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[Towards using pseudo-prions against neurodegenerative diseases]. 用伪朊病毒治疗神经退行性疾病的研究
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025055
Marc Dhenain, Marina Celestine, Muriel Jacquier-Sarlin, Alain Buisson
{"title":"[Towards using pseudo-prions against neurodegenerative diseases].","authors":"Marc Dhenain, Marina Celestine, Muriel Jacquier-Sarlin, Alain Buisson","doi":"10.1051/medsci/2025055","DOIUrl":"https://doi.org/10.1051/medsci/2025055","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"318-320"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Eclipse of science]. [科学的衰落]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025074
Alain Fischer
{"title":"[Eclipse of science].","authors":"Alain Fischer","doi":"10.1051/medsci/2025074","DOIUrl":"https://doi.org/10.1051/medsci/2025074","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"303-304"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Has the Holy Grail of humanized mice been found ?] [人类化老鼠的圣杯找到了吗？]
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025050
Marie Naturel, Gilles Marodon
{"title":"[Has the Holy Grail of humanized mice been found ?]","authors":"Marie Naturel, Gilles Marodon","doi":"10.1051/medsci/2025050","DOIUrl":"https://doi.org/10.1051/medsci/2025050","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"308-309"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Increasing social inequalities in quality of life after early breast cancer]. [早期乳腺癌后生活质量的社会不平等加剧]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025041
Gwenn Menvielle, José Luis Sandoval
{"title":"[Increasing social inequalities in quality of life after early breast cancer].","authors":"Gwenn Menvielle, José Luis Sandoval","doi":"10.1051/medsci/2025041","DOIUrl":"https://doi.org/10.1051/medsci/2025041","url":null,"abstract":"<p><p>Using data from the French CANTO cohort (n=5,915), we assessed the socioeconomic inequalities in quality of life after breast cancer and their time trends over two years after diagnosis. Socioeconomic position was measured using self-reported financial difficulties. Quality of life was assessed with the QLQ-C30 summary score. Social inequalities were quantified using the slope index of inequality (SII). Social inequalities in QLQ-C30 summary score at baseline were observed after adjustment for age at diagnosis, Charlson Comorbidity Index, disease stage, and treatment. These inequalities significantly increased in year 1 and year 2 postdiagnosis.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"380-383"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[From brain mosaicism to epilepsy: toward a novel targeted therapeutic strategy]. [从大脑嵌合到癫痫：一种新的靶向治疗策略]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025053
Théo Ribierre, Stéphanie Baulac
{"title":"[From brain mosaicism to epilepsy: toward a novel targeted therapeutic strategy].","authors":"Théo Ribierre, Stéphanie Baulac","doi":"10.1051/medsci/2025053","DOIUrl":"https://doi.org/10.1051/medsci/2025053","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"316-318"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Nobel Prize in chemistry 2024: David Baker, Demis Hassabis et John M. Jumper. The revolution of artificial intelligence in structural biology]. 2024年诺贝尔化学奖：大卫·贝克、戴米斯·哈萨比斯和约翰·m·跳普。人工智能在结构生物学中的革命]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025060
Stéphanie Aguéro-Pizzolo, Emmanuel Bettler, Patrice Gouet
{"title":"[Nobel Prize in chemistry 2024: David Baker, Demis Hassabis et John M. Jumper. The revolution of artificial intelligence in structural biology].","authors":"Stéphanie Aguéro-Pizzolo, Emmanuel Bettler, Patrice Gouet","doi":"10.1051/medsci/2025060","DOIUrl":"https://doi.org/10.1051/medsci/2025060","url":null,"abstract":"<p><p>The 2024 Nobel Prize in chemistry has been awarded to Demis Hassabis and John M. Jumper (Google DeepMind) for the development of artificial intelligence-guided protein structure prediction and to David Baker (University of Washington, Seattle, USA) for the development of computational protein design. This event marks a revolution in the field of structural biology that has led, among other things, to the generation of a library of nearly 200 million predicted protein structures designed to speed up research. This revolution in AI has also led to the design of several artificial proteins of medical interest presented in this review.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"367-373"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Medical nomadism: from past to present]. 医学游牧：从过去到现在。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025043
Anne-Marie Moulin
{"title":"[Medical nomadism: from past to present].","authors":"Anne-Marie Moulin","doi":"10.1051/medsci/2025043","DOIUrl":"https://doi.org/10.1051/medsci/2025043","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"392-393"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cellular models used to study the pathogenesis associated with ocular inflammation in the anterior part of the eye]. [用于研究眼部前部炎症发病机制的细胞模型]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025046
Gabrielle Raîche-Marcoux, Sylvain Guérin, Élodie Boisselier
{"title":"[Cellular models used to study the pathogenesis associated with ocular inflammation in the anterior part of the eye].","authors":"Gabrielle Raîche-Marcoux, Sylvain Guérin, Élodie Boisselier","doi":"10.1051/medsci/2025046","DOIUrl":"https://doi.org/10.1051/medsci/2025046","url":null,"abstract":"<p><p>Several multifactorial pathologies in ophthalmology that affect the anterior segment of the eye are partly inflammatory. To better understand the role and impact of inflammation in dry eye and corneal healing, many research teams have used in vitro models to mimic different aspects of these diseases. Several in vitro models have been developed to elucidate the signaling cascades involved in pathogenesis. They also offer the experimental flexibility to adjust environmental parameters, facilitating the validation of innovative therapies and the identification of new pharmacological targets. This review focuses on two-dimensional in vitro models, but also highlights the progress made in 3D models obtained by tissue engineering, which mimic inflammation in these ocular pathologies. The origin of the cells (human or animal), their tissue source, the type of cells (epithelial, endothelial, vascular, conjunctival), as well as the various experimental conditions used to mimic an inflammatory aspect according to the stages of progression of these pathologies, are thoroughly reported in this review of the literature.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"327-335"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Sepsis-trained macrophages promote antitumoral tissue-resident T cells]. [脓毒症训练的巨噬细胞促进抗肿瘤组织驻留T细胞]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025056
Jérémie Poschmann, Alexis Broquet, Antoine Roquilly
{"title":"[Sepsis-trained macrophages promote antitumoral tissue-resident T cells].","authors":"Jérémie Poschmann, Alexis Broquet, Antoine Roquilly","doi":"10.1051/medsci/2025056","DOIUrl":"https://doi.org/10.1051/medsci/2025056","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"321-323"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Matilda effect]. [玛蒂尔达效应]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025054
Anna Salvetti
{"title":"[The Matilda effect].","authors":"Anna Salvetti","doi":"10.1051/medsci/2025054","DOIUrl":"https://doi.org/10.1051/medsci/2025054","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"385"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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