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[Drug repurposing to combat viral infectious diseases: principles and illustration with Prozac®]. [药物再利用以对抗病毒性传染病：百忧解®的原理和说明]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-08-01 Epub Date: 2026-09-14 DOI: 10.1051/medsci/2026123
Marine O Faucher, Karine Barral, Bruno Coutard
{"title":"[Drug repurposing to combat viral infectious diseases: principles and illustration with Prozac<sup>®</sup>].","authors":"Marine O Faucher, Karine Barral, Bruno Coutard","doi":"10.1051/medsci/2026123","DOIUrl":"https://doi.org/10.1051/medsci/2026123","url":null,"abstract":"<p><p>Drug repurposing represents a strategic approach aimed at accelerating the development of treatments against viral infections. This review presents three repurposing strategies, illustrated with therapeutic compounds notably fluoxetine (Prozac<sup>®</sup>), a selective serotonin reuptake inhibitor antidepressant that also exhibits several antiviral mechanisms of action. The examples discussed in this review highlight both the potential and the limitations of drug repurposing, particularly in a \"plug-and-play\" approach.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 8-9","pages":"691-700"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Blocking the transmission of malaria using transgenic mosquitoes]. [利用转基因蚊子阻止疟疾的传播]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-08-01 Epub Date: 2026-09-14 DOI: 10.1051/medsci/2026116
Stéphanie Blandin, Chen-An Yeh, Asrar Ba-Ashn, Arnaud Chêne
{"title":"[Blocking the transmission of malaria using transgenic mosquitoes].","authors":"Stéphanie Blandin, Chen-An Yeh, Asrar Ba-Ashn, Arnaud Chêne","doi":"10.1051/medsci/2026116","DOIUrl":"https://doi.org/10.1051/medsci/2026116","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 8-9","pages":"657-660"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Why species do not really exist]. [为什么物种并不真正存在]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-08-01 Epub Date: 2026-09-14 DOI: 10.1051/medsci/2026114
Marc-André Selosse
{"title":"[Why species do not really exist].","authors":"Marc-André Selosse","doi":"10.1051/medsci/2026114","DOIUrl":"https://doi.org/10.1051/medsci/2026114","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 8-9","pages":"751-755"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Syphilis and human treponemes: a long evolutionary history revealed by paleogenomics]. 梅毒和人类密螺旋体：古基因组学揭示的漫长进化史。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-08-01 Epub Date: 2026-09-14 DOI: 10.1051/medsci/2026124
Éric Crubézy
{"title":"[Syphilis and human treponemes: a long evolutionary history revealed by paleogenomics].","authors":"Éric Crubézy","doi":"10.1051/medsci/2026124","DOIUrl":"10.1051/medsci/2026124","url":null,"abstract":"<p><p>Recent discoveries in paleogenomics have revolutionized our understanding of syphilis and other human treponematoses. Far from being a pathogen that suddenly appeared in Europe in the late Middle Ages, we now know that Treponema pallidum has been circulated among human populations for millennia. Ancient genomes recovered from pre-Columbian contexts in the Americas show that major treponemal lineages had already diversified well before the modern era, often in the absence of recognizable skeletal lesions. Genomic analyses further indicate that treponemal diversity is not the result of extensive genetic acquisition, but rather of small-scale modulation of a highly conserved genome, notably via antigenic variation involving the tpr gene family. Combined with data on endemic treponematoses, congenital syphilis, and historical pathology collections, these findings support a model in which syphilis, yaws, and bejel represent context-dependent expressions of an ancient treponemal continuum, with implications for diagnosis, epidemiology, and vaccine design.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 8-9","pages":"701-709"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mobilization of Long Covid patients: from lived experience to the co-construction of research and care pathways]. [动员长冠患者：从亲身经历到研究和护理途径的共同构建]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-08-01 Epub Date: 2026-09-14 DOI: 10.1051/medsci/2026125
Pauline Oustric, Isabelle Leibl, Mylène Rahel Damamme, Faustine Hélie, Stéphane Corbel, Daniel Christien, Céline Grassien, Sandra Guerrero, Tom Lachaise, Claude Odile Cossalter, Pauline Nexon, Céline Lesprit, Séverine Delahaye-Grélois
{"title":"[Mobilization of Long Covid patients: from lived experience to the co-construction of research and care pathways].","authors":"Pauline Oustric, Isabelle Leibl, Mylène Rahel Damamme, Faustine Hélie, Stéphane Corbel, Daniel Christien, Céline Grassien, Sandra Guerrero, Tom Lachaise, Claude Odile Cossalter, Pauline Nexon, Céline Lesprit, Séverine Delahaye-Grélois","doi":"10.1051/medsci/2026125","DOIUrl":"10.1051/medsci/2026125","url":null,"abstract":"<p><p>Since 2020 Long Covid has prompted a global mobilization of patients, who have documented their symptoms, named the condition, and created support groups. This article analyses, through two associations, #ApresJ20 and Covid Long Enfants, how knowledge derived from patients' experiences has been integrated into the clinical definition of Long Covid, the organization of care pathways, and participatory research, in collaboration with clinicians and researchers. It highlights both the decisive contribution of this mobilization to the recognition and management of Long Covid and the persistent gaps in institutional support regarding prevention and investment in research and care.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 8-9","pages":"719-728"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Genetics of bicuspid aortic valve: an integrative study]. [二尖瓣主动脉瓣遗传学：一项综合研究]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-08-01 Epub Date: 2026-09-14 DOI: 10.1051/medsci/2026117
Damien Marchese, Adèle Faucherre, Stéphane Zaffran
{"title":"[Genetics of bicuspid aortic valve: an integrative study].","authors":"Damien Marchese, Adèle Faucherre, Stéphane Zaffran","doi":"10.1051/medsci/2026117","DOIUrl":"https://doi.org/10.1051/medsci/2026117","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 8-9","pages":"665-670"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cancer risks in people living with HIV: an incomplete normalization in the era of effective therapy]. [艾滋病毒感染者的癌症风险：有效治疗时代的不完全正常化]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-08-01 Epub Date: 2026-09-14 DOI: 10.1051/medsci/2026133
Sophie Grabar, Jean-Philippe Spano, Alain Makinson, Dominique Costagliola
{"title":"[Cancer risks in people living with HIV: an incomplete normalization in the era of effective therapy].","authors":"Sophie Grabar, Jean-Philippe Spano, Alain Makinson, Dominique Costagliola","doi":"10.1051/medsci/2026133","DOIUrl":"https://doi.org/10.1051/medsci/2026133","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 8-9","pages":"687-690"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A cancer at the hearth of cancer research: the growing threat of research paper mills]. [癌症研究中心的癌症：研究造纸厂日益增长的威胁]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-08-01 Epub Date: 2026-09-14 DOI: 10.1051/medsci/2026131
Baptiste Scancar, David Causeur
{"title":"[A cancer at the hearth of cancer research: the growing threat of research paper mills].","authors":"Baptiste Scancar, David Causeur","doi":"10.1051/medsci/2026131","DOIUrl":"10.1051/medsci/2026131","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 8-9","pages":"739-743"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Admixture networks between archaic and modern humanities: the Denisovan case and its adaptive legacy]. [古代和现代人文的混合网络：丹尼索瓦人案例及其适应性遗产]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-08-01 Epub Date: 2026-09-14 DOI: 10.1051/medsci/2026127
Charlotte Antoine-Derouet, Céline Bon
{"title":"[Admixture networks between archaic and modern humanities: the Denisovan case and its adaptive legacy].","authors":"Charlotte Antoine-Derouet, Céline Bon","doi":"10.1051/medsci/2026127","DOIUrl":"https://doi.org/10.1051/medsci/2026127","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 8-9","pages":"756-759"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The unequal distribution of mitochondria initiates neuronal differentiation]. [线粒体分布不均引发神经元分化]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-08-01 Epub Date: 2026-09-14 DOI: 10.1051/medsci/2026121
Benjamin Bunel, Rémi Leclercq, Rosette Goïame, Arnaud Gautier, Xavier Morin, Évelyne Fischer
{"title":"[The unequal distribution of mitochondria initiates neuronal differentiation].","authors":"Benjamin Bunel, Rémi Leclercq, Rosette Goïame, Arnaud Gautier, Xavier Morin, Évelyne Fischer","doi":"10.1051/medsci/2026121","DOIUrl":"https://doi.org/10.1051/medsci/2026121","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 8-9","pages":"676-679"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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