Mayo Clinic proceedings最新文献

{"title":"Association Between Sodium-Glucose Cotransporter 2 Inhibitors and Risk of Inflammatory Bowel Disease in Patients With Type 2 Diabetes Mellitus.","authors":"Shih-Chieh Shao, Daniel Hsiang-Te Tsai, Xiu-Wei Li, Edward Chia-Cheng Lai","doi":"10.1016/j.mayocp.2025.07.007","DOIUrl":"https://doi.org/10.1016/j.mayocp.2025.07.007","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"69-Year-Old Man With Epigastric Pain.","authors":"Bruin Pollard, Robert Kraichely","doi":"10.1016/j.mayocp.2024.10.027","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.10.027","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"30-Year-Old Woman With Jaundice and Altered Mental Status.","authors":"Fatima Warsame, Daniel D Penrice, Omar Y Mousa","doi":"10.1016/j.mayocp.2024.09.027","DOIUrl":"https://doi.org/10.1016/j.mayocp.2024.09.027","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Genetic Associations Between Kidney Stones, Obesity, Type 2 Diabetes, and Hypertension.","authors":"Le-Ting Zhou, Isaac W Stark, Ahmed E Ali, Muthuvel Jayachandran, Zejfa Haskic, Peter C Harris, Kevin Koo, Shannon K McDonnell, Nicholas B Larson, John C Lieske","doi":"10.1016/j.mayocp.2025.04.030","DOIUrl":"10.1016/j.mayocp.2025.04.030","url":null,"abstract":"<p><strong>Objective: </strong>Investigate shared genetic changes that contribute to the association of kidney stones with cardiometabolic comorbidities.</p><p><strong>Patients and methods: </strong>Genome-wide association studies (GWAS) and meta-analyses were performed using the UK Biobank, Mayo Clinic Biobank, and FinnGen, complemented by secondary genetic association analyses.</p><p><strong>Results: </strong>Genetic correlation analyses confirmed modest but significant positive associations between kidney stones and hypertension, obesity, and type 2 diabetes (r_g=0.14 ∼ 0.19, all P<.001). Single nucleotide variants near FTO (for expansion of gene symbols, use search tool at www.genenames.org) were identified as shared risk loci across all conditions. Mendelian randomization analyses demonstrated that higher body mass index (BMI) and waist-hip ratio (WHR) significantly increased the risk of kidney stones, type 2 diabetes, and hypertension. Subsequent GWAS analyses adjusting for BMI or WHR revealed a slightly reduced yet significant genetic correlation between kidney stones and type 2 diabetes (BMI-adjusted: r_g=0.18; 95% CI, 0.07 to 0.28; P=.001; WHR-adjusted: r_g=0.16; 95% CI, 0.06 to 0.25; P<.001), whereas the association of kidney stones with hypertension was nearly eliminated. A multi-trait analysis of GWAS identified one potential shared risk locus between BMI-adjusted kidney stones and type 2 diabetes on chromosome 6 near LINC02537. Further analyses indicated this locus is associated with thyroid-stimulating hormone and free thyroxine levels.</p><p><strong>Conclusion: </strong>Our study highlights a critical role for shared obesity-related genetic changes in the comorbid relationship between kidney stones and cardiometabolic conditions. There are additional genetic features related to thyroid function that are shared between kidney stones and type 2 diabetes, which appear to be independent of obesity.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Misdiagnosed Thoracic Outlet Syndrome With Extensive Upper Extremity Thrombosis.","authors":"Steven Callori, Thomas C Bower, Robert D McBane","doi":"10.1016/j.mayocp.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.mayocp.2025.05.005","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear Associations and Isocaloric Substitution of Macronutrients With Incident Type 2 Diabetes.","authors":"Jirapitcha Boonpor, John C Mathers, Naveed Sattar, Jill P Pell, Stuart R Gray, Carlos Celis-Morales, Frederick K Ho","doi":"10.1016/j.mayocp.2025.04.021","DOIUrl":"https://doi.org/10.1016/j.mayocp.2025.04.021","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the associations between dietary intake of macronutrient components and incident type 2 diabetes, potential mediation via adiposity, and isocaloric substitution of macronutrients associated with higher risk.</p><p><strong>Participants and methods: </strong>A prospective cohort study of 176,057 UK Biobank participants was conducted, following up participants registered from March 13, 2006, to November 30, 2022. Dietary intake of macronutrient components was expressed as a percentage of total energy intake (%E). Cox proportional hazards models with penalized cubic splines, adjusting for major confounders, were used to examine nonlinear associations. The mediating roles of body mass index and waist to height ratio were tested using a g-formula approach, which simulates potential outcomes for various exposure values. Isocaloric substitution analysis was conducted for macronutrients that were statistically significantly associated with higher type 2 diabetes risk (hazard ratio >1; P<.05).</p><p><strong>Results: </strong>Over a median follow-up of 11 years, 5078 (2.9%) of the 176,057 participants had development of type 2 diabetes. Higher risk of type 2 diabetes was observed in people with higher intake of free sugar (>12%E; free sugar included any added sugar and sugar in honey, syrup, and juices), starch (>25%E), and animal protein, and in people with lower intake of non-free sugar (<10%E; any sugar that is not free sugar), omega-3 (<1.5%E) and omega-6 PUFA (<6%E), and plant protein (<5%E). Waist to height ratio explained 31% and 25% of the excess type 2 diabetes risk associated with free sugar and starch, respectively, and fully explained that with animal protein. Substituting free sugar, starch, and animal protein with non-free sugar or plant protein was associated with 16%, 18%, and 12% lower type 2 diabetes risk, respectively.</p><p><strong>Conclusion: </strong>In this study, excess free sugar, starch, and animal protein were associated with higher type 2 diabetes risk. People at risk of diabetes who have a high intake of these macronutrients should consider substitution with non-free sugar and plant protein.</p>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mayo Clinic Proceedings in the Last Century: Seminal Contributions by Mayo Clinic Physicians and Researchers to the Field of Neurogastroenterology","authors":"Michael Camilleri MD, DSc,&nbsp;Nicholas J. Talley AC, MD, PhD","doi":"10.1016/j.mayocp.2025.07.012","DOIUrl":"10.1016/j.mayocp.2025.07.012","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1458-1462"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Myeloid Leukemia With Mutated NPM1 Mimicking Acute Promyelocytic Leukemia","authors":"Husam A. Jum’ah MBBS,&nbsp;Jennifer L. Herrick MD","doi":"10.1016/j.mayocp.2025.04.004","DOIUrl":"10.1016/j.mayocp.2025.04.004","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1575-1577"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General Information","authors":"","doi":"10.1016/S0025-6196(25)00436-7","DOIUrl":"10.1016/S0025-6196(25)00436-7","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Page A7"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older Populations: The Impact of Smoking and Diet and the Prevalence of Polypharmacy—Limelight, September 2025","authors":"Karl A. Nath MBChB (Editor-in-Chief)","doi":"10.1016/j.mayocp.2025.07.026","DOIUrl":"10.1016/j.mayocp.2025.07.026","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 9","pages":"Pages 1455-1457"},"PeriodicalIF":6.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}