Bidirectional Association of Rheumatoid Arthritis and Irritable Bowel Syndrome: A Large-Scale Prospective Cohort Study.

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings Pub Date : 2025-08-02 DOI:10.1016/j.mayocp.2025.04.031

Yijun Chen, Yesheng Zhou, Si Liu, Qian Zhang, Shutian Zhang, Shengtao Zhu, Shanshan Wu

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引用次数: 0

Abstract

Objective: To investigate the bidirectional prospective association between rheumatoid arthritis (RA) and irritable bowel syndrome (IBS) in a large-scale, long-term population-based cohort.

Patients and methods: Participants without any cancer at baseline were included between 2006 and 2010. Overall, 5455 prevalent RA cases and 419,670 non-RA participants in cohort 1 were included to examine the risk of incident IBS, and 22,126 prevalent IBS cases and 419,670 non-IBS participants in cohort 2 were included to assess the risk of incident RA. A multivariable Cox proportional hazards model was employed to estimate adjusted hazard ratio.

Results: Overall, 8984 new IBS cases were identified in cohort 1 during a total of 5,980,083 person-years of follow-up. After adjustment for multiple confounders, RA patients exhibited a 1.30-fold increased risk (95% CI, 1.12 to 1.51) for development of IBS, with an even 1.4-fold higher risk in those with RA duration of 10 years or more. By contrast, a total of 5777 incident RA cases were identified during a median follow-up of 14.3 years in cohort 2. Patients with IBS demonstrated a 1.53-fold increased risk (95% CI, 1.39 to 1.68) for development of RA. Sensitivity and subgroup analyses yielded similar results.

Conclusion: The findings indicate that RA is associated with an increased risk for development of IBS, and conversely, IBS is associated with an increased risk for development of RA. Further research is necessary to confirm these findings and to elucidate the underlying biologic mechanisms.

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类风湿性关节炎和肠易激综合征的双向关联：一项大规模前瞻性队列研究。

目的：在一项大规模、长期人群为基础的队列研究中，探讨类风湿性关节炎（RA）和肠易激综合征（IBS）之间的双向前瞻性关联。患者和方法：在2006年至2010年期间纳入基线时无任何癌症的参与者。总体而言，队列1纳入了5455例常见RA病例和419670例非RA参与者，以检查发生IBS的风险；队列2纳入了22126例常见IBS病例和419670例非IBS参与者，以评估发生RA的风险。采用多变量Cox比例风险模型估计调整后的风险比。结果：总体而言，在总共5,980,083人年的随访期间，队列1中发现了8984例新的IBS病例。在对多个混杂因素进行调整后，RA患者发生IBS的风险增加了1.30倍（95% CI， 1.12至1.51），持续时间为10年或以上的RA患者的风险甚至增加了1.4倍。相比之下，在队列2中位14.3年的随访期间，共发现5777例RA病例。IBS患者发生RA的风险增加了1.53倍（95% CI, 1.39 - 1.68）。敏感性和亚组分析得出了相似的结果。结论：研究结果表明，RA与IBS发生风险增加相关，反之，IBS与RA发生风险增加相关。需要进一步的研究来证实这些发现并阐明潜在的生物学机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mayo Clinic proceedings 医学-医学：内科

CiteScore

16.80

自引率

1.10%

发文量

383

审稿时长

37 days

期刊介绍： Mayo Clinic Proceedings is a premier peer-reviewed clinical journal in general medicine. Sponsored by Mayo Clinic, it is one of the most widely read and highly cited scientific publications for physicians. Since 1926, Mayo Clinic Proceedings has continuously published articles that focus on clinical medicine and support the professional and educational needs of its readers. The journal welcomes submissions from authors worldwide and includes Nobel-prize-winning research in its content. With an Impact Factor of 8.9, Mayo Clinic Proceedings is ranked #20 out of 167 journals in the Medicine, General and Internal category, placing it in the top 12% of these journals. It invites manuscripts on clinical and laboratory medicine, health care policy and economics, medical education and ethics, and related topics.