Mayo Clinic proceedings最新文献

{"title":"General Information","authors":"","doi":"10.1016/S0025-6196(25)00485-9","DOIUrl":"10.1016/S0025-6196(25)00485-9","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 10","pages":"Page A7"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes Incidence According to Statin Intensity Regimen, Body Mass Index, and Cardiorespiratory Fitness.","authors":"Peter Kokkinos, Charles Faselis, Andreas Pittaras, Immanuel Babu Henry Samuel, Cristina Cadenas-Sánchez, Eric Nylen, Carl Lavie, Barry Franklin, Steven K Malin, Rayelynn Murphy, Jonathan Myers","doi":"10.1016/j.mayocp.2025.06.004","DOIUrl":"10.1016/j.mayocp.2025.06.004","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the association between statin therapy, cardiorespiratory fitness (CRF), body mass index (BMI), and type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>A nationwide cohort of dyslipidemic patients (n=311,269; age 60.8±9.2 years) was treated with statins for 6 months or longer, with no T2DM before statin initiation. All completed a standardized exercise treadmill test between October 1, 1999, and September 3, 2020, with no evidence of ischemia. We formed age- and gender-specific five CRF categories according to peak metabolic equivalents (METs) achieved, four BMI categories, and two statin intensity categories.</p><p><strong>Results: </strong>During a median follow-up of 10.9 years (3,421,650 person-years of observation), 56,994 developed T2DM (incidence rate 16.7 events/1000-person-years). The adjusted risk was 23% higher in patients on high-intensity compared with those on low-intensity statins (HR, 1.23; 95% CI, 1.21 to 1.25). The T2DM risk increased progressively with higher BMI and high-intensity statin regimen to a 4.44-fold increase (HR, 4.44; 95% CI, 4.22 to 4.67) for obese patients. Conversely, the CRF-T2DM association was inverse and graded regardless of BMI or static-intensity regimen and was approximately 30% to 60% lower risk for patients achieving greater than or equal to 8.4±1.2 METs. Compared with least-fit/low-intensity statin-treated patients, T2DM risk was 21% higher for least-fit/high-intensity statin-treated patients (HR, 1.21; 95% CI, 1.18 to 1.25), and 47% lower (HR, 0.53; 95% CI, 0.51 to 0.56) in highly fit/high-intensity statin-treated patients.</p><p><strong>Conclusion: </strong>High-intensity statin therapy was associated with an increased risk of T2DM. The risk increased progressively with higher BMI and decreased with higher CRF. Strategies to improve fitness and weight loss in patients on high-intensity statins can potentially lower T2DM risk.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower Rates of Abdominal Aortic Aneurysm Repair and Higher Long-term Aortic Mortality in Women Compared With Men: Results of a Population-Based Study Spanning 4 Decades","authors":"Indrani Sen MBBS ,&nbsp;Jill Colglazier MD ,&nbsp;Jennifer St. Sauver PhD ,&nbsp;William S. Harmsen MS ,&nbsp;Jay Mandrekar PhD ,&nbsp;Manju Kalra MBBS","doi":"10.1016/j.mayocp.2024.11.027","DOIUrl":"10.1016/j.mayocp.2024.11.027","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the population-level impact of screening and endovascular repair as well as mortality in women with abdominal aortic aneurysms (AAAs).</div></div><div><h3>Patients and Methods</h3><div><span>We conducted a population-based cohort study of patients from Olmsted County, Minnesota, in whom AAA was diagnosed between January 1, 1980, and December 31, 2017. The AAAs were identified using the </span><span><em>International Classification of Diseases</em><em>, Ninth</em></span> and <em>Tenth Revisions</em> and <span><em>Current Procedural Terminology</em></span><span> codes with medical record review to confirm the diagnosis and identify late events. Survival analysis for overall and aortic mortality was performed and stratified based on sex and repair status.</span></div></div><div><h3>Results</h3><div>There were 1537 patients in our study cohort (75% [1156] male; median age, 74 years). Compared with men, women were older (80 vs 73 years; <em>P</em>&lt;.001), had smaller initial aneurysm size (4 vs 4.3 cm; <em>P</em><span>&lt;.001), underwent AAA repair less frequently (26% [99] vs 41% [475]; </span><em>P</em>&lt;.001), and had similar 30-day mortality from AAA repair (4% [4 of 381] vs 5% [22 of 1156]; <em>P</em>=.50). Median follow-up was 18 years. Aortic and all-cause mortality at 10 and 20 years were highest in females who did not undergo repair (hazard ratio, 3; 95% CI, 1.8 to 4.5; <em>P</em>&lt;.001), as compared with all men and women who underwent AAA repair. Cumulative aortic mortality analyzed with non–aortic-related deaths as a competing risk factor remained significantly higher in NRF (15% [40 of 282] vs 5% to 8% in other groups; 5/99 in females undergoing repair, 39/681 in non repaired males and 37/475 in males who underwent repair, <em>P</em>=.001). All patients with aortic-related mortality had refused repair due to older age and comorbidities, except 2 females with ruptures of 4.8 and 5.5 cm AAAs awaiting repair.</div></div><div><h3>Conclusion</h3><div>Abdominal aortic aneurysms are diagnosed in women almost a decade later and repaired less often than in men. There is a 3-fold greater long-term aortic-related mortality in women not undergoing AAA repair compared with men and women who underwent AAA repair.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 10","pages":"Pages 1782-1793"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Toxicity From Chlorhexidine Surgical Site Preparation","authors":"Amika Kamath BA ,&nbsp;Sanjay V. Patel MD","doi":"10.1016/j.mayocp.2025.04.007","DOIUrl":"10.1016/j.mayocp.2025.04.007","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 10","pages":"Pages 1794-1795"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Hysterectomy With Hypertension Incidence in Korean Women: A Nationwide Cohort Study","authors":"Jin-Sung Yuk MD, PhD ,&nbsp;Gwang Sil Kim MD ,&nbsp;Dong-Gil Kim MD ,&nbsp;Young Sup Byun MD ,&nbsp;Myoung-Hwan Kim MD ,&nbsp;Sang-Hee Yoon MD ,&nbsp;Gwan Hee Han MD ,&nbsp;Byoung Kwon Lee MD ,&nbsp;Byung Gyu Kim MD","doi":"10.1016/j.mayocp.2025.04.015","DOIUrl":"10.1016/j.mayocp.2025.04.015","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the association between hysterectomy and the development of hypertension in Korean women aged 40 to 59 years.</div></div><div><h3>Patients and Methods</h3><div>In this Korean nationwide cohort study, 802,916 women aged 40 to 59 years were selected for analysis from January 1, 2002, to December 31, 2011. In total, 13,650 pairs were included in the hysterectomy and nonhysterectomy groups after 1:1 propensity score matching in several covariates. The participants were followed-up until December 31, 2020. The primary outcome was the development of hypertension during follow-up.</div></div><div><h3>Results</h3><div>During median follow-up periods (10.6 years [IQR, 9.2 to 12.6 years]; 10.9 years [IQR, 9.2 to 12.8 years]), the incidence of hypertension was 22 per 1000 person-years and 20 per 1000 person-years for the hysterectomy and nonhysterectomy groups, respectively. The hysterectomy group had a significantly higher rate of development of hypertension than that of the nonhysterectomy group (hazard ratio, 1.11; 95% CI, 1.05 to 1.17; <em>P</em>&lt;.001). The risk was prominent in women whose hemoglobin level increased by 2 g/dL or more after hysterectomy. In women who had an adnexa-sparing hysterectomy, the incidence of hypertension was higher (hazard ratio, 1.15; 95% CI, 1.08 to 1.23; <em>P</em>&lt;.001) than that in the nonhysterectomy group.</div></div><div><h3>Conclusion</h3><div>The findings of this cohort study suggest that women who undergo hysterectomy have a higher risk of hypertension than those with an intact uterus.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 10","pages":"Pages 1771-1781"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"29-Year-Old Woman With Jaundice and Right Upper Quadrant Abdominal Pain","authors":"Jacob Bauss MD ,&nbsp;Matthew L. Vincent MBBS, MS ,&nbsp;David M. Phelan MD","doi":"10.1016/j.mayocp.2024.09.028","DOIUrl":"10.1016/j.mayocp.2024.09.028","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 10","pages":"Pages 1819-1823"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Topical Corticosteroids and Risk of Upper Gastrointestinal Complications","authors":"Cho-Hsun Hsieh MD ,&nbsp;Dereck Shen MS ,&nbsp;Yung-Tsu Cho MD, PhD ,&nbsp;Chao-Hsiun Tang PhD ,&nbsp;Chia-Yu Chu MD, PhD ,&nbsp;Tom C. Chan MD","doi":"10.1016/j.mayocp.2025.07.002","DOIUrl":"10.1016/j.mayocp.2025.07.002","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 10","pages":"Pages 1848-1850"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant Testicular Sex Cord–Stromal Tumor With Signet Ring Stromal Features Associated With Familial Adenomatous Polyposis","authors":"Burak Tekin MD,&nbsp;Lori A. Erickson MD,&nbsp;Sounak Gupta MBBS, PhD","doi":"10.1016/j.mayocp.2025.06.016","DOIUrl":"10.1016/j.mayocp.2025.06.016","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 10","pages":"Pages 1857-1859"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle Factors in the Association of Shift Work With Kidney Stone Events","authors":"Man He MD,&nbsp;Xiuping Dou MD,&nbsp;Yang Su MD,&nbsp;Zilong Zhang PhD,&nbsp;Hualiang Lin PhD,&nbsp;Yin Yang PhD","doi":"10.1016/j.mayocp.2025.03.032","DOIUrl":"10.1016/j.mayocp.2025.03.032","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the associations of shift work, its type and frequency, and working years with kidney stone events and to further explore the mediating role of lifestyles in this association.</div></div><div><h3>Participants and Methods</h3><div>A total of 226,459 participants of the UK Biobank recruited between December 19, 2006, and October 1, 2010, and followed up until May 1, 2023, were included in this study. During the baseline investigation, we questioned participants about their occupational status, including shift work, shift type, shift frequency, and years of shift work. Lifestyles included physical activity, smoking status, dietary characteristics, sleep duration, sedentary time, body mass index, and fluid intake. Cox proportional hazards regression models were used to analyze the association of shift work with kidney stone events, and mediation analyses were used to examine the mediating effects of lifestyles.</div></div><div><h3>Results</h3><div>During a median follow-up of 13.7 years, a kidney stone developed in 2893 participants. In the fully adjusted models, individuals who did shift work had a higher risk of kidney stone events (hazard ratio, 1.15; 95% CI, 1.04 to 1.26). These associations were more pronounced among younger participants (less than 50 years old) and workers who never or rarely dealt with heavy manual labor. Smoking, sleep duration, sedentary time, body mass index, and fluid intake were identified as the potential mediators.</div></div><div><h3>Conclusion</h3><div>In this study, shift work was positively associated with the risk of kidney stone events, and lifestyles partially mediated the associations. These findings suggest that shift work should be considered as a risk factor for kidney stones and emphasize the need for promoting healthy lifestyles among shift workers.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 10","pages":"Pages 1731-1744"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the Doctor’s Sex Matter? Long-term Outcomes in Rheumatoid Arthritis Revisited","authors":"Thomas Khoo MBBS, FRACP,&nbsp;Susanna Proudman MBBS, FRACP","doi":"10.1016/j.mayocp.2025.08.014","DOIUrl":"10.1016/j.mayocp.2025.08.014","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 10","pages":"Pages 1687-1689"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}