M S-medecine SciencesPub Date : 2024-10-01Epub Date: 2024-10-25DOI: 10.1051/medsci/2024110
Camille Cosson, Romane Riou, Bénédicte F Py
{"title":"[Functional diversity of NLRP3 gain-of-function mutations and impact on the diagnosis of CAPS hereditary auto-inflammation disease].","authors":"Camille Cosson, Romane Riou, Bénédicte F Py","doi":"10.1051/medsci/2024110","DOIUrl":"https://doi.org/10.1051/medsci/2024110","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 10","pages":"707-710"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S-medecine SciencesPub Date : 2024-10-01Epub Date: 2024-10-25DOI: 10.1051/medsci/2024109
Camille Bouchard, Kelly Godbout, Jacques P Tremblay
{"title":"[Correcting pathogenic mutations using prime editing: an overview].","authors":"Camille Bouchard, Kelly Godbout, Jacques P Tremblay","doi":"10.1051/medsci/2024109","DOIUrl":"https://doi.org/10.1051/medsci/2024109","url":null,"abstract":"<p><p>Gene editing is an ever-evolving field and Prime editing technology is among the latest ones. It makes it possible to modify a gene using a Cas9 nickase that cuts a single strand of DNA. This Cas9 nickase is fused with a reverse transcriptase that copies a single guide RNA synthetized by the researcher. This technique is used on one hand to create pathogenic mutations to obtain cell or animal models with a specific mutation. On the other hand, Prime editing is also used in research to treat hereditary diseases by correcting mutations associated with a pathogenic effect. The mode of delivery of the treatment to the affected cells in living organisms constitutes a main challenge. Different methods are studied to reach the organs specific to each disease. This review article presents the latest results in the field as well as the challenges to solve to optimize the possible uses of Prime editing.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 10","pages":"748-756"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S-medecine SciencesPub Date : 2024-10-01Epub Date: 2024-10-25DOI: 10.1051/medsci/2024123
Thanina Medjbeur, Jean Personnaz, Léon Kautz
{"title":"[FGL1 : a new target for the treatment of anemia ?]","authors":"Thanina Medjbeur, Jean Personnaz, Léon Kautz","doi":"10.1051/medsci/2024123","DOIUrl":"https://doi.org/10.1051/medsci/2024123","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 10","pages":"722-724"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S-medecine SciencesPub Date : 2024-10-01Epub Date: 2024-10-25DOI: 10.1051/medsci/2024116
Philippe Desprès, Dominique Salmon, Laurent Bellec, André Cabié, Marie-Lise Gougeon
{"title":"[The dengue vaccine: a major scientific challenge and a public health issue].","authors":"Philippe Desprès, Dominique Salmon, Laurent Bellec, André Cabié, Marie-Lise Gougeon","doi":"10.1051/medsci/2024116","DOIUrl":"https://doi.org/10.1051/medsci/2024116","url":null,"abstract":"<p><p>Almost half of the world's population is exposed to the risk of transmission of the four dengue virus serotypes (DENV 1-4), by mosquitoes of the genus Aedes. A dengue vaccine is effective if it induces prolonged protective immunity against all circulating viral strains, irrespective of the age and infection history of the vaccinated subject. An effective vaccine strategy against dengue is based on the injection of live attenuated viruses in a tetravalent formulation. In this review, we present the most promising candidate vaccines against dengue, their successes and also the questions raised by the correlates of protection that have been adopted to assess their level of effectiveness against the disease.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 10","pages":"737-747"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}