M S-medecine SciencesPub Date : 2026-06-01Epub Date: 2026-07-17DOI: 10.1051/medsci/2026115
Stéphane Bertagnoli, Louis Buscail, Jean Cacheux, Sylvain Cussat-Blanc, Franck Gallardo, Pierre Cordelier
{"title":"[Oncolytic viruses and pancreatic cancer: rethinking the approach to overcome therapeutic resistance].","authors":"Stéphane Bertagnoli, Louis Buscail, Jean Cacheux, Sylvain Cussat-Blanc, Franck Gallardo, Pierre Cordelier","doi":"10.1051/medsci/2026115","DOIUrl":"https://doi.org/10.1051/medsci/2026115","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 6-7","pages":"539-540"},"PeriodicalIF":0.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S-medecine SciencesPub Date : 2026-06-01Epub Date: 2026-07-17DOI: 10.1051/medsci/2026094
Mouna Chajadine, Ludivine Laurans, Soraya Taleb
{"title":"[Tryptophan metabolism: a key player in cardiometabolic diseases].","authors":"Mouna Chajadine, Ludivine Laurans, Soraya Taleb","doi":"10.1051/medsci/2026094","DOIUrl":"https://doi.org/10.1051/medsci/2026094","url":null,"abstract":"<p><p>Tryptophan (Trp), an essential amino acid, plays a central role in metabolism, inflammation, immunity, and energy homeostasis. It is primarily metabolized through the kynurenine, indole, and serotonin pathways, generating metabolites with either protective or harmful effects depending on the physiological and tissue context. Dysregulation of these pathways contributes to obesity, diabetes, and cardiovascular diseases. Understanding these mechanisms paves the way for personalized nutritional and therapeutic strategies to prevent and manage cardiometabolic diseases.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 6-7","pages":"590-599"},"PeriodicalIF":0.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S-medecine SciencesPub Date : 2026-05-01Epub Date: 2026-05-29DOI: 10.1051/medsci/2026089
Garance Chabannes, Tessa Martins, Helena Montereale, Elisa Montredon, Sophie Tronnet
{"title":"[Vibrio-host interactions: from the environmental niche to virulence].","authors":"Garance Chabannes, Tessa Martins, Helena Montereale, Elisa Montredon, Sophie Tronnet","doi":"10.1051/medsci/2026089","DOIUrl":"https://doi.org/10.1051/medsci/2026089","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 5","pages":"525-529"},"PeriodicalIF":0.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S-medecine SciencesPub Date : 2026-05-01Epub Date: 2026-05-29DOI: 10.1051/medsci/2026080
Lucas Rebuffet, Éric Vivier
{"title":"[A new nomenclature for natural killer cells].","authors":"Lucas Rebuffet, Éric Vivier","doi":"10.1051/medsci/2026080","DOIUrl":"10.1051/medsci/2026080","url":null,"abstract":"<p><p>Recent advances in single-cell transcriptomics have profoundly renewed our understanding of immune cells. They have enabled us to better characterize the heterogeneity of Natural Killer (NK) cells and establish a classification that integrates all their characteristics. These approaches have also shed light on the behavior of NK cells infiltrating the tumor microenvironment, the mechanisms of their dysfunction, and the limits of their antitumor activity. Finally, they are essential for understanding the mechanisms of action of new therapies targeting NK cells.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 5","pages":"451-458"},"PeriodicalIF":0.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S-medecine SciencesPub Date : 2026-05-01Epub Date: 2026-05-29DOI: 10.1051/medsci/2026065
Ambrine Arrar, Saad El Mallem, Magalie A Ravier, Safia Costes
{"title":"[Links between type 2 diabetes and Parkinson's disease: pathophysiological and therapeutic evidence].","authors":"Ambrine Arrar, Saad El Mallem, Magalie A Ravier, Safia Costes","doi":"10.1051/medsci/2026065","DOIUrl":"10.1051/medsci/2026065","url":null,"abstract":"<p><p>Type 2 diabetes and Parkinson's disease are two age-related diseases, each considered a major public health problem worldwide. While one is known as a metabolic disorder and the other as a neurodegenerative disease, recent data suggest that they may be epidemiologically linked. The accumulation of amyloidogenic proteins, insulin resistance, and hyperglycemia are as many pathogenic conditions that could explain an epidemiological and biological association between these two diseases. This synthesis aims to describe the common mechanisms of alteration and explore recent therapeutic perspectives common to both diseases.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 5","pages":"467-475"},"PeriodicalIF":0.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S-medecine SciencesPub Date : 2026-05-01Epub Date: 2026-05-29DOI: 10.1051/medsci/2026074
Catalina Salinas-Luypaert, Daniele Fachinetti
{"title":"[DNA methylation shapes human centromere position and stability].","authors":"Catalina Salinas-Luypaert, Daniele Fachinetti","doi":"10.1051/medsci/2026074","DOIUrl":"https://doi.org/10.1051/medsci/2026074","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 5","pages":"421-424"},"PeriodicalIF":0.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S-medecine SciencesPub Date : 2026-05-01Epub Date: 2026-05-29DOI: 10.1051/medsci/2026072
Zuleyha Yildirim, Françoise Dantzer
{"title":"[PARP3: a Swiss army knife orchestrating DNA repair, cancer aggressiveness and cell differentiation].","authors":"Zuleyha Yildirim, Françoise Dantzer","doi":"10.1051/medsci/2026072","DOIUrl":"https://doi.org/10.1051/medsci/2026072","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 5","pages":"415-419"},"PeriodicalIF":0.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S-medecine SciencesPub Date : 2026-05-01Epub Date: 2026-05-29DOI: 10.1051/medsci/2026067
Éric Pichard
{"title":"[The history of the yellow fever vaccine].","authors":"Éric Pichard","doi":"10.1051/medsci/2026067","DOIUrl":"10.1051/medsci/2026067","url":null,"abstract":"<p><p>After three centuries of devastation caused by yellow fever, which hindered trade and colonization, a live attenuated vaccine was produced and is still in use today. Its development took place in a context of commercial and colonial rivalry between Europeans and Americans. The history of this vaccine, widely used in endemic areas and among travelers, has been marked by specific challenges, including international health regulations governing its use and its integration into childhood immunization programs in endemic regions. Shortages triggered by the resurgence of epidemics in Africa and Latin America led to measures such as extending the validity of vaccination and reducing the administered dose. Many uncertainties remain regarding the significance and mechanisms of the adverse effects observed after vaccination, which are rare but potentially fatal. The development of a vaccine that is equally effective but easier to produce and associated with fewer side effects is a central issue in the present and future history of this nearly century-old vaccine.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 5","pages":"501-505"},"PeriodicalIF":0.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}