Media Penelitian dan Pengembangan Kesehatan最新文献

{"title":"Status Endemisitas Filariasis dan Faktor Perilaku Masyarakat Terkait Eliminasi Filariasis di Kabupaten Enrekang, Sulawesi Selatan","authors":"Nurul Hidayah, Sitti Chadijah, Neflita Nelfita, Rosmini Rosmini","doi":"10.22435/mpk.v31i4.3919","DOIUrl":"https://doi.org/10.22435/mpk.v31i4.3919","url":null,"abstract":"Enrekang district is one of the regions in South Sulawesi Province that has been declared endemic for filariasis since the first case was found in the fingerblood survey (SDJ) in 2006. In Enrekang district, the Filariasis Mass Prevention Drug Administration (POPM) program has been implemented for five years continuously from 2007 to 2011, and passed the TAS-3 (Transmission Assessment Survey), also received a filariasis-free certificate from the Ministry of Health in 2016. This research aimed to determine the microfilaremia rate after passing TAS–3 and identify community behavioral factors related to filariasis elimination in filariasis endemic areas in Enrekang District, South Sulawesi Province. The research design was cross-sectional and conducted from February to December 2017. Data collections were carried out in two sentinel villages, namely Potokullin village Buntu Batu Sub District and Parombean village located in Curio Sub District, Enrekang District. Data were collected through fingerblood survey and interviews with 310 residents (minimum sample size) for each of these villages. The results of SDJ showed that there were no microfilariae in all samples examined. Enrekang District can be declared as a filariasis-free area. The behavior of community in using mosquito nets and closed clothing as an effort to avoid mosquito bites and community participation in taking filariasis mass drug greatly contributed to the succes of filariasis elimination in Enrekang District, South Sulawesi Province.  \u0000Abstrak \u0000Kabupaten Enrekang merupakan salah satu wilayah di Provinsi Sulawesi Selatan yang dinyatakan endemis filariasis sejak ditemukan kasus pertama pada kegiatan survei darah jari (SDJ) di tahun 2006. Di Kabupaten Enrekang telah dilaksanakan program Pemberian Obat Pencegahan Massal (POPM) filariasis selama lima tahun terus-menerus dari tahun 2007 sampai dengan tahun 2011, dan lulus TAS-3 (Transmission Assesment Survey), serta menerima sertifikat bebas filariasis dari Kementerian Kesehatan pada tahun 2016. Penelitian ini bertujuan untuk menentukan angka mikrofilaremia paska lulus TAS – 3 dan mengidentifikasi faktor-faktor perilaku masyarakat yang berkaitan dengan eliminasi filariasis di wilayah endemis filariasis di Kabupaten Enrekang Provinsi Sulawesi Selatan. Desain penelitian adalah cross sectional. Penelitian dilakukan pada bulan Februari sampai dengan bulan Desember tahun 2017. Kegiatan dilaksanakan di dua desa sentinel, yaitu Desa Potokullin, Kecamatan Buntu Batu dan Desa Parombean, Kecamatan Curio Kabupaten Enrekang. Pengumpulan data dilakukan dengan survei darah jari dan wawancara terhadap 310 penduduk (jumlah sampel minimum) untuk masing-masing desa tersebut. Hasil SDJ menunjukkan bahwa tidak terdapat mikrofilaria dari keseluruhan sampel yang diperiksa. Kabupaten Enrekang dapat dinyatakan sebagai daerah yang bebas filariasis. Perilaku masyarakat dalam menggunakan kelambu dan pakaian tertutup sebagai upaya untuk menghindari gigitan nyamuk sert","PeriodicalId":18323,"journal":{"name":"Media Penelitian dan Pengembangan Kesehatan","volume":"5 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74371303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faktor Risiko Gangguan Kognitif pada Penyalahguna Narkoba di Enam Balai Rehabilitasi Badan Narkotika Nasional Tahun 2019","authors":"E. Antasari, M. K. Sudaryo","doi":"10.22435/mpk.v31i4.4886","DOIUrl":"https://doi.org/10.22435/mpk.v31i4.4886","url":null,"abstract":"In 2018, more than a quarter-billion people worldwide used drugs. Continuous use of drugs can cause changes in the nervous system of the brain. The purpose of this analysis was to identify risk factors for cognitive impairment in drug abusers. This research is a secondary data analysis from a crosssectional study of Health Research on the Impact of Drug Abuse conducted by the National Narcotics Board at the BNN Rehabilitation Center. The dependent variable in this study is sociodemography, duration of drug use, age at first using drugs, the number of substances used and, the type of drugs used. While the independent variable is cognitive impairment. The data analyzed were 601 drug abusers aged 15-50 years. Data analysis used descriptive, bivariate and, multivariate cox regression. The results showed that the factors associated with cognitive impairment in drug abusers were the use of marijuana (PR=1.33: p=0.007) and prescription drugs abuse (PR=1.26: p=0.046). Cognitive impairment in drug abusers in this study was associated with the use of cannabis and triheksifenidil and dekstrometrofan abuse. These findings provide recommendation for rehabilitation administrators to use cognitive impairment examination results as a determination of treatment plan for rehabilitation clients and become recommendation for the government to formulate policies related to drug abuse that are more comprehensive in terms of production, distribution and buyers / abusers. \u0000Abstrak \u0000Pada tahun 2018, lebih dari seperempat milyar orang di seluruh dunia menggunakan narkoba. Penggunaan narkoba secara terus-menerus dapat menyebabkan perubahan pada sistem syaraf otak. Tujuan analisis ini adalah mengidentifikasi faktor risiko gangguan kognitif pada penyalahguna narkoba. Penelitian ini merupakan analisis data sekunder dari studi cross sectional Riset Kesehatan Dampak Penyalahgunaan Narkoba yang dilakukan oleh Badan Narkotika Nasional (BNN) di enam Balai Rehabilitasi BNN. Variabel terikat dalam penelitian ini adalah lama pemakaian narkoba, usia pertama kali menggunakan narkoba, jumlah zat yang digunakan dan jenis narkoba yang digunakan. Sedangkan variabel bebas ialah gangguan kognitif. Data yang dianalisis sebanyak 601 orang penyalahguna narkoba yang berusia 15-50 tahun. Analisis data menggunakan deskriptif, bivariat dan multivariat dengan cox regression. Hasil penelitian menunjukkan faktor yang berhubungan dengan gangguan kognitif pada penyalahguna narkoba adalah penggunaan ganja (PR=1,33: p=0,007) dan penyalahgunaan triheksifenidil dan dekstrometrofan (PR=1,26: p=0,043). Gangguan kognitif pada penyalahguna narkoba pada penelitian ini terkait dengan penggunaan narkotika jenis ganja dan penyalahgunaan triheksifenidil dan dekstrometrofan. Temuan ini memberikan masukan bagi penyelenggara rehabilitasi untuk menjadikan hasil pemeriksaan gangguan kognitif sebagai dasar penentuan rencana pengobatan bagi klien rehabilitasi dan menjadi masukan bagi pemerintah untuk menyusun kebijakan ter","PeriodicalId":18323,"journal":{"name":"Media Penelitian dan Pengembangan Kesehatan","volume":"2012 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87881151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Pijat Kehamilan Terhadap Kualitas Tidur Ibu Hamil Trimester III di Desa Abiansemal Kabupaten Badung Provinsi Bali Tahun 2020","authors":"Ni Gusti Ayu Pramita Aswitami, Fitria Fitria, Apri Sulistianingsih, N. L. P. K. Udayani","doi":"10.22435/mpk.v31i4.4409","DOIUrl":"https://doi.org/10.22435/mpk.v31i4.4409","url":null,"abstract":"Sleep disturbance is a common complaint in third-trimester pregnant women. Decreased sleep quality as reduced sleep duration in pregnant women, is a form of sleep disorder. The effect that occurs in pregnant women who experience sleep disorders is a reduction in the quality of life of pregnant women and affects the growth and development of the fetus they contain. One of the non-pharmacological therapies that can improve the quality of sleep for pregnant women is pregnancy massage. Pregnant women need to do everything in their power to support a happy and healthy pregnancy. Massage therapy can help mothers stay more relaxed and respond more positively to the discomfort associated with pain. The purpose of this study was to determine the effect of pregnancy massage on the sleep quality of pregnant women. The design of this study used a Quasy Experiment with Pre-Posttest Design With Nonequivalent Control Group. Purposive sampling for 196 pregnant women who were divided into a control group was given antenatal care (ANC) services according to the ANC service procedure and the treatment group was pregnancy massage according to the SOP. Measurement of sleep quality using the PSQI questionnaire. The research was conducted from March 2019 to February 2020 in Abiansemal Village, Badung Regency. Data analysis for the control group and the treatment group used the Mann Whitney Test. The results showed there was a significant effect of pregnancy massage on improving sleep quality in pregnant women compared to ANC services with an average PSQI score both indifference and percentage with p<0.001. It is concluded that pregnancy massage significantly improves sleep quality in pregnant women. \u0000Abstrak \u0000Gangguan tidur adalah keluhan yang sering terjadi pada ibu hamil trimester tiga. Penurunan kualitas tidur yaitu berkurangnya durasi tidur pada ibu hamil merupakan salah satu bentuk gangguan tidur. Efek yang terjadi pada ibu hamil yang mengalami gangguan tidur adalah berkurangnya kualitas hidup ibu hamil dan memengaruhi tumbuh kembang pada janin yang dikandungnya. Salah satu terapi nonfarmakologi yang dapat meningkatkan kualitas tidur ibu hamil adalah pregnancy massage / pijat kehamilan. Wanita hamil perlu melakukan segala daya untuk mendukung kehamilan yang bahagia dan sehat. Terapi pijat bisa membantu ibu tetap dalam keadaan lebih rileks dan merespon lebih positif terhadap ketidaknyamanan yang berhubungan dengan rasa sakit. Tujuan penelitian ini adalah untuk mengetahui pengaruh pijat kehamilan terhadap kualitas tidur ibu hamil. Desain penelitian ini menggunakan Quasy Experiment dengan Pre-Posttest Design With Nonequivalent Control Group. Pengambilan sampel secara purposive untuk 196 ibu hamil yang terbagi menjadi kelompok kontrol diberikan layanan antenatal care (ANC) sesuai prosedur layanan ANC dan kelompok perlakuan adalah pijat kehamilan sesuai SOP. Pengukuran kualitas tidur menggunakan kuesioner PSQI. Penelitian dilaksanakan pada bulan Maret 2019 sampai denga","PeriodicalId":18323,"journal":{"name":"Media Penelitian dan Pengembangan Kesehatan","volume":"2 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79130661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gambir (Uncaria gambir Roxb.) as A Potential Alternative Treatment for Hyperlipidemia","authors":"N. Yunarto, N. Sulistyaningrum, Arifayu Addiena Kurniatri, B. Elya","doi":"10.22435/mpk.v31i3.4472","DOIUrl":"https://doi.org/10.22435/mpk.v31i3.4472","url":null,"abstract":"Gambir (Uncaria gambir Roxb.) is a member of family of Rubiaceae. In Asia including Indonesia, extracts of gambir are empirically used daily to weed out. The high content of catechin flavonoids in gambir has a pharmacological effect in the treatment of hyperlipidemia that potential to be developed into traditional medicine. This literature review aimed to examine the potency of pharmacological effect of gambir as hyperlipidemia treatment therapy based on the results of studies in silico, in vitro, in vivo pharmacological effects and its safety to provide evidence of scientific information to the community. The literatures used for analysis in this study including evidence-based articles on both pharmacology and safety which are available in Pubmed and Google Scholar. The results showed a very strong potency of gambir plants in the treatment of hyperlipidemia with catechin as bioactive compounds. In silico study revealed mechanism action of catechin as antihyperlipidemic using 2 pathways, inhibition of the enzyme HMG-CoA reductase and increase the LDL receptors. In vitro studies of catechin are able to inhibit lipid absorption in the intestine through inhibition of pancreatic lipase activity, lipid hydrolysis and emulsification, micelle cholesterol deposition. Pre-clinical tests on animals showed that the ethyl acetate fraction of gambir leaves was able to reduce the levels of total cholesterol, triglycerides, LDL and increase blood plasma HDL. The long-term use of gambir leaves has been proven to be safe, not mutagenic, no hematological, clinical biochemical abnormalities and no abnormalities in the vital organs of the animal models. \u0000Abstrak \u0000Gambir (Uncaria gambir Roxb) adalah tumbuhan perdu dari suku Rubiaceae. Di Asia termasuk Indonesia, secara empiris ekstrak gambir digunakan sehari-hari untuk menyirih. Kandungan flavonoid katekin yang tinggi dalam gambir memiliki efek farmakologi dalam pengobatan hiperlipidemia yang berpotensi untuk dikembangkan menjadi obat tradisional. Kajian literatur ini bertujuan untuk mengkaji potensi farmakologi gambir sebagai terapi pengobatan hiperlipidemia berdasarkan hasil studi efek farmakologi in silico, in vitro, in vivo efek farmakologi dan keamanannya, sehingga memberikan bukti informasi ilmiah kepada masyakarat. Literatur yang digunakan dalam proses review meliputi literatur dengan berbasis bukti baik farmakologi maupun keamanan yang tersedia di Pubmed dan Google Scholar. Hasil kajian menunjukkan potensi yang sangat kuat dari tanaman gambir dalam pengobatan hiperlipidemia dengan katekin sebagai senyawa bioaktif utama. Studi in silico menunjukkan mekanisme aksi katekinsebagai antihiperlipidemia menggunakan dua jalur yaitu penghambatan enzim HMG-CoA reduktase dan peningkatan reseptor LDL. Studi in vitro katekin mampu menghambat penyerapan lipid di usus melalui penghambatan aktivitas lipase pankreas, hidrolisis lipid dan emulsifikasi, serta pengendapan kolesterol misel. Studi in vivo menunjukkan fraksi etil as","PeriodicalId":18323,"journal":{"name":"Media Penelitian dan Pengembangan Kesehatan","volume":"81 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80949251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kebahagiaan dan Hubungannya dengan Hipertensi di Indonesia : Analisis Data Indonesian Family Life Survey (IFLS5) Tahun 2014","authors":"Olwin Nainggolan, Effendy Nainggolan, Urbanus Sihotang","doi":"10.22435/mpk.v31i3.4036","DOIUrl":"https://doi.org/10.22435/mpk.v31i3.4036","url":null,"abstract":"Happiness in several studies is mentioned to have a correlation with several diseases such as hypertension, cardiovascular disease and obesity. Happy people tend to live longer and live healthier lives. The purpose of the study was to look at the association and the magnitude of the risk of happiness with the incidence of hypertension in Indonesia. This study used secondary data from the 2014 Indonesian Family Life Survey (IFLS5) with respondents aged ≥19 years old with normal weight (BMI 18,5-24,9). Conceptual framework with a risk factor model approach. Association of happiness to hypertension using multiple logistic regression analysis with the significance of p value <0.05. Prevalence of hypertension aged ≥19 years old in Indonesia based on IFLS5 data is 23.1%. Proportion of respondents very happy was 11.6% and happy was 78.0%. The results of multivariate analysis showed that happiness did not have a strong enough relationship with the incidence of hypertension. Age variable is the factor with thestrongest influence on the incidence of hypertension with OR 5.63 (95% CI 5.02-6.32). \u0000Abstrak \u0000Kebahagiaan pada beberapa penelitian disebutkan memiliki korelasi dengan beberapa penyakit seperti hipertensi, penyakit kardiovaskular dan kegemukan. Orang yang merasa bahagia cenderung memiliki umur yang lebih panjang dan memiliki hidup yang lebih sehat. Tujuan dari analisis adalah melihat hubungan dan besaran risiko kebahagiaan terhadap kejadian hipertensi di Indonesia. Penelitian ini menggunakan data sekunder Indonesian Family Life Survey tahun 2014 (IFLS5) dengan responden berumur ≥19 tahun yang memiliki berat badan normal (IMT 18,5-24,9). Kerangka konsep yang dipergunakan adalah dengan pendekatan model faktor risiko. Untuk melihat hubungan kebahagiaan dengan hipertensi digunakan analisis regresi logistik berganda dengan kemaknaan p value < 0,05. Prevalensi hipertensi umur ≥19 tahun di Indonesia berdasarkan data IFLS5 adalah sebesar 23,1%. Proporsi responden yang merasa sangat bahagia 11,6% dan merasa bahagia sebesar 78,0%. Hasil analisis multivariat memperlihatkan kebahagiaan tidak memiliki hubungan yang cukup kuat terhadap kejadian hipertensi (p value = 0,62). Variabel umur merupakan faktor yang paling kuat pengaruhnya terhadap kejadian hipertensi dengan OR 5,63 (95%CI 5,02-6,32).","PeriodicalId":18323,"journal":{"name":"Media Penelitian dan Pengembangan Kesehatan","volume":"98 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76057191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studi In Silico Senyawa Fenolik Madu sebagai Kandidat Inhibitor Mpro SARS-CoV-2","authors":"Pamungkas Rizki Ferdian, Rizki Rabeca Elfirta, Azra Zahrah Nadhirah Ikhwani, Kasirah Kasirah, H. Haerul, Dodi Sutardi, Gunawan Ruhiat","doi":"10.22435/mpk.v31i3.4920","DOIUrl":"https://doi.org/10.22435/mpk.v31i3.4920","url":null,"abstract":"SARS-CoV-2 has caused a global COVID-19 pandemic since late 2019 and the reported cases have not ended until now. One way to overcome the Covid-19 pandemic is to find the main viral protease inhibitor (Mpro) SARS-CoV-2 which is a key enzyme of virus replication. Honey is a bee-derived product that contains various phenolic compounds and has antiviral activity. This study aimed to find candidate Mpro SARS-CoV-2 inhibitors from honey phenolic compounds using molecular docking simulations in a directed manner. A total of 27 test ligands (from honey’s phenolic compounds), 4 comparison ligands (from synthetic antiviral compounds), and reference ligands (N3 compound) were screened for their character as drug compounds by Lipinski’s rules and for their toxicity by admetSAR. All ligands were docked to the Mpro SARS-CoV-2 receptor code 7BQY using AutoDock Tools 1.5.6 and Autodock Vina with center of coordinates: X = 10,398; Y = -1,254; Z = 23.473 and grid size: X = 40; Y = 46; Z = 40. Molecular docking simulation produces affinity energy and molecular interactions data. The results showed that the best candidate for Mpro SARS-CoV-2 inhibitor from honey’s phenolic compounds was genistein because it complied with all Lipinski rules, was non-toxigenic, not a carcinogen, had an affinity energy of -7.6 kCal/mol, 80% similarity to the reference ligand N3, and occupies 63,64% of the tethercoverage area. The results of this study are expected to be used in further research, both in vitro and in vivo. \u0000Abstrak \u0000SARS-CoV-2 menyebabkan pandemi COVID-19 secara global sejak akhir 2019 dan kasusnya dilaporkan belum berakhir sampai saat ini. Salah satu cara untuk mengatasi pandemi COVID-19 diantaranya dengan menemukan inhibitor main viral protease (Mpro) SARS-CoV-2 yang merupakan enzim kunci pada replikasi virus. Madu merupakan produk turunan lebah yang mengandung berbagai senyawa fenolik dan memiliki aktivitas antivirus. Penelitian ini bertujuan untuk menemukan kandidat inhibitor Mpro SARS-CoV-2 dari senyawa fenolik madu menggunakan simulasi penambatan molekuler secara terarah. Sebanyak 27 ligan uji (dari senyawa fenolik madu), 4 ligan pembanding (dari senyawa antiviral sintetik), dan ligan acuan (senyawa N3) diskrining karakternya sebagai senyawa obat dengan aturan Lipinski dan toksisitasnya dengan admetSAR. Semua ligan ditambatkan ke reseptor Mpro SARS-CoV-2 kode 7BQY menggunakan AutoDock Tools 1.5.6 dan Autodock Vina dengan pusat koordinat: X= 10,398; Y= -1,254; Z= 23,473 dan ukuran kisi: X= 40; Y= 46; Z= 40. Simulasi penambatan molekuler menghasilkan data energi afinitas dan interaksi molekuler. Hasil penelitian menunjukkan kandidat inhibitor Mpro SARSCoV-2 terbaik dari senyawa fenolik madu adalah genistein karena memenuhi semua aturan Lipinski, tidak toksik, bukan karsinogen, memiliki energi afinitas -7,6 kKal/mol, kemiripan 80% dengan ligan acuan N3, dan menempati 63,64% area cakupan penambatan. Hasil penelitian ini diharapkan dapat digunakan dalam penelitian sel","PeriodicalId":18323,"journal":{"name":"Media Penelitian dan Pengembangan Kesehatan","volume":"83 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85314106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faktor-faktor yang Mempengaruhi Praktik Vaksinasi Rabies pada Anjing di Kecamatan Cililin Kabupaten Bandung Barat dengan Pendekatan Health Belief Model","authors":"Maria Lidwina Soetanto, Okta Wismandanu, I. Afriandi","doi":"10.22435/mpk.v31i3.3385","DOIUrl":"https://doi.org/10.22435/mpk.v31i3.3385","url":null,"abstract":"Rabies is a zoonotic viral disease that attacks all warm-blooded animals and humans through bites. Rabies is responsible for more than 3.7 million peoples Disability Adjusted Life Years (DALYs) annually. It is known that 95% of human deaths are from dog bites. Deaths due to rabies are common in rural areas because access to information tends to be minimal, so that people do not have knowledge about prevention of rabies. This study was designed to determine public’s perceptions of rabies and various possible rabies interventions. The research used a case control method with data collection using a questionnaire. The main concept of the Health Belief Model (HBM) was chosen because it has a function to predict individual beliefs. This individual beliefs will then influence the individual’s practice in carrying out rabies vaccination. In this study, it is known that the practice of rabies vaccination by the owner has a very significant relationship with knowledge related to rabies as a dangerous disease and individual beliefs that are reviewed through the HBM concept. Individual belief factors that have a significant relationship are severity and self efficacy variables. The results of this study can be a source of information and consideration for policy makers in Indonesia in making programs related to rabies prevention. Studies in the target area can provide knowledge about the characteristics of the population, so that the extension program can be conducted right on target and ultimately be able to reduce the overall incidence of rabies. \u0000Abstrak \u0000Rabies merupakan penyakit viral zoonotik yang menyerang semua hewan berdarah panas dan manusia melalui gigitan. Penyakit rabies bertanggung jawab atas lebih dari 3,7 juta Disability Adjusted Life Year (DALYs) setiap tahunnya. Diketahui bahwa 95% dari jumlah kematian manusia berasal dari gigitan anjing. Kematian akibat penyakit rabies lebih banyak terjadi di daerah perdesaan karena akses informasi cenderung minim, sehingga masyarakat tidak memiliki pengetahuan tentang pencegahanpencegahan terhadap penyakit rabies. Penelitian ini didesain untuk mengetahui persepsi masyarakat tentang penyakit rabies dan berbagai kemungkinan tindakan intervensi rabies. Desain penelitian yang digunakan adalah kasus kontrol dengan metode pengambilan data menggunakan kuesioner. Konsep utama Health Belief Model (HBM) dipilih karena memiliki fungsi untuk memprediksi keyakinan individu. Keyakinan individu ini kemudian akan memengaruhi praktik individu dalam melaksanakan vaksinasi rabies. Pada penelitian ini, diketahui bahwa praktik vaksinasi rabies oleh pemilik memiliki hubungan yang sangat signifikan dengan pengetahuan terkait rabies sebagai penyakit berbahaya dan keyakinan individu yang ditinjau melalui konsep HBM. Faktor keyakinan individu yang memiliki hubungan signifikan adalah variabel severity dan self efficacy. Hasil penelitian ini dapat menjadi sumber informasi dan konsiderasi bagi pemangku kebijakan di Indonesia dalam m","PeriodicalId":18323,"journal":{"name":"Media Penelitian dan Pengembangan Kesehatan","volume":"161 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86206770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtipe Molekuler Kanker Payudara di RSUD Madiun dan Hubungannya dengan Grading Histopatologi","authors":"Dadik Subiyanto, Threeyana Ariyati Kadi, Ismaiyah Ismaiyah, Naufal Abdurrahman, Yudha Prasetyo Utomo, Arif Reynaldi Alifiansyah, Ika Fidianingsih","doi":"10.22435/mpk.v31i3.4986","DOIUrl":"https://doi.org/10.22435/mpk.v31i3.4986","url":null,"abstract":"Breast cancer is a complex disease with variable molecular characteristics and shows different tumor behavior, therapeutic response, and prognosis. The regional general hospital Madiun has begun to improve services for breast cancer patients since 2015 with the availability of immunohistochemical examinations. This effort was made because breast cancer therapy is currently guided by these examinations. This study aimed to determine the distribution of various molecular subtypes of breast cancer in Madiun Hospital and also the relationship between molecular subtypes and histopathological grading. This study was a retrospective study with a cross-sectional design taken from the Anatomical Pathology Laboratory of Madiun Hospital data from 2015 to 2018. A total of 281 breast cancer cases were examined for immunohistochemical of estrogen receptor (ER), progesterone receptor (PR), and human epidermal receptor 2 (HER2), and a total of 91 breast cancer patients plus Ki-67 examination were then classified into luminal A, luminal B, HER2 and triple-negative (TN). The statistical test used was the Chi-Square test with a 95% confidence level. The most common molecular subtypes of breast cancer in Madiun Hospital were luminal B (28,5%) followed by TN (27,5%), luminal A (22%), and HER2 (22%). The mean age of breast cancer patients was 52.8 ± 10.57. The most common histological types and grades of breast cancer were invasive ductal carcinoma (85.1%) and tumor grade 1 (58.71%). There was a correlation between the immunohistochemical features of ER, PR, HER2, and Ki67 withhistopathological grading. Positive ER and PR were more well differentiated but e HER2 positive andKi67 were more poorly differented. \u0000Abstrak \u0000Kanker payudara merupakan penyakit kompleks dengan gambaran molekuler bervariasi dan menunjukkan perilaku tumor, respon terapi, dan prognosis yang berbeda. Rumah Sakit Umum Daerah (RSUD) Madiun mulai meningkatkan layanan untuk pasien kanker payudara sejak tahun 2015 dengan tersedianya pemeriksaan imunohistokimia. Upaya ini dilakukan karena terapi kanker payudara saat ini berpedoman atas pemeriksaan tersebut. Penelitian ini bertujuan untuk mengetahui distribusi berbagai subtipe molekuler kanker payudara di RSUD Madiun dan juga hubungan antar subtipe molekuler dengan grading histopatologi. Penelitian ini adalah studi retrospektif dengan desain cross sectional yang diambil dari data Laboratorium Patologi Anatomi RS Madiun selama tahun 2015 sampai 2018. Total 281 kasus kanker payudara dilakukan pemeriksaan imunohistokimia estrogen receptor (ER), progesteron receptor (PR) dan human epidermal epidermal receptor 2 (HER2) dan total 91 pasien kanker payudara ditambah pemeriksaan Ki-67 kemudian diklasifikasikan menjadi luminal A, luminal B, HER2, dan triple negative (TN). Uji statistik yang digunakan adalah uji Chi Square dengan taraf kepercayaan 95%. Subtipe molekuler kanker payudara di RS Madiun yang paling banyak adalah luminal B (28,5%) diikuti TN (27,5%), lum","PeriodicalId":18323,"journal":{"name":"Media Penelitian dan Pengembangan Kesehatan","volume":"10 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85131521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship of Delayed Appendectomy to the Incidence of Surgical Site Infection (SSI) in Acute Appendicitis Patients: A Narrative Review","authors":"Wahyuning Ati Ashari, E. Suswati, Erfan Efendi","doi":"10.22435/mpk.v31i3.4775","DOIUrl":"https://doi.org/10.22435/mpk.v31i3.4775","url":null,"abstract":"Acute appendicitis is one of the most common causes of surgery worldwide. Appendectomy is a skeptical surgical intervention associated with the risk of Surgical Site Infection (SSI). The purpose of this analysis was to describe the relationship between delayed appendectomy in acute appendicitis and the incidence of SSI. Reviewers selected articles containing data on the incidence of SSI due to appendectomy delays for 3 to 48 hours from seven databases, namely Pubmed, Nature, SpringerLink, Science Direct, ProQuest, Oxford Open Access Journal, and Cochrane Library. The data source was secondary data from international articles published in 2011 to 2020 based on the PICO criteria. The data obtained were then grouped and synthesized without meta-analysis/Synthesis Without Metaanalysis (SWiM) descriptively. A total of 2,778 articles were collected, of which 24 studies met the inclusion criteria. A total of 4 articles showed an association between appendectomy delay and SSI while the other 20 articles did not show a relationship between the two. There was no relationship between appendectomy delays for less than 48 hours since hospital admission to surgery with the incidence of SSI, however a delayed for more than 48 hours showed a significant value. The results showed there was no relationship between delayed appendectomy for less than 48 hours since the time the patientwas admitted to the hospital until the surgery took place, but a delayed appendectomy delay for more than 48 hours showed a significant relationship with the incidence of SSI. This narrative review supports early surgical intervention of acute appendicitis cases by considering the severity of the patient to avoid other surgical complications. \u0000Abstrak \u0000Apendisitis akut menjadi salah satu penyebab pembedahan yang paling sering ditemukan di seluruh dunia. Apendektomi merupakan intervensi bedah skeptis yang berhubungan dengan risiko terjadinya Surgical Site Infection (SSI). Tujuan analisis ini untuk mendapatkan gambaran hubungan antara penundaan apendektomi pada apendisitis akut dengan kejadian SSI. Reviewer memilih artikel yang memuat data kejadian SSI akibat penundaan apendektomi selama 3 sampai 48 jam dari tujuh basis data yaitu Pubmed, Nature, SpringerLink, Science Direct, ProQuest, Oxford Open Access Journal, dan Cochrane Library. Sumber data berupa data sekunder dari artikel internasional yang diterbitkan pada tahun 2011 hingga 2020 berdasarkan kriteria PICO. Data yang didapatkan kemudian dikelompokkan dan disintesis tanpa meta-analisis/Synthesis Without Meta-analysis (SWiM) secara deskriptif. Total artikel yang dikumpulkan adalah 2.778 artikel, sebanyak 24 studi memenuhi kriteria inklusi. Sebanyak 4 artikel menunjukkan hubungan antara keterlambatan apendektomi dengan SSI sedangkan 20 artikel lainnya tidak menunjukkan hubungan keduanya.Tidak ada hubungan penundaan apendektomi kurang dari 48 jam sejak masuk rumah sakit hingga operasi dengan insidensi SSI namun penundaan lebih dari 48","PeriodicalId":18323,"journal":{"name":"Media Penelitian dan Pengembangan Kesehatan","volume":"34 7 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77233285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelaksanaan Program Indonesia Sehat dengan Pendekatan Keluarga (PIS-PK) di Puskesmas","authors":"Nova Sri Hartati, Eva Sulistiowati, M. Susilawati","doi":"10.22435/mpk.v31i3.3381","DOIUrl":"https://doi.org/10.22435/mpk.v31i3.3381","url":null,"abstract":"The Healthy Indonesia Program is one of the programs of the nawacita agenda, in order to improve the health and nutritional status of the community through health efforts and community empowerment. This program makes the puskesmas as a pioneer in the implementation by prioritizing the family approach. In this way it is expected to increase the reach, target and improve access to health services in the working area. The Healthy Indonesia Program with a Family Approach (PIS-PK) also emphasized the essence of puskesmas’ functions as promoting and preventing efforts. The purpose of this paper was to know PIS-PK implementation process at 8 puskesmas in 5 provinces, namely Wayurang, Karanganyar, Tanjung Sari, and Tanjung Bintang (Lampung Selatan Regency, Lampung), Banjarnegara 1 (Banjarnegara Regency, Central Java), Lahihuruk (Waikabubak Regency, East Nusa Tenggara), Giri Mulya (Tanahbumbu District, South Kalimantan), and Tawaeli Health Center (Palu City, Central Sulawesi) conducted during 2018. This analysis was part of the PIS-PK implementation research conducted using the approach Participatory Action Research (PAR), through qualitative methods; in-depth interviews, Focus Group Discussion (FGD), and seeing the results of updating the data conducted by officers. Based on the results of the FGD with officers and in-depth interviews with the head of the puskesmas, it was found that all locus puskesmas had carried out preparations for the implementation of home visits including the preparation of human resources, carrying out on the job training (OJT), preparing logistics, conducting external socialization before conducting home visits. Home visit had only been conducted by data collection phase. It had not been integrated in existing program in puskesmas. \u0000Abstrak \u0000Program Indonesia Sehat merupakan salah satu program dari agenda nawacita, dalam rangka meningkatkan derajat kesehatan dan status gizi masyarakat melalui upaya kesehatan dan pemberdayaan masyarakat. Program ini menjadikan puskesmas sebagai pelopor pelaksanaan dengan mengedepankan pendekatan keluarga. Dengan cara ini diharapkan dapat meningkatkan jangkauan, sasaran, dan meningkatkan akses pelayanan kesehatan di wilayah kerjanya. Program Indonesia Sehat dengan Pendekatan Keluarga (PIS-PK) juga menekankan esensi fungsi puskesmas pusat kesehatan masyarakat (puskesmas) dalam upaya promotif dan preventif. Tujuan dari penulisan ini adalah untuk mengetahui proses pelaksanaan PIS-PK pada delapan puskesmas di lima provinsi, yaitu Puskesmas Wayurang, Puskesmas Karanganyar, Puskesmas Tanjung Sari, dan Puskesmas Tanjung Bintang (Kabupaten Lampung Selatan, Lampung), Puskesmas Banjarnegara 1 (Kabupaten Banjarnegara, Jawa Tengah), Puskesmas Lahihuruk (Kabupaten Waikabubak, Nusa Tenggara Timur), Puskesmas Giri Mulya (Kabupaten Tanahbumbu, Kalimantan Selatan), dan Puskesmas Tawaeli (Kota Palu, Sulawesi Tengah) yang dilakukan selama tahun 2018. Analisis ini merupakan bagian dari riset implementasi PIS-PK yang ","PeriodicalId":18323,"journal":{"name":"Media Penelitian dan Pengembangan Kesehatan","volume":"11 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88528389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}