and the leading cause of cancer deaths in females globally. In the United States, more than 300,000 new cases of invasive BC are diagnosed annually, and more than 40,000 patients die of metastatic BC. Herein, we discuss the current and evolving management of invasive BC. Despite major progress, ongoing challenges include how best to optimize treatment based on BC subtype and how to address treatment resistance for patients with metastatic BC. Efforts to further refine surgical approaches, radiation therapy, and preoperative and postoperative systemic therapies are under way, as are attempts to further elucidate the utility of immunotherapy and targeted therapies in various BC care settings.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1788-1817"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolving Role of Large Language Models in Health Care Research and Scientific Communication","authors":"Jaleh Zand PhD,&nbsp;Milovan Suvakov PhD,&nbsp;Shauna M. Overgaard PhD,&nbsp;Carmen J. Silvano,&nbsp;Laura M. Meiners MBA,&nbsp;Jungwei W. Fan PhD,&nbsp;Rickey E. Carter PhD,&nbsp;Mark L. Wieland MD, MPH,&nbsp;Christi A. Patten PhD,&nbsp;Sagar B. Dugani MD, PhD, MPH,&nbsp;Heidi L. Dieter MBA,&nbsp;Chung-li Wi MD,&nbsp;Young J. Juhn MD, MPH,&nbsp;Felicity T. Enders PhD, MPH,&nbsp;Matthew R. Callstrom MD, PhD,&nbsp;Vijay H. Shah MD,&nbsp;Vesna D. Garovic MD, PhD","doi":"10.1016/j.mayocp.2026.04.007","DOIUrl":"10.1016/j.mayocp.2026.04.007","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1681-1686"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13170483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disinfected Mail","authors":"David P. Steensma MD","doi":"10.1016/j.mayocp.2026.07.026","DOIUrl":"10.1016/j.mayocp.2026.07.026","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1890-1894"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Hemodiafiltration or Hemofiltration Compared With Hemodialysis on Mortality in Patients With End-Stage Renal Disease: A Meta-Analysis","authors":"Fan Zhang MD,&nbsp;Jing Liao BD,&nbsp;Yifei Zhong PhD","doi":"10.1016/j.mayocp.2026.07.009","DOIUrl":"10.1016/j.mayocp.2026.07.009","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1871-1874"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General Information","authors":"","doi":"10.1016/S0025-6196(26)18723-0","DOIUrl":"10.1016/S0025-6196(26)18723-0","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Page A7"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Loss in Astronauts","authors":"Moshe Gertzulin MD,&nbsp;Matthew T. Drake MD, PhD","doi":"10.1016/j.mayocp.2026.08.010","DOIUrl":"10.1016/j.mayocp.2026.08.010","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1673-1675"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality and Morbidity Following Heart Failure Hospitalization in Adults With and Without Congenital Heart Disease","authors":"Pradyumna Agasthi MD,&nbsp;Holly K. Van Houten BA,&nbsp;C. Xiaoxi Yao PhD,&nbsp;Elaine M. Griffeth MD,&nbsp;C. Charles Jain MD,&nbsp;Alexander C. Egbe MBBS, MPH,&nbsp;Carole A. Warnes MD,&nbsp;William R. Miranda MD,&nbsp;Shannon M. Dunlay MD, MS,&nbsp;Elizabeth H. Stephens MD, PhD,&nbsp;Jonathan N. Johnson,&nbsp;Angela M. Kosecn APRN, CNP, DNP,&nbsp;Heidi M. Connolly MD,&nbsp;Luke J. Burchill MBBS, PhD","doi":"10.1016/j.mayocp.2025.10.013","DOIUrl":"10.1016/j.mayocp.2025.10.013","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare the clinical profile and outcomes after heart failure (HF) hospitalization in adults with and without congenital heart disease.</div></div><div><h3>Methods</h3><div>Leveraging a national database of commercially insured and Medicare Advantage patients in the United States, this study included patients hospitalized for HF with adult congenital heart disease (ACHD+) and without adult congenital heart disease (ACHD–) between January 1, 2010, and December 31, 2021. The association of baseline characteristics with mortality, major adverse cardiac and cerebrovascular events (MACCE), and health resource utilization was examined using cox proportional hazard regressions.</div></div><div><h3>Results</h3><div>Of 287,616 unique HF admissions, 5805 (2%) were ACHD+ and 281,811 (98%) were ACHD–. Over a mean follow-up period of 1.98±2.04 years, ACHD+ patients had a lower risk of mortality (HR, 0.74; 95% CI, 0.69 to 0.80; <em>P</em>&lt;.001), MACCE (HR, 0.93; 95% CI, 0.89 to 0.97; <em>P</em>=.002), and rehospitalization (HR, 0.91; 95% CI, 0.88 to 0.95; <em>P</em>&lt;.001). One-third (32.6%) of ACHD+ patients experienced a MACCE during follow-up, most commonly due to atrial fibrillation (n=939; 16.1%), recurrent HF (n=696; 12.0%), stroke (n=398; 6.8%) or intracranial bleed (n=102; 1.8%), myocardial infarction (n=276; 4.8%), and cardiac arrest (n=176; 3.0%).</div></div><div><h3>Conclusion</h3><div>Compared with the general HF population, ACHD patients had substantially lower mortality risk after HF hospitalization. Despite this, the risk of complications following HF hospitalization was high, reinforcing the importance of discharge planning and post-acute care for improving outcomes in ACHD HF patients.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 10","pages":"Pages 1738-1750"},"PeriodicalIF":6.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}