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[The universal review of health and pandemic preparedness: a new mechanism at WHO]. [普遍审查卫生和大流行病防范：世卫组织的新机制]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-06-01 Epub Date: 2025-07-07 DOI: 10.1051/medsci/2025082
Nathalie Odounlami Beugger
{"title":"[The universal review of health and pandemic preparedness: a new mechanism at WHO].","authors":"Nathalie Odounlami Beugger","doi":"10.1051/medsci/2025082","DOIUrl":"https://doi.org/10.1051/medsci/2025082","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"593-595"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Epistasis]. (上位)。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-06-01 Epub Date: 2025-07-07 DOI: 10.1051/medsci/2025078
Hélène Gilgenkrantz
{"title":"[Epistasis].","authors":"Hélène Gilgenkrantz","doi":"10.1051/medsci/2025078","DOIUrl":"https://doi.org/10.1051/medsci/2025078","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"601"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Gene editing by direct delivery of Cas9 protein in the retina]. [通过在视网膜中直接递送Cas9蛋白进行基因编辑]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-06-01 Epub Date: 2025-07-07 DOI: 10.1051/medsci/2025091
Hugo Malki, Juliette Pulman, Deniz Dalkara
{"title":"[Gene editing by direct delivery of Cas9 protein in the retina].","authors":"Hugo Malki, Juliette Pulman, Deniz Dalkara","doi":"10.1051/medsci/2025091","DOIUrl":"https://doi.org/10.1051/medsci/2025091","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"540-542"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pierre Tiollais (1934-2024), a pioneer in genetic engineering with a lifelong commitment to the hepatitis B virus]. 皮埃尔·蒂奥莱（Pierre Tiollais, 1934-2024），终身致力于乙肝病毒研究的基因工程先驱。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-06-01 Epub Date: 2025-07-07 DOI: 10.1051/medsci/2025079
Christian Bréchot, Patrick Charnay, Hugues de Thé, Anne Dejean, Marie-Louise Michel, Pascal Pineau, Pierre Sonigo, Simon Wain-Hobson, Yu Wei, Jean Weissenbach
{"title":"[Pierre Tiollais (1934-2024), a pioneer in genetic engineering with a lifelong commitment to the hepatitis B virus].","authors":"Christian Bréchot, Patrick Charnay, Hugues de Thé, Anne Dejean, Marie-Louise Michel, Pascal Pineau, Pierre Sonigo, Simon Wain-Hobson, Yu Wei, Jean Weissenbach","doi":"10.1051/medsci/2025079","DOIUrl":"https://doi.org/10.1051/medsci/2025079","url":null,"abstract":"<p><p>Pierre Tiollais, a French physician-biologist, died on August 5, 2024, at 89. He is celebrated for cloning and sequencing the hepatitis B virus (HBV) genome and developing one of the first recombinant HBV vaccines. Professor at the Pasteur Institute and the University Paris VII (now University Paris Cité), Pierre Tiollais has played a key role in the application of molecular biology and genetic engineering in medical research, notably in the fight against HBV and human immunodeficiency virus (HIV). His work has helped saving millions of lives through vaccination campaigns. Pierre Tiollais was also renowned for his benevolent mentorship and commitment to the scientific community.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"596-600"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cellular RNA-binding proteins during viral infection: known factors and new approaches to identify novel targets]. [病毒感染过程中的细胞rna结合蛋白：已知因素和识别新靶标的新方法]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-06-01 Epub Date: 2025-07-07 DOI: 10.1051/medsci/2025094
Charline Pasquier, Sébastien Pfeffer, Erika Girardi
{"title":"[Cellular RNA-binding proteins during viral infection: known factors and new approaches to identify novel targets].","authors":"Charline Pasquier, Sébastien Pfeffer, Erika Girardi","doi":"10.1051/medsci/2025094","DOIUrl":"https://doi.org/10.1051/medsci/2025094","url":null,"abstract":"<p><p>Viruses are obligate intracellular parasites that rely heavily on host components and metabolism to replicate their genome. Most of the emerging viruses responsible for recent epidemic have an RNA genome. This viral RNA serves both as a template for replication and as a messenger for the production of viral proteins. Interactions between viral RNA and host RNA-binding proteins play a crucial role in viral replication and immune evasion. Some RNA-binding proteins act as antiviral factors by recognizing and restricting foreign viral RNA, while others, once hijacked by the virus, support its replication. Identification these viral RNA-protein interactions is essential for the development of new antiviral strategies. This review explores the role of cellular RNA-binding proteins in the recognition, modification, and degradation of viral RNA, focusing on pathogenic human RNA viruses and new technologies for studying these interactions.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"561-569"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical trials « off-piste »?] [临床试验«越野»？］
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-06-01 Epub Date: 2025-07-07 DOI: 10.1051/medsci/2025080
Anne-Marie Moulin
{"title":"[Clinical trials « off-piste »?]","authors":"Anne-Marie Moulin","doi":"10.1051/medsci/2025080","DOIUrl":"https://doi.org/10.1051/medsci/2025080","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"605-606"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Acquisition of epithelial plasticity in human chronic liver disease]. [人慢性肝病中上皮可塑性的获得]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-06-01 Epub Date: 2025-07-07 DOI: 10.1051/medsci/2025089
Maïa Pesic, Ludovic Vallier, Dylan Liabeuf
{"title":"[Acquisition of epithelial plasticity in human chronic liver disease].","authors":"Maïa Pesic, Ludovic Vallier, Dylan Liabeuf","doi":"10.1051/medsci/2025089","DOIUrl":"https://doi.org/10.1051/medsci/2025089","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"551-554"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[DNA methylation profiling or the future of neuro-oncology?] DNA甲基化分析还是神经肿瘤学的未来？］
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-06-01 Epub Date: 2025-07-07 DOI: 10.1051/medsci/2025095
Alix Fontaine, Laëtitia Basset, Joris Argentin, Audrey Rousseau
{"title":"[DNA methylation profiling or the future of neuro-oncology?]","authors":"Alix Fontaine, Laëtitia Basset, Joris Argentin, Audrey Rousseau","doi":"10.1051/medsci/2025095","DOIUrl":"https://doi.org/10.1051/medsci/2025095","url":null,"abstract":"<p><p>Diagnosis of central nervous system tumors is based on the histopathologic features and molecular alterations. For certain entities, this histomolecular diagnosis now includes DNA methylation profiles. Methylation profiles reflect the cell of origin and epigenetic modifications that occur during tumorigenesis and may help classify central nervous system tumors via artificial intelligence algorithms. This powerful approach to tumor classification has revolutionized the field of neuro-oncology, allowing more reliable diagnosis and prognostic assessment, particularly for pediatric neoplasms. The analysis of methylation profiles currently requires data to be shared with the developer of the AI algorithms. As DNA methylation profiling may be useful in a growing number of cancers, local alternatives, such as those based on the nanopore technology, need to be developed.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"570-577"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A common health: antidote to excess, dumping and fake]. 【共同养生：解药过量、倾销与假冒】。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-06-01 Epub Date: 2025-07-07 DOI: 10.1051/medsci/2025077
Ioan Negrutiu
{"title":"[A common health: antidote to excess, dumping and fake].","authors":"Ioan Negrutiu","doi":"10.1051/medsci/2025077","DOIUrl":"https://doi.org/10.1051/medsci/2025077","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"602-604"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Administration timing may improve the anti-tumor efficacy of immunotherapies]. [给药时机可提高免疫疗法的抗肿瘤疗效]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-06-01 Epub Date: 2025-07-07 DOI: 10.1051/medsci/2025087
Annabelle Ballesta
{"title":"[Administration timing may improve the anti-tumor efficacy of immunotherapies].","authors":"Annabelle Ballesta","doi":"10.1051/medsci/2025087","DOIUrl":"https://doi.org/10.1051/medsci/2025087","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"547-550"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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