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[Myonuclear domain settings by microtubules and MACF1]. [通过微管和 MACF1 设置肌核域]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024134
Alireza Ghasemizadeh, Vincent Gache
{"title":"[Myonuclear domain settings by microtubules and MACF1].","authors":"Alireza Ghasemizadeh, Vincent Gache","doi":"10.1051/medsci/2024134","DOIUrl":"https://doi.org/10.1051/medsci/2024134","url":null,"abstract":"<p><p>Skeletal myofibers are syncytia made from the fusion of dozens or hundreds of mononuclear progenitor cells. Along myogenesis, the arriving nuclei from the progenitor cells have a long journey before being positioned at the periphery of a mature myofiber. Once at the periphery, nuclei are regularly spaced and each nucleus is transcriptionally responsible for its surrounding proportion of cytoplasm, known as the myonuclear domain. Disruption of these domains can be observed in various myopathies, suggesting their importance for skeletal muscle functionality. However, little is known about mechanisms regulating the myonuclear domain stability and organization. Here we take the example of MACF1, a microtubule-associated protein, as an essential actor in myonuclear domain organization, to highlight the potential role of microtubules and their associated proteome network for the stability of these domains and hence for proper myofiber functionality.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Force-Velocity-Endurance (FoVE) Model: a new method for functional striated skeletal muscle in situ evaluation in murine models]. [力-速度-耐力（FoVE）模型：在小鼠模型中原位评估横纹骨骼肌功能的新方法]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024137
Maximilien Bowen, Christophe Hourdé, Anne-Cécile Durieux, Damien Freyssenet, Pierre Samozino, Baptiste Morel
{"title":"[Force-Velocity-Endurance (FoVE) Model: a new method for functional striated skeletal muscle in situ evaluation in murine models].","authors":"Maximilien Bowen, Christophe Hourdé, Anne-Cécile Durieux, Damien Freyssenet, Pierre Samozino, Baptiste Morel","doi":"10.1051/medsci/2024137","DOIUrl":"https://doi.org/10.1051/medsci/2024137","url":null,"abstract":"<p><p>The FoVE model is a new theoretical framework coupled with innovative modeling to evaluate the striated skeletal muscle function. The theoretical model is based on two fundamental relationships: the force-velocity relationship and the force-time relationship. These relationships describe the muscle force production capacity as a function of contraction velocity and exercise duration, respectively. By combining them, the FoVE model offers a comprehensive view of the muscle functional capacities at various velocities, with and without fatigue. A unique experimental protocol has been developed using an isokinetic force measurement system to obtain the FoVE parameters of the model. This protocol enables muscle force to be measured at various contraction velocities for a total duration of 3 minutes. Applied to mouse model, the results obtained with the FoVE model show significant differences in the functional capacity of the tibialis anterior muscle. Females have a higher normalized initial maximal force. Conversely, males have a higher initial maximum velocity capacity under fatigue conditions. This approach provides a comprehensive mapping of muscle function, surpassing traditional assessments of isometric strength. It can be applied to basic research in pre-clinical models and translational research in humans.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Tamoxifen, a high-potential molecule to treat all centronuclear myopathies]. [他莫昔芬，治疗所有中心核肌病的高潜力分子]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024130
Charlotte Gineste, Jocelyn Laporte
{"title":"[Tamoxifen, a high-potential molecule to treat all centronuclear myopathies].","authors":"Charlotte Gineste, Jocelyn Laporte","doi":"10.1051/medsci/2024130","DOIUrl":"https://doi.org/10.1051/medsci/2024130","url":null,"abstract":"<p><p>Centronuclear myopathies are rare congenital disorders characterized by muscle weakness and mislocalization of organelles. The main genes associated to these muscle diseases are MTM1, DNM2, BIN1 and RYR1. To date, no therapy is available. Nevertheless, tamoxifen, a pharmacological compound already used in clinics for breast cancer, showed beneficial effects on the muscle phenotypes in mouse models for centronuclear myopathies. Here, the effects of tamoxifen on muscle phenotypes will be compared in the various forms of this muscle disease.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Parasport and neuromuscular diseases]. [Parasport 和神经肌肉疾病]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024163
Orianne Lopez
{"title":"[Parasport and neuromuscular diseases].","authors":"Orianne Lopez","doi":"10.1051/medsci/2024163","DOIUrl":"https://doi.org/10.1051/medsci/2024163","url":null,"abstract":"<p><p>The benefits of physical activity, on an organic and psychological level, have been demonstrated. In patients suffering from a neuromuscular disease, adapted physical activity and parasport are also means of combating a sedentary lifestyle which adds to that imposed by the disease. Whatever the motor skills of the subject, whether he walks or not, whether he has good upper limb strength or only minimal preserved distal function, a parasport can be practiced. Indeed certain disciplines are possible for patients with very weak motor functions. One of the missions of those involved in the life course of the person suffering from a neuromuscular disease is to talk about this subject. It is essential to make the patient, from a very young age, and their caregivers aware of this field of possibilities and its importance - all respecting possible contraindications or partial incapacities. Supporting a parasport practice means having to \"get out of the hospital\" and interact with local collaborators, to facilitate orientation, organize the initiation and introduction of the activity in the daily life of the patient. The time given to the patient and his caregivers to address this subject and guide them illustrates the overall care for this patient and the concern for his inclusion and his physical and mental health.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The pangenome integrates the vast genetic diversity of the human population]. [庞基因组整合了人类巨大的遗传多样性]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024126
Louise Benarroch
{"title":"[The pangenome integrates the vast genetic diversity of the human population].","authors":"Louise Benarroch","doi":"10.1051/medsci/2024126","DOIUrl":"https://doi.org/10.1051/medsci/2024126","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The SFM and the myology… in Olympic form!] [奥林匹克形式的 "SFM "和 "Myology"！]
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024159
Bénédicte Chazaud, Cyril Gitiaux
{"title":"[The SFM and the myology… in Olympic form!]","authors":"Bénédicte Chazaud, Cyril Gitiaux","doi":"10.1051/medsci/2024159","DOIUrl":"https://doi.org/10.1051/medsci/2024159","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[From gene to cell: Functional validation of RYR1 variants]. [从基因到细胞：RYR1 变体的功能验证]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024135
Robin Reynaud Dulaurier, Julie Brocard, John Rendu, Nagi Debbah, Julien Fauré, Isabelle Marty
{"title":"[From gene to cell: Functional validation of RYR1 variants].","authors":"Robin Reynaud Dulaurier, Julie Brocard, John Rendu, Nagi Debbah, Julien Fauré, Isabelle Marty","doi":"10.1051/medsci/2024135","DOIUrl":"https://doi.org/10.1051/medsci/2024135","url":null,"abstract":"<p><p>Genetic screening of rare diseases allows identification of the responsible gene(s) in about 50% of patients. The remaining cases are in a diagnostic deadlock as current knowledge fails to identify the correct gene or determine if the detected variant on the gene is pathogenic. These are named \"variants of unknown significance\" (VUS). In the case of neuromuscular diseases, the RYR1 gene is often implicated, with the majority of variants classified as VUS, requiring reliable classification to help patient diagnosis. Our project aims to create an efficient classification pipeline, integrating artificial intelligence, structural biology data, and functional analyses to enhance genetic diagnosis of RYR1-related diseases.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Metabolic dysfunctions in type I myotonic dystrophy: A potential therapeutic target]. [I 型肌营养不良症的代谢功能障碍：潜在的治疗目标]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024129
Lola Lessard, Laure Gallay, Rémi Mounier
{"title":"[Metabolic dysfunctions in type I myotonic dystrophy: A potential therapeutic target].","authors":"Lola Lessard, Laure Gallay, Rémi Mounier","doi":"10.1051/medsci/2024129","DOIUrl":"https://doi.org/10.1051/medsci/2024129","url":null,"abstract":"<p><p>Myotonic dystrophy type I (DM1) is a genetic disease characterized by a multisystemic RNA metabolism dysregulation and splicing toxicity. Numerous signaling pathways are deregulated, and especially AMPK, a key sensor and regulator of cellular metabolism. To restore AMPK signaling activity in DM1 muscle tissue and cells could improve mitochondrial biogenesis and dynamics, mitophagy and oxidative stress, energy production and, in fine, skeletal muscle tissue homeostasis.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Therapeutic perspectives for lysosomal storage disorders caused by acid ceramidase deficiency]. [酸性神经酰胺酶缺乏引起的溶酶体贮积症的治疗前景]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024162
Marion Derome, Jérôme Denard, Martina Marinello, Thierry Levade, Odile Boespflug-Tanguy, Ana Buj-Bello
{"title":"[Therapeutic perspectives for lysosomal storage disorders caused by acid ceramidase deficiency].","authors":"Marion Derome, Jérôme Denard, Martina Marinello, Thierry Levade, Odile Boespflug-Tanguy, Ana Buj-Bello","doi":"10.1051/medsci/2024162","DOIUrl":"https://doi.org/10.1051/medsci/2024162","url":null,"abstract":"<p><p>Farber disease and spinal muscular atrophy with progressive myoclonic epilepsy are two ultra-rare lysosomal storage disorders resulting from loss-of-function mutations in the ASAH1 gene encoding for acid ceramidase (ACDase). ACDase deficiency leads to the intracellular accumulation of ceramides with an inflammatory response in tissues. These two diseases manifest differently but are part of a clinical continuum with variable severity affecting the nervous system and/or peripheral tissues, including the neuromuscular system. To date, no specific or curative treatments are available for patients affected by acid ceramidase deficiency. Here, we summarize the clinical features, enzyme function, mouse models and therapeutic perspectives for these allelic diseases.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Benefit of treatment with rituximab in autoimmune myasthenia gravis in children]. [利妥昔单抗治疗儿童自身免疫性肌无力症的益处]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024132
Agathe Molimard, Cyril Gitiaux, Christine Barnerias, Frédérique Audic, Arnaud Isapof, Ulrike Walther-Louvier, Claude Cances, Caroline Espil-Taris, Davion Jean-Baptiste, Susana Quijano-Roy, Coraline Grisel, Brigitte Chabrol, Isabelle Desguerre
{"title":"[Benefit of treatment with rituximab in autoimmune myasthenia gravis in children].","authors":"Agathe Molimard, Cyril Gitiaux, Christine Barnerias, Frédérique Audic, Arnaud Isapof, Ulrike Walther-Louvier, Claude Cances, Caroline Espil-Taris, Davion Jean-Baptiste, Susana Quijano-Roy, Coraline Grisel, Brigitte Chabrol, Isabelle Desguerre","doi":"10.1051/medsci/2024132","DOIUrl":"https://doi.org/10.1051/medsci/2024132","url":null,"abstract":"<p><p>The therapeutic management of autoimmune myasthenia gravis in children presents several particularities, which motivate the optimization of therapeutic management. On the one hand, corticosteroids are recommended as first-line immunosuppressive therapy, despite their significant adverse effects on growth, behavior, bone development, etc. On the other hand, in the absence of clinical trials in children, the place of promising new immunosuppressive therapies remains ill-defined. Rituximab is the non-steroidal immunosuppressant most widely used in France for autoimmune myasthenia gravis in children. Its use, without standardization of practices or monitoring of efficacy and safety, remains non-consensual. The aim of this study is to propose a new role for rituximab in the management of autoimmune myasthenia in children.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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