Janis Timsans MD , Anne M. Kerola MD, PhD , Vappu M. Rantalaiho MD, PhD , Kia N. Hakkarainen MD , Hannu J. Kautiainen MSc , Markku J. Kauppi MD, PhD
{"title":"“Metabolic” Type of Hyperuricemia Increases Mortality Mainly by Leading to Premature Death From Cardiovascular Disease","authors":"Janis Timsans MD , Anne M. Kerola MD, PhD , Vappu M. Rantalaiho MD, PhD , Kia N. Hakkarainen MD , Hannu J. Kautiainen MSc , Markku J. Kauppi MD, PhD","doi":"10.1016/j.mayocp.2024.07.011","DOIUrl":"10.1016/j.mayocp.2024.07.011","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 11","pages":"Pages 1835-1837"},"PeriodicalIF":6.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Highlights from the Current Issue – Audiovisual Summary","authors":"Karl A. Nath MBChB","doi":"10.1016/j.mayocp.2024.10.012","DOIUrl":"10.1016/j.mayocp.2024.10.012","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 11","pages":"Page e1"},"PeriodicalIF":6.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142571663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Darah Dilmaghani MD , Alessandra J. Ainsworth MD , Karl A. Nath MD , Vesna D. Garovic MD, PhD
{"title":"Decreasing Fertility Rate in the United States: Demographics, Challenges, and Consequences","authors":"Darah Dilmaghani MD , Alessandra J. Ainsworth MD , Karl A. Nath MD , Vesna D. Garovic MD, PhD","doi":"10.1016/j.mayocp.2024.09.004","DOIUrl":"10.1016/j.mayocp.2024.09.004","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 11","pages":"Pages 1693-1697"},"PeriodicalIF":6.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Surprise “Thank You” US Postage Stamp for Health Care Workers","authors":"David P. Steensma MD","doi":"10.1016/j.mayocp.2024.09.002","DOIUrl":"10.1016/j.mayocp.2024.09.002","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 11","pages":"Pages 1846-1847"},"PeriodicalIF":6.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142571661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhen Wang PhD , Juliana H. VanderPluym MD , Rashmi B. Halker Singh MD , Reem A. Alsibai MD , Daniel L. Roellinger BS , Mohammed Firwana MBBS , Mohammad Hassan Murad MD, MPH
{"title":"Safety of Triptans in Patients Who Have or Are at High Risk for Cardiovascular Disease","authors":"Zhen Wang PhD , Juliana H. VanderPluym MD , Rashmi B. Halker Singh MD , Reem A. Alsibai MD , Daniel L. Roellinger BS , Mohammed Firwana MBBS , Mohammad Hassan Murad MD, MPH","doi":"10.1016/j.mayocp.2024.03.023","DOIUrl":"10.1016/j.mayocp.2024.03.023","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the safety of triptans in migraine patients with cardiovascular disease or elevated cardiovascular risk.</div></div><div><h3>Patients and Methods</h3><div>We retrieved data from a multistate US-based health system (January 2000 to August 2022) on adults with migraine and confirmed cardiovascular/cerebrovascular disease, or at least two cardiovascular risk factors. We compared the effect of triptans to nontriptan treatments on major adverse cardiovascular events (MACE) and its components at 60 days of starting treatments. We emulated a target trial and used propensity score matching for analysis.</div></div><div><h3>Results</h3><div>The 3518 patients in the triptan group were matched to the 3518 patients in the nontriptan group (median age, 55 years; 80.60% female). At 60 days, 52 patients (1.48%) in the triptan group had MACE, compared with 13 patients (0.37%) in the nontriptan group (relative risk [RR], 4.00; 95% CI, 2.24 to 7.14). Patients treated with triptans also had significantly higher risk of nonfatal myocardial infarction (15 patients (0.43%) vs 0 patients (0.00%)); heart failure (RR, 4.50; 95% CI, 1.91 to 10.61); and nonfatal stroke (RR, 8.00; 95% CI, 1.00 to 63.96). Five patients (0.14%) in each group died. The findings were consistent when analyses were restricted to sumatriptan, oral administration of triptan, patients with chronic migraine, history of cardiovascular disease, or history of cerebrovascular disease.</div></div><div><h3>Conclusion</h3><div>Triptans likely increase the risk of MACE; however, the incidence of MACE remains low in migraine patients with cardiovascular disease or elevated cardiovascular risk.</div></div><div><h3>Trial Registration</h3><div>Treatments of Migraine With Triptans in Individuals With Elevated Cardiovascular Risk and in Pregnant Women. <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> Identifier: <span><span>NCT05854992</span><svg><path></path></svg></span> (<span><span>https://classic.clinicaltrials.gov/ct2/show/NCT05854992</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 11","pages":"Pages 1722-1731"},"PeriodicalIF":6.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}