Mayo Clinic proceedings最新文献_第6页

Healthy Lifestyle, Genetic Susceptibility and Risk of Kidney Stone Disease in the UK Biobank: A Prospective Cohort Study. 英国生物库中健康生活方式、遗传易感性和肾结石疾病风险：一项前瞻性队列研究

IF 6.5 2区医学

Mayo Clinic proceedings Pub Date : 2026-09-18 DOI: 10.1016/j.mayocp.2026.08.023

Kun Xu, Zichuan Yao, Yuge Wang, Lei Na, Junlong Liu, Yang Xia, Xing Jin, Zhenhua Li, Yashu Liu, Song Bai

{"title":"Healthy Lifestyle, Genetic Susceptibility and Risk of Kidney Stone Disease in the UK Biobank: A Prospective Cohort Study.","authors":"Kun Xu, Zichuan Yao, Yuge Wang, Lei Na, Junlong Liu, Yang Xia, Xing Jin, Zhenhua Li, Yashu Liu, Song Bai","doi":"10.1016/j.mayocp.2026.08.023","DOIUrl":"https://doi.org/10.1016/j.mayocp.2026.08.023","url":null,"abstract":"Objective: To explore the association between modifiable lifestyle and kidney stone disease (KSD) risk, and to investigate whether genetic susceptibility modifies this association.Patients and methods: We included 300,875 participants without KSD from the UK Biobank cohort (recruited between March 13, 2006, and October 10, 2010) in this analysis. A healthy lifestyle score was constructed based on seven lifestyle items: regular physical activity, BMI < 25 kg/m2, lower sedentary time, adequate sleep duration, no smoking, adequate fluid intake, and a healthy diet. Based on this score, participants were classified into unfavorable, intermediate, and favorable lifestyle groups. Genetic susceptibility to KSD was assessed by a polygenic risk score. We employed Cox proportional hazards models to estimate HRs and 95% CIs for incident KSD.Results: A total of 3,088 incident KSD cases were identified during a median follow-up of 12.3 years. Compared with the unfavorable lifestyle group, the multivariable-adjusted HR (95% CI) was 0.51 (0.44-0.59) for incident KSD in the favorable lifestyle group. No significant multiplicative interaction was observed (P for multiplicative interaction = .39), while a significant additive interaction was observed between an unfavorable lifestyle and high genetic susceptibility to KSD risk (relative excess risk due to interaction [RERI] = 1.14, 95% CI: 0.49-1.79). Compared with individuals with favorable lifestyle and low genetic susceptibility, the HR (95% CI) for those with unfavorable lifestyle and high genetic risk was 3.08 (2.49-3.80).Conclusions: Healthy lifestyle was inversely associated with KSD risk, and a significant additive interaction was observed between lifestyle and genetic susceptibility.","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reassessing US Obesity Prevalence Under the 2025 Lancet Commission's Anthropometric Criteria. 根据2025年《柳叶刀》委员会的人体测量标准重新评估美国肥胖症患病率。

IF 6.5 2区医学

Mayo Clinic proceedings Pub Date : 2026-09-18 DOI: 10.1016/j.mayocp.2026.08.025

Ibrahim Hassan, Martha Gulati, Carl J Lavie, Shady Abohashem

引用次数: 0

Rapamycin in Frail Older Subjects with Heart Failure with Preserved Ejection Fraction. 雷帕霉素在老年体弱多病心力衰竭伴射血分数保留患者中的应用。

IF 6.5 2区医学

Mayo Clinic proceedings Pub Date : 2026-09-18 DOI: 10.1016/j.mayocp.2026.09.006

Conor M Lane, Jericha Mill, Paige Ellingson, Isabella James, Barry A Borlaug, Thomas P Olson, Monique Simone Bagwell, Bradley R Lewis, Brenden S Ingraham, Samuel Huxley, Atta Behfar, James L Kirkland, Dudley W Lamming, Judith A Simcox, Mandeep Singh

引用次数: 0

83-Year-Old Woman With Abdominal Distention and Lower Limb Swelling. 83岁女性，腹胀及下肢肿胀。

IF 6.5 2区医学

Mayo Clinic proceedings Pub Date : 2026-09-12 DOI: 10.1016/j.mayocp.2025.12.023

Agata K Sularz, Stefan L Farrugia, Richard M Elias

引用次数: 0

Chief Wellness Officer Roles and Organizational Structures: Insights From the CHARM Network Survey. 首席健康官角色和组织结构：来自CHARM网络调查的见解。

IF 6.5 2区医学

Mayo Clinic proceedings Pub Date : 2026-09-12 DOI: 10.1016/j.mayocp.2026.09.003

Laxmi S Mehta, Tait Shanafelt, Gregory Wallingford, Jonathan Ripp

引用次数: 0

The 2026 Ebola Outbreak: A Brief Perspective. 2026年埃博拉疫情：一个简短的视角。

IF 6.5 2区医学

Mayo Clinic proceedings Pub Date : 2026-09-03 DOI: 10.1016/j.mayocp.2026.08.022

Joya-Rita Hindy, Kristina Sokol, Pritish K Tosh, John C O'Horo, Colin M Bucks, Priya Sampathkumar, Aditya S Shah

引用次数: 0

Incidence and Risk Factors for Severe Postoperative Hypotension in General Care Wards. 普通监护病房术后严重低血压的发生率及危险因素分析。

IF 6.5 2区医学

Mayo Clinic proceedings Pub Date : 2026-09-02 DOI: 10.1016/j.mayocp.2026.08.015

Toby N Weingarten, Mika N Underwood, Melissa K Grafe, Aurelia Zodl, Charles R Sims, Atousa Deljou, Darrell R Schroeder, Juraj Sprung

{"title":"Incidence and Risk Factors for Severe Postoperative Hypotension in General Care Wards.","authors":"Toby N Weingarten, Mika N Underwood, Melissa K Grafe, Aurelia Zodl, Charles R Sims, Atousa Deljou, Darrell R Schroeder, Juraj Sprung","doi":"10.1016/j.mayocp.2026.08.015","DOIUrl":"https://doi.org/10.1016/j.mayocp.2026.08.015","url":null,"abstract":"Objective: To determine the incidence and predictors of severe postoperative hypotension (SPOH) among patients in general care wards.Patients and methods: We performed a retrospective study of adult patients who underwent general anesthesia at Mayo Clinic between May 5, 2018, and December 31, 2020, and were discharged from the postanesthesia care unit (PACU) to general care wards. Multivariable logistic regression models were used to identify potential predictors of SPOH (defined as mean arterial pressure [MAP] ≤55 mm Hg within 48 hours after a surgical procedure that resulted in rapid response team activation or advanced interventions).Results: Among 23,656 eligible patients, 172 (0.7%; 95% CI, 0.6-0.9) had SPOH. Independent predictors included lower body mass index (OR, 0.83 per 5-unit increase; 95% CI, 0.73-0.95; P=.006), longer procedure duration (OR, 1.14 per 1 hour; 95% CI, 1.07-1.22; P<.001), and intraoperative blood transfusion (OR, 4.32; 95% CI, 2.92-6.38; P<.001). A significant interaction was observed between preoperative and lowest PACU MAPs (P=.04); SPOH risk was highest for patients with low preoperative and PACU MAPs. Patients with a preoperative MAP of 70 mm Hg or less and a PACU MAP of 60 mm Hg or less had 9.84-fold higher odds of SPOH (reference, 93.3 mm Hg).Conclusion: Lower preoperative and PACU MAPs are associated with higher odds of SPOH. These findings highlight the need for greater postoperative surveillance of surgical patients with low perioperative blood pressure.","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zephyr, Vega, Milo, and Bell: “Living” Art at Mayo: The Mayo Clinic Peregrine Falcon Program 西风，维加，米洛和贝尔：梅奥诊所的“生活”艺术：梅奥诊所游隼计划

IF 6.5 2区医学

Mayo Clinic proceedings Pub Date : 2026-09-01 DOI: 10.1016/j.mayocp.2026.07.001

Margaret R. Wentz

引用次数: 0

Hepatitis B Vaccine: Time to Rethink Our Correlate of Protection 乙型肝炎疫苗：是时候重新思考我们的保护关系了。

IF 6.5 2区医学

Mayo Clinic proceedings Pub Date : 2026-09-01 Epub Date: 2026-04-10 DOI: 10.1016/j.mayocp.2026.04.004

Nawras Habash MBBS, Imad Absah MD

{"title":"Hepatitis B Vaccine: Time to Rethink Our Correlate of Protection","authors":"Nawras Habash MBBS, Imad Absah MD","doi":"10.1016/j.mayocp.2026.04.004","DOIUrl":"10.1016/j.mayocp.2026.04.004","url":null,"abstract":"<div><div>Hepatitis B virus (HBV) remains a major global public health concern despite the transformative impact of widespread vaccination. Although the introduction of universal immunization programs has markedly reduced HBV prevalence, particularly in children, the persistence of infection in high-risk adult populations underscores the need for continued vigilance. This review synthesizes current data on the global and United States burden of hepatitis B, the natural immune responses to infection, and the mechanisms by which vaccine-induced protection is sustained. A central focus is the long-term durability of immune memory, even in the setting of declining or undetectable antibody to hepatitis B surface antigen levels. Drawing from epidemiologic cohorts and mechanistic studies, we highlight the role of T- and B-cell memory in conferring sustained protection and argue for a reevaluation of current revaccination strategies. The evidence reviewed challenges the clinical overreliance on static serologic thresholds and supports a model of pathogen-specific immunologic assessment, particularly for viruses with prolonged incubation periods such as HBV. These findings have direct implications for public health policy and underscore the need for nuanced, mechanistically grounded approaches to booster vaccination and immunity surveillance.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 9","pages":"Pages 1602-1614"},"PeriodicalIF":6.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Featuring Neurology—Limelight, September 2026 2026年9月《神经病学焦点》特刊

IF 6.5 2区医学

Mayo Clinic proceedings Pub Date : 2026-09-01 DOI: 10.1016/j.mayocp.2026.07.025

Karl A. Nath MBChB (Editor-in-Chief)

引用次数: 0