Mayo Clinic proceedings最新文献_第8页

Highlights from the Current Issue – Audiovisual Summary 本期亮点 - 视听摘要

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-09-01 DOI: 10.1016/j.mayocp.2024.08.006

Karl A. Nath MBChB

引用次数: 0

Path to Fall, Nature Speaks, Enchanted Path, and Colors of Fall by Kit Mahoney 秋天之路》、《自然之语》、《魔法之路》和《秋天的颜色》，作者 Kit Mahoney

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-09-01 DOI: 10.1016/j.mayocp.2024.06.013

Margaret R. Wentz BA

引用次数: 0

High Baseline High-Sensitivity Cardiac Troponin T Concentrations and Risk of Index Acute Myocardial Infarction 基线高敏心肌肌钙蛋白 T 浓度高与指数急性心肌梗死的风险。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-09-01 DOI: 10.1016/j.mayocp.2023.12.019

{"title":"High Baseline High-Sensitivity Cardiac Troponin T Concentrations and Risk of Index Acute Myocardial Infarction","authors":"","doi":"10.1016/j.mayocp.2023.12.019","DOIUrl":"10.1016/j.mayocp.2023.12.019","url":null,"abstract":"<div><h3>Objective</h3><p><span>To evaluate the diagnostic performance of the previously recommended baseline high-sensitivity cardiac </span>troponin T<span> (hs-cTnT) thresholds of 52 and 100 ng/L in identifying patients at high risk of acute myocardial infarction (AMI).</span></p></div><div><h3>Patients and Methods</h3><p>This study compared the positive predictive value (PPV) for index AMI of these high-risk hs-cTnT thresholds in adult patients in the emergency department undergoing hs-cTnT measurement.</p></div><div><h3>Results</h3><p><span>The adjudicated MAyo Southwest Wisconsin 5th Gen Troponin T ImplementatiON cohort included 2053 patients, with 157 (7.6%) who received a diagnosis of AMI. The hs-cTnT concentrations of greater than 52 and greater than 100 ng/L resulted in PPVs of 41% (95% CI, 35%-48%) and 57% (95% CI, 48%-66%). In patients with chest discomfort, hs-cTnT concentrations greater than 52 ng/L resulted in a PPV of 66% (95% CI, 56%-76%) and hs-cTnT concentrations greater than 100 ng/L resulted in a PPV of 77% (95% CI, 65%-87%). The CV </span>Data Mart Biomarker cohort included 143,709 patients, and 3003 (2.1%) received a diagnosis of AMI. Baseline hs-cTnT concentrations greater than 52 and greater than 100 ng/L resulted in PPVs of 12% (95% CI, 11%-12%) and 17% (95% CI, 17%-19%), respectively. In patients with chest pain and hs-cTnT concentrations greater than 52 ng/L, the PPV for MI was 17% (95% CI, 15%-18%) and in those with concentrations greater than 100 ng/L, only 22% (95% CI, 19%-25%).</p></div><div><h3>Conclusion</h3><p><span>In unselected patients undergoing hs-cTnT measurement, the hs-cTnT thresholds of greater than 52 and greater than 100 ng/L provide suboptimal performance for identifying high-risk patients. In patients with chest discomfort, an hs-cTnT concentration of greater than 100 ng/L, but not the European Society of Cardiology–recommended threshold of greater than 52 ng/L, provides an acceptable performance but should be used only with other </span>clinical features.</p></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 9","pages":"Pages 1435-1442"},"PeriodicalIF":6.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Impending Paradoxical Embolism 一例罕见的即将发生的并发症栓塞。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-09-01 DOI: 10.1016/j.mayocp.2024.05.012

Kevin Stanko MD , Samuel Jang MD , Lawrence Sinak MD

引用次数: 0

In Reply: Cannabis for Fibromyalgia: Hope or Hype? 回复中：大麻治疗纤维肌痛：希望还是炒作？

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-09-01 DOI: 10.1016/j.mayocp.2024.05.015

Abhinav Singla MD

引用次数: 0

The Princeton IV Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease 普林斯顿第四届勃起功能障碍和心血管疾病管理共识建议》。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-09-01 DOI: 10.1016/j.mayocp.2024.06.002

Tobias S. Köhler MD , Robert A. Kloner MD, PhD , Raymond C. Rosen PhD , Arthur L. Burnett MD, MBA , Michael J. Blaha MD , Peter Ganz MD , Irwin Goldstein MD , Noel N. Kim PhD , Tom Lue MD, ScD , Kevin T. McVary MD , John P. Mulhall MD, MSc , Sharon J. Parish MD , Hossein Sadeghi-Nejad MD , Richard Sadovsky MD , Ira D. Sharlip MD , Martin Miner MD

{"title":"The Princeton IV Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease","authors":"Tobias S. Köhler MD , Robert A. Kloner MD, PhD , Raymond C. Rosen PhD , Arthur L. Burnett MD, MBA , Michael J. Blaha MD , Peter Ganz MD , Irwin Goldstein MD , Noel N. Kim PhD , Tom Lue MD, ScD , Kevin T. McVary MD , John P. Mulhall MD, MSc , Sharon J. Parish MD , Hossein Sadeghi-Nejad MD , Richard Sadovsky MD , Ira D. Sharlip MD , Martin Miner MD","doi":"10.1016/j.mayocp.2024.06.002","DOIUrl":"10.1016/j.mayocp.2024.06.002","url":null,"abstract":"<div><p>The Princeton Consensus (Expert Panel) Conference is a multispecialty collaborative symposium dedicated to optimizing sexual function and preserving cardiovascular health. The Fourth Princeton Consensus Conference was convened on March 10-11, 2023, at the Huntington Medical Research Institutes in Pasadena, California. Princeton panels I to III addressed the clinical management of men with erectile dysfunction (ED) who also had cardiovascular disease. Thirteen years since Princeton III, Princeton IV builds on previous foundations in several key areas. Mounting evidence supports the need for providers to treat men with ED as being at risk for cardiac events until proven otherwise. Algorithms for the diagnosis and treatment of ED are updated with new recommendations for coronary artery calcium scoring for advanced cardiovascular risk stratification. Optimization of oral phosphodiesterase type 5 inhibitors in the treatment of men with ED and cardiovascular disease is thoroughly explored, including recent evidence of potential cardioprotective effects of these drugs.</p></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 9","pages":"Pages 1500-1517"},"PeriodicalIF":6.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0025619624002763/pdfft?md5=41d6a2428b6fbd62dc40a04ec3cf465a&pid=1-s2.0-S0025619624002763-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Serum Creatinine– and Cystatin C–Based Sarcopenia Index on Renal Outcomes in Non–Dialysis-Dependent Chronic Kidney Disease Patients: Results From the KNOW-CKD Study 基于血清肌酸酐和胱抑素 C 的骨质疏松指数对非透析依赖型慢性肾病患者肾功能预后的影响：KNOW-CKD研究的结果。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-09-01 DOI: 10.1016/j.mayocp.2024.03.009

Donghyuk Kang MD , Kyu-Beck Lee MD, PhD , Tae-Hyun Yoo MD, PhD , Soo Wan Kim MD, PhD , Kook-Hwan Oh MD, PhD , Yaeni Kim MD, PhD

{"title":"Impact of Serum Creatinine– and Cystatin C–Based Sarcopenia Index on Renal Outcomes in Non–Dialysis-Dependent Chronic Kidney Disease Patients: Results From the KNOW-CKD Study","authors":"Donghyuk Kang MD , Kyu-Beck Lee MD, PhD , Tae-Hyun Yoo MD, PhD , Soo Wan Kim MD, PhD , Kook-Hwan Oh MD, PhD , Yaeni Kim MD, PhD","doi":"10.1016/j.mayocp.2024.03.009","DOIUrl":"10.1016/j.mayocp.2024.03.009","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the impact of the serum creatinine– and cystatin C–based new sarcopenia index (SI) on renal outcomes in non–dialysis-dependent patients with chronic kidney disease (CKD).</p></div><div><h3>Methods</h3><p>In this observational Korean Cohort Study for Outcome in Patients With CKD (KNOW-CKD), 1957 patients with CKD stage 1 to stage 4 were analyzed from 2011 to 2019. Men and women were separately assigned to quartile groups according to their SI. The primary outcome was a composite renal outcome consisting of 50% reduction in estimated glomerular filtration rate or end-stage kidney disease. With use of Fine and Gray subdistribution hazard models, the association between the SI and the primary outcome was analyzed.</p></div><div><h3>Results</h3><p>During a median follow-up of 6.0 (4.2 to 7.7) years, the primary composite renal outcome occurred in 528 (28.6%) patients within a median of 3.0 (1.8 to 5.0) years. In unadjusted and adjusted models, lower SI groups had a poor primary outcome compared with the highest group (quartile 4). The hazard ratios for quartiles 1, 2, and 3 compared with quartile 4 in the fully adjusted model were 4.47 (95% CI, 3.05 to 6.56; <em>P</em><.001), 3.08 (95% CI, 2.13 to 4.48; <em>P</em><.001), and 2.09 (95% CI, 1.45 to 3.01; <em>P</em><.001), respectively. Restricted cubic spline regression analyses found a relatively inverse linear relationship between the SI and the composite renal outcome.</p></div><div><h3>Conclusion</h3><p>The new SI is an independent predictor of renal outcomes. A low SI is associated with poor renal outcome.</p></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 9","pages":"Pages 1388-1398"},"PeriodicalIF":6.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CKD: A Potentially Self-Perpetuating Cycle of Injury to the Kidney and Other Organs 慢性肾脏病：肾脏和其他器官损伤的潜在自我延续循环

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-09-01 DOI: 10.1016/j.mayocp.2024.07.023

Karl A. Nath MBChB (Editor-in-Chief), Matthew D. Griffin MB BCh BAO, DMed, FRCPI

引用次数: 0

Hansen Disease 汉森氏病

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-09-01 DOI: 10.1016/j.mayocp.2024.04.012

Jack McHugh MB, BCh, BAO , James Vaillant MD , Bobbi Pritt MD

引用次数: 0

Injury-Related Mortality on Weekends in the United States 美国周末与伤害相关的死亡率。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-09-01 DOI: 10.1016/j.mayocp.2024.05.016

Vishal R. Patel MD, MPH , Michael Liu MPhil , Alex B. Haynes MD, MPH , Anupam B. Jena MD, PhD

引用次数: 0