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[Brain imaging and the first success of precision psychiatry]. [脑成像和精确精神病学的首次成功]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025061
Charles Laidi, Noomane Bouaziz, Emmanuel Haffen, Philippe Domenech, Edouard Duchesnay, Pauline Favre, Éric Fakra, Josselin Houenou, Anton Iftimovici, Antoine Lefrere, Mircea Polosan, Guillaume Sescousse, Anne Sauvaget, Renaud Jardri
{"title":"[Brain imaging and the first success of precision psychiatry].","authors":"Charles Laidi, Noomane Bouaziz, Emmanuel Haffen, Philippe Domenech, Edouard Duchesnay, Pauline Favre, Éric Fakra, Josselin Houenou, Anton Iftimovici, Antoine Lefrere, Mircea Polosan, Guillaume Sescousse, Anne Sauvaget, Renaud Jardri","doi":"10.1051/medsci/2025061","DOIUrl":"https://doi.org/10.1051/medsci/2025061","url":null,"abstract":"<p><p>Magnetic resonance imaging (MRI) can be used to investigate the neurobiological basis of psychiatric disorders such as schizophrenia, bipolar disorders, autism spectrum disorders and resistant depression. Although differences in cortical thickness between patients and controls have been well demonstrated, there is currently no valid MRI-based biomarker for psychiatric disorders. The challenge of precision psychiatry is to develop biomarkers, that are specific for a given pathology or clinical dimension, but also capable of predicting clinical evolution or response to treatment, to transform patient management. Functional magnetic resonance imaging could also be a promising tool for the individualized targeting of non-invasive neuromodulation in depression or resistant hallucinations, as well as for functional magnetic resonance imaging-based neurofeedback.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"500-507"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Neurodevelopment: a transnosographic dimension]. [神经发育：跨门诊学的维度]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025071
Anton Iftimovici, Renaud Jardri, Aline Lefebvre, Jasmina Mallet, Antoine Lefrere
{"title":"[Neurodevelopment: a transnosographic dimension].","authors":"Anton Iftimovici, Renaud Jardri, Aline Lefebvre, Jasmina Mallet, Antoine Lefrere","doi":"10.1051/medsci/2025071","DOIUrl":"https://doi.org/10.1051/medsci/2025071","url":null,"abstract":"<p><p>The neurodevelopmental dimension represents a major challenge for the future of precision psychiatry. It provides a transdiagnostic framework, that allows for the redefinition of psychiatric disorders beyond traditional diagnostic categories, such as autism spectrum disorders, attention-deficit/hyperactivity disorder, schizophrenia, and bipolar disorder. This model is based on the identification of deviations in brain developmental trajectories during critical periods of vulnerability. Using multimodal approaches that integrate clinical, biological, neuroimaging, and neurophysiological data, this framework aims to define an individualized neurodevelopmental burden, opening up new prospects for stratification and the development of personalized treatments tailored to each developmental profile.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"451-459"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Physical exposures in psychiatry: the promises of the PEPR "PROPSY"]. 精神病学中的身体暴露：PEPR“提案”的承诺。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025069
Baptiste Pignon, Franck Schürhoff
{"title":"[Physical exposures in psychiatry: the promises of the PEPR \"PROPSY\"].","authors":"Baptiste Pignon, Franck Schürhoff","doi":"10.1051/medsci/2025069","DOIUrl":"10.1051/medsci/2025069","url":null,"abstract":"<p><p>This article examines the links between exposure to infections and air pollution and the risk of psychiatric disorders. Infections are associated with an increased risk of autism spectrum disorders, schizophrenia, and mood disorders. High levels of air pollution (especially particulate matter and nitrogen dioxide) are associated with psychotic, anxiety and depressive disorders. The research program PROPSY aims to advance knowledge in this field, particularly in relation to air pollution, through multimodal assessments of 2,500 patients and 500 controls, along with precise estimates of their environmental exposures throughout the life.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"508-515"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Challenges and objectives of precision psychiatry]. [精确精神病学的挑战和目标]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025067
Marion Leboyer
{"title":"[Challenges and objectives of precision psychiatry].","authors":"Marion Leboyer","doi":"10.1051/medsci/2025067","DOIUrl":"https://doi.org/10.1051/medsci/2025067","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"409-410"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Suicidal ideation and behaviors: a transdiagnostic dimension for precision psychiatry]. [自杀意念和行为：精确精神病学的跨诊断维度]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1051/medsci/2025066
Aiste Lengvenyte, Émilie Olié, Marion Leboyer, Philippe Courtet
{"title":"[Suicidal ideation and behaviors: a transdiagnostic dimension for precision psychiatry].","authors":"Aiste Lengvenyte, Émilie Olié, Marion Leboyer, Philippe Courtet","doi":"10.1051/medsci/2025066","DOIUrl":"https://doi.org/10.1051/medsci/2025066","url":null,"abstract":"<p><p>Suicidal thoughts and behaviors represent a transdiagnostic dimension independent of traditional psychiatric diagnoses. This specificity is supported by genetic studies, biomarkers, and preclinical research on endophenotypes associated with suicidal behaviors, such as impulsivity, anhedonia, and hopelessness. Clear mechanisms involving inflammation, the stress response, the serotonergic system, and neuroplasticity are emerging. Specific treatments, such as lithium and ketamine, target these mechanisms. The French Minds cohort of the PEPR PROPSY will identify the biological signatures and trajectories of this dimension using comprehensive multimodal approaches.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"460-468"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Towards using pseudo-prions against neurodegenerative diseases]. 用伪朊病毒治疗神经退行性疾病的研究
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025055
Marc Dhenain, Marina Celestine, Muriel Jacquier-Sarlin, Alain Buisson
{"title":"[Towards using pseudo-prions against neurodegenerative diseases].","authors":"Marc Dhenain, Marina Celestine, Muriel Jacquier-Sarlin, Alain Buisson","doi":"10.1051/medsci/2025055","DOIUrl":"https://doi.org/10.1051/medsci/2025055","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"318-320"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Eclipse of science]. [科学的衰落]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025074
Alain Fischer
{"title":"[Eclipse of science].","authors":"Alain Fischer","doi":"10.1051/medsci/2025074","DOIUrl":"https://doi.org/10.1051/medsci/2025074","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"303-304"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Has the Holy Grail of humanized mice been found ?] [人类化老鼠的圣杯找到了吗？]
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025050
Marie Naturel, Gilles Marodon
{"title":"[Has the Holy Grail of humanized mice been found ?]","authors":"Marie Naturel, Gilles Marodon","doi":"10.1051/medsci/2025050","DOIUrl":"https://doi.org/10.1051/medsci/2025050","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"308-309"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Increasing social inequalities in quality of life after early breast cancer]. [早期乳腺癌后生活质量的社会不平等加剧]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025041
Gwenn Menvielle, José Luis Sandoval
{"title":"[Increasing social inequalities in quality of life after early breast cancer].","authors":"Gwenn Menvielle, José Luis Sandoval","doi":"10.1051/medsci/2025041","DOIUrl":"https://doi.org/10.1051/medsci/2025041","url":null,"abstract":"<p><p>Using data from the French CANTO cohort (n=5,915), we assessed the socioeconomic inequalities in quality of life after breast cancer and their time trends over two years after diagnosis. Socioeconomic position was measured using self-reported financial difficulties. Quality of life was assessed with the QLQ-C30 summary score. Social inequalities were quantified using the slope index of inequality (SII). Social inequalities in QLQ-C30 summary score at baseline were observed after adjustment for age at diagnosis, Charlson Comorbidity Index, disease stage, and treatment. These inequalities significantly increased in year 1 and year 2 postdiagnosis.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"380-383"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[From brain mosaicism to epilepsy: toward a novel targeted therapeutic strategy]. [从大脑嵌合到癫痫：一种新的靶向治疗策略]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025053
Théo Ribierre, Stéphanie Baulac
{"title":"[From brain mosaicism to epilepsy: toward a novel targeted therapeutic strategy].","authors":"Théo Ribierre, Stéphanie Baulac","doi":"10.1051/medsci/2025053","DOIUrl":"https://doi.org/10.1051/medsci/2025053","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"316-318"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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