{"title":"[Plague in the modern era, understanding the transmission of Yersinia pestis by fleas].","authors":"Florent Sebbane, Amélie Dewitte, Alexandre Baillez","doi":"10.1051/medsci/2025096","DOIUrl":null,"url":null,"abstract":"<p><p>Plague, caused by the bacterium Yersinia pestis, remains a deadly disease on a global scale. This pathogen is primarily transmitted by fleas, in which it adapts to the hostile environment of the digestive tract, multiplies, and forms a dense biofilm that obstructs the entry of blood. This obstruction promotes bacterial transmission through regurgitation during a blood meal. This process relies on a molecular program initiated in the rodent and sustained within the insect. In this review, we describe the environment in which Y. pestis evolves to infect fleas, as well as the modes of transmission and the molecular mechanisms involved, while adopting a critical perspective to better understand the interactions between Y. pestis and its vector, and to explore new strategies to control the spread of the plague agent.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 6-7","pages":"578-584"},"PeriodicalIF":0.6000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"M S-medecine Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1051/medsci/2025096","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/7 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Plague, caused by the bacterium Yersinia pestis, remains a deadly disease on a global scale. This pathogen is primarily transmitted by fleas, in which it adapts to the hostile environment of the digestive tract, multiplies, and forms a dense biofilm that obstructs the entry of blood. This obstruction promotes bacterial transmission through regurgitation during a blood meal. This process relies on a molecular program initiated in the rodent and sustained within the insect. In this review, we describe the environment in which Y. pestis evolves to infect fleas, as well as the modes of transmission and the molecular mechanisms involved, while adopting a critical perspective to better understand the interactions between Y. pestis and its vector, and to explore new strategies to control the spread of the plague agent.
期刊介绍：
m/s offers high-quality review articles in French, covering all areas of biomedical and health research, in a monthly magazine format (10 issues / year). m/s is read by the whole French-speaking community, in France but also in Belgium, Switzerland, Canada, Morocco, Algeria, Tunisia etc. m/s is not a primary publication, and thus will not consider unpublished data. Most articles are invited by the Editors, but spontaneous proposals are welcomed. Each issue combines news and views on the most recent scientific publications, as well as broadly accessible and updated review articles on a specific topic, and essays on science and society, history of science, public health, or reactions to published articles. Each year, m/s also publishes one or two thematic issues focused on a research topic of high interest. All review articles and essays are peer-reviewed.
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