Mayo Clinic proceedings最新文献_第7页

68-Year-Old Man With Shortness of Breath and Chest Pain 68 岁男子呼吸急促并伴有胸痛。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-10-01 DOI: 10.1016/j.mayocp.2023.12.015

William H. Swain MD , Luis R. Gasca MD , Panithaya Chareonthaitawee MD

引用次数: 0

Effect of Relative Protein Intake on Hypertension and Mediating Role of Physical Fitness and Circulating Fatty Acids 相对蛋白质摄入量对高血压的影响以及体能和循环脂肪酸的中介作用：孟德尔随机研究。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-10-01 DOI: 10.1016/j.mayocp.2024.02.019

Chaojie Ye MD, Dong Liu MD, Lijie Kong MD, Yiying Wang MD, Chun Dou MD, Min Xu MD, PhD, Jie Zheng MD, PhD, Ruizhi Zheng MD, PhD, Mian Li MD, PhD, Zhiyun Zhao MD, PhD, Jieli Lu MD, PhD, Yuhong Chen MD, PhD, Weiqing Wang MD, PhD, Yufang Bi MD, PhD, Yu Xu MD, PhD, Tiange Wang MD, PhD, Guang Ning MD, PhD

{"title":"Effect of Relative Protein Intake on Hypertension and Mediating Role of Physical Fitness and Circulating Fatty Acids","authors":"Chaojie Ye MD, Dong Liu MD, Lijie Kong MD, Yiying Wang MD, Chun Dou MD, Min Xu MD, PhD, Jie Zheng MD, PhD, Ruizhi Zheng MD, PhD, Mian Li MD, PhD, Zhiyun Zhao MD, PhD, Jieli Lu MD, PhD, Yuhong Chen MD, PhD, Weiqing Wang MD, PhD, Yufang Bi MD, PhD, Yu Xu MD, PhD, Tiange Wang MD, PhD, Guang Ning MD, PhD","doi":"10.1016/j.mayocp.2024.02.019","DOIUrl":"10.1016/j.mayocp.2024.02.019","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the causal effect of protein intake on hypertension and the related mediating pathways.</div></div><div><h3>Patients and Methods</h3><div><span>Using genome-wide association study summary statistics of European ancestry, we applied univariable and multivariable Mendelian randomization<span> to estimate the bidirectional associations of relative protein intake and related </span></span>metabolomic<span><span> signatures with hypertension (FinnGen: Ncase=42,857/Ncontrol=162,837; UK Biobank: Ncase=77,723/Ncontrol=330,366) and blood pressure (International Consortium of Blood Pressure: N=757,601) and two-step </span>Mendelian randomization to assess the mediating roles of 40 cardiometabolic factors therein. Mendelian randomization estimates of hypertension from FinnGen and UK Biobank were meta-analyzed without heterogeneity. We performed the study from May 15, 2023, to September 15, 2023.</span></div></div><div><h3>Results</h3><div><span><span>Each 1-SD higher relative protein intake was causally associated with 69% (odds ratio, 0.31; 95% CI, 0.11 to 0.89) lower hypertension risk independent of the effects of other macronutrients, and was the only macronutrient associated with 2.21 (95% CI, 0.52 to 3.91) mm Hg lower pulse pressure, in a unidirectional manner. Higher plant protein–related metabolomic<span> signature (glycine) was associated with lower hypertension risk and pulse pressure, whereas higher animal protein–related metabolomic signatures (leucine, </span></span>isoleucine, </span>valine<span><span>, and isovalerylcarnitine [only systolic blood pressure]) were associated with higher hypertension risk, pulse pressure, and systolic blood pressure<span>. The effect of relative protein intake on hypertension was causally mediated by frailty index (mediation proportion, 40.28%), </span></span>monounsaturated fatty acids<span> (13.81%), saturated fatty acids (11.39%), grip strength (5.34%), standing height (3.99%), and sitting height (3.61%).</span></span></div></div><div><h3>Conclusion</h3><div>Higher relative protein intake causally reduces the risk of hypertension, partly mediated by physical fitness and circulating fatty acids.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 10","pages":"Pages 1589-1605"},"PeriodicalIF":6.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accidental Deaths, Suicide, and Impulsivity: Potential Connections and Targets for Intervention to Mitigate Suicide Risk 意外死亡、自杀和冲动：降低自杀风险的潜在联系和干预目标》（Potential Connections and Targets for Intervention to Mitigate Suicide Risk.

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-10-01 DOI: 10.1016/j.mayocp.2024.08.020

Bhanu Prakash Kolla MD, FRCPsych

引用次数: 0

Bird Platters by Dwo Wen Chen 鸟类拼盘，作者 Dwo Wen Chen。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-10-01 DOI: 10.1016/j.mayocp.2024.08.009

Margaret R. Wentz BA

引用次数: 0

Metabolic Syndrome and Metabolic Dysfunction-Associated Steatotic Liver Disease in Premenopausal Women 绝经前妇女的代谢综合征和代谢功能障碍相关性脂肪肝：到 2040 年的全球趋势和预测》。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-10-01 DOI: 10.1016/j.mayocp.2023.12.025

{"title":"Metabolic Syndrome and Metabolic Dysfunction-Associated Steatotic Liver Disease in Premenopausal Women","authors":"","doi":"10.1016/j.mayocp.2023.12.025","DOIUrl":"10.1016/j.mayocp.2023.12.025","url":null,"abstract":"<div><h3>Objective</h3><div>To quantify the burden of metabolic dysfunction–associated steatotic liver disease (MASLD) and related metabolic disorders<span> in premenopausal women.</span></div></div><div><h3>Patients and Methods</h3><div><span><span>Between 2010 and 2019, global evaluations of prevalence, mortality, disability-adjusted life years (DALYs), and their age-standardized rate (ASR) were conducted for metabolic conditions such as MASLD, type 2 diabetes mellitus, </span>dyslipidemia, hypertension (HTN), obesity, and </span>polycystic ovarian syndrome. Subgroup assessments were conducted according to geographical regions and the sociodemographic index. The predictive models were established to estimate mortality and DALYs through 2040.</div></div><div><h3>Results</h3><div><span>In 2019, the most significant ASR of deaths was found in HTN (11.37; 9.52 to 13.45), followed by obesity (10.49; 7.57 to 13.64). In contrast, the greatest ASR of DALYs was attributed to obesity (816.13; 581.41 to 1073.32), followed by HTN (634.73; 536.75 to 744.77). The mortality rates<span> for dyslipidemia (</span></span><sup>–</sup>0.55%) and HTN (<sup>–</sup>0.72%) have been decreasing over time, but there has been an increase in obesity (<sup>+</sup>0.58%), type 2 diabetes mellitus (<sup>+</sup>0.85%), and MASLD (<sup>+</sup>0.51%). Lower sociodemographic index countries exhibit a higher disability-to-prevalence ratio. In 2040, obesity is predicted to cause the most deaths (<sup>+</sup>41.59% from 2019).</div></div><div><h3>Conclusion</h3><div>The escalating impact of metabolic syndrome<span>, the rising trends in death rates linked to obesity, and the disparities based on region and socioeconomic status in premenopausal women underscore the alarming increase in the global burden of metabolic syndrome.</span></div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 10","pages":"Pages 1615-1628"},"PeriodicalIF":6.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Statin Use for the Secondary Prevention of Atherosclerotic Cardiovascular Disease in US Adults by Age, 1999-2020 1999-2020 年按年龄划分的美国成年人使用他汀类药物进行动脉粥样硬化性心血管疾病二级预防的趋势。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-10-01 DOI: 10.1016/j.mayocp.2024.06.003

Junwen Wang MD, Yuyang Ye MM, Xuefeng Chen MM, Xinru Hu MM, Yong Peng MD

引用次数: 0

A Pause to Explore the Impact of Physicians’ Work on Personal Relationships 探讨医生工作对人际关系的影响。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-10-01 DOI: 10.1016/j.mayocp.2024.08.021

Kristine Olson MD, MSc, Chantal Brazeau MD

引用次数: 0

41-Year-Old Woman With Ascites 41 岁女性腹水患者。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-10-01 DOI: 10.1016/j.mayocp.2023.11.025

引用次数: 0

Familial Coaggregation of Suicide, Accidental Death, and Major Psychiatric Disorders in First-Degree Relatives of Individuals Dying Accidentally 意外死亡者一级亲属中自杀、意外死亡和主要精神障碍的家族聚集。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-10-01 DOI: 10.1016/j.mayocp.2024.06.014

Mu-Hong Chen MD, PhD , Shih-Jen Tsai MD , Chih-Ming Cheng MD , Wen-Han Chang MS , Ya-Mei Bai MD, PhD , Tung-Ping Su MD , Tzeng-Ji Chen MD, PhD

{"title":"Familial Coaggregation of Suicide, Accidental Death, and Major Psychiatric Disorders in First-Degree Relatives of Individuals Dying Accidentally","authors":"Mu-Hong Chen MD, PhD , Shih-Jen Tsai MD , Chih-Ming Cheng MD , Wen-Han Chang MS , Ya-Mei Bai MD, PhD , Tung-Ping Su MD , Tzeng-Ji Chen MD, PhD","doi":"10.1016/j.mayocp.2024.06.014","DOIUrl":"10.1016/j.mayocp.2024.06.014","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the risks of suicide, accidental death, and major psychiatric disorders in first-degree relatives (FDRs) of people who die accidentally. Evidence has shown that the endophenotypes of impulsivity and risk-taking are known to coaggregate with major psychiatric disorders, suicide, and accidental deaths within families.</div></div><div><h3>Methods</h3><div>In total, 136,011 FDRs of individuals who died from accidents and 544,044 individuals matched for age and sex who served as a control group were included in the present study. The relative risks of accidental death and suicide were assessed between these groups. Differences in the frequencies of major psychiatric disorders, including schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder, and attention deficit hyperactivity disorder (ADHD) between the groups were also identified.</div></div><div><h3>Results</h3><div>The FDRs of individuals who died from accidents were more likely to themselves die from accidents (relative risk [RR] = 4.62) and by suicide (RR = 1.54) compared with individuals in the control group. The FDRs of individuals who died from accidents had an increased risk of developing schizophrenia (RR = 1.24), bipolar disorder (RR = 1.18), major depressive disorder (RR = 1.26), and attention deficit hyperactivity disorder (RR = 1.10) compared with the FDRs of individuals who did not die from accidents.</div></div><div><h3>Conclusion</h3><div>Our findings may serve as a reminder to public health officials and clinicians to monitor closely the mental health of the FDRs of individuals who die from accidents.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"99 10","pages":"Pages 1558-1566"},"PeriodicalIF":6.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

79-Year-Old Man With Dysuria, Fever, and Back Pain 79 岁男子伴有排尿困难、发烧和背痛。

IF 6.9 2区医学

Mayo Clinic proceedings Pub Date : 2024-09-01 DOI: 10.1016/j.mayocp.2023.10.023

引用次数: 0