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[The first successes of the immuno-metabolic track in precision psychiatry]. [精确精神病学中免疫代谢轨迹的第一次成功]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025063
Ophélia Godin, Ariel Frajerman, Aiste Lengvenyte, Jeremy Bernard, Ana C Andreazza, Bruno Etain, Marion Leboyer
{"title":"[The first successes of the immuno-metabolic track in precision psychiatry].","authors":"Ophélia Godin, Ariel Frajerman, Aiste Lengvenyte, Jeremy Bernard, Ana C Andreazza, Bruno Etain, Marion Leboyer","doi":"10.1051/medsci/2025063","DOIUrl":"https://doi.org/10.1051/medsci/2025063","url":null,"abstract":"<p><p>Psychiatric disorders are associated with a high prevalence of cardiovascular and metabolic risk factors such as diabetes, obesity, and metabolic syndrome, as well as specific symptoms: hyperphagia, weight gain, hypersomnia, fatigue, and anhedonia. Non-pharmacological therapeutic strategies (exercise, Mediterranean or ketogenic diets) as well as pharmacological approaches, such as repositioning molecules (metformin or GLP1 receptor agonists), are available and could be proposed to these patients. In addition, targeting immuno-inflammatory pathways may be beneficial for these individuals.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"490-499"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Sleep health as a marker and target for health interventions in psychiatric disorders]. [睡眠健康作为精神疾病健康干预的标志和目标]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025065
Julien Coelho, Ludovic Samalin, Antoine Yrondi, Anton Iftimovici, Pierre Philip, Jean-Arthur Micoulaud-Franchi
{"title":"[Sleep health as a marker and target for health interventions in psychiatric disorders].","authors":"Julien Coelho, Ludovic Samalin, Antoine Yrondi, Anton Iftimovici, Pierre Philip, Jean-Arthur Micoulaud-Franchi","doi":"10.1051/medsci/2025065","DOIUrl":"https://doi.org/10.1051/medsci/2025065","url":null,"abstract":"<p><p>Psychiatric disorders (schizophrenia disorder, bipolar disorder, major depressive disorder, autism spectrum disorder) are characterized by complaints of insomnia or hypersomnolence associated with sleep disorder (e.g. obstructive sleep apnea syndrome) or an inappropriate sleep behavior (e.g. irregular sleep-wake cycle). These complaints, disorders, and behaviors define sleep health, a new public health concept that includes six dimensions: duration, regularity, temporality, efficiency, sleep satisfaction and daytime alertness. Sleep health is often impaired in psychiatric disorders, with numerous genetic, biological, anatomical and psychological arguments underpinning this interaction. Interventions aimed at improving sleep health show efficacy on the symptomatology and prognosis of these psychiatric disorders. The aim of this review is to analyze the place of sleep health as a marker and preferred therapeutic target of health in psychiatric disorders. The impact on more general mental health are not addressed.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"477-489"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Anhedonia: from clinical practice to biomarkers]. [快感缺乏症：从临床实践到生物标志物]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025062
Antoine Yrondi, Romain Rey, Linda Scoriels, Ophélia Godin, Marion Leboyer
{"title":"[Anhedonia: from clinical practice to biomarkers].","authors":"Antoine Yrondi, Romain Rey, Linda Scoriels, Ophélia Godin, Marion Leboyer","doi":"10.1051/medsci/2025062","DOIUrl":"https://doi.org/10.1051/medsci/2025062","url":null,"abstract":"<p><p>Anhedonia, a complex symptom, is characterized by a decrease in experience of pleasure, reduced motivation, and/or impaired reward learning. Although these aspects are often linked to dopaminergic pathways, recent research shows that immuno-inflammatory alterations present in psychiatric disorders may also play a role, affecting dopaminergic, glutamatergic, and opioid pathways, as well as cellular immune responses (such as the mTOR pathway). These perturbations, through inflammation in the central nervous system, affect reward and motor circuits, contributing to the anhedonia and the psychomotor slowing that are often-associated. Animal models show that chronic inflammation can reduce motivation, providing a preclinical model for anhedonia. This dysfunction is not specific to a single pathology but is common to a variety ofpsychiatric disorders, including psychotic, mood, and neurodevelopmental disorders. These common dimensions of anhedonia across different pathologies open up perspects for targeted treatments, including dopaminergic treatments, glutamatergic treatments (such as ketamine), anti-inflammatory therapies, and the development of new molecules.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"425-433"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Building precision psychiatry: why and how?] [建立精确精神病学：为什么？如何？]]
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025072
Boris Chaumette, Antoine Yrondi, Ophélia Godin, Marie-Odile Krebs, Laurent Boyer, Ludovic Samalin, Pierre-Michel Llorca, Marion Leboyer
{"title":"[Building precision psychiatry: why and how?]","authors":"Boris Chaumette, Antoine Yrondi, Ophélia Godin, Marie-Odile Krebs, Laurent Boyer, Ludovic Samalin, Pierre-Michel Llorca, Marion Leboyer","doi":"10.1051/medsci/2025072","DOIUrl":"https://doi.org/10.1051/medsci/2025072","url":null,"abstract":"<p><p>Precision psychiatry aims to identify homogeneous subgroups of patients using biomarkers, which could revolutionize current diagnostic frameworks and raise hopes for personalized treatments. Early examples in neuropsychiatry demonstrate the feasibility of this approach, such as the reclassification of dementias in neurology based on biomarkers such as amyloid plaques and tau proteins, and significant advances in neurodevelopmental disorders such as autism, where genetic heterogeneity has reshaped diagnostic perspectives. To achieve this vision, major challenges must be overcome, including the establishment of large transdiagnostic cohorts, the integration of multimodal data such as imaging, genomics, or digital phenotyping, and the application of advanced statistical methods such as clustering, normative modeling and digital twins. While this strategy promises more precise and effective care tailored to individual needs, it also challenges traditional classifications and forces the psychiatric community to rethink its foundational paradigms in light of biological knowledge.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"416-424"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Sensory anomalies: an objective and quantifiable dimension in mental health]. [感觉异常：心理健康的客观和可量化维度]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025070
Anouck Amestoy, Jasmina Mallet, Anton Iftimovici, Aline Lefebvre, Florian Stéphan
{"title":"[Sensory anomalies: an objective and quantifiable dimension in mental health].","authors":"Anouck Amestoy, Jasmina Mallet, Anton Iftimovici, Aline Lefebvre, Florian Stéphan","doi":"10.1051/medsci/2025070","DOIUrl":"https://doi.org/10.1051/medsci/2025070","url":null,"abstract":"<p><p>Sensory anomalies, which are trans-diagnostic in mood disorders, autism spectrum disorders, and schizophrenia, affect social interactions, behaviors, and cognitive functions. Affecting multiple sensory channels (auditory, visual, olfactory), they appear to be central to these pathologies. Animal models, which reveal glutamate-GABA imbalances associated with cognitive alterations and excitation/inhibition dysregulation, facilitate the transfer of findings to humans through the applicability of the paradigms. The French Minds cohort, which studies brain mechanism using clinical tools, functional magnetic resonance imaging and electroencephalogram, is exploring these dimensions to redefine diagnostic and personalized therapeutic approaches to these disorders.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"469-476"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Neurophysiology of psychiatric disorders: building a national high-density electroencephalography platform]. [精神障碍神经生理学：构建国家高密度脑电图平台]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025076
Anton Iftimovici, Mahmoud Hassan, David M Alexander, Laura Dugué, Martine Gavaret, Renaud Jardri, Aline Lefebvre
{"title":"[Neurophysiology of psychiatric disorders: building a national high-density electroencephalography platform].","authors":"Anton Iftimovici, Mahmoud Hassan, David M Alexander, Laura Dugué, Martine Gavaret, Renaud Jardri, Aline Lefebvre","doi":"10.1051/medsci/2025076","DOIUrl":"10.1051/medsci/2025076","url":null,"abstract":"<p><p>The PEPR PROPSY EEG-MIND project aims to develop transdiagnostic EEG biomarkers for psychiatric disorders, such as autism, schizophrenia and mood disorders. It combines experimental tasks (rest, mismatch negativity, sensori-motor, audiovisual) to study brain connectivity and neurophysiological abnormalities at the individual level. The aim is to identify markers of oscillatory anomalies, excitation/inhibition ratio, wave propagation and connectivity, and then apply normative models to highlight specific neurocognitive profiles associated to the underlying neurophysiology, which could benefit from personalized targeted approaches such as neuromodulation.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"516-524"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Towards precision psychiatry?] [走向精确精神病学？]
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025073
Robert Dantzer
{"title":"[Towards precision psychiatry?]","authors":"Robert Dantzer","doi":"10.1051/medsci/2025073","DOIUrl":"https://doi.org/10.1051/medsci/2025073","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"407-408"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A dimensional approach to negative symptoms in psychiatric disorders]. [对精神疾病中阴性症状的维度分析]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025068
Jasmina Mallet, Baptiste Pignon, Stefan Kaiser, Federico Cevoli
{"title":"[A dimensional approach to negative symptoms in psychiatric disorders].","authors":"Jasmina Mallet, Baptiste Pignon, Stefan Kaiser, Federico Cevoli","doi":"10.1051/medsci/2025068","DOIUrl":"10.1051/medsci/2025068","url":null,"abstract":"<p><p>Negative symptoms play a central role in psychiatric disorders, including schizophrenia, bipolar, autism spectrum disorder, and depression. These symptoms, which include social withdrawal, anhedonia, avolition, alogia, and blunted affect, are often difficult to treat and are overlooked in comparison to positive symptoms such as hallucinations. However, their impact on patients' quality of life and long-term functional outcomes warrants in-depth exploration. The transdiagnostic approach makes it possible to study of these symptoms beyond traditional clinical categories. The SNS scale will be used in the French Mind cohort to analyse the prevalence of negative symptoms in the general population and in people with psychiatric disorders. Digital and psychosocial therapies are showing promising results, paving the way for more personalized and effective treatments.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"434-442"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cognitive flexibility: a key cognitive dimension]. [认知灵活性：关键的认知维度]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025075
Corentin J Gosling, Ariane Cartigny, Linda Scoriels, Céline Portalier, Charles Laidi, Jasmina Mallet
{"title":"[Cognitive flexibility: a key cognitive dimension].","authors":"Corentin J Gosling, Ariane Cartigny, Linda Scoriels, Céline Portalier, Charles Laidi, Jasmina Mallet","doi":"10.1051/medsci/2025075","DOIUrl":"https://doi.org/10.1051/medsci/2025075","url":null,"abstract":"<p><p>Cognitive flexibility, an essential executive function, allows adaptation to environmental changes and represents a fundamental pillar of executive function in neuropsychological models. Based on neurobiological advances and clinical observations, it has emerged as a promising transdiagnostic marker for several psychiatric pathologies, including mood disorders, schizophrenia, and autism spectrum disorders. This review examines the specific role of cognitive flexibility among other cognitive functions, explores potential therapeutic approaches, and presents its evaluation in human and animal models as part of PEPR PROPSY. As the chapters unfold, readers will deepen their understanding of cognitive flexibility while discovering promising avenues for both assessment methods and intervention strategies.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"443-450"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The research program in precision psychiatry (PEPR PROPSY), issues and challenges]. [精准精神病学研究项目（PEPR PROPSY），问题与挑战]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025064
Marion Leboyer, Pierre-Michel Llorca
{"title":"[The research program in precision psychiatry (PEPR PROPSY), issues and challenges].","authors":"Marion Leboyer, Pierre-Michel Llorca","doi":"10.1051/medsci/2025064","DOIUrl":"10.1051/medsci/2025064","url":null,"abstract":"<p><p>Current psychiatry, based on categorical descriptions of diagnostic entities, defined by international diagnostic manuals, is moving from this \"one size fits all\" strategy to a \"precision psychiatry\" that aims to be clinically informed by a dimensional, transdiagnostic perspective enriched by the use of objective, quantifiable and continuous markers such as omics, brain imaging, environmental and lifestyle variability of each individual. By recognizing the heterogeneity of existing categorical diagnostic entities, determined by the underlying biology, this approach aims to improve patient care. Precision medicine can be used to characterize and identify individuals with or at risk for a disorder, predict their prognosis, and make more specific choices of treatment strategies such as medications, psychological interventions, lifestyle rules, and/or brain stimulation, thereby improving prognosis and cost-effectiveness of the treatments.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"411-415"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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