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[Protective effect of a CREB3 gain-offunction variant in amyotrophic lateral sclerosis]. CREB3增益功能变异在肌萎缩性侧索硬化症中的保护作用。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-03-01 Epub Date: 2026-03-20 DOI: 10.1051/medsci/2026027
Nathan Burt-Oberecken, Salim Megat, Caroline Rouaux
{"title":"[Protective effect of a CREB3 gain-offunction variant in amyotrophic lateral sclerosis].","authors":"Nathan Burt-Oberecken, Salim Megat, Caroline Rouaux","doi":"10.1051/medsci/2026027","DOIUrl":"https://doi.org/10.1051/medsci/2026027","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 3","pages":"234-237"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[How to classify living beings?] 如何给生物分类？］
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-03-01 Epub Date: 2026-03-20 DOI: 10.1051/medsci/2026042
Marc-André Selosse
{"title":"[How to classify living beings?]","authors":"Marc-André Selosse","doi":"10.1051/medsci/2026042","DOIUrl":"https://doi.org/10.1051/medsci/2026042","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 3","pages":"308-310"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[When organelle positioning drives tumor progression]. [当细胞器定位驱动肿瘤进展]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-03-01 Epub Date: 2026-03-20 DOI: 10.1051/medsci/2026033
Katerina Jerabkova-Roda, Vincent Hyenne, Jacky G Goetz
{"title":"[When organelle positioning drives tumor progression].","authors":"Katerina Jerabkova-Roda, Vincent Hyenne, Jacky G Goetz","doi":"10.1051/medsci/2026033","DOIUrl":"10.1051/medsci/2026033","url":null,"abstract":"<p><p>Long considered mere degradative compartments, lysosomes are now recognized as key regulators of metabolism, signaling, and tumor invasion. Here, we discuss how their intracellular localization controls their function, signaling, and secretion. In melanoma, the peripheral distribution of lysosomes promotes aggressiveness and metastasis. Similar changes exist in other types of cancer, highlighting the role of lysosomal trafficking as a factor in malignancy and as a promising biomarker for diagnosis and treatment.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 3","pages":"258-262"},"PeriodicalIF":0.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Assessing the risk-benefit balance of medicines: Some lessons from Covid-19]. [评估药物的风险-收益平衡：从Covid-19吸取的一些教训]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-03-01 Epub Date: 2026-03-20 DOI: 10.1051/medsci/2026040
Jean-Luc Cracowski, Mathieu Molimard, Vincent Richard, Matthieu Roustit, Charles Khouri
{"title":"[Assessing the risk-benefit balance of medicines: Some lessons from Covid-19].","authors":"Jean-Luc Cracowski, Mathieu Molimard, Vincent Richard, Matthieu Roustit, Charles Khouri","doi":"10.1051/medsci/2026040","DOIUrl":"10.1051/medsci/2026040","url":null,"abstract":"<p><p>The efficacy of medications is evaluated by clinical trials. However, such trials are not designed to assess adverse effects, particularly when those are rare. A robust pharmacovigilance system is therefore required to assess risks, supplemented as requested by pharmacoepidemiology studies. The benefits of medications are expressed in either relative or absolute terms and they vary depending on the baseline risk of the disease (its severity, potential complications, progression, and its incidence for the population-level benefits). This is not the case for adverse effects, which are influenced by the drug characteristics and the population receiving the treatment. In this context, can we truly balance the benefits and risks of medications? The experience of Covid-19 illustrates the complexity of this concept. It clearly highlights the need for a comprehensive approach, integrating analysis of clinical trials, pharmacovigilance monitoring, pharmacoepidemiology studies, and the detection of potential drug interactions. Finally, it is essential to inform and educate the general public about medications. This empowers individuals to accurately understand the complex concept of benefit-risk balance, prevents misleading over simplifications, and helps effectively counter misinformation.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 3","pages":"295-305"},"PeriodicalIF":0.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chromosome dispersion and clustering: the dual function of Ki67 during mitosis]. [染色体分散和聚集：Ki67在有丝分裂中的双重功能]。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-03-01 Epub Date: 2026-03-20 DOI: 10.1051/medsci/2026031
Olivier Albagli, Hélène Pelczar
{"title":"[Chromosome dispersion and clustering: the dual function of Ki67 during mitosis].","authors":"Olivier Albagli, Hélène Pelczar","doi":"10.1051/medsci/2026031","DOIUrl":"https://doi.org/10.1051/medsci/2026031","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 3","pages":"250-253"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pinocytosis and phagocytosis: eating and drinking…]. [嗜饮与吞噬：饮食…]。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-03-01 Epub Date: 2026-03-20 DOI: 10.1051/medsci/2026037
Hélène Gilgenkrantz
{"title":"[Pinocytosis and phagocytosis: eating and drinking…].","authors":"Hélène Gilgenkrantz","doi":"10.1051/medsci/2026037","DOIUrl":"https://doi.org/10.1051/medsci/2026037","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 3","pages":"306"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Palliative care: does the term need to be revised?] 缓和医疗：这个术语需要修改吗？］
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-03-01 Epub Date: 2026-03-20 DOI: 10.1051/medsci/2026038
Hélène Gilgenkrantz
{"title":"[Palliative care: does the term need to be revised?]","authors":"Hélène Gilgenkrantz","doi":"10.1051/medsci/2026038","DOIUrl":"https://doi.org/10.1051/medsci/2026038","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 3","pages":"307"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Metallophilic macrophages of the splenic marginal zone: myeloid sentinels capable of cross-priming CD8+ T cell antitumor immunity]. [脾边缘区嗜金属巨噬细胞：能够交叉启动CD8+ T细胞抗肿瘤免疫的髓系哨兵]。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-03-01 Epub Date: 2026-03-20 DOI: 10.1051/medsci/2026029
François-Xavier Mauvais, Peter van Endert
{"title":"[Metallophilic macrophages of the splenic marginal zone: myeloid sentinels capable of cross-priming CD8<sup>+</sup> T cell antitumor immunity].","authors":"François-Xavier Mauvais, Peter van Endert","doi":"10.1051/medsci/2026029","DOIUrl":"https://doi.org/10.1051/medsci/2026029","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 3","pages":"248-250"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Liver organoids: from promise to functional complexity]. [肝类器官：从前景到功能复杂性]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-03-01 Epub Date: 2026-03-20 DOI: 10.1051/medsci/2026035
Eléanor Luce, Jean-Charles Duclos-Vallée
{"title":"[Liver organoids: from promise to functional complexity].","authors":"Eléanor Luce, Jean-Charles Duclos-Vallée","doi":"10.1051/medsci/2026035","DOIUrl":"10.1051/medsci/2026035","url":null,"abstract":"<p><p>Recent advances in stem cell biology and tissue engineering have profoundly renewed the field of liver organoids. More mature and complex, they now incorporate functional canalicular networks, metabolic gradients, and co-cultures including cholangiocytes, stellate cells, and macrophages. Advances in vascularization, bioprinting, and microfluidics are improving their stability and functionality, thereby enhancing their usefulness for disease modeling, pharmacology, personalized medicine, and future therapeutic applications.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 3","pages":"270-279"},"PeriodicalIF":0.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Are we giving ourselves the means for an ambitious cancer prevention policy?] 我们是否为自己提供了一项雄心勃勃的癌症预防政策的手段？］
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-03-01 Epub Date: 2026-03-20 DOI: 10.1051/medsci/2026043
Marc Billaud
{"title":"[Are we giving ourselves the means for an ambitious cancer prevention policy?]","authors":"Marc Billaud","doi":"10.1051/medsci/2026043","DOIUrl":"https://doi.org/10.1051/medsci/2026043","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 3","pages":"221-222"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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