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[The new generations of CAR-T cells]. [新一代 CAR-T 细胞]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-12-10 DOI: 10.1051/medsci/2024151
Djamel Messaoudi, Franck Perez, Zélia Gouveia
{"title":"[The new generations of CAR-T cells].","authors":"Djamel Messaoudi, Franck Perez, Zélia Gouveia","doi":"10.1051/medsci/2024151","DOIUrl":"https://doi.org/10.1051/medsci/2024151","url":null,"abstract":"<p><p>Chimeric antigen receptor (CAR)-T is one of the most promising modern cancer immunotherapies. In the recent years, impressive results have been obtained in the treatment of cancer which led to FDA approval for the treatment of liquid tumors. In this cell-based therapy, immune cells (e.g. T and NK cells) are engineered to express a synthetic receptor CAR to specifically recognize and eliminate cells expressing a target antigen. CAR has evolved through different generations aiming to boost its biological activity and overcome limitations such as low persistence, limited potency, life-threatening toxicity and inefficient activity against solid tumor. The present review provides an overview of the different CAR generations, starting from the 1<sup>st</sup> generation with limited cytotoxic activity until the latest generation, the 5<sup>th</sup> generation or new generation, developed to overcome various limitations of CAR T therapy. The current ongoing clinical trials in cancer and autoimmune diseases, and the limitation associated with CAR-T cells in cancer therapy, are also discussed.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 11","pages":"848-857"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Myonuclear domain settings by microtubules and MACF1]. [通过微管和 MACF1 设置肌核域]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024134
Alireza Ghasemizadeh, Vincent Gache
{"title":"[Myonuclear domain settings by microtubules and MACF1].","authors":"Alireza Ghasemizadeh, Vincent Gache","doi":"10.1051/medsci/2024134","DOIUrl":"10.1051/medsci/2024134","url":null,"abstract":"<p><p>Skeletal myofibers are syncytia made from the fusion of dozens or hundreds of mononuclear progenitor cells. Along myogenesis, the arriving nuclei from the progenitor cells have a long journey before being positioned at the periphery of a mature myofiber. Once at the periphery, nuclei are regularly spaced and each nucleus is transcriptionally responsible for its surrounding proportion of cytoplasm, known as the myonuclear domain. Disruption of these domains can be observed in various myopathies, suggesting their importance for skeletal muscle functionality. However, little is known about mechanisms regulating the myonuclear domain stability and organization. Here we take the example of MACF1, a microtubule-associated protein, as an essential actor in myonuclear domain organization, to highlight the potential role of microtubules and their associated proteome network for the stability of these domains and hence for proper myofiber functionality.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 Hors série n° 1 ","pages":"64-68"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Urban soils and microbial biodiversity]. [城市土壤与微生物生物多样性]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-12-10 DOI: 10.1051/medsci/2024147
Pierre-Alain Maron, Lionel Ranjard
{"title":"[Urban soils and microbial biodiversity].","authors":"Pierre-Alain Maron, Lionel Ranjard","doi":"10.1051/medsci/2024147","DOIUrl":"https://doi.org/10.1051/medsci/2024147","url":null,"abstract":"<p><p>Aware of the degradation of their environment, cities engage in a transition towards sustainable development models. They are based on the search for solutions promoting the \"return of nature to the city\", which is acclaimed by citizen wishing to improve their living environment. As a support of this nature, there is a knowledge issue regard soil to define management practices and design methods to optimize its functioning. Among this knowledge, that relating to the ecology and microbial diversity of the soil is essential since microorganisms are responsible for many of the services essential to the sustainability of urban systems. This article provides a brief overview of knowledge on the microbial diversity of urban soils and the tools available to assess it. It also presents examples of ongoing projects to study soil biodiversity in major French cities.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 11","pages":"858-863"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The pangenome integrates the vast genetic diversity of the human population]. [庞基因组整合了人类巨大的遗传多样性]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024126
Louise Benarroch
{"title":"[The pangenome integrates the vast genetic diversity of the human population].","authors":"Louise Benarroch","doi":"10.1051/medsci/2024126","DOIUrl":"https://doi.org/10.1051/medsci/2024126","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 Hors série n° 1 ","pages":"75"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The SFM and the myology… in Olympic form!] [奥林匹克形式的 "SFM "和 "Myology"！]
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024159
Bénédicte Chazaud, Cyril Gitiaux
{"title":"[The SFM and the myology… in Olympic form!]","authors":"Bénédicte Chazaud, Cyril Gitiaux","doi":"10.1051/medsci/2024159","DOIUrl":"https://doi.org/10.1051/medsci/2024159","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 Hors série n° 1 ","pages":"5"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Tamoxifen, a high-potential molecule to treat all centronuclear myopathies]. [他莫昔芬，治疗所有中心核肌病的高潜力分子]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024130
Charlotte Gineste, Jocelyn Laporte
{"title":"[Tamoxifen, a high-potential molecule to treat all centronuclear myopathies].","authors":"Charlotte Gineste, Jocelyn Laporte","doi":"10.1051/medsci/2024130","DOIUrl":"10.1051/medsci/2024130","url":null,"abstract":"<p><p>Centronuclear myopathies are rare congenital disorders characterized by muscle weakness and mislocalization of organelles. The main genes associated to these muscle diseases are MTM1, DNM2, BIN1 and RYR1. To date, no therapy is available. Nevertheless, tamoxifen, a pharmacological compound already used in clinics for breast cancer, showed beneficial effects on the muscle phenotypes in mouse models for centronuclear myopathies. Here, the effects of tamoxifen on muscle phenotypes will be compared in the various forms of this muscle disease.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 Hors série n° 1 ","pages":"34-39"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Tunneling nanotubes (TNTs): An essential yet overlooked modality of inter-cellular communication]. [隧道纳米管（TNTs）：一种重要却被忽视的细胞间通信方式]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-12-10 DOI: 10.1051/medsci/2024152
Malalaniaina Rakotobe, Chiara Zurzolo
{"title":"[Tunneling nanotubes (TNTs): An essential yet overlooked modality of inter-cellular communication].","authors":"Malalaniaina Rakotobe, Chiara Zurzolo","doi":"10.1051/medsci/2024152","DOIUrl":"https://doi.org/10.1051/medsci/2024152","url":null,"abstract":"<p><p>Tunneling nanotubes (TNTs) are open membranous protrusions that allow direct communication between distant cells. Recent research has revealed their significant biological roles, prompting a reassessment of many physiological and pathological processes, especially in the nervous system where TNT properties could play a key physiological role. TNT-like connections have been observed in the developing brain and are implicated in neurodegenerative diseases, brain cancers, as well as in other diseases, underscoring their importance in pathophysiological events. This review covers the key features of TNTs, including their structural properties, formation mechanisms, and detection challenges. We also explore their functions, focusing on the nervous system. The discovery of TNTs may lead to a reconsideration of brain function as a physically connected neuronal network, as proposed by Golgi, complementing Cajal's theory of neurons as separate entities.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 11","pages":"829-836"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Lupus under UNC93B1 surveillance]. [UNC93B1 监控下的狼疮]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-12-10 DOI: 10.1051/medsci/2024146
Clémence David, Julien Fouchet, Bénédicte Manoury, Marie-Louise Frémond, Alice Lepelley
{"title":"[Lupus under UNC93B1 surveillance].","authors":"Clémence David, Julien Fouchet, Bénédicte Manoury, Marie-Louise Frémond, Alice Lepelley","doi":"10.1051/medsci/2024146","DOIUrl":"https://doi.org/10.1051/medsci/2024146","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 11","pages":"825-828"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Parasport and neuromuscular diseases]. [Parasport 和神经肌肉疾病]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024163
Orianne Lopez
{"title":"[Parasport and neuromuscular diseases].","authors":"Orianne Lopez","doi":"10.1051/medsci/2024163","DOIUrl":"10.1051/medsci/2024163","url":null,"abstract":"<p><p>The benefits of physical activity, on an organic and psychological level, have been demonstrated. In patients suffering from a neuromuscular disease, adapted physical activity and parasport are also means of combating a sedentary lifestyle which adds to that imposed by the disease. Whatever the motor skills of the subject, whether he walks or not, whether he has good upper limb strength or only minimal preserved distal function, a parasport can be practiced. Indeed certain disciplines are possible for patients with very weak motor functions. One of the missions of those involved in the life course of the person suffering from a neuromuscular disease is to talk about this subject. It is essential to make the patient, from a very young age, and their caregivers aware of this field of possibilities and its importance - all respecting possible contraindications or partial incapacities. Supporting a parasport practice means having to \"get out of the hospital\" and interact with local collaborators, to facilitate orientation, organize the initiation and introduction of the activity in the daily life of the patient. The time given to the patient and his caregivers to address this subject and guide them illustrates the overall care for this patient and the concern for his inclusion and his physical and mental health.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 Hors série n° 1 ","pages":"12-16"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Benefit of treatment with rituximab in autoimmune myasthenia gravis in children]. [利妥昔单抗治疗儿童自身免疫性肌无力症的益处]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024132
Agathe Molimard, Cyril Gitiaux, Christine Barnerias, Frédérique Audic, Arnaud Isapof, Ulrike Walther-Louvier, Claude Cances, Caroline Espil-Taris, Davion Jean-Baptiste, Susana Quijano-Roy, Coraline Grisel, Brigitte Chabrol, Isabelle Desguerre
{"title":"[Benefit of treatment with rituximab in autoimmune myasthenia gravis in children].","authors":"Agathe Molimard, Cyril Gitiaux, Christine Barnerias, Frédérique Audic, Arnaud Isapof, Ulrike Walther-Louvier, Claude Cances, Caroline Espil-Taris, Davion Jean-Baptiste, Susana Quijano-Roy, Coraline Grisel, Brigitte Chabrol, Isabelle Desguerre","doi":"10.1051/medsci/2024132","DOIUrl":"https://doi.org/10.1051/medsci/2024132","url":null,"abstract":"<p><p>The therapeutic management of autoimmune myasthenia gravis in children presents several particularities, which motivate the optimization of therapeutic management. On the one hand, corticosteroids are recommended as first-line immunosuppressive therapy, despite their significant adverse effects on growth, behavior, bone development, etc. On the other hand, in the absence of clinical trials in children, the place of promising new immunosuppressive therapies remains ill-defined. Rituximab is the non-steroidal immunosuppressant most widely used in France for autoimmune myasthenia gravis in children. Its use, without standardization of practices or monitoring of efficacy and safety, remains non-consensual. The aim of this study is to propose a new role for rituximab in the management of autoimmune myasthenia in children.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 Hors série n° 1 ","pages":"22-25"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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