Mayo Clinic proceedings最新文献

{"title":"Lithium and Kidney Disease.","authors":"Mete Ercis, Maria L Gonzalez Suarez, Balwinder Singh","doi":"10.1016/j.mayocp.2024.10.008","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.10.008","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Informal Caregiving and Menopause Symptoms in Midlife Women: A Cross-Sectional Study.","authors":"Mariam Saadedine, Nancy Safwan, Ekta Kapoor, Chrisandra L Shufelt, Juliana M Kling, Mary S Hedges, Rajeev Chaudhry, Kristin Cole, Stacey J Winham, Joan M Griffin, Stephanie S Faubion","doi":"10.1016/j.mayocp.2024.07.009","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.07.009","url":null,"abstract":"<p><strong>Objective: </strong>To assess the association between caregiving and menopause symptom burden in midlife women.</p><p><strong>Patients and methods: </strong>A cross-sectional analysis was conducted among women aged 45 to 60 years receiving primary care at 1 of 4 Mayo Clinic geographic locations between March 1 and June 30, 2021, who completed a survey study. Caregiving status was self-reported, and menopause symptoms were assessed using the Menopause Rating Scale. The primary outcome was moderate or worse menopause symptoms.</p><p><strong>Results: </strong>A total of 4295 women (mean age, 54.6 years) were included, 845 (19.7%) of whom self-identified as caregivers. Among all 4295 women, 1614 (37.6%) reported moderate to very severe menopause symptoms. The proportion of women with moderate or worse menopause symptoms in at least one symptom domain increased as the number of caregiving hours increased: 92 of 270 (34.1%) in the less than 5 hours per week group, 123 of 289 (42.6%) in the 5 to 14 hours per week group, and 144 of 286 (50.4%) in the 15 or more hours per week group (P<.001). In univariate analysis, caregiving for 15 or more hours per week significantly increased the odds of having moderate or worse menopause symptoms in at least one symptom domain compared to no caregiving (odds ratio, 1.77; 95% CI, 1.39 to 2.26; P<.001). The association remained significant in multivariable analysis after adjusting for potential confounders (odds ratio, 1.37; 95% CI, 1.05 to 1.78; P=.02).</p><p><strong>Conclusion: </strong>This study identified a positive association between caregiving hours and menopause symptom burden. Given the aging US population and likely resultant increases in caregiving burden, there is a critical need to address menopause symptoms and to provide support for midlife women in caregiving roles.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Clear Cell Hidradenoma.","authors":"Ruifeng Guo, Margot S Peters, Julio C Sartori-Valinotti","doi":"10.1016/j.mayocp.2024.09.012","DOIUrl":"10.1016/j.mayocp.2024.09.012","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":"2000-2001"},"PeriodicalIF":6.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In the Limelight: December 2024.","authors":"Karl A Nath","doi":"10.1016/j.mayocp.2024.10.015","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.10.015","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 12","pages":"1851-1853"},"PeriodicalIF":6.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Hypothyroidism-A Less Known Mimicker of Amyloid Cardiomyopathy?","authors":"Luca Fazzini, Matteo Castrichini, Melanie C Bois, Neena Natt, Ian C Chang, Martha Grogan, Naveen L Pereira, Omar F AbouEzzeddine","doi":"10.1016/j.mayocp.2024.09.014","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.09.014","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 12","pages":"2008-2011"},"PeriodicalIF":6.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lutetium 177 Radionuclide Therapy-Induced Proliferative Arrest in a Metastatic High-Grade Rectal Neuroendocrine Tumor.","authors":"Aruz Mesci, Carly C Barron, Ozgur Mete","doi":"10.1016/j.mayocp.2024.08.023","DOIUrl":"10.1016/j.mayocp.2024.08.023","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":"1867-1868"},"PeriodicalIF":6.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities.","authors":"Mohammad Abdel Jawad, James H O'Keefe, Nathan Tintle, Evan L O'Keefe, W Grant Franco, Luc Djousse, Nathan Ryder, William S Harris","doi":"10.1016/j.mayocp.2024.08.007","DOIUrl":"10.1016/j.mayocp.2024.08.007","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between plasma omega-3 levels and incident heart failure (HF) and to examine their relationship with total and cardiovascular (CV) mortality among patients with preexisting HF.</p><p><strong>Patients and methods: </strong>The UK Biobank is an ongoing prospective cohort study of individuals recruited in the United Kingdom between April 1, 2007, and December 31. 2010. We used Cox proportional hazards models to predict incident HF in those without baseline HF and total and CV mortality in those with baseline HF, all as a function of baseline plasma omega-3 levels.</p><p><strong>Results: </strong>In participants without HF at baseline (n=271,794), a generally linear inverse association was observed between omega-3 levels and incident HF during a median follow-up of 13.7 years. The risk was 21% lower in the highest quintile of omega-3 compared with the lowest quintile (hazard ratio, 0.79; 95% CI, 0.74 to 0.84; P<.001) in multivariable models. In parallel models in participants with prevalent HF (n=1239), risk for all-cause and CV mortality were both reduced by approximately 50% comparing top to bottom omega-3 quintiles (hazard ratio, 0.53; 95% CI, 0.33 to 0.86; and hazard ratio, 0.50; 95% CI, 0.31 to 0.79, respectively; both P<.01).</p><p><strong>Conclusion: </strong>Higher plasma levels of marine omega-3 fatty acids were associated with a lower incidence of HF. Furthermore, among patients with preexisting HF, higher omega-3 levels were associated with lower risks of all-cause mortality and CV mortality. These findings suggest that increasing plasma omega-3 levels, whether by diet or supplementation, could reduce both risk for development of HF and death in those with prevalent HF.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 12","pages":"1895-1904"},"PeriodicalIF":6.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Pulmonary Embolism Syndrome-A Diagnostic Dilemma and Challenging Management.","authors":"Kajal P Shah, Christopher Lee, Robert D McBane, Gregory Piazza, Robert P Frantz, Damon E Houghton, Ana I Casanegra, Stanislav Henkin","doi":"10.1016/j.mayocp.2024.07.008","DOIUrl":"10.1016/j.mayocp.2024.07.008","url":null,"abstract":"<p><p>Historically, research on pulmonary embolism (PE) management has focused on short-term outcomes, such as acute cardiovascular collapse, change in right ventricular function, and in-hospital mortality. However, long-standing functional impairments from acute PE occur in up to half of all patients. This chronic syndrome has been termed the post-PE syndrome, which describes patients who have persistent or worsening symptoms, functional limitations, and cardiorespiratory impairment not explained by a comorbid condition. Diagnosis and management are challenging, and post-PE syndrome remains an underrecognized and undertreated condition. This review seeks to increase awareness of the syndrome that affects a significant portion of PE survivors. The epidemiology, pathophysiology, and clinical features are discussed, followed by a description of imaging findings and management options across the entire spectrum of post-PE syndrome.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":"1965-1982"},"PeriodicalIF":6.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Associated Differences in Clinical Outcomes After Septal Reduction Therapies in Hypertrophic Cardiomyopathy.","authors":"Nirav Patel, Naman S Shetty, Akhil Pampana, Mokshad Gaonkar, Nehal Vekariya, Peng Li, Anjali T Owens, Christopher Semsarian, Garima Arora, Pankaj Arora","doi":"10.1016/j.mayocp.2024.05.026","DOIUrl":"10.1016/j.mayocp.2024.05.026","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate sex-associated differences in the short- and long-term outcomes of patients with hypertrophic cardiomyopathy (HCM) undergoing septal myectomy and alcohol septal ablation.</p><p><strong>Methods: </strong>This retrospective cohort study used electronic health record data from the TriNetX research database. International Classification of Diseases, Ninth Revision and Tenth Revision diagnosis and procedure codes were used to identify patients with HCM who underwent septal myectomy and alcohol septal ablation in the United States between January 2002 and March 2023. The outcomes were long-term mortality and postprocedural complications (<30 days), including death, stroke, major bleeding, and renal failure. Multivariable adjusted Cox models were used to assess the association of outcomes by sex, taking female patients as reference.</p><p><strong>Results: </strong>Of 11,680 adults (32.0% female; median age, 63 [interquartile range, 54 to 71] years), 1916 (16.4%) and 9764 (83.6%) underwent septal myectomy and alcohol septal ablation, respectively. For those who underwent septal myectomy, sex was not associated with short-term (adjusted hazard ratio [HR_adj], 1.57 [0.64 to 3.87]) and long-term (HR_adj, 1.05 [0.87 to 1.26]) mortality. Male patients had a higher risk of acute renal failure compared with female patients after septal myectomy (HR_adj, 1.69 [1.33 to 2.15]). Of those who underwent alcohol septal ablation, male patients (HR_adj, 1.07 [0.99 to 1.16]) had a similar risk of long-term mortality to that of female patients. Compared with female patients, the risk of acute renal failure was higher in male patients (HR_adj, 1.23 [1.02 to 1.48]) after alcohol septal ablation.</p><p><strong>Conclusion: </strong>This nationwide study found that the risk of short- and long-term mortality was similar for male and female patients undergoing septal myectomy and alcohol septal ablation for HCM. The sex-based differences in the clinical presentation should not prevent consideration of septal reduction therapies.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":"1933-1944"},"PeriodicalIF":6.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement of Doppler Flow Velocity Reserve With PET Flow Reserve in Patients With Angina Without Obstructive Coronary Arteries.","authors":"Mahmoud Ismayl, Claire E Raphael, Abhiram Prasad, Panithaya Chareonthaitawee, John P Bois","doi":"10.1016/j.mayocp.2024.08.003","DOIUrl":"10.1016/j.mayocp.2024.08.003","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":"2005-2007"},"PeriodicalIF":6.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}