Multimorbidity and the Risk of Sudden Cardiac Death: Findings From a Prospective Cohort Study.

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings Pub Date : 2025-10-06 DOI:10.1016/j.mayocp.2025.06.021

Jari A Laukkanen, Jussi Kauhanen, Sudhir Kurl, Carl J Lavie, Setor K Kunutsor

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引用次数: 0

Abstract

Objective: To assess the prospective associations of multimorbidity status and level with the risk of sudden cardiac death (SCD).

Methods: Multimorbidity was defined as the presence of at least two multiple long-term conditions (hypertension, cardiovascular disease, type 2 diabetes, chronic kidney disease, chronic bronchitis, and other chronic lung conditions) among 2598 men 42 to 61 years of age who were recruited into the KIHD (Kuopio Ischemic Heart Disease) study from March 1, 1984, to December 31, 1989. Hazard ratios with 95% CIs were estimated.

Results: During a median follow-up of 27.8 years, 296 SCDs were recorded. In analysis adjusted for several established cardiovascular risk factors including socioeconomic and lifestyle characteristics, the HR (95% CI) for SCD comparing men with multimorbidity vs no multimorbidity was 1.97 (95% CI, 1.54 to 2.51). Compared with men with no multimorbidity, the corresponding adjusted HRs (95% CIs) for SCD were 1.93 (95% CI, 1.50 to 2.47) for men with two to three conditions and 2.66 (95% CI, 1.34 to 5.28) for men with four to five conditions.

Conclusion: In middle-aged and older men, multimorbidity is strongly linked to an increased risk of SCD, independent of known cardiovascular risk factors. Furthermore, the risk of SCD rises progressively with the number of coexisting health conditions.

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多病与心源性猝死的风险：一项前瞻性队列研究的结果

目的：评价多病状态和多病水平与心源性猝死（SCD）风险的潜在关联。方法：从1984年3月1日至1989年12月31日，纳入Kuopio缺血性心脏病研究的2598名42 - 61岁男性中，多病定义为至少存在两种多重长期疾病（高血压、心血管疾病、2型糖尿病、慢性肾脏疾病、慢性支气管炎和其他慢性肺部疾病）。估计95% ci的风险比。结果：在27.8年的中位随访期间，记录了296例scd。在对包括社会经济和生活方式特征在内的几个已确定的心血管危险因素进行校正的分析中，多重发病男性与无多重发病男性的SCD HR （95% CI）为1.97 （95% CI, 1.54 - 2.51）。与无多病的男性相比，伴有2 - 3种情况的男性SCD的相应调整hr （95% CI）为1.93 (95% CI, 1.50 - 2.47)，伴有4 - 5种情况的男性SCD的相应调整hr （95% CI, 1.34 - 5.28）。结论：在中老年男性中，多病与SCD风险增加密切相关，独立于已知的心血管危险因素。此外，SCD的风险随着同时存在的健康状况的数量而逐渐增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mayo Clinic proceedings 医学-医学：内科

CiteScore

16.80

自引率

1.10%

发文量

383

审稿时长

37 days

期刊介绍： Mayo Clinic Proceedings is a premier peer-reviewed clinical journal in general medicine. Sponsored by Mayo Clinic, it is one of the most widely read and highly cited scientific publications for physicians. Since 1926, Mayo Clinic Proceedings has continuously published articles that focus on clinical medicine and support the professional and educational needs of its readers. The journal welcomes submissions from authors worldwide and includes Nobel-prize-winning research in its content. With an Impact Factor of 8.9, Mayo Clinic Proceedings is ranked #20 out of 167 journals in the Medicine, General and Internal category, placing it in the top 12% of these journals. It invites manuscripts on clinical and laboratory medicine, health care policy and economics, medical education and ethics, and related topics.