M S-medecine SciencesPub Date : 2025-06-01Epub Date: 2025-07-07DOI: 10.1051/medsci/2025081
Marc-André Selosse
{"title":"[Chemolithotrophy, an overlooked but common metabolism].","authors":"Marc-André Selosse","doi":"10.1051/medsci/2025081","DOIUrl":"https://doi.org/10.1051/medsci/2025081","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"607-610"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Molecular epidemiology of viruses sequenced from wastewater].","authors":"Juejun Chen, Sarah Aherfi, Pauline Steichen, Géraldine Rios, Rainer Waldmann, Pascal Barbry","doi":"10.1051/medsci/2025083","DOIUrl":"https://doi.org/10.1051/medsci/2025083","url":null,"abstract":"<p><p>Virus surveillance using metagenomic analysis of sequences from wastewater appears to be a promising epidemiological tool for monitoring the spread of viruses in large populations. Its use during the COVID-19 pandemic enabled the monitoring of SARS-CoV-2 circulation without requiring the collection of multiple individual samples. This approach allows both symptomatic and asymptomatic infections to be monitored in a highly cost-effective way. Initially based on PCR detection, the introduction of nucleic acid sequencing has improved this tool by providing more detailed metagenomic information. Experience with COVID-19 pandemics suggests that this epidemiological tool should now be extended to other viruses detectable in wastewater. This review discusses the different methods used, highlighting the challenges of a rapid deployment on an international scale to better understand the global circulation of viral pathogens.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"585-592"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S-medecine SciencesPub Date : 2025-06-01Epub Date: 2025-07-07DOI: 10.1051/medsci/2025097
Bertrand Jordan
{"title":"[DNA sequencing: the end of a near-monopoly].","authors":"Bertrand Jordan","doi":"10.1051/medsci/2025097","DOIUrl":"10.1051/medsci/2025097","url":null,"abstract":"<p><p>For the last decade, the field of DNA sequencing has been dominated by a single company, Illumina, with very limited competition. However, a new method with superior performance and lower cost has recently been announced by Roche, a major pharmaceutical and diagnostics company, and promises to have a large impact, especially (but not exclusively) for medical applications.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"611-614"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S-medecine SciencesPub Date : 2025-06-01Epub Date: 2025-07-07DOI: 10.1051/medsci/2025088
Christophe Leterrier, Stéphane Vassilopoulos
{"title":"[Diving into the heart of axonal endocytosis].","authors":"Christophe Leterrier, Stéphane Vassilopoulos","doi":"10.1051/medsci/2025088","DOIUrl":"https://doi.org/10.1051/medsci/2025088","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"537-539"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Plague in the modern era, understanding the transmission of Yersinia pestis by fleas].","authors":"Florent Sebbane, Amélie Dewitte, Alexandre Baillez","doi":"10.1051/medsci/2025096","DOIUrl":"https://doi.org/10.1051/medsci/2025096","url":null,"abstract":"<p><p>Plague, caused by the bacterium Yersinia pestis, remains a deadly disease on a global scale. This pathogen is primarily transmitted by fleas, in which it adapts to the hostile environment of the digestive tract, multiplies, and forms a dense biofilm that obstructs the entry of blood. This obstruction promotes bacterial transmission through regurgitation during a blood meal. This process relies on a molecular program initiated in the rodent and sustained within the insect. In this review, we describe the environment in which Y. pestis evolves to infect fleas, as well as the modes of transmission and the molecular mechanisms involved, while adopting a critical perspective to better understand the interactions between Y. pestis and its vector, and to explore new strategies to control the spread of the plague agent.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"578-584"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S-medecine SciencesPub Date : 2025-05-01Epub Date: 2025-05-26DOI: 10.1051/medsci/2025063
Ophélia Godin, Ariel Frajerman, Aiste Lengvenyte, Jeremy Bernard, Ana C Andreazza, Bruno Etain, Marion Leboyer
{"title":"[The first successes of the immuno-metabolic track in precision psychiatry].","authors":"Ophélia Godin, Ariel Frajerman, Aiste Lengvenyte, Jeremy Bernard, Ana C Andreazza, Bruno Etain, Marion Leboyer","doi":"10.1051/medsci/2025063","DOIUrl":"https://doi.org/10.1051/medsci/2025063","url":null,"abstract":"<p><p>Psychiatric disorders are associated with a high prevalence of cardiovascular and metabolic risk factors such as diabetes, obesity, and metabolic syndrome, as well as specific symptoms: hyperphagia, weight gain, hypersomnia, fatigue, and anhedonia. Non-pharmacological therapeutic strategies (exercise, Mediterranean or ketogenic diets) as well as pharmacological approaches, such as repositioning molecules (metformin or GLP1 receptor agonists), are available and could be proposed to these patients. In addition, targeting immuno-inflammatory pathways may be beneficial for these individuals.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 5","pages":"490-499"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}