Mayo Clinic proceedings最新文献

{"title":"Red Blood Cell Dynamics Over Time: Dapsone, Then Iron","authors":"Walker M. Schmidt MD, Angela M. Collie MD, PhD, Richard C. Godby MD","doi":"10.1016/j.mayocp.2026.04.006","DOIUrl":"10.1016/j.mayocp.2026.04.006","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 9","pages":"Pages 1469-1470"},"PeriodicalIF":6.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maxillary Sinus Recirculation Syndrome","authors":"Kanupriya Gupta MD, Spencer C. Payne MD, Prem P. Batchala MD","doi":"10.1016/j.mayocp.2026.04.013","DOIUrl":"10.1016/j.mayocp.2026.04.013","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 9","pages":"Pages 1558-1560"},"PeriodicalIF":6.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse Bilateral Pulmonary Nodules and Calcifications During Third Kidney Transplant Evaluation","authors":"Sandhya R. Nagarakanti MD, FIDSA, Girish K. Mour MD, Michael B. Gotway MD, Holenarasipur R. Vikram MD, FIDSA","doi":"10.1016/j.mayocp.2026.06.009","DOIUrl":"10.1016/j.mayocp.2026.06.009","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 9","pages":"Pages 1657-1658"},"PeriodicalIF":6.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessing Cancer Attribution and Methodologic Limitations in PLA2R-Associated Membranous Nephropathy","authors":"Chang Li MSc, Gang Tian MD","doi":"10.1016/j.mayocp.2026.06.005","DOIUrl":"10.1016/j.mayocp.2026.06.005","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 9","pages":"Page 1659"},"PeriodicalIF":6.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights from the Current Issue – Audiovisual Summary","authors":"Karl A. Nath MBChB","doi":"10.1016/j.mayocp.2026.08.005","DOIUrl":"10.1016/j.mayocp.2026.08.005","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 9","pages":"Page e1"},"PeriodicalIF":6.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing an Alzheimer Disease Therapeutics Clinic: Experience From a Year of Evaluations","authors":"Bryan J. Neth MD, PhD,&nbsp;Jonathan Graff-Radford MD,&nbsp;Petrice M. Cogswell MD, PhD,&nbsp;Derek R. Johnson MD,&nbsp;Hugo Botha MD,&nbsp;Stuart J. McCarter MD,&nbsp;David T. Jones MD,&nbsp;Megan M. Conkins MS,&nbsp;Dale B. Hardin MPH, MBA,&nbsp;Jodi J. Spence BA,&nbsp;Carolyn L. Rhegness BS,&nbsp;Laura A. Allen APRN, CNP, MS,&nbsp;Ryan P. Coburn MD,&nbsp;Johnson D. Pounders MD,&nbsp;Brian J. Burkett MD,&nbsp;Jay J. Pillai MD,&nbsp;Gregory S. Day MD,&nbsp;Neill R. Graff-Radford MD,&nbsp;Christian Lachner MD,&nbsp;Steven A. Messina MD,&nbsp;Vijay K. Ramanan MD, PhD","doi":"10.1016/j.mayocp.2025.09.019","DOIUrl":"10.1016/j.mayocp.2025.09.019","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the establishment and initial experience of a multidisciplinary Alzheimer disease treatment clinic (ADTC), focusing on the evaluation of eligibility for novel disease-modifying therapies, as well as the treatment and monitoring of qualifying patients.</div></div><div><h3>Patients and Methods</h3><div>We completed a retrospective review of cases seen through the Mayo Clinic ADTC between October 2, 2023, and December 31, 2024. Typical evaluations occurred over 4 to 5 days and included multimodal testing, office visits, and a weekly case conference modeled on tumor board meetings.</div></div><div><h3>Results</h3><div>Patients evaluated in the ADTC (N=232) ranged from 52 to 85 years of age (mean age, 71.2 years). Most patients had mild cognitive impairment (128 of 232 [55%]) or mild dementia (72 of 232 [31%]) syndromes. Overall, 121 patients (52%) were judged eligible for antiamyloid therapy. Eligibility rates were higher among internal (from our institution) referrals compared with external referrals (63% [146 of 232] vs 37% [86 of 232). Reasons for treatment ineligibility were typically multiple but commonly included magnetic resonance imaging features, too severe cognitive/functional impairment, and general health conditions believed likely to increase therapeutic risks. In some cases, the ADTC evaluation uniquely identified treatment risk factors, such as cerebral amyloid angiopathy, that had not been previously discussed with patients. Through shared decision making, approximately 30% of eligible patients (25 of 81) ultimately deferred antiamyloid therapy. In addition, approximately 10% of patients evaluated in the ADTC were amyloid-negative by positron emission tomography, suggesting non–Alzheimer disease diagnoses for their presentations.</div></div><div><h3>Conclusion</h3><div>The ADTC facilitated systematic implementation of antiamyloid therapies for early Alzheimer disease and provided a scalable foundation for integrating future approved treatment options.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 9","pages":"Pages 1497-1511"},"PeriodicalIF":6.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering Usage and Expenditures of Complementary Medicine: A Five-Year Longitudinal Data Analysis of 205,423 Individuals","authors":"David De Ridder DDR, MEng, PhD,&nbsp;Christophe Bagnoud CB, MSc, PhD,&nbsp;Stéphane Joost SJ, MEng, PhD,&nbsp;Idris Guessous IG, MD, PhD","doi":"10.1016/j.mayocp.2025.09.018","DOIUrl":"10.1016/j.mayocp.2025.09.018","url":null,"abstract":"<div><h3>Objective</h3><div>To identify factors associated with complementary and alternative medicine (CAM) use, investigate regional patterns, and examine whether CAM usage is associated with decreased expenditures in conventional medicine (CM).</div></div><div><h3>Participants and Methods</h3><div>We conducted a retrospective analysis of Swiss health insurance claims data from January 1, 2017, to December 31, 2021, including mandatory health insurance (MHI) and supplementary insurance (SI) schemes. We analyzed 816,080 person-years from 205,423 Swiss residents with dual coverage using 2-part multilevel models and geographic clustering analyses.</div></div><div><h3>Results</h3><div>CAM utilization differed markedly between schemes: 59% (481,176 of 816,080) used CAM (SI) while 2.2% (18,023) used CAM (MHI). Women had nearly double the odds of CAM (MHI) usage (adjusted odds ratio, 1.97; <em>P</em>&lt;.001) and 56% higher odds of CAM (SI) usage (adjusted odds ratio, 1.56; <em>P</em>&lt;.001). Higher socioeconomic status was associated with dose-response relationships, with increased usage across both schemes. Substantial geographic variations emerged, with French-speaking regions having 33% lower odds of CAM (MHI) usage (adjusted odds ratio, 0.67; <em>P</em>&lt;.001) yet 26.6% higher expenditures (<em>P</em>&lt;.001) among users. CAM users initially incurred 49.1% higher CM expenditures, but this gap narrowed to 34.2% by year 5, representing a 14.9 percentage point convergence. This pattern was most pronounced among individuals without chronic conditions based on medication patterns (CAM MHI: 139.7% to 20.1% difference) and patients with cancer (CAM SI: expenditure differences shifted from +13.9% to −5.9%).</div></div><div><h3>Conclusion</h3><div>CAM serves distinct populations through different insurance schemes, with initial higher CM costs but slower expenditure growth over time. These findings suggest expenditure patterns that warrant further mechanistic investigation to optimize integrative health care delivery.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 9","pages":"Pages 1529-1557"},"PeriodicalIF":6.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Updated Algorithm for the Management of Restless Legs Syndrome","authors":"Michael H. Silber MBChB,&nbsp;J. Andrew Berkowski MD,&nbsp;Mark J. Buchfuhrer MD,&nbsp;Lourdes M. DelRosso MD, PhD,&nbsp;Christopher J. Earley MBBCh, PhD,&nbsp;Melissa C. Lipford MD,&nbsp;Mauro Manconi MD,&nbsp;John W. Winkelman MD, PhD,&nbsp;Rochelle S. Zak MD","doi":"10.1016/j.mayocp.2026.05.010","DOIUrl":"10.1016/j.mayocp.2026.05.010","url":null,"abstract":"<div><div>Restless legs syndrome (RLS), a common disorder, is largely managed by primary care providers. Much has changed in its management since the last version of this algorithm was published in 2021. The Scientific and Medical Advisory Board of the RLS Foundation has written this new paper as a practical algorithmic guide to current treatment based on a review of the literature published since 2020 and consensus expert opinion. This updated algorithm includes management of intermittent RLS, with behavioral approaches; new indications for oral and intravenous iron therapy; the role of medications in exacerbating RLS; gabapentinoids as first-line pharmacologic therapy for chronic persistent RLS; the risks of dopamine agonists and the precautions needed if they are used; the management of dopamine agonist augmentation; the important role of low-dose opioids in management and how to safely use them; novel therapies including peroneal nerve stimulation and buprenorphine; and RLS in children, during pregnancy and lactation, in end-stage renal failure, and in the perioperative period. Alternative, investigative, and potential future approaches are addressed.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 9","pages":"Pages 1561-1588"},"PeriodicalIF":6.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148042761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct Oral Anticoagulant Monotherapy Reduces Mortality in Patients With Atrial Fibrillation and Stable Coronary Artery Disease","authors":"Aditi Ujjawal MD,&nbsp;André Rivera MD,&nbsp;Flavia Queiroga MD,&nbsp;Deepak L. Bhatt MD, MPH, MBA,&nbsp;Alec A. Schmaier MD, PhD,&nbsp;Eric A. Secemsky MD, MSc,&nbsp;Brett J. Carroll MD","doi":"10.1016/j.mayocp.2026.06.018","DOIUrl":"10.1016/j.mayocp.2026.06.018","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 9","pages":"Pages 1652-1656"},"PeriodicalIF":6.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic Prostate Carcinoma Exclusively in Bone Marrow Trabeculae","authors":"Aruna Rangan MBBS,&nbsp;Rong He MD","doi":"10.1016/j.mayocp.2026.05.007","DOIUrl":"10.1016/j.mayocp.2026.05.007","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 9","pages":"Pages 1647-1648"},"PeriodicalIF":6.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}