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[The circadian clock: a new therapeutic target for liver fibrosis]. [生物钟：肝纤维化的新治疗靶点]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025052
Émilie Crouchet, Catherine Schuster, Thomas F Baumert
{"title":"[The circadian clock: a new therapeutic target for liver fibrosis].","authors":"Émilie Crouchet, Catherine Schuster, Thomas F Baumert","doi":"10.1051/medsci/2025052","DOIUrl":"https://doi.org/10.1051/medsci/2025052","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"312-315"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hepatitis E: Epidemiology, pathology and prevention]. [戊型肝炎：流行病学、病理学和预防]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025047
Nancy León-Janampa, Denys Brand, Julien Marlet
{"title":"[Hepatitis E: Epidemiology, pathology and prevention].","authors":"Nancy León-Janampa, Denys Brand, Julien Marlet","doi":"10.1051/medsci/2025047","DOIUrl":"https://doi.org/10.1051/medsci/2025047","url":null,"abstract":"<p><p>Hepatitis E virus (HEV) is a major cause of acute hepatitis. HEV genotypes 1 and 2 are associated with oro-faecal epidemics and fulminant hepatitis in pregnant women. HEV genotypes 3 and 4 are a zoonosis transmitted by uncooked pork. Infection is usually spontaneously resolutive. Chronic hepatitis may occur in immunocompromised patients. Extrahepatic disease is also possible. Prevention is based on hygiene, especially in high-risk patients, and access to safe drinking water for all. A recombinant vaccine against HEV has been developed and is currently being validated by the WHO.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"346-354"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Finally, an understanding of Huntington's disease!] 终于了解了亨廷顿舞蹈症！］
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025059
Bertrand Jordan
{"title":"[Finally, an understanding of Huntington's disease!]","authors":"Bertrand Jordan","doi":"10.1051/medsci/2025059","DOIUrl":"https://doi.org/10.1051/medsci/2025059","url":null,"abstract":"<p><p>A beautiful piece of work using extensive single-cell studies illuminates the mechanism of Huntington's disease: the somatic expansion of the (CAG)n tract, very slow at first but accelerating once a critical repeat length is reached, drives extensive changes in gene expression in striatal neurons and eventually leads to cell death and atrophy of the striatum. This explains many puzzling features of the disease and may have important implications for possible therapy and for the understanding of other triplet repeat disorders.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"394-397"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Membrane protrusions and myoblast fusion: a new role of phosphoinositides in myogenesis]. 膜突出和成肌细胞融合：磷酸肌苷在肌发生中的新作用。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025049
Mélanie Mansat, Afi Oportune Kpotor, Gaëtan Chicanne, Anne Mazars, Bernard Payrastre, Julien Viaud
{"title":"[Membrane protrusions and myoblast fusion: a new role of phosphoinositides in myogenesis].","authors":"Mélanie Mansat, Afi Oportune Kpotor, Gaëtan Chicanne, Anne Mazars, Bernard Payrastre, Julien Viaud","doi":"10.1051/medsci/2025049","DOIUrl":"https://doi.org/10.1051/medsci/2025049","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"305-307"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Atrial natriuretic peptide: A protective factor against type 2 diabetes?] 心房利钠肽：预防2型糖尿病的保护因子？］
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025058
Marlène Lac, Cédric Moro
{"title":"[Atrial natriuretic peptide: A protective factor against type 2 diabetes?]","authors":"Marlène Lac, Cédric Moro","doi":"10.1051/medsci/2025058","DOIUrl":"https://doi.org/10.1051/medsci/2025058","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"323-325"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[When Neanderthal meets Sapiens: what we know and what we still don't know about their interbreeding]. [当尼安德特人遇到智人：关于他们的杂交，我们知道什么，我们还不知道什么]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025042
Céline Bon
{"title":"[When Neanderthal meets Sapiens: what we know and what we still don't know about their interbreeding].","authors":"Céline Bon","doi":"10.1051/medsci/2025042","DOIUrl":"https://doi.org/10.1051/medsci/2025042","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"386-391"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Role of CD4 T cells in the immune response]. CD4 T细胞在免疫应答中的作用
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025048
Hugo Roux, Olivier Lantz
{"title":"[Role of CD4 T cells in the immune response].","authors":"Hugo Roux, Olivier Lantz","doi":"10.1051/medsci/2025048","DOIUrl":"https://doi.org/10.1051/medsci/2025048","url":null,"abstract":"<p><p>CD4 T cells orchestrate the immune response, facilitating cytotoxic and humoral responses while preventing the destruction of one's own tissues by more autoreactive T cells. However, unlike complete CD4 T cell deficiency, the apparent deficiency caused by mutations in the CD4 gene that prevent its expression does not result in severe combined immunodeficiency in humans. The absence of the CD4 molecule limits the number of clones selected in the thymus on the basis of major histocompatibility complex type II, but does not prevent the acquisition of the T helper lymphocyte program, allowing them to retain most of their effector capacity. This observation raises new questions about the function of CD4 T cells and, in particular, the intrinsic role of the CD4 molecule.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"336-345"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Efficacy of intermittent fasting on metabolic liver disease, fibrosis and hepatocellular carcinoma]. [间歇性禁食对代谢性肝病、纤维化和肝细胞癌的疗效]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025051
Hélène Gilgenkrantz
{"title":"[Efficacy of intermittent fasting on metabolic liver disease, fibrosis and hepatocellular carcinoma].","authors":"Hélène Gilgenkrantz","doi":"10.1051/medsci/2025051","DOIUrl":"https://doi.org/10.1051/medsci/2025051","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"310-312"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Metabolism and therapy in acute myeloid leukemia with isocitrate dehydrogenase 1/2 mutations]. 异柠檬酸脱氢酶1/2突变急性髓系白血病的代谢和治疗。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025045
Ludovic Gabellier, Enzo Bosetta, Maël Heiblig, Jean-Emmanuel Sarry
{"title":"[Metabolism and therapy in acute myeloid leukemia with isocitrate dehydrogenase 1/2 mutations].","authors":"Ludovic Gabellier, Enzo Bosetta, Maël Heiblig, Jean-Emmanuel Sarry","doi":"10.1051/medsci/2025045","DOIUrl":"https://doi.org/10.1051/medsci/2025045","url":null,"abstract":"<p><p>Isocitrate dehydrogenase IDH1 and IDH2, key enzymes in central and energy metabolism, are frequently mutated in acute myeloid leukemia (AML). They catalyze the production of the oncometabolite R-2-hydroxyglurate, which plays a key role in leukemogenesis and relapse of patients after standard AML treatments. Although the recent introduction of selective inhibitors of IDH1 (ivosidenib) and IDH2 (enasidenib) has improved the prognosis of patients with IDH1- and IDH2-mutant AML, several mechanisms of resistance to these treatments have already been identified, including metabolic reprogramming. The study of these mechanisms has opened up new therapeutic opportunities for the monitoring and treatment of patients with this subtype of AML.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"355-366"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Haematological malignancies in pregnancy]. [妊娠期血液恶性肿瘤]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025044
Justine Decroocq, Sangsong Wu, Mathilde Barrois, Pierre Pinson, Ismaël Boussaid, Rudy Birsen
{"title":"[Haematological malignancies in pregnancy].","authors":"Justine Decroocq, Sangsong Wu, Mathilde Barrois, Pierre Pinson, Ismaël Boussaid, Rudy Birsen","doi":"10.1051/medsci/2025044","DOIUrl":"https://doi.org/10.1051/medsci/2025044","url":null,"abstract":"<p><p>The management of haematological malignancies in pregnancy represents a complex medical challenge. These rare conditions require multidisciplinary collaboration to address both the maternal risks associated with physiological changes and the foetal risks, such as malformations or prematurity associated with treatment. However, data to guide the care of these patients are still limited. Comprehensive research is needed to better understand these diseases, assess the impact of treatments and optimise care, including the involvement of pregnant patients in clinical trials to improve their access to innovative therapies. This article provides an overview of the issues involved in the management of haematological malignancies during pregnancy, highlighting the diagnostic, therapeutic and prognostic challenges.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"374-379"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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