Mayo Clinic proceedings最新文献

{"title":"Widespread Yellowish to Brownish Plaques and Nodules","authors":"Yi-Hsuan Shen MD , Wei-Yu Chen MD , Ying-Yi Chiang MD","doi":"10.1016/j.mayocp.2025.12.029","DOIUrl":"10.1016/j.mayocp.2025.12.029","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 5","pages":"Pages 807-808"},"PeriodicalIF":6.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Spectrum: High-Functioning Autism and Its Contemporary Relevance","authors":"J. Michael Bostwick MD, MFA,&nbsp;Alastair J.S. McKean MD","doi":"10.1016/j.mayocp.2026.02.016","DOIUrl":"10.1016/j.mayocp.2026.02.016","url":null,"abstract":"<div><div>With publication of the <em>Diagnostic and Statistical Manual of Mental Disorders</em>, fifth edition (DSM-5) in 2013, autism’s prevalence in the United States nearly doubled to more than 2% of the population. In reconceptualizing the condition, DSM-5 collapsed 4 diagnoses into 1 diagnosis: autism spectrum disorder. What the 4 had in common were deficits in 2 broad areas: restricted, repetitive behaviors or interests; and deficits in social communication. Three of the 4 were severe forms easily recognized in childhood. The fourth, constituting most of the increase in prevalence, was Asperger disorder, or high-functioning autism, frequently going undiagnosed until adulthood. These patients typically have fluent language, intact intellect, and highly developed compensatory strategies including social “masking.” The adult diagnosis is manifested in struggles to maintain employment or friendships both platonic and intimate. Nonpsychiatric providers are likely to encounter patients with autism spectrum disorder seeking care for myriad comorbid psychiatric and physical problems. Complicating matters is that many adult psychiatrists are unfamiliar with what was until recently the purview of child psychiatrists. Autism has neither cure nor specific pharmacologic treatments, but addressing comorbidities, with psychiatric and medical referrals where indicated, mitigates suffering. Services targeting employment and educational support, occupational therapy focused on activities of daily living, and skill-based psychotherapies that aim to improve social interactions can reduce stress and anxiety while enhancing function, reducing isolation, and encouraging satisfying relationships.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 5","pages":"Pages 846-853"},"PeriodicalIF":6.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147806644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Proportionate Mortality Patterns in Patients With Systemic Lupus Erythematosus in the United States From 1999 to 2020","authors":"Omer N. Pamuk MD,&nbsp;Ansaam A. Daoud MD,&nbsp;Marina N. Magrey MD","doi":"10.1016/j.mayocp.2025.07.005","DOIUrl":"10.1016/j.mayocp.2025.07.005","url":null,"abstract":"<div><h3>Objective</h3><div>To determine proportionate mortality (PM) patterns in patients with systemic lupus erythematosus (SLE) in the last 2 decades in the United States.</div></div><div><h3>Methods</h3><div>This retrospective cohort study used multiple causes of death files from the Centers for Disease Control and Prevention database to analyze the trends of PM rates in SLE between 1999 and 2020. We specifically determined PM for various underlying causes of death in SLE and the general population (GP). We investigated trends over time for PM in SLE and the general US population.</div></div><div><h3>Results</h3><div>During the study period, the PM for both cardiovascular disease, ischemic heart disease, and cerebrovascular disease significantly decreased in the GP, whereas it remained stable in the SLE group except for a significant decline in ischemic heart disease PM between 1999 and 2004. Proportionate mortality for hypertensive heart disease, diabetes mellitus/obesity, respiratory diseases, and nervous system diseases increased significantly in both SLE and GP. In contrast, PM for malignant neoplasms (MNs) and hematologic malignancies (HMNs) increased significantly in the SLE population, whereas it decreased in the GP. Pairwise trend analysis further demonstrated that trends in PM for MN and HMN were significantly different between the SLE and GP populations.</div></div><div><h3>Conclusion</h3><div>In the last 2 decades, PM trends of SLE followed different paths compared with the GP. Cardiovascular disease and cerebrovascular disease PM remained stable in SLE while it decreased in the GP. In contrast to the GP, PM of MN and HMN increased in SLE.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 5","pages":"Pages 796-806"},"PeriodicalIF":6.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mayo Clinic Framework for Community-Engaged Research: Development, Implementation, and Impact","authors":"Sagar B. Dugani MD, PhD, MPH ,&nbsp;Jon C. Tilburt MD ,&nbsp;Richard O. White MD, MSc ,&nbsp;Emily J. Sabey MPH ,&nbsp;Adeline Abbenyi CPH ,&nbsp;Nuwanthi Heendeniya MBA ,&nbsp;Noreen Stephenson MA, MEd ,&nbsp;Tabetha A. Brockman MA ,&nbsp;Monica Albertie MHA ,&nbsp;Doug Murrell MPA ,&nbsp;Laura Meiners MBA ,&nbsp;Rosa Nichols BA ,&nbsp;Marty Aleman RN, PHN, MAN ,&nbsp;Suganya Karuppana MD, MSHD ,&nbsp;Julie Elworth PhD ,&nbsp;LaPrincess C. Brewer MD, MPH ,&nbsp;Folakemi Odedina PhD ,&nbsp;Christi A. Patten MA, PhD ,&nbsp;Prajakta Adsul MBBS, MPH, PhD ,&nbsp;Nina B. Wallerstein DrPH ,&nbsp;Mark L. Wieland MD, MPH","doi":"10.1016/j.mayocp.2026.03.002","DOIUrl":"10.1016/j.mayocp.2026.03.002","url":null,"abstract":"<div><div>Mayo Clinic addresses community health needs by integrating community expertise and collaboratively identifying and responding to community health priorities. Community-engaged research (CEnR), encompassing a continuum of engagement from raising awareness to co-ownership of research efforts, helps operationalize this commitment. Mayo Clinic’s CEnR efforts are guided by principles that emphasize community context, sustained partnerships, integration of community perspectives across the research process, and evaluation of community-centered outcomes. The CEnR Program at Mayo Clinic is coordinated through the Center for Clinical and Translational Science (CCaTS), an enterprise-wide hub supporting education, career development, and translational research. It is also implemented in collaboration with Community Outreach and Engagement Research Services (COERS), a shared resource coordinated by the CCaTS and the Mayo Clinic Comprehensive Cancer Center. The CCaTS supports CEnR through community advisory boards, community health needs assessments, and an awards program; COERS advances engagement through Community Engagement Studios, a Community Scientist Program, and related outreach activities. In 2023-2024, we devised and refined a strategic framework for CEnR, bringing together a multidisciplinary group of academic and community partners and informed by a multisite evaluation. The evaluation identified key facilitators of and barriers to academic-community partnerships and generated actionable recommendations. These efforts culminated in the Mayo Clinic CEnR logic model, integrating national guidelines, institutional commitments, and evaluation findings. This logic model serves as a framework for current and future CEnR initiatives within Mayo Clinic and may inform similar efforts nationally. We describe the key elements required to establish and sustain a cross-location CEnR program within a values-based health care institution.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 5","pages":"Pages 809-825"},"PeriodicalIF":6.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"20-Year-Old Woman Presenting With Acute Onset Retrosternal Chest Pain","authors":"Katlin T. Schmitz MD ,&nbsp;Matteo Castrichini MD ,&nbsp;LaPrincess C. Brewer MD, MPH","doi":"10.1016/j.mayocp.2025.03.033","DOIUrl":"10.1016/j.mayocp.2025.03.033","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 5","pages":"Pages 870-875"},"PeriodicalIF":6.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"53-Year-Old Woman With Dyspnea, Lightheadedness, and Syncope","authors":"Steven Tessier MD, MS ,&nbsp;Aref Al-Kali MD","doi":"10.1016/j.mayocp.2025.01.032","DOIUrl":"10.1016/j.mayocp.2025.01.032","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 5","pages":"Pages 854-858"},"PeriodicalIF":6.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"91-Year-Old Man With Rash and Paresthesias","authors":"Olivia Man MD ,&nbsp;Jack McHugh MB BCh, BAO ,&nbsp;Madiha Fida MBBS","doi":"10.1016/j.mayocp.2025.01.031","DOIUrl":"10.1016/j.mayocp.2025.01.031","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 5","pages":"Pages 859-864"},"PeriodicalIF":6.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorespiratory Fitness, Genetic Risk, and Incident Atherosclerotic Cardiovascular Events: A Prospective Cohort Study","authors":"Paul J. Collings PhD ,&nbsp;Mengyao Wang PhD ,&nbsp;Ziyuan Chen MS ,&nbsp;Qiaoxin Shi BM ,&nbsp;Shan Luo PhD ,&nbsp;Shiu Lun Au Yeung PhD ,&nbsp;Tomas I. Gonzales PhD ,&nbsp;Stephen J. Sharp MSc ,&nbsp;Søren Brage PhD ,&nbsp;Youngwon Kim PhD","doi":"10.1016/j.mayocp.2025.07.036","DOIUrl":"10.1016/j.mayocp.2025.07.036","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the prospective relationship of cardiorespiratory fitness (CRF) with incident atherosclerotic cardiovascular disease (ASCVD) across genetic susceptibility strata.</div></div><div><h3>Participants and Methods</h3><div>We conducted a prospective study of 69,447 UK Biobank participants (mean age, 57.6 years; 37,554 [54.1%] female) who performed a fitness test between December 7, 2009, and June 7, 2013. Maximal oxygen consumption was estimated using a validated bike ergometry procedure, standardized within sex and age strata. Genetic susceptibility to ischemic heart disease was quantified with weighted polygenic risk scores. Participants were assigned to low (20th percentile), intermediate (20th to 80th percentile), and high (80th percentile) fitness and genetic risk groups, respectively. Cox regression models were used to estimate the hazard of development of ASCVD.</div></div><div><h3>Results</h3><div>During a median follow-up of 12 years, there were 5448 incident ASCVD events. Each 1-SD difference in sex- and age-standardized CRF (equivalent to 5.6 mLO₂/kg per minute) was associated with an 8% (hazard ratio [HR], 0.92; 95% CI, 0.89 to 0.95) lower hazard of ASCVD, independent of demographic, lifestyle, and health-related factors and genetic risk. There was weak evidence of multiplicative interaction (<em>P</em>=.06), suggesting that the associations might be slightly stronger in the low genetic risk group (HR, 0.87; 95% CI, 0.80 to 0.94) compared with intermediate (HR, 0.94; 95% CI, 0.90 to 0.98] and high genetic risk groups (HR, 0.91; 95% CI, 0.86 to 0.97). There was no evidence of additive interaction (<em>P</em>=.79). The 10-year absolute risk differences between low and high CRF groups were 1.2% and 1.6% within high and low genetic risk categories, respectively.</div></div><div><h3>Conclusion</h3><div>Across all strata of genetic risk for cardiovascular disease, higher CRF was strongly associated with lower risk of ASCVD. Adults should be encouraged to increase or maintain CRF levels, irrespective of genetic susceptibility.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 5","pages":"Pages 782-795"},"PeriodicalIF":6.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Somatic Transformation of Germ Cell Tumor to Carcinoma With Pancreatic Differentiation","authors":"Sounak Gupta MBBS, PhD,&nbsp;Burak Tekin MD,&nbsp;Lori A. Erickson MD","doi":"10.1016/j.mayocp.2026.01.012","DOIUrl":"10.1016/j.mayocp.2026.01.012","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 5","pages":"Pages 891-893"},"PeriodicalIF":6.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Perinephric Fat Tells a Deeper Story: Rethinking Risk After Radical Nephrectomy","authors":"Fabrizio Di Maida MD, PhD,&nbsp;Andrea Minervini Prof","doi":"10.1016/j.mayocp.2026.03.015","DOIUrl":"10.1016/j.mayocp.2026.03.015","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 5","pages":"Pages 711-713"},"PeriodicalIF":6.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147807387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}