Mayo Clinic proceedings最新文献

{"title":"Causal Associations of Insomnia With Chronic Kidney Diseases and Underlying Blood Proteins: An Observational and Mendelian Randomization Study","authors":"Kunying Wang MD ,&nbsp;Shuo Ye MD ,&nbsp;Hongliang Feng MD, PhD ,&nbsp;Yannis Yan Liang MD, PhD ,&nbsp;Sheng Guo MD ,&nbsp;Rui Zheng BEng, BSc (Hons) ,&nbsp;Yujing Zhou MD, PhD ,&nbsp;Guangbo Jia MD ,&nbsp;Lu Qi MD, PhD ,&nbsp;Guoan Zhao MD, PhD ,&nbsp;Jihui Zhang MD, PhD ,&nbsp;Sizhi Ai MD, PhD","doi":"10.1016/j.mayocp.2024.12.020","DOIUrl":"10.1016/j.mayocp.2024.12.020","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the causal association between insomnia and chronic kidney disease (CKD) and to explore the underlying protein pathways.</div></div><div><h3>Methods</h3><div>In primary analyses, multivariate regression and 1-sample mendelian randomization (1SMR) analyses were performed to estimate the associations between insomnia and CKD in the UK Biobank cohort. The study was conducted from March 13, 2006, to November 12, 2021. Thereafter, a 2-sample MR (2SMR) analysis was used to validate the findings from primary analyses. Finally, proteome-wide MR analysis was conducted to pinpoint CKD-associated blood proteins, supplemented by the colocalization analysis. In addition, the potential mediation effects of blood proteins on the pathway of insomnia giving rise to CKD were explored through a 2-step MR design.</div></div><div><h3>Results</h3><div>Across the multivariate regression, 1SMR, and their sensitivity analyses, we found consistent evidence suggesting that more frequent insomnia was associated with a higher risk of CKD (multivariate regression: hazard ratio, 1.21 [95% CI, 1.17 to 1.25; <em>P</em>&lt;.001]; 1SMR: odds ratio, 1.35 [95% CI, 1.02 to 1.79; <em>P</em>=.04]). Consistent evidence was obtained by using 2SMR (odds ratio,1.06; 95% CI, 1.02 to 1.11; <em>P</em>=.009). Genetically predicted 124 circulating proteins were associated with CKD in proteome-wide MR analysis. ENPP5 is a promising novel target that mediates the association between insomnia and CKD.</div></div><div><h3>Conclusion</h3><div>More frequent insomnia is causally associated with increased risk of CKD, and ENPP5 as a potential blood protein mediates the association between insomnia and CKD. These findings indicate that addressing insomnia could serve as a viable and valid intervention to mitigate CKD risk.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 7","pages":"Pages 1127-1141"},"PeriodicalIF":6.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights from the Current Issue – Audiovisual Summary","authors":"Karl A. Nath MBChB","doi":"10.1016/j.mayocp.2025.06.006","DOIUrl":"10.1016/j.mayocp.2025.06.006","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 7","pages":"Page e1"},"PeriodicalIF":6.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Plasma Proteomics to Interrogate the Biologic Footprint of Ischemic Heart Disease in Heart Failure","authors":"Hamed Tavolinejad MD,&nbsp;Julio A. Chirinos MD, PhD","doi":"10.1016/j.mayocp.2025.05.020","DOIUrl":"10.1016/j.mayocp.2025.05.020","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 7","pages":"Pages 1095-1097"},"PeriodicalIF":6.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"79-Year-Old Man With Melena and Dyspnea","authors":"Deandra K. Chetram MD ,&nbsp;Saam Dilmaghani MD, MPH ,&nbsp;Hannah C. Nordhues MD","doi":"10.1016/j.mayocp.2024.06.016","DOIUrl":"10.1016/j.mayocp.2024.06.016","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 7","pages":"Pages 1231-1235"},"PeriodicalIF":6.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Opioid Prescriptions and Short-term Mortality Outcomes for Patients With Chronic Kidney Disease and Chronic Pain","authors":"Satya Surbhi PhD, MS, BPharm ,&nbsp;Yamini Mallisetty MS, MPH ,&nbsp;Prabin Shrestha PhD ,&nbsp;Keiichi Sumida MD, MPH, PhD ,&nbsp;Fridtjof Thomas PhD ,&nbsp;Kamyar Kalantar-Zadeh MD, MPH, PhD ,&nbsp;Csaba P. Kovesdy MD","doi":"10.1016/j.mayocp.2025.03.028","DOIUrl":"10.1016/j.mayocp.2025.03.028","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 7","pages":"Pages 1248-1251"},"PeriodicalIF":6.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer: Metabolic Risk Factors, Regional Prevalence, and the Warburg Effect - Limelight, July 2025","authors":"Karl A. Nath MBChB (Editor-in-Chief)","doi":"10.1016/j.mayocp.2025.05.021","DOIUrl":"10.1016/j.mayocp.2025.05.021","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 7","pages":"Pages 1089-1091"},"PeriodicalIF":6.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mayo Clinic Proceedings’ Centennial Celebration: Advances by Mayo Clinic Department of Laboratory Medicine and Pathology","authors":"Lori A. Erickson MD,&nbsp;Eric D. Hsi MD","doi":"10.1016/j.mayocp.2025.05.011","DOIUrl":"10.1016/j.mayocp.2025.05.011","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 7","pages":"Pages 1092-1094"},"PeriodicalIF":6.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply: Ischemic Stroke, Type 2 Diabetes, Glucose-Lowering Drugs, and Cardiovascular Events","authors":"Jae Hyun Bae MD, PhD,&nbsp;Jimi Choi PhD,&nbsp;Nam Hoon Kim MD, PhD,&nbsp;Sin Gon Kim MD, PhD","doi":"10.1016/j.mayocp.2025.04.009","DOIUrl":"10.1016/j.mayocp.2025.04.009","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 7","pages":"Pages 1255-1257"},"PeriodicalIF":6.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The US Narcotic Tax Revenue Stamps","authors":"David P. Steensma MD FACP","doi":"10.1016/j.mayocp.2025.05.002","DOIUrl":"10.1016/j.mayocp.2025.05.002","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 7","pages":"Pages 1262-1264"},"PeriodicalIF":6.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General Information","authors":"","doi":"10.1016/S0025-6196(25)00316-7","DOIUrl":"10.1016/S0025-6196(25)00316-7","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 7","pages":"Page A7"},"PeriodicalIF":6.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}