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The effect of osteoprotegerin nanocomplex on osteoprotegerin and arteriosclerosis in mice 骨保护蛋白纳米复合物对骨保护蛋白和小鼠动脉硬化的影响
IF 0.7 4区 材料科学
Materials Express Pub Date : 2023-12-01 DOI: 10.1166/mex.2023.2573
Zhiwen He, Shuang Wang, Xiaoxuan Xia
{"title":"The effect of osteoprotegerin nanocomplex on osteoprotegerin and arteriosclerosis in mice","authors":"Zhiwen He, Shuang Wang, Xiaoxuan Xia","doi":"10.1166/mex.2023.2573","DOIUrl":"https://doi.org/10.1166/mex.2023.2573","url":null,"abstract":"Osteoprotegerin (OPG), as one of the tumor necrosis factor receptors, is believed to be related with Osteoprotegerin (OP) and arteriosclerosis (AS). This study aims to explore the effect of OPG on osteoblasts (OB) and AS. The nanocomplex Poly(ethylene glycol)-Poly(L-Lysine)-Osteoprotegerin\u0000 (PPO) was prepared by introducing OPG plasmid to Poly(ethylene glycol)-Poly(L-Lysine). Healthy group, AS group, AS combined with OP group were designed to measure apoptosis, activity, adhesion, and calcification of OB in Polycaprolactone (PCL) by flow cytometry, MTT method, alizarin red staining,\u0000 scanning electron microscope and other methods. The effect of PPO on bone mineral density and arteriosclerosis of ApoE−/−/RANKL+/+ mice was observed. Bone Mineral Density (BMD) was positively correlated with ABI while negatively correlated with pulse wave\u0000 velocity. OPG in AS combined with OP group was higher than healthy group, and AS group was also higher than healthy group. PPO-administered mice had dense bone trabeculae and higher bone density while the control group was the opposite. The effect of PPO on the stable expression of OPG in\u0000 mice reduced the plaque area and the degree of vascular calcification. PPO can enhance OB activity in vitro, inhibit cell apoptosis, promote cell calcification and PCL adhesion, decrease the area of atherosclerotic plaque and calcification, and increase the BMD of the femoral neck.\u0000 PPO can promote the adhesion and calcification of MC3T3-E1 on PCL, which is of great significance for maintaining sufficient bone strength and reducing blood calcium. In addition, PPO compound drugs can increase bone density, reduce arterial plaque area and vascular calcification.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 15","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138615893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation and application of amphiphilic polymer nanomaterials for ischemic injury 制备和应用两亲性聚合物纳米材料治疗缺血性损伤
IF 0.7 4区 材料科学
Materials Express Pub Date : 2023-12-01 DOI: 10.1166/mex.2023.2557
Jiayu Li, Yili Xu
{"title":"Preparation and application of amphiphilic polymer nanomaterials for ischemic injury","authors":"Jiayu Li, Yili Xu","doi":"10.1166/mex.2023.2557","DOIUrl":"https://doi.org/10.1166/mex.2023.2557","url":null,"abstract":"With the increasing popularity of competitive sports, martial arts routines have attracted great attention. However, myocardial ischemic injury is one of the most common sports-related diseases in martial arts routines. In this study, γ-Fe2O3 nanoparticles\u0000 were used as a treatment for myocardial injury. The safety of these nanoparticles was determined by assessing apoptosis rates and reactive oxygen species levels in myocardial cells, as well as biochemical indicators such as lactate dehydrogenase and superoxide dismutase. The results showed\u0000 that the aforementioned indicators were normal, indicating that γ-Fe2O3 nanoparticles are safe for myocardial cells. Additionally, the application of γ-Fe2O3 nanoparticles to hypoxic environments significantly improved anti-hypoxia\u0000 ability, alleviated calcium overload in myocardial cells, and reduced intracellular reactive oxygen species content, thereby protecting myocardial cells from hypoxia damage. Therefore, this study provides an effective strategy for treating ischemic injury in martial arts athletes and establishes\u0000 an experimental foundation for the clinical management of myocardial ischemic injury.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 46","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138617587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The inhibitory effect of quercetin on chemotherapeutic drug resistance of gastric cancer through forkhead box D3 signaling pathway 槲皮素通过叉头盒子 D3 信号通路对胃癌化疗耐药性的抑制作用
IF 0.7 4区 材料科学
Materials Express Pub Date : 2023-12-01 DOI: 10.1166/mex.2023.2558
Liqian Chang, Yuan Gao, Na An
{"title":"The inhibitory effect of quercetin on chemotherapeutic drug resistance of gastric cancer through forkhead box D3 signaling pathway","authors":"Liqian Chang, Yuan Gao, Na An","doi":"10.1166/mex.2023.2558","DOIUrl":"https://doi.org/10.1166/mex.2023.2558","url":null,"abstract":"Most gastric cancer patients have cancer cell metastasis at the time of being diagnosed. Cisplatin chemotherapy can slow down the development of gastric cancer, but the drug resistance will develop after a long time of chemotherapy. Previous studies have found that quercetin improves\u0000 resistance of chemotherapy drugs. Therefore, this study intends to explore quercetin’s role in gastric cancer. SGC-7901 drug-resistant cell line was cultured and intervened. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay assessed cell proliferation, cell survival\u0000 rate, IC50 value and sensitivity along with analysis of cell apoptosis, proliferation by colony formation assay and qRT-PCR (real-time reverse transcription-PCR) and Western blot detection of FOXD3 (Forkhead box D3) levels. Gastric cancer xenograft tumor mouse model was established to assess\u0000 its in vivo role. The drug-resistant cell model of gastric cancer was successfully constructed and quercetin inhibited cell survival to a certain extent and improved its chemosensitivity. The pro-apoptotic effect of quercetin on cisplatin chemotherapy resistance in gastric cancer is\u0000 related to the increased FOXD3 level. Quercetin can directly regulate the expression of FOXD3, which is an activation effect. The inhibition rate of gastric cancer mice in vivo was the most prominent in the quercetin+drug resistance group. The tumor-bearing site was significantly reduced\u0000 and the number of surviving mice was the highest, whose tumor volume was consistently lower than that of other groups. Conclusively, quercetin has a strong anti-tumor effect. It can inhibit gastric cancer cell activity and accelerate apoptosis by activating FOXD3 signaling pathway.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138614588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of smart sportswear based on multi-walled carbon nanotubes for safety in college physical education classes 基于多壁碳纳米管的智能运动服在大学体育课中的安全应用
IF 0.7 4区 材料科学
Materials Express Pub Date : 2023-12-01 DOI: 10.1166/mex.2023.2585
Nan Hu, Baixu Wang
{"title":"Application of smart sportswear based on multi-walled carbon nanotubes for safety in college physical education classes","authors":"Nan Hu, Baixu Wang","doi":"10.1166/mex.2023.2585","DOIUrl":"https://doi.org/10.1166/mex.2023.2585","url":null,"abstract":"As physical education advances, college physical education classrooms are becoming increasingly diverse, but this development also brings security concerns. Intelligent sportswear, serving as a real-time monitoring device for human data, can enhance safety for both teachers and students.\u0000 This study focuses on developing a conductive filler for flexible piezoresistive sensors using modified multi-walled carbon nanotubes (MWCNTs). Firstly, the tunneling theory and permeability effects are employed to establish a sensing mechanism model and analyze the conductivity and piezoresistive\u0000 effects. Subsequently, silane coupling agents (KH550) and sodium dodecyl benzene sulfonate (SDBS) are chosen to enhance the conductive filler’s performance. Finally, smart gloves, smart insoles, and smart vests are designed for the detection of hand pressure, foot pressure, and respiratory\u0000 rate. This aims to enhance safety measures in physical education classrooms. Furthermore, their performance is validated through simulation experiments. Results indicate that MWCNTs were modified with KH550 and SDBS, showing improved conductivity with higher filler concentration. KH550-SDBS-MWNT/PU\u0000 material demonstrates 108.3% increased elongation at break, 9% reduction in nonlinear error, enhanced linearity, and 2.972 sensitivity increase. Displacement deviation analysis reveals load change trends based on filler concentration. Empirical analysis of smart clothing, like smart insoles,\u0000 aligns sensor data with theoretical principles, highlighting the potential for flexible sensor performance enhancement. In conclusion, the modified MWCNs have demonstrated potential for enhancing the performance of flexible sensors.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"10 32","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138623977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Specification of the optimal gas metal arc welding (GMAW) parameters to enhance the mild steel strength (MS1018) 确定提高低碳钢(MS1018)强度的最佳气体金属弧焊(GMAW)参数
IF 0.7 4区 材料科学
Materials Express Pub Date : 2023-12-01 DOI: 10.1166/mex.2023.2562
G. R. Sanjay Krishna, K. Sai Sarath, B. Nageswara Rao, V. Atgur, N. Banapurmath, Chandramouli Vadlamudi, Sanjay Krishnappa, M. A. Umarfarooq, A. M. Sajjan
{"title":"Specification of the optimal gas metal arc welding (GMAW) parameters to enhance the mild steel strength (MS1018)","authors":"G. R. Sanjay Krishna, K. Sai Sarath, B. Nageswara Rao, V. Atgur, N. Banapurmath, Chandramouli Vadlamudi, Sanjay Krishnappa, M. A. Umarfarooq, A. M. Sajjan","doi":"10.1166/mex.2023.2562","DOIUrl":"https://doi.org/10.1166/mex.2023.2562","url":null,"abstract":"Arc fusion processes, such as high-efficiency gas metal arc welding (GMAW), have become increasingly prevalent in various industries. To optimize the GMAW parameters and enhance the strength of MS 1018, Monika and Chauhan conducted experiments using the low carbon steel filler wire\u0000 (ER 70 S6). They used a Taguchi L9 OA (orthogonal array) to generate test data focusing on 3 GMAW parameters such as gas flow rate, arc voltage, and welding current. The performance characteristics considered were tensile strength (TS), weld zone hardness (WZH), and heat-affected\u0000 zone hardness (HAZH). The effect of GMAW parameters investigated using the S/N (signal-to-noise ratio) transformation of individual test data, which is valid to account for variations observed in repeated tests. By conducting a thorough analysis of variance (ANOVA) on this transformed data,\u0000 they were able to identify the optimal GMAW parameters for achieving high TS, WZH, and HAZH. Given that HAZH exhibited higher values than WZH, it was evident that TS had the most significant impact on the GMAW process. Consequently, the researchers established empirical relationships for TS,\u0000 WZH, and HAZH in terms of the GMAW parameters. Their test data aligned reasonably well with the expected range of performance indicators, supporting the validity of their findings. Overall, Monika and Chauhan’s modified Taguchi approach, based on the L9 OA, allowed them to\u0000 efficiently conduct a limited number of tests while obtaining comprehensive information on the optimal GMAW parameters for enhancing the strength of MS 1018.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 39","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138613715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication of self-assembly iguratimod prodrug into polymeric nanoparticles delivery for the care of breast cancer therapy 将iguratimod原药自组装成聚合物纳米颗粒,用于乳腺癌治疗
IF 0.7 4区 材料科学
Materials Express Pub Date : 2023-12-01 DOI: 10.1166/mex.2023.2547
Xue Wang, Bing Wang
{"title":"Fabrication of self-assembly iguratimod prodrug into polymeric nanoparticles delivery for the care of breast cancer therapy","authors":"Xue Wang, Bing Wang","doi":"10.1166/mex.2023.2547","DOIUrl":"https://doi.org/10.1166/mex.2023.2547","url":null,"abstract":"Based on occurrence, death and prevalence in 2019, GLOBOCAN reports 36 forms of cancer in 185 countries. At the moment, chemotherapy is the furthermost commonly utilized cancer management by resistant systems, gene and hormone therapeutics. Herein, we define a precise straightforward\u0000 and cost-effective method that therapeutically incorporates drug reconstruction, macromolecular nano-assembled and specific tumor targeting to overcome the various experiments modelled via the distribution of the potential anticancer Iguratimod (IGU) drug. The IGU drugs were empowered to instinctually\u0000 assembly into admirable, stable nanoparticles on the conjugations covalent interactions of hydrophobic linoleic acid bonded with an amide group of ∼100 nm. Various microscopic methods have proven synthesized IGU-NP morphology. Following effective fabrication, the IGU and IGU-NP anti-cancer\u0000 properties of MCF-7 (breast carcinoma) and 4T1 (breast carcinoma) cell lines were assessed. Additional studies include AO-EB (acridine bromide orange ethidium), nuclear staining. In contrast with IGU, the IGU-NPs showed excellent cytocompatibility, this investigation explained that IGU-NPs\u0000 are a healthy and encouraging solution in breast cancer chemotherapy and are worthy of further clinical assessment.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 46","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138614330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healing processes of burn wounds with honey and vaseline as ointment forms: An in-vivo study in Wistar rats 以蜂蜜和凡士林为软膏的烧伤创面愈合过程:对 Wistar 大鼠的体内研究
IF 0.7 4区 材料科学
Materials Express Pub Date : 2023-12-01 DOI: 10.1166/mex.2023.2569
Fadi Baakdah, Abrar Ashi, Sarah Almaghrabi, K. A. Ismail, R. Sami, G. Alshehry, Huda Aljumayi, Eman Algarni, Jamal A Alorabi, Mohammad Y. Alshahrani, Naseh A Algehainy, Mohammad A Alanazi
{"title":"Healing processes of burn wounds with honey and vaseline as ointment forms: An in-vivo study in Wistar rats","authors":"Fadi Baakdah, Abrar Ashi, Sarah Almaghrabi, K. A. Ismail, R. Sami, G. Alshehry, Huda Aljumayi, Eman Algarni, Jamal A Alorabi, Mohammad Y. Alshahrani, Naseh A Algehainy, Mohammad A Alanazi","doi":"10.1166/mex.2023.2569","DOIUrl":"https://doi.org/10.1166/mex.2023.2569","url":null,"abstract":"Burn wounds need enhanced healing by using some workable agent for better treatments. The current work aimed to make a comparison between four types of honey and vaseline in ointment forms in-vivo using experimental rats. Several parameters have been evaluated such as wound epithelialization\u0000 and vascular endothelial growth factor expression (VEGF) rates for skins. Some biochemical parameters such as nitrites (NO2) and fluorescence recovery after photobleaching (FRAP) were detected for serum. TNF-α immune response and hydroxyproline contents were also determined\u0000 colorimetrically. Microbial infection of the burns was examined against Pseudomonas aeruginosa and Staphylococcus aureus strains. The wound epithelialization rate among animal groups after 15 days of treatment ranged from 52.13% to 89.58%. The highest VEGF expression rate was\u0000 achieved by using the ointment formed by side honey (SIH) at 9.21% followed by pumpkin honey (PUH) at 8.54%, moringa honey (MOH) at 8.11%, and nigellasativa honey (NSH) as 7.02%, while vaseline group reported 5.22% VEGF expression. The ointment formed by the NSH rat group detected the\u0000 highest NO2 at the end of the experimental work to reach (0.07 μmol/L) followed by SIH (0.06 μmol/L), while MOH and PUH groups reported equal values (0.05 μmol/L). The FRAP values varied in rat groups from 735.19 μmol TE/g (SIH) to 877.89\u0000 μmol TE/g (NSH). NSH reported the highest value for TNF-α immune response at 589.47 U/mL followed by SIH at 560.89 U/mL, while MOH reported the lowest value at 489.58 U/mL. For the microbial infections, the MOH group had the lowest zone of inhibition 5.18 mm, while the\u0000 vaseline group reported the highest 19.88 mm against Pseudomonas aeruginosa. It was observed that the highest zone of inhibition (19.22 mm) against Staphylococcus aureus was for the vaseline group, while the lowest zone of inhibition (5.33 mm) against Staphylococcus aureus\u0000 was for SIH. All honey varieties, especially MOH had better results for NO2, TNF-α immune response, and successfully inhibited microbial infections in-vivo.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138615824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of chaetocin on retinoblastoma progression by modulating the miR-124/SBK1 axis 通过调节 miR-124/SBK1 轴抑制视网膜母细胞瘤的发展
IF 0.7 4区 材料科学
Materials Express Pub Date : 2023-12-01 DOI: 10.1166/mex.2023.2510
Qiaoling Sun, Xiaozhao Zhao, Bei Jin, Baotong Shu, Yu Ma
{"title":"Inhibition of chaetocin on retinoblastoma progression by modulating the miR-124/SBK1 axis","authors":"Qiaoling Sun, Xiaozhao Zhao, Bei Jin, Baotong Shu, Yu Ma","doi":"10.1166/mex.2023.2510","DOIUrl":"https://doi.org/10.1166/mex.2023.2510","url":null,"abstract":"We conducted cellular and animal experiments to investigate the correlation between miR-124/SBK1 and retinoblastoma (RB) progression, as well as to elucidate the anti-cancer efficacy of chaetocin in RB. Initially, miR-124 levels showed a significant decrease in RB tissues and cells,\u0000 which further declined with increasing tumor diameter and clinical stage. In cellular experiments, inhibiting miR-124 expression significantly enhanced the viability and invasiveness of Y79 cells, while up-regulating miR-124 suppressed the malignant biology of Y79 cells by targeting SBK1 levels,\u0000 thereby reducing their viability and invasiveness. Subsequent animal experiments provided further evidence that SBK1 was the functional target of miR-124, and its up-regulation significantly facilitated RB progression. Additionally, chaetocin demonstrated anti-tumor effects through the upregulation\u0000 of miR-124 and downregulation of SBK1. Therefore, chaetocin can effectively inhibit RB progression by targeting the upregulation of miR-124 and downregulation of SBK1.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 45","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138612482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of customisable 3D-printed bite blocks combined with nano head, neck and shoulder mask to head and neck neoplasm radiotherapy 将可定制的 3D 打印咬合块与纳米头颈肩罩结合应用于头颈部肿瘤放疗
IF 0.7 4区 材料科学
Materials Express Pub Date : 2023-12-01 DOI: 10.1166/mex.2023.2578
Chunyuan Zheng, Xueya Li, Luchao Zhu, Zhiqiang Zhang, Yuanzhang Wang, Yihang Lin, Qiong Wu, Meiling Zhang
{"title":"Application of customisable 3D-printed bite blocks combined with nano head, neck and shoulder mask to head and neck neoplasm radiotherapy","authors":"Chunyuan Zheng, Xueya Li, Luchao Zhu, Zhiqiang Zhang, Yuanzhang Wang, Yihang Lin, Qiong Wu, Meiling Zhang","doi":"10.1166/mex.2023.2578","DOIUrl":"https://doi.org/10.1166/mex.2023.2578","url":null,"abstract":"This study investigated the effectiveness of customisable 3D-printed bite blocks combined with nano head, neck and shoulder mask in radiotherapy for head and neck neoplasms. The images of 50 patients with head and neck neoplasms treated at our hospital from 2020 to 2022 were collected\u0000 using CBCT. The patients were divided into two groups: 25 in the mask group and 25 in the combination group. The mask group utilized thermoplastic polyurethane (TPU) nanofiber membrane to stabilize the position of the patients’ head, shoulder, and neck. On the other hand, the combined\u0000 group added a personalized bite block produced by 3D printing technology on the basis of the mask group. Cone beam CT (CBCT) was used to calibrate any errors, and the set-up errors and number of head rotations after image calibration were analyzed between the two groups. The conformation number\u0000 (CN) and heterogeneity index (HI) in the target area of the intensity-modulated radiation therapy (IMRT) plan of the two groups were calculated, and the dose-volume parameters of the tongue and other organs at risk, including Dmax and Dmean, were compared using paired tests. Follow-up observations\u0000 were performed to assess the occurrence of adverse reactions to radiation damage among the patients. The findings revealed a statistically significant difference in the Y -axis set-up error between the combination group and the mask group (P < 0.05). Additionally, the combination\u0000 group exhibited a higher proportion of set-up errors < 2 mm in both the Y -axis and Z-axis directions compared to the mask group. Significantly fewer images showed head rotation in the combination group than in the mask group. In terms of the target area, there were no significant\u0000 differences observed in the conformation number (CN) and heterogeneity index (HI) between the two groups. However, wearing the personalized bite block resulted in significantly lower Dmax and Dmean values for the tongue. In contrast, the mask group experienced a higher incidence of oral mucositis\u0000 and taste disorders. By utilizing customizable 3D-printed bite blocks in conjunction with a nano-mask, accurate repositioning for chemotherapy was achieved, leading to a reduction in set-up error and a significant decrease in radiation dose to the tongue and its surface oral mucosa. Consequently,\u0000 the occurrence of adverse reactions such as oral mucositis and taste disorders was also reduced. The production of personalized bite blocks is simple, with accurate radiotherapy, making it a technique that should be widely adopted.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 4","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138616211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soft intercalated slope stability optimization with a modified polymer curing agent 使用改性聚合物固化剂优化软插层斜坡稳定性
IF 0.7 4区 材料科学
Materials Express Pub Date : 2023-12-01 DOI: 10.1166/mex.2023.2559
Yun He
{"title":"Soft intercalated slope stability optimization with a modified polymer curing agent","authors":"Yun He","doi":"10.1166/mex.2023.2559","DOIUrl":"https://doi.org/10.1166/mex.2023.2559","url":null,"abstract":"The demand for high-grade roads is significantly higher in developing countries. However, slopes containing coal gangue weak interlayer pose significant safety risks to highways, railways, and other infrastructures. To address this issue, this study aims to find the best polymer cement\u0000 ratio scheme of traditional pure acrylic emulsion polymer curing agents. Based on this scheme, a reinforcement method was designed, which combined modified polyvinyl acetate with the coal gangue soft interlayer. The slope test results using a rigid model box showed that the shear strength\u0000 of the root–soil composite in the PVAC group was higher than that in the pure acrylic emulsion group under different vertical consolidation pressures. Over time, the cumulative soil loss rate of the pure acrylic emulsion group gradually increased, and the soil pH decreased. Conversely,\u0000 the PVAC group showed minimal changes in these two indicators with time. Under the same conditions, the slope shear strength of the PVAC group remained stronger than that of the pure acrylic emulsion group. The standard deviations of multiple tests for the PVAC group and pure acrylic emulsion\u0000 group, under a vertical consolidation pressure of 100 kPa, were 7.2 kPa and 9.2 kPa, respectively, indicating greater stability in the PVAC group. With a stability coefficient of 3.39, which surpasses that of the pure acrylic emulsion group, the PVAC group exhibited enhanced slope stability.\u0000 These results indicate that this method can effectively enhance the stability of coal gangue soft interlayer slopes without causing environmental pollution.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" 27","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138618581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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