Niloofar Nobakht MD , Yalda Afshar MD, PhD , Marmar Vaseghi MD, PhD , Zhaoping Li MD, PhD , Ines Donangelo MD, PhD , Helen Lavretsky MD, MS , Thalia Mok MD , Christina S. Han MD , Susanne B. Nicholas MD, MPH, PhD
{"title":"Hypertension Management in Women With a Multidisciplinary Approach","authors":"Niloofar Nobakht MD , Yalda Afshar MD, PhD , Marmar Vaseghi MD, PhD , Zhaoping Li MD, PhD , Ines Donangelo MD, PhD , Helen Lavretsky MD, MS , Thalia Mok MD , Christina S. Han MD , Susanne B. Nicholas MD, MPH, PhD","doi":"10.1016/j.mayocp.2024.10.005","DOIUrl":"10.1016/j.mayocp.2024.10.005","url":null,"abstract":"<div><div>Current clinical practice guidelines were established by several organizations to guide the diagnosis and treatment of hypertension in men and women in a similar manner despite data demonstrating differences in underlying mechanisms. Few publications have provided a contemporary and comprehensive review focused on characteristics of hypertension that are unique to women across their life spectrum. We performed a computerized search using PubMed, OVID, EMBASE, and Cochrane library databases between 1995 and 2023 that highlighted relevant clinical studies, challenges to the management of hypertension in women, and multidisciplinary approaches to hypertension control in women, including issues unique to racial and ethnic minority groups. Despite our current understanding of underlying mechanisms and strategies to manage hypertension in women, numerous challenges remain. Here, we discuss potential factors contributing to hypertension in women, differences related to effects of lifestyle modifications and drug therapy between men and women, the impact of sleep, and the importance of recognizing disparities in socioeconomic conditions and access to care. This review outlines several opportunities for future studies to fill gaps in knowledge to achieve optimal control of hypertension in women using a multidisciplinary approach, particularly related to sex-specific treatment approaches while considering socioeconomic conditions and life stages from premenopause through the transition to menopause.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 3","pages":"Pages 514-533"},"PeriodicalIF":6.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea N. Leep Hunderfund MD, MHPE , Shannon K. Laughlin-Tommaso MD , Barbara L. Jordan MA , Valerie A. Melson BS , Monique M. Montenegro MD , Felicity Enders PhD , Daniel V. Satele BS , Colin P. West MD, PhD , Liselotte N. Dyrbye MD, MHPE
{"title":"Bias Experiences and Burnout: A Multispecialty, Cross-Sectional Survey of Residents and Fellows at a Multisite US Academic Medical Center","authors":"Andrea N. Leep Hunderfund MD, MHPE , Shannon K. Laughlin-Tommaso MD , Barbara L. Jordan MA , Valerie A. Melson BS , Monique M. Montenegro MD , Felicity Enders PhD , Daniel V. Satele BS , Colin P. West MD, PhD , Liselotte N. Dyrbye MD, MHPE","doi":"10.1016/j.mayocp.2024.07.014","DOIUrl":"10.1016/j.mayocp.2024.07.014","url":null,"abstract":"<div><h3>Objective</h3><div>To explore associations of bias frequency, sources, and types with burnout in a large, multispecialty sample of residents and fellows and to determine whether and how odds of burnout change after adjustment for bias experiences in multiple demographic subgroups.</div></div><div><h3>Methods</h3><div>Trainees in graduate medical education programs at Mayo Clinic sites were surveyed between October 12, 2020, and November 22, 2020. Survey items measured personal experiences with bias (frequency, sources, types), burnout (2 Maslach Burnout Inventory items), and demographic characteristics (age, gender, race/ethnicity, lesbian-gay-bisexual-transgender-queer-nonbinary-other identification, disability, socioeconomic background, year in school, specialty). The <em>χ</em><sup>2</sup> test and logistic regression analyses examined relationships between variables.</div></div><div><h3>Results</h3><div>Of 1825 trainees surveyed, 942 (52%) from 77 programs responded. Overall, 16% (137/881) of respondents reported 1 or more personal bias experiences. Trainees reporting bias experiences weekly or more often had markedly higher odds of burnout in adjusted analyses (odds ratio [OR], 8.00; 95% CI, 2.68 to 23.89; <em>P</em><.001). Bias from education leaders/staff, fellow learners, and faculty was independently associated with burnout, whereas bias from patients/companions and other staff/employees was not. Trainees with a disability (OR, 3.16; 95% CI, 1.05 to 9.53; <em>P</em>=.04) and trainees from a low-income background (OR, 1.53; 95% CI, 1.03 to 2.26; <em>P</em>=.03) had higher odds of burnout in unadjusted analyses, but these associations were no longer statistically significant after adjustment for bias frequency.</div></div><div><h3>Conclusion</h3><div>Self-reported bias experiences relate strongly to trainee burnout. Some bias sources may be more strongly associated with burnout than others. More frequent bias experiences could account, at least in part, for higher odds of burnout in some demographic subgroups.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 3","pages":"Pages 465-477"},"PeriodicalIF":6.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Barry A. Franklin PhD , Thijs M.H. Eijsvogels PhD , Paul D. Thompson MD
{"title":"Major Snowstorms: An Underappreciated Trigger of Acute Cardiac Events in Men","authors":"Barry A. Franklin PhD , Thijs M.H. Eijsvogels PhD , Paul D. Thompson MD","doi":"10.1016/j.mayocp.2025.01.005","DOIUrl":"10.1016/j.mayocp.2025.01.005","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 3","pages":"Pages 416-419"},"PeriodicalIF":6.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anja C. Roden MD , Lara A. Walkoff MD , Sahar A. Saddoughi MD, PhD
{"title":"Type A Thymoma","authors":"Anja C. Roden MD , Lara A. Walkoff MD , Sahar A. Saddoughi MD, PhD","doi":"10.1016/j.mayocp.2024.11.008","DOIUrl":"10.1016/j.mayocp.2024.11.008","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 3","pages":"Pages 499-500"},"PeriodicalIF":6.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carl J. Lavie MD, Jari A. Laukkanen MD, PhD, Karl A. Nath MB.ChB (Editor-in-Chief)
{"title":"Cardiorespiratory Fitness and Mayo Clinic Proceedings","authors":"Carl J. Lavie MD, Jari A. Laukkanen MD, PhD, Karl A. Nath MB.ChB (Editor-in-Chief)","doi":"10.1016/j.mayocp.2025.01.015","DOIUrl":"10.1016/j.mayocp.2025.01.015","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 3","pages":"Pages 402-404"},"PeriodicalIF":6.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mackenzie D. Maberry MD , Jordan S. Nunnelee MD , Wilson I. Gonsalves MD
{"title":"68-Year-Old Man With “Thick Blood” and Fatigue","authors":"Mackenzie D. Maberry MD , Jordan S. Nunnelee MD , Wilson I. Gonsalves MD","doi":"10.1016/j.mayocp.2024.03.013","DOIUrl":"10.1016/j.mayocp.2024.03.013","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 3","pages":"Pages 540-545"},"PeriodicalIF":6.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter Schnohr MD, DMSc , James H. O’Keefe MD , Carl J. Lavie MD , Charlotte Suetta MD, DMSc , Gorm Boje Jensen MD, DMSc , Jacob Louis Marott MSc, PhD
{"title":"Comparison of Muscle Strength and Cardiorespiratory Fitness in Relation to Cardiovascular and All-Cause Mortality: The Copenhagen City Heart Study","authors":"Peter Schnohr MD, DMSc , James H. O’Keefe MD , Carl J. Lavie MD , Charlotte Suetta MD, DMSc , Gorm Boje Jensen MD, DMSc , Jacob Louis Marott MSc, PhD","doi":"10.1016/j.mayocp.2024.08.013","DOIUrl":"10.1016/j.mayocp.2024.08.013","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the association between muscle strength (MS), cardiorespiratory fitness (CRF), and all-cause and cardiovascular disease (CVD) mortality.</div></div><div><h3>Methods</h3><div>The Copenhagen City Heart Study is a prospective longitudinal study comprising a random sample of adults; we excluded participants with a history of coronary heart disease or cancer, leaving 9896 men and women for analyses. A self-administered questionnaire at baseline (from October 10, 1991, to September 16, 1994) documented self-rated MS and CRF, categorized as low, moderate, or high. MS was measured in 3299 participants by a hand grip strength of the dominant hand with isometric dynamometry. Multivariable adjusted analyses were performed adjusting for potential confounders.</div></div><div><h3>Results</h3><div>During follow-up of 27 years, 4971 all-cause deaths and 2128 CVD deaths occurred. Compared with moderate CRF, high CRF was associated with lower all-cause mortality (hazard ratio, 0.82; 95% CI, 0.75 to 0.90) and lower CVD mortality (hazard ratio, 0.81; 95% CI, 0.70 to 0.93). There were approximately 10% higher risk reductions for CRF than for MS in comparing high with moderate levels for both all-cause and CVD mortality; comparing moderate with low levels, CRF was 19% (95% CI, −5% to 48%) better than MS for decreasing risk of all-cause mortality and 33% (95% CI, −6% to 89%) better for reducing CVD mortality. The self-rated MS reports corresponded well with the hand grip results.</div></div><div><h3>Conclusion</h3><div>Both CRF and MS are inversely associated with CVD mortality and all-cause mortality, but of the 2, CRF confers stronger protection.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 3","pages":"Pages 488-498"},"PeriodicalIF":6.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}