Mayo Clinic proceedings最新文献_第2页

Long-term Outcomes of Hypertension and Antihypertensive Drugs in Healthy Young Adults: A Nationwide Population-Based Prospective Cohort Study in Korea 健康年轻人高血压和抗高血压药物的长期预后：韩国一项基于全国人群的前瞻性队列研究

IF 6.7 2区医学

Mayo Clinic proceedings Pub Date : 2025-10-01 DOI: 10.1016/j.mayocp.2025.03.016

In Tae Moon MD , Yung Ki Park MD, PhD , Hyeong-Joong Yi MD, PhD , Hyoung-Joon Chun MD, PhD , Kyu-Sun Choi MD, PhD , Young-Jun Lee MD, PhD , Hyun Young Kim MD, PhD

{"title":"Long-term Outcomes of Hypertension and Antihypertensive Drugs in Healthy Young Adults: A Nationwide Population-Based Prospective Cohort Study in Korea","authors":"In Tae Moon MD , Yung Ki Park MD, PhD , Hyeong-Joong Yi MD, PhD , Hyoung-Joon Chun MD, PhD , Kyu-Sun Choi MD, PhD , Young-Jun Lee MD, PhD , Hyun Young Kim MD, PhD","doi":"10.1016/j.mayocp.2025.03.016","DOIUrl":"10.1016/j.mayocp.2025.03.016","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the effect of hypertension (HTN) and antihypertensive medications on the incidence of cardiovascular disease in healthy young adults (approximately 20 to 45 years).</div></div><div><h3>Patients and Methods</h3><div>In total, 4,590,597 young Korean adults without comorbidities who underwent regular health examinations were included in this study. They were stratified into 4 groups according to their blood pressure (BP) (optimal BP, normal BP, high normal BP, and HTN). The primary outcome was a composite of the incidence of myocardial infarction and ischemic and hemorrhagic stroke, obtained by tracking the medical use data of the first-ever <em>International Classification of Diseases, Tenth Revision</em> codes. Subgroup analysis was conducted by categorizing the HTN group into 2 subgroups according to the prescription ratios of the antihypertensive drugs during the follow-up period.</div></div><div><h3>Results</h3><div>The average age was 33.8 years, and the median follow-up duration was 15.9 years. Hypertension elevated the incidence risk of major cardiovascular disease by 2.16 times compared with that of the optimal BP group. Dyslipidemia and HTN were the most dominant risk factors for myocardial infarction and stroke, respectively. In the subgroup analysis, antihypertensive medications decreased the incidence of cardiovascular disease by 70% in all diseases.</div></div><div><h3>Conclusion</h3><div>Cardiovascular risk factors, including HTN, contribute to major cardiovascular disease incidence in young adults. Antihypertensive medications decreased the major cardiovascular disease incidence estimates.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 10","pages":"Pages 1758-1770"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Early Career Phase: Fostering Physician Well-being Over the Career Life Cycle 早期职业阶段：在职业生命周期中培养医生的幸福感。

IF 6.7 2区医学

Mayo Clinic proceedings Pub Date : 2025-10-01 DOI: 10.1016/j.mayocp.2025.05.025

Lisa Rotenstein MD , Elizabeth Harry MD , Tait Shanafelt MD

{"title":"The Early Career Phase: Fostering Physician Well-being Over the Career Life Cycle","authors":"Lisa Rotenstein MD , Elizabeth Harry MD , Tait Shanafelt MD","doi":"10.1016/j.mayocp.2025.05.025","DOIUrl":"10.1016/j.mayocp.2025.05.025","url":null,"abstract":"<div><div>This article is the second chapter in a series of 5 articles considering the different stages of physicians’ career life cycle. The present article focuses on exploring the early career phase. The early career phase represents an exciting time when physicians establish themselves in independent practice and develop their professional identity. Despite the excitement and opportunity of this phase, it is marked by several challenges, including those related to navigating new practice settings, defining and integrating one’s personal and professional priorities, and developing a long-term approach to a physician career. Organizations can support physicians’ effective navigation of the early career phase in multiple ways, ranging from the provision of individual supports such as mentorship and coaching to enhancing care processes and provision of standard supports for supporting work-life integration. Ultimately, organizations have a unique opportunity to bring early career physicians into the fold as satisfied colleagues and ensure they are set on the path to long and fulfilling careers.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 10","pages":"Pages 1836-1845"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skinspan^TM: A Healthy Longevity Framework for Skin Aging. 皮肤老化的健康长寿框架：重新定义皮肤老化的标志和寿命。

IF 6.7 2区医学

Mayo Clinic proceedings Pub Date : 2025-10-01 DOI: 10.1016/j.mayocp.2025.07.027

Saranya P Wyles, Hasina S Maredia, Ryeim B Ansaf, Moudar R Dweydari, Ryan T Hurt, Sara L Bonnes, Sundeep Khosla, Nathan K LeBrasseur, Zoe Diana Draelos, Mark D P Davis

{"title":"Skinspan<sup>TM</sup>: A Healthy Longevity Framework for Skin Aging.","authors":"Saranya P Wyles, Hasina S Maredia, Ryeim B Ansaf, Moudar R Dweydari, Ryan T Hurt, Sara L Bonnes, Sundeep Khosla, Nathan K LeBrasseur, Zoe Diana Draelos, Mark D P Davis","doi":"10.1016/j.mayocp.2025.07.027","DOIUrl":"10.1016/j.mayocp.2025.07.027","url":null,"abstract":"<p><p>Skin aging is an inherent biological component of human aging. As the global population ages, the incidence of age-related skin conditions has become increasingly prevalent. Both intrinsic and extrinsic factors, collectively known as the skin \"exposome,\" contribute to visible and physiological changes. The skin's layers, including the epidermis, dermis, and hypodermis, function both independently and interdependently in these aging processes. Intrinsic factors such as hormonal fluctuations, genetic predispositions, and cellular senescence, defined as an irreversible cell cycle arrest, drive physiological age-related skin changes. These changes are underpinned by several interconnected hallmarks of aging, including genomic instability, telomere attrition, epigenetic alterations, and loss of proteostasis, all of which impair cell renewal and dermal structure. Stem cell exhaustion and mitochondrial dysfunction reduce the skin's capacity to regenerate and adapt to stress, whereas altered intercellular communication and chronic low-grade inflammation (\"inflammaging\") further accelerate aging phenotypes such as loss of elasticity, epidermal thinning, and delayed wound healing. Extrinsic factors, including ultraviolet radiation, air pollution, smoking, and poor nutrition, compound these effects by increasing oxidative stress, DNA damage, and activating senescence-associated secretory phenotypes. Lifelong sun protection, nutritious dietary habits, regular physical activity, and topical interventions such as sunscreen and moisturizers help maintain a resilient skin microenvironment. This review highlights the urgent need to recognize, prevent, and treat skin aging. Emerging therapies targeting root-cause mechanisms may revolutionize dermatologic care and extend skin healthspan - now known as skinspan.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women’s Health and Hypertension: Pregnancy, Age, and Post-Hysterectomy—Limelight, October 2025 女性健康与高血压：怀孕、年龄和子宫切除术后——《limelight》杂志，2025年10月

IF 6.7 2区医学

Mayo Clinic proceedings Pub Date : 2025-10-01 DOI: 10.1016/j.mayocp.2025.08.017

Karl A. Nath MBChB

引用次数: 0

Long-term Outcomes Based on the Sex of the Rheumatologist in a Prospective Cohort of Rheumatoid Arthritis Patients 类风湿关节炎患者前瞻性队列中基于风湿病学家性别的长期预后

IF 6.7 2区医学

Mayo Clinic proceedings Pub Date : 2025-10-01 DOI: 10.1016/j.mayocp.2025.06.017

Alessandro Giollo PhD, Mariangela Salvato MD, Francesca Frizzera MD, Kiren Khalid MD, Costantino Botsios PhD, Margherita Zen PhD, Roberta Ramonda PhD, Andrea Doria PhD

{"title":"Long-term Outcomes Based on the Sex of the Rheumatologist in a Prospective Cohort of Rheumatoid Arthritis Patients","authors":"Alessandro Giollo PhD, Mariangela Salvato MD, Francesca Frizzera MD, Kiren Khalid MD, Costantino Botsios PhD, Margherita Zen PhD, Roberta Ramonda PhD, Andrea Doria PhD","doi":"10.1016/j.mayocp.2025.06.017","DOIUrl":"10.1016/j.mayocp.2025.06.017","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the influence of the physician's sex on long-term outcomes in patients with rheumatoid arthritis (RA) undergoing targeted therapy.</div></div><div><h3>Methods</h3><div>A prospective, single-center cohort study of adult RA patients treated with biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) was conducted between 2014 and 2022. The physician’s sex was the main exposure. The primary outcome was disease activity score in 28 joints (DAS28), and the secondary outcomes were DAS28 subcomponents and glucocorticoid use. The association between the physician's sex and outcomes was assessed by generalized estimating equations. Covariates were selected through regularization techniques.</div></div><div><h3>Results</h3><div>We included 1151 patients (81% female) with a mean age of 57 years, a mean disease duration of 14 years, and a median observation of 4 years. At the time of inclusion, 68% of the patients had moderate-high DAS28. Management by female physicians yielded significantly lower mean DAS28 (2.80 [95% CI, 2.65 to 2.97] vs 3.00 [95% CI, 2.87 to 3.19]; <em>P</em>=.004) and a higher likelihood of DAS28 remission (adjusted odds ratio, 1.84 [95% CI, 1.16 to 2.17]; <em>P</em><.0001) compared with male physicians. Secondary outcome analyses also found lower C-reactive protein level (2.5 vs 3.5 mg/L; <em>P</em><.0001) and swollen joint count in 28 joints (0.9 vs 1.4; <em>P</em><.0001) and no significant differences in glucocorticoid use. Sensitivity analyses found that the effect of the physician’s sex was mostly directed at male patients.</div></div><div><h3>Conclusion</h3><div>The sex of the physician can significantly influence disease control in patients with RA, with female rheumatologists achieving better outcomes in terms of disease activity and remission.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 10","pages":"Pages 1706-1718"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Best Practices for Addressing Differences in Antimicrobial Resistance Through Quality Improvement Projects in Antimicrobial Stewardship in Low-Resource Settings 通过低资源环境中抗菌素管理质量改进项目解决抗菌素耐药性差异的最佳做法。

IF 6.7 2区医学

Mayo Clinic proceedings Pub Date : 2025-10-01 DOI: 10.1016/j.mayocp.2025.06.019

Katherine Kemper MBA , Workeabeba Abebe MD, MPH , Leonardo S.L. Bastos PhD , Alemseged Beyene Berha BPharm, MSc , Fernando A. Bozza MD, PhD , Thomas Kesteman MD, PhD , Carl Llor PhD , Nosheen Nasir MBBS, MSc , Michael Okorie MD, PhD , Dana Marie Parke MA , Sarah K. Parker MD , Debendra Pattanaik MD , Tebello Violet Sarele MS, MA , Catherine Sartino MS , Bilal Jawed MD , Faith Sila MSN , Geehan Suleyman MD , Nathan Cummins MD

引用次数: 0

Secondary Hyperparathyroidism Complicated With Skeletal Muscle Metastatic Calcification 继发性甲状旁腺功能亢进合并骨骼肌转移性钙化。

IF 6.7 2区医学

Mayo Clinic proceedings Pub Date : 2025-10-01 DOI: 10.1016/j.mayocp.2025.04.005

Zhifeng Jiang MM, Tao Li MM, Ming Yang MM

引用次数: 0

56-Year-Old Woman With Lower Extremity Pain and Edema, Nausea, and Chest Pain 56岁女性，下肢疼痛，水肿，恶心，胸痛。

IF 6.7 2区医学

Mayo Clinic proceedings Pub Date : 2025-10-01 DOI: 10.1016/j.mayocp.2024.10.028

Katherine A. Hill MD, MHS , Angela R. Grassi MD , Rowlens M. Melduni MD, MPH

引用次数: 0

Role of the Complement System in Acute Kidney Injury: A Narrative Review 补体系统在急性肾损伤中的作用：综述。

IF 6.7 2区医学

Mayo Clinic proceedings Pub Date : 2025-10-01 DOI: 10.1016/j.mayocp.2025.06.005

Lifang Wei MD, PhD , Juan Pablo Domecq Garces MD , Mehdi Kashani MD , Yue Dong MD , Kianoush B. Kashani MD, MS

{"title":"Role of the Complement System in Acute Kidney Injury: A Narrative Review","authors":"Lifang Wei MD, PhD , Juan Pablo Domecq Garces MD , Mehdi Kashani MD , Yue Dong MD , Kianoush B. Kashani MD, MS","doi":"10.1016/j.mayocp.2025.06.005","DOIUrl":"10.1016/j.mayocp.2025.06.005","url":null,"abstract":"<div><div>Acute kidney injury (AKI) remains a significant cause of morbidity and mortality worldwide, particularly in critically ill patients. Acute kidney injury often results from a combination of underlying conditions, such as sepsis or ischemia and nephrotoxic drugs, leading to a rapid decline in renal function. A significant proportion of AKI survivors have development of chronic kidney disease, which increases long-term health burdens. In recent years, increasing attention has been paid to the role of the immune system, particularly the complement system, in the pathophysiology of AKI. The complement system is a critical part of the innate immune response, with its activation playing a dual role in tissue damage and repair. Excessive complement activation, however, can exacerbate inflammation and tissue injury, contributing to the severity of AKI. Despite emerging research suggesting a strong link between complement activation and AKI, the extent of this relationship remains underexplored, particularly in clinical settings. In this narrative review, after a literature search using engines such as PubMed, MEDLINE, and EMBASE, we consolidated current evidence on the role of complement in AKI, examining underlying mechanisms and potential diagnostic and therapeutic interventions based on the complement system.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 10","pages":"Pages 1796-1809"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrophysiologic and Anatomic Changes in Patients With oHCM on Mavacamten: 1-Year Insights From AI-ECG and Echocardiography Data 马伐卡坦治疗oHCM患者的电生理和解剖变化：来自AI-ECG和超声心动图数据的1年见解。

IF 6.7 2区医学

Mayo Clinic proceedings Pub Date : 2025-10-01 DOI: 10.1016/j.mayocp.2025.07.006

Mustafa Suppah MD , Humam Abo Abdullah MD , Amro Badr MD , Kaitlin Roehl PA , Reza Arsanjani MD , Dan Sorajja MD , Jeffrey B. Geske MD , Said Alsidawi MD

引用次数: 0