Mayo Clinic proceedings最新文献

{"title":"Mayo Clinic Proceedings and Progress in Solid Organ Transplantation","authors":"Matthew D. Griffin MB BCh BAO, DMed, FRCPI","doi":"10.1016/j.mayocp.2025.02.009","DOIUrl":"10.1016/j.mayocp.2025.02.009","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 4","pages":"Pages 590-592"},"PeriodicalIF":6.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Debris Field of Scientific Publications Authored by Artificial Intelligence","authors":"Anthony H. Kashou MD, Nandan S. Anavekar MB, BCh, Joseph G. Murphy MD","doi":"10.1016/j.mayocp.2025.02.013","DOIUrl":"10.1016/j.mayocp.2025.02.013","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 4","pages":"Pages 596-598"},"PeriodicalIF":6.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerometer-Derived \"Weekend Warrior\" Physical Activity and All-Cause and Cause-Specific Mortality","authors":"Chen Huang BA ,&nbsp;Yahang Liu BS ,&nbsp;Ruilang Lin BS ,&nbsp;Ce Wang PhD ,&nbsp;Ye Yao PhD ,&nbsp;Guoyou Qin PhD ,&nbsp;Yiliang Zhang MD ,&nbsp;Yongfu Yu PhD","doi":"10.1016/j.mayocp.2024.10.022","DOIUrl":"10.1016/j.mayocp.2024.10.022","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the association of “weekend warrior” (WW) pattern and physical activity distributed throughout the week with mortality risk.</div></div><div><h3>Participants and Methods</h3><div>In this cohort study of 95,468 participants in the UK Biobank from 2013 through 2015, participants were grouped by accelerometer-derived physical activity levels: inactive (moderate to vigorous physical activity [MVPA] &lt;150 min/wk using World Health Organization guidelines), active WW (≥150 minutes of MVPA per week and ≥50% of total MVPA over 1 to 2 days), and active regular (≥150 minutes of MVPA but not active WW). Cox regression analyzed associations of activity patterns with all-cause mortality and 10 categories of cause-specific mortality and whether the association differed by sedentary time (<span><math><mrow><mo>≤</mo></mrow></math></span>6, 7 to 12, or ≥13 hours) and light physical activity (<span><math><mrow><mo>≤</mo></mrow></math></span>60, 61 to 150, or ≥151 min/d).</div></div><div><h3>Results</h3><div>During the median 7.92 years of follow-up, 3539 deaths occurred. Compared with the inactive participants, the hazard ratio for all-cause mortality was 0.74 (95% CI, 0.68 to 0.82) in active regular participants and 0.72 (95% CI, 0.67 to 0.78) in active WW participants. Similar risk reductions were noted in most cause-specific deaths, especially for those from cancer, cardiovascular disease, and respiratory diseases. These benefits were more profound among participants with 13 or more hours of sedentary time (active regular: 0.58 [0.41 to 0.83]; active WW: 0.70 [0.55 to 0.88]) or 60 min/d or less of light physical activity (active regular: 0.59 [0.42 to 0.83]; active WW: 0.47 [0.35 to 0.63]). A similar reduction in all-cause mortality risk was observed across different age groups regardless of activity frequency and timing.</div></div><div><h3>Conclusion</h3><div>Physical activity evenly distributed throughout the week and concentrated within 1 to 2 days are both associated with similar lower risks of all-cause mortality and most categories of cause-specific mortality.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 4","pages":"Pages 609-621"},"PeriodicalIF":6.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming Hepatocellular Carcinoma Treatment in Lower Income Countries","authors":"Channa R. Jayasekera MD ,&nbsp;Chrishanthi Rajasooriyar MBBS, MD ,&nbsp;Clayton Richards MBA ,&nbsp;Sanjeev Arora MD ,&nbsp;Mitesh J. Borad MD","doi":"10.1016/j.mayocp.2024.12.011","DOIUrl":"10.1016/j.mayocp.2024.12.011","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 4","pages":"Pages 605-608"},"PeriodicalIF":6.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic Arch Morphology Is Associated With Long-term Mortality After Transcatheter Aortic Valve Replacement","authors":"Gerardo V. Lo Russo MD ,&nbsp;Hasan Alarouri MBBS ,&nbsp;Ke-Wei Chen MD ,&nbsp;Ju-Hsin Chang MD ,&nbsp;Chia-Hao Liu MD ,&nbsp;Ghasaq Saleh MD ,&nbsp;Shih-Sheng Chang MD ,&nbsp;Hoda Hatoum PhD ,&nbsp;Mohamad Alkhouli MD, MBA","doi":"10.1016/j.mayocp.2025.01.001","DOIUrl":"10.1016/j.mayocp.2025.01.001","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 4","pages":"Pages 749-750"},"PeriodicalIF":6.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic Profile of Ischemic Heart Disease in Heart Failure: A Community Study.","authors":"Kayode O Kuku, Maryam Hashemian, Jungnam Joo, Joseph J Shearer, Carolina G Downie, Mohit Aggarwal, Suzette J Bielinski, Véronique L Roger","doi":"10.1016/j.mayocp.2024.12.016","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.12.016","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical characteristics, outcomes, and proteomic profiles of prevalent ischemic heart disease (IHD) in heart failure (HF) in a clinically phenotyped cohort.</p><p><strong>Methods: </strong>We studied an HF community cohort (N=1351) enrolled between September 10, 2003, and September 18, 2012, with linked medical records and measured 7289 plasma protein targets using an aptamer-based assay. Ischemic heart disease was defined by prior myocardial infarction, angiographic coronary disease, or revascularization. Cause-specific hazards model was used to test the association between IHD status and cardiovascular (CV) mortality while considering the interaction by ejection fraction (EF) group. Linear regression adjusting for age, sex, and estimated glomerular filtration rate with multiple testing correction was used to evaluate the cross-sectional association of proteins with IHD status and with CV risk factors.</p><p><strong>Results: </strong>There were 678 patients with IHD (median age, 78 years [interquartile range, 69 to 84 years]; 271 [40%] female). The association between IHD status and CV mortality was markedly influenced by EF (P_interaction=.002). Ischemic heart disease was associated with excess 5-year CV mortality in the reduced EF group (hazard ratio, 2.14; 95% CI, 1.42 to 3.21) but not in the preserved EF group (hazard ratio, 1.04; 95% CI, 0.80 to 1.36). Fifty-two proteins (31 up-regulated, 21 down-regulated) were associated with IHD compared with non-IHD, including 42 proteins associated with risk factors and 10 with no association with risk factors.</p><p><strong>Conclusion: </strong>These data suggest that unique proteomic profiles reveal biologic signatures of IHD in HF, emphasizing the importance of molecular data in classifying HF phenotypes. In addition, our findings underscore the prognostic significance of IHD in HF with reduced EF.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Associations of Insomnia With Chronic Kidney Diseases and Underlying Blood Proteins: An Observational and Mendelian Randomization Study.","authors":"Kunying Wang, Shuo Ye, Hongliang Feng, Yannis Yan Liang, Sheng Guo, Rui Zheng, Yujing Zhou, Guangbo Jia, Lu Qi, Guoan Zhao, Jihui Zhang, Sizhi Ai","doi":"10.1016/j.mayocp.2024.12.020","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.12.020","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the causal association between insomnia and chronic kidney disease (CKD) and to explore the underlying protein pathways.</p><p><strong>Methods: </strong>In primary analyses, multivariate regression and 1-sample mendelian randomization (1SMR) analyses were performed to estimate the associations between insomnia and CKD in the UK Biobank cohort. The study was conducted from March 13, 2006, to November 12, 2021. Thereafter, a 2-sample MR (2SMR) analysis was used to validate the findings from primary analyses. Finally, proteome-wide MR analysis was conducted to pinpoint CKD-associated blood proteins, supplemented by the colocalization analysis. In addition, the potential mediation effects of blood proteins on the pathway of insomnia giving rise to CKD were explored through a 2-step MR design.</p><p><strong>Results: </strong>Across the multivariate regression, 1SMR, and their sensitivity analyses, we found consistent evidence suggesting that more frequent insomnia was associated with a higher risk of CKD (multivariate regression: hazard ratio, 1.21 [95% CI, 1.17 to 1.25; P<.001]; 1SMR: odds ratio, 1.35 [95% CI, 1.02 to 1.79; P=.04]). Consistent evidence was obtained by using 2SMR (odds ratio,1.06; 95% CI, 1.02 to 1.11; P=.009). Genetically predicted 124 circulating proteins were associated with CKD in proteome-wide MR analysis. ENPP5 is a promising novel target that mediates the association between insomnia and CKD.</p><p><strong>Conclusion: </strong>More frequent insomnia is causally associated with increased risk of CKD, and ENPP5 as a potential blood protein mediates the association between insomnia and CKD. These findings indicate that addressing insomnia could serve as a viable and valid intervention to mitigate CKD risk.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Lipid-Lowering Combination Therapy With Statins and Ezetimibe vs Statin Monotherapy on the Reduction of Cardiovascular Outcomes: A Meta-analysis.","authors":"Maciej Banach, Vikash Jaiswal, Song Peng Ang, Aanchal Sawhney, Novonil Deb, Pierre Amarenco, Dan Gaita, Zeljko Reiner, Ivan Pećin, Carl J Lavie, Peter E Penson, Peter P Toth","doi":"10.1016/j.mayocp.2025.01.018","DOIUrl":"https://doi.org/10.1016/j.mayocp.2025.01.018","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of combination lipid-lowering therapy (LLT) compared with statin monotherapy for low-density lipoprotein cholesterol (LDL-C) reduction, associated adverse events, and outcomes.</p><p><strong>Methods: </strong>A systematic literature search was conducted using PubMed, Embase, and ClinicalTrials.gov to identify relevant articles published from inception until the end of June 2024. The outcomes were assessed using pooled odds ratios (ORs) for categorical data and mean difference for continuous data, with corresponding 95% CIs.</p><p><strong>Results: </strong>A total of 14 studies (11 randomized controlled trials and 3 cohort studies) with 108,373 very high-risk patients were included in the final analysis. The mean age of the patients in the combination LLT group and the statin monotherapy group was 67.31 and 67.89 years, respectively. Pooled analysis revealed that combination LLT significantly more effectively reduced the LDL-C level from baseline (mean difference, -12.96 mg/dL; 95% CI, -17.27 to -8.65; P<.001) and significantly reduced all-cause mortality (OR, 0.81; 95% CI, 0.67 to 0.97; P=.02), major adverse cardiovascular events (OR, 0.82; 95% CI, 0.69 to 0.97; P=.02), and stroke incidence (OR, 0.83; 95% CI, 0.75 to 0.91; P<.001), with an insignificant effect on cardiovascular mortality (OR, 0.86; 95% CI, 0.65 to 1.12; P=.26) when compared with statin monotherapy. The risk of adverse events and the therapy discontinuation rate were comparable between groups.</p><p><strong>Conclusion: </strong>Combination LLT was associated with an overall greater reduction in LDL-C, the same risk of adverse effects, and significantly lower risk of all-cause mortality, major adverse cardiovascular events, and stroke compared with statin monotherapy. Forthcoming guidelines should consider the lipid-lowering combination therapy as early as possible, preferably up-front, for more effective LDL-C goal achievement and significant reduction of cardiovascular disease outcomes and mortality in high- and very high-risk patients.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Contemporary Assessment of the Prevalence of Chronic Diseases That Contribute to Health Care Utilization.","authors":"Harold I Salmons, Dirk R Larson, Rachel E Gullerud, Hilal Maradit Kremers, Jennifer L St Sauver, Arjun S Sebastian, Daniel J Berry, Jennifer J Westendorf, Matthew P Abdel","doi":"10.1016/j.mayocp.2024.10.023","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.10.023","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the most prevalent diagnosed conditions contributing to health care visitations in a defined US population by age and racial group, educational level, and socioeconomic deprivation.</p><p><strong>Patients and methods: </strong>The Rochester Epidemiology Project is a medical records-linkage system that captures medical care provided to residents of Olmsted County, Minnesota. The Rochester Epidemiology Project was queried for all Olmsted County residents. International Classification of Diseases codes were obtained for individuals included in the project between January 1, 2014, and December 31, 2019, and they were categorized into 46 broad disease groups. Age- and sex-specific prevalences were estimated by dividing the number of individuals within each group by the corresponding population.</p><p><strong>Results: </strong>In total, 154,254 individuals were included, and 122,627 (65,782 [53.6%] female) had at least one diagnosis of interest. Arthritis/joint disorders and back problems (ie, musculoskeletal disorders) were the most prevalent across all ages (42%), followed by skin (40%) and anxiety/depression/bipolar disorders (24%). Lower education and a higher area deprivation index score were associated with certain modifiable chronic diseases.</p><p><strong>Conclusion: </strong>Musculoskeletal diseases were the most prevalent diagnosed conditions contributing to health care visitations within a defined US population. Individual level of education and socioeconomic deprivation were associated with modifiable diseases. An emphasis on effective diagnosis and management of musculoskeletal conditions in health care delivery models and more focused preventative efforts in disadvantaged communities are imperative.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charting a New Path Forward in Addressing Employee Well-being in Health Care","authors":"Kaisa C. Wieneke MPH ,&nbsp;Bridget E. Berkland MA, NBC-HWC ,&nbsp;Gretl C. Kruse MS, MHA ,&nbsp;Melissa R. Priestley MPA ,&nbsp;Danielle M. Teal MAOL, PMP ,&nbsp;Colin P. West MD, PhD","doi":"10.1016/j.mayocp.2024.11.018","DOIUrl":"10.1016/j.mayocp.2024.11.018","url":null,"abstract":"<div><div>Health care worker well-being is critical to delivering optimal care to our patients. With greater understanding of these issues, evidence-informed models of employee well-being have been developed to guide efforts to improve well-being in the workplace. To ensure that organizational approaches resonate with staff needs, these models can be improved for local application by engaging employees in a co-creation process in which they actively participate in developing and refining the institutional framework for employee well-being. This article describes how the Mayo Clinic Employee Well-Being team, led by Mayo Clinic’s first organization-level medical director and administrator of Employee Well-Being, integrated employee input with existing well-being models through a comprehensive process to define a program structure reflecting the most important staff needs. The novel features of this approach are intended to serve as a guide for health care organizations as we work together to promote learning and working environments in medicine in which every member of the health care team can thrive.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 3","pages":"Pages 501-513"},"PeriodicalIF":6.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}