Mayo Clinic proceedings最新文献

{"title":"Association Between Cognitive Function and Risk of Chronic Kidney Disease: A Longitudinal Cohort and Mendelian Randomization Study","authors":"Sisi Yang MD,&nbsp;Chun Zhou MD,&nbsp;Ziliang Ye MD,&nbsp;Mengyi Liu MD,&nbsp;Yanjun Zhang MD,&nbsp;Xiaoqin Gan MD,&nbsp;Yu Huang MD,&nbsp;Hao Xiang MD,&nbsp;Panpan He MD,&nbsp;Yuanyuan Zhang MD,&nbsp;Xianhui Qin MD","doi":"10.1016/j.mayocp.2024.04.017","DOIUrl":"10.1016/j.mayocp.2024.04.017","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the causal dose-response association between cognitive function and the risk of chronic kidney disease (CKD) by a longitudinal cohort and mendelian randomization study.</p></div><div><h3>Methods</h3><p>The longitudinal cohort study included 396,600 participants without prior dementia and CKD from the UK Biobank. Cognitive function (including prospective memory, numeric memory, visuospatial memory, reaction time, and reasoning ability) was assessed by computerized touchscreen tests. Global cognitive function was defined as a composite score of those specific cognitive domains. A 2-stage mendelian randomization analysis was conducted with 12,979 cases of CKD and 379,424 controls. Genetically predicted global cognitive function was instrumented with 91 confirmed genome-wide significant variants. The study outcome was new-onset CKD. The study was conducted from March 13, 2006, to September 30, 2021.</p></div><div><h3>Results</h3><p>During a median follow-up of 12.5 years, new-onset CKD developed in 13,090 participants. Per 1 SD score increments in reaction time (adjusted hazard ratio [HR], 0.97; 95% CI, 0.95 to 0.99), reasoning ability (adjusted HR, 0.91; 95% CI, 0.88 to 0.94), and global cognitive function (adjusted HR, 0.96; 95% CI, 0.95 to 0.98) were associated with a significantly lower risk of new-onset CKD. Compared with an incorrect answer in the prospective memory test, a correct answer was associated with a lower risk of new-onset CKD (adjusted HR, 0.82; 95% CI, 0.76 to 0.88). Mendelian randomization analyses found that per 1 SD score increments in genetically predicted global cognitive function resulted in a significantly (7%; 95% CI, 2% to 12%) lower risk of new-onset CKD.</p></div><div><h3>Conclusion</h3><p>A better cognitive function is causally associated with a lower risk of CKD in participants without prior dementia.</p></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 9","pages":"Pages 1399-1410"},"PeriodicalIF":6.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colchicine, a Novel Treatment of Peripheral Artery Disease","authors":"Robert D. McBane II MD","doi":"10.1016/j.mayocp.2024.07.021","DOIUrl":"10.1016/j.mayocp.2024.07.021","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 9","pages":"Pages 1354-1355"},"PeriodicalIF":6.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0025619624003689/pdfft?md5=2655b7107d22850f138a46a883500ebd&pid=1-s2.0-S0025619624003689-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pragmatic Clinical Trials","authors":"Laszlo T. Vaszar MD ,&nbsp;Richard R. Sharp PhD ,&nbsp;Rickey E. Carter PhD ,&nbsp;R. Scott Wright MD","doi":"10.1016/j.mayocp.2024.05.001","DOIUrl":"10.1016/j.mayocp.2024.05.001","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 9","pages":"Pages 1369-1373"},"PeriodicalIF":6.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0025619624002465/pdfft?md5=ac49d95d7b23ab684b8ec91eff3548e1&pid=1-s2.0-S0025619624002465-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Biomarkers of First All-Civilian Space Flight to the International Space Station","authors":"Armin Garmany BS ,&nbsp;Satsuki Yamada MD, PhD ,&nbsp;Sungjo Park PhD ,&nbsp;Andre Terzic MD, PhD","doi":"10.1016/j.mayocp.2024.05.024","DOIUrl":"10.1016/j.mayocp.2024.05.024","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 9","pages":"Pages 1523-1525"},"PeriodicalIF":6.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0025619624002726/pdfft?md5=b8703bff612cbc354ce1e05a86fd0ebc&pid=1-s2.0-S0025619624002726-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"70-Year-Old Woman With Altered Mental Status","authors":"","doi":"10.1016/j.mayocp.2023.10.021","DOIUrl":"10.1016/j.mayocp.2023.10.021","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 9","pages":"Pages 1488-1493"},"PeriodicalIF":6.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0025619623005207/pdfft?md5=f8a4a7236127377dd73bf5ee6b06373c&pid=1-s2.0-S0025619623005207-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperhomocysteinemia Is Associated With a Myriad of Age-Related Illnesses: A Potential Role for Metal Toxicity","authors":"","doi":"10.1016/j.mayocp.2024.04.016","DOIUrl":"10.1016/j.mayocp.2024.04.016","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 9","pages":"Pages 1362-1368"},"PeriodicalIF":6.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0025619624002131/pdfft?md5=7d02cba08d92950ae09886531a88a577&pid=1-s2.0-S0025619624002131-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141457959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General Information","authors":"","doi":"10.1016/S0025-6196(24)00382-3","DOIUrl":"10.1016/S0025-6196(24)00382-3","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 9","pages":"Page A7"},"PeriodicalIF":6.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"73-Year-Old Man With Worsening Hematuria","authors":"","doi":"10.1016/j.mayocp.2023.10.024","DOIUrl":"10.1016/j.mayocp.2023.10.024","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 9","pages":"Pages 1494-1499"},"PeriodicalIF":6.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0025619623005232/pdfft?md5=a8317e9714db4c9867f8d807be369965&pid=1-s2.0-S0025619623005232-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arsenical Keratosis in Chronic Arsenic Intoxication","authors":"Pei-Chun Weng MD ,&nbsp;Chun-Yu Cheng MD","doi":"10.1016/j.mayocp.2024.04.020","DOIUrl":"10.1016/j.mayocp.2024.04.020","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 9","pages":"Pages 1518-1519"},"PeriodicalIF":6.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0025619624002180/pdfft?md5=6f3c3f1771b63417f78e9bf1422e3aa9&pid=1-s2.0-S0025619624002180-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis for Fibromyalgia: Hope or Hype?","authors":"Siddhant Yadav MD,&nbsp;Basant E. Katamesh MBBCh,&nbsp;Ann Vincent MD","doi":"10.1016/j.mayocp.2024.05.014","DOIUrl":"10.1016/j.mayocp.2024.05.014","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 9","pages":"Page 1526"},"PeriodicalIF":6.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0025619624002593/pdfft?md5=c1e6f25b87f3a4411e9d5f3c6d960c44&pid=1-s2.0-S0025619624002593-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}