Mayo Clinic proceedings最新文献

{"title":"Acute Myeloperoxidase Inhibition: The Search for HFpEF Therapies Continues","authors":"Navin Suthahar MD, MSc, PhD, FESC","doi":"10.1016/j.mayocp.2025.07.017","DOIUrl":"10.1016/j.mayocp.2025.07.017","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1465-1467"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Ewing Sarcoma of the Kidney","authors":"Ahmed Abdelfattah MB, BCh, BAO, Burak Tekin MD, Lori A. Erickson MD","doi":"10.1016/j.mayocp.2025.06.015","DOIUrl":"10.1016/j.mayocp.2025.06.015","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1673-1674"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tie a Yellow Ribbon to That Old Postal Cover: Disease Advocacy Ribbons on Stamps and Beyond","authors":"David P. Steensma MD FACP","doi":"10.1016/j.mayocp.2025.07.008","DOIUrl":"10.1016/j.mayocp.2025.07.008","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1675-1679"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monarch by Steve Hemingway","authors":"Margaret R. Wentz BA","doi":"10.1016/j.mayocp.2025.07.004","DOIUrl":"10.1016/j.mayocp.2025.07.004","url":null,"abstract":"<div><div>Art is integrated into the Mayo Clinic environment. Since the original Mayo Clinic Building was finished in 1914, many pieces have been donated or commissioned for patients and staff to enjoy. Each issue of <em>Mayo Clinic Proceedings</em> features a work of art (as interpreted by the author) that is displayed in a building or on the grounds of Mayo Clinic campuses.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Page 1680"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"26-Year-Old Woman With Headache and Left Foot Drop","authors":"Rachel J. Anderson MD ,&nbsp;Rafid Mustafa MD","doi":"10.1016/j.mayocp.2024.08.031","DOIUrl":"10.1016/j.mayocp.2024.08.031","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1638-1642"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"55-Year-Old Man With Fever and Left Lower Extremity Pain","authors":"Nathaniel P. Rogers Jr. MD ,&nbsp;Nadia Toumeh MD ,&nbsp;Nirosha D. Perera MD","doi":"10.1016/j.mayocp.2024.09.025","DOIUrl":"10.1016/j.mayocp.2024.09.025","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1632-1637"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"eGFR Decline at Initiation of Sodium-Glucose Cotransporter 2 Inhibitors","authors":"Macaulay Amechi Chukwukadibia Onuigbo MD, MSc, FWACP, FASN, MBA","doi":"10.1016/j.mayocp.2025.05.023","DOIUrl":"10.1016/j.mayocp.2025.05.023","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1670-1671"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Team Consistency as a Determinant of Outcomes After Radical Prostatectomy","authors":"Steven J. Weissbart MD","doi":"10.1016/j.mayocp.2025.07.016","DOIUrl":"10.1016/j.mayocp.2025.07.016","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1463-1464"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Body Mass Index and Age at End-Stage Renal Disease in Patients With Autosomal Dominant Polycystic Kidney Disease in the United States and Japan","authors":"Tatsuya Suwabe MD, MSc, PhD ,&nbsp;Vicente E. Torres MD, PhD ,&nbsp;Lisa E. Vaughan MSc ,&nbsp;Chuck D. Madsen CCRP ,&nbsp;Peter C. Harris PhD ,&nbsp;Yosuke Shimada PhD ,&nbsp;Shinya Nakatani MD, PhD ,&nbsp;Junichi Hoshino MD, MPH, PhD ,&nbsp;Saori Nishio MD, PhD ,&nbsp;Toshio Mochizuki MD, PhD ,&nbsp;Eiichiro Kanda MD, MPH, PhD ,&nbsp;Norio Hanafusa MD, PhD ,&nbsp;Masanori Abe MD, PhD ,&nbsp;Satoru Muto MD, PhD","doi":"10.1016/j.mayocp.2024.12.019","DOIUrl":"10.1016/j.mayocp.2024.12.019","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the association between body mass index (BMI) and age at initiation of renal replacement therapy (RRT) of patients with autosomal dominant polycystic kidney disease (ADPKD) in the United States and Japan, 2 populations with different dietary habits and BMIs.</div></div><div><h3>Methods</h3><div>We performed a cross-sectional analysis using data from the United States Renal Data System (USRDS) and the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) to compare age, BMI, and other clinical characteristics of the patients who initiated RRT in the 2 countries between January 1, 2006, and December 31, 2007.</div></div><div><h3>Results</h3><div>This study included 3556 patients (1877 men and 1679 women) with RRT from the USRDS (n=2491) and JRDR (n=1065). Mean ages at RRT were 56.6±13.1 years in the United States and 61.6±12.5 years in Japan (<em>P</em>&lt;.001). The BMI was 28.2±7.1 kg/m² in the USRDS and 22.0±3.3 kg/m² in the JRDR (<em>P</em>&lt;.001). Japanese participants were the oldest, followed in descending order by Asian Americans, White Americans, and African Americans. Japanese participants had the lowest BMI, followed in ascending order by Asian Americans, White Americans, and African Americans. Univariable and adjusted analyses found that BMI was significantly and inversely associated with age at RRT, both overall and separately in American and Japanese populations.</div></div><div><h3>Conclusion</h3><div>Lower BMI is significantly associated with older age at RRT in patients with ADPKD in both the United States and Japan. Japanese individuals had lower BMI and were older than US people of various ethnicities. Lower BMI in Japan is likely to be associated with a slower progression of ADPKD.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1535-1550"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypharmacy and Potentially Inappropriate Medications in Adults ≥75 Years of Age by Dementia and Frailty Status: The ARIC Study","authors":"Pamela L. Lutsey PhD, MPH ,&nbsp;Jeffrey R. Misialek MPH ,&nbsp;Eric A. Whitsel MD, MPH ,&nbsp;Kamakshi Lakshminarayan MBBS, PhD ,&nbsp;Anna M. Kucharska-Newton PhD, MPH ,&nbsp;B. Gwen Windham MD, MHS ,&nbsp;Kevin J. Sullivan PhD ,&nbsp;Alex Secora PhD, MPH ,&nbsp;Morgan E. Grams MD, PhD ,&nbsp;Joel F. Farley PhD","doi":"10.1016/j.mayocp.2024.11.030","DOIUrl":"10.1016/j.mayocp.2024.11.030","url":null,"abstract":"<div><h3>Objective</h3><div>To estimate the prevalence of polypharmacy<span><span> (concomitant use of ≥5 medications), hyperpolypharmacy (≥10 medications), and potentially inappropriate medication (PIM) use among older adults according to dementia and </span>frailty status.</span></div></div><div><h3>Patients and Methods</h3><div>Cross-sectional data (2016-2017) from 3912 participants aged 71 to 94 years (mean ± SD, 79.6±4.8 years; 59.2% female; 24.5% Black race) from the community-based Atherosclerosis<span> Risk in Communities (ARIC) study were used. Dementia and mild cognitive impairment<span> status was based on comprehensive neurocognitive assessment, informant interviews, and adjudication by an expert panel. Participants were classified as frail, prefrail, or robust according to the Fried frailty phenotype definition. Medication containers were brought to the clinic. The PIMs were defined using a modified version of the Beers Criteria.</span></span></div></div><div><h3>Results</h3><div>Polypharmacy, hyperpolypharmacy, and PIM use were prevalent in 67.1%, 18.8%, and 23.9% of participants, respectively, and 7.9% were classified as having dementia and 8.0% as frail. The demographic-adjusted relative risk ratio (95% CI) for participants with dementia vs normal cognition was 1.79 (1.27 to 2.51) for hyperpolypharmacy, and the odds ratio (95% CI) for PIM use was 1.58 (1.21 to 2.06). The relative risk ratios (95% CIs) for hyperpolypharmacy were 8.35 (5.57 to 12.54) for frail and 2.70 (2.14 to 3.41) for prefrail compared with robust.</div></div><div><h3>Conclusion</h3><div>Polypharmacy, hyperpolypharmacy, and PIM use were common in this community-based sample of adults approximately 80 years old. These patterns of use were even more common among participants with dementia and frailty, who are at elevated risk for adverse outcomes.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1551-1562"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}