Mayo Clinic proceedings最新文献_第8页

Mpox in a Patient With a Signal Transducer and Activator of Transcription 1 Gain-of-Function Mutation m痘患者的信号换能器和转录激活子1功能获得突变

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2025-03-01 DOI: 10.1016/j.mayocp.2024.11.022

Jack W. McHugh MB BCh BAO , Eric O. Gomez MD , Omar M. Abu-Saleh MB BS , Cristina G. Corsini Campioli MD , Supavit Chesdachai MD , Saadiya Nazli MB BS , Nicholas T. Streck PhD , Shama Cash-Goldwasser MD , Agam K. Rao MD , Michelle L. Meyer PhD , Avni Y. Joshi MD , Kevin P. Boyd MD , Julian A. Villalba MD , Reade A. Quinton MD , Pritish K. Tosh MD , Aditya S. Shah MB BS

引用次数: 0

The Father Mathew Remedy, Temperance, and Private Die Revenue Stamps 马修神父补救、节制和私模收入邮票

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2025-03-01 DOI: 10.1016/j.mayocp.2025.01.008

David P. Steensma MD

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Hypertrophic Cardiomyopathy: State of the Art 肥厚性心肌病：最新进展

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2025-03-01 DOI: 10.1016/j.mayocp.2024.07.013

Steve R. Ommen MD , Rick A. Nishimura MD , Hartzell V. Schaff MD , Joseph A. Dearani MD

{"title":"Hypertrophic Cardiomyopathy: State of the Art","authors":"Steve R. Ommen MD , Rick A. Nishimura MD , Hartzell V. Schaff MD , Joseph A. Dearani MD","doi":"10.1016/j.mayocp.2024.07.013","DOIUrl":"10.1016/j.mayocp.2024.07.013","url":null,"abstract":"<div><div>Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy. Patients with HCM who are treated according to modern guidelines can reasonably be expected to have normal longevity and good quality of life. Nevertheless, effort intolerance, heart failure, arrhythmias, and sudden cardiac death can occur in some patients. Comprehensive and longitudinal assessment with echocardiography, ambulatory electrocardiography, stress testing, and in some cases cardiac magnetic resonance imaging helps guide therapy. Symptomatic patients can be treated with medications including a new class, cardiac myosin inhibitors, developed specifically to treat the cellular pathophysiologic mechanism of HCM. For patients whose symptoms do not respond to medical therapy or in whom medical therapy is not desired, invasive options to relieve symptoms, when performed at expert centers, have robust data for successful outcomes. The goal of management is to encourage and help patients with HCM lead an active, healthy lifestyle that includes regular exercise similar to activity recommendations for the general public.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 3","pages":"Pages 557-566"},"PeriodicalIF":6.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlights from the Current Issue – Audiovisual Summary 从当前问题的亮点-视听摘要

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2025-03-01 DOI: 10.1016/j.mayocp.2025.02.007

Karl A. Nath MBChB

引用次数: 0

Individual and Combined Association Between Healthy Behaviors and All-Cause and Premature Mortality 健康行为与全因和过早死亡之间的个体和联合关联：一项22年随访队列。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2025-03-01 DOI: 10.1016/j.mayocp.2024.07.025

Adilson Marques PhD , Marcelo Maio Nascimento PhD , Gerson Ferrari PhD , Élvio R. Gouveia PhD , Paola Cortés Almanzar PhD , Miguel Peralta PhD

{"title":"Individual and Combined Association Between Healthy Behaviors and All-Cause and Premature Mortality","authors":"Adilson Marques PhD , Marcelo Maio Nascimento PhD , Gerson Ferrari PhD , Élvio R. Gouveia PhD , Paola Cortés Almanzar PhD , Miguel Peralta PhD","doi":"10.1016/j.mayocp.2024.07.025","DOIUrl":"10.1016/j.mayocp.2024.07.025","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the impact of individual and combined healthy behaviors on all-cause and premature mortality risk in Mexican adults.</div></div><div><h3>Methods</h3><div>Data on physical activity, fruit and vegetable intake, sleep hours, alcohol intake, and smoking from 95,142 adults from the MCPS (Mexico City Prospective Study) were used. All-cause mortality was monitored for up to 22 years, until December 31, 2020. Cox proportional hazards regression was used to assess mortality risk.</div></div><div><h3>Results</h3><div>Physical activity (HR, 0.88; 95% CI, 0.84 to 0.92), fruit and vegetable intake (HR, 0.94; 95% CI, 0.91 to 0.98), no excessive alcohol consumption (HR, 0.86; 95% CI, 0.81 to 0.92), and not smoking (HR, 0.93; 95% CI, 0.89 to 0.97) were individually associated with lower mortality. All-cause mortality risk decreased progressively by 8% (95% CI: 0.86 to 0.99) to 29% (95% CI, 0.63 to 0.81) for each additional healthy behavior attained. Similarly, premature mortality risk decreased by 13% (95% CI, 0.80 to 0.95) to 30% (95% CI, 0.59 to 0.83).</div></div><div><h3>Conclusion</h3><div>Over 22 years, adopting a healthier life was linked with lower all-cause and premature mortality risk, decreasing with the clustering of one additional healthy behavior. Law and policy changes as well as efforts to address the root causes of not adopting healthy behaviors in low- and middle-income countries, such as creating structural conditions for people to engage in physical activity or strong social marketing to raise awareness of the daily consumption of fruits and vegetables, are needed for improving health and delaying mortality.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 3","pages":"Pages 478-487"},"PeriodicalIF":6.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

67-Year-Old Man With Syncope 67 岁男子晕厥。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2025-03-01 DOI: 10.1016/j.mayocp.2024.03.024

Jenny J.L. Cao MB, BChir , Nader James Al-Shakarchi MBBS , Dayne Voelker MD

引用次数: 0

General Information 一般信息

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2025-03-01 DOI: 10.1016/S0025-6196(25)00053-9

引用次数: 0

In the Limelight: March 2025 焦点：2025年3月

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2025-03-01 DOI: 10.1016/j.mayocp.2025.01.016

Karl A. Nath MBChB (Editor-in-Chief)

引用次数: 0

Do Statins “Shape” Diabetes Risk? 他汀类药物“影响”糖尿病风险吗？

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2025-03-01 DOI: 10.1016/j.mayocp.2025.01.013

Vinaya Simha MD

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Eplerenone vs Spironolactone and Cardiac Remodeling in Heart Failure With Reduced Ejection Fraction: A Meta-Analysis 埃普利酮vs螺内酯与心力衰竭伴射血分数降低的心脏重构：一项荟萃分析

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2025-03-01 DOI: 10.1016/j.mayocp.2024.11.009

Ahmed Elshahat MD , Ahmed Abdelaziz MD , Ahmed Mansour MD , Toshiki Kuno MD , Robert J. Mentz MD , Leandro Slipczuk MD, PhD , Carl J. Lavie MD

引用次数: 0