[Drug repurposing to combat viral infectious diseases: principles and illustration with Prozac^®].

IF 0.5 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

M S-medecine Sciences Pub Date : 2026-08-01 Epub Date: 2026-09-14 DOI:10.1051/medsci/2026123

Marine O Faucher, Karine Barral, Bruno Coutard

引用次数: 0

Abstract

Drug repurposing represents a strategic approach aimed at accelerating the development of treatments against viral infections. This review presents three repurposing strategies, illustrated with therapeutic compounds notably fluoxetine (Prozac^®), a selective serotonin reuptake inhibitor antidepressant that also exhibits several antiviral mechanisms of action. The examples discussed in this review highlight both the potential and the limitations of drug repurposing, particularly in a "plug-and-play" approach.

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[药物再利用以对抗病毒性传染病：百忧解®的原理和说明]。

药物再利用是一种战略方法，旨在加速开发对抗病毒感染的治疗方法。这篇综述提出了三种重新利用策略，以治疗性化合物为例，特别是氟西汀（百忧解®），一种选择性血清素再摄取抑制剂抗抑郁药，也显示出几种抗病毒机制的作用。本综述中讨论的例子强调了药物再利用的潜力和局限性，特别是在“即插即用”方法中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

M S-medecine Sciences 医学-医学：研究与实验

CiteScore

0.80

自引率

14.30%

发文量

182

审稿时长

4-8 weeks

期刊介绍： m/s offers high-quality review articles in French, covering all areas of biomedical and health research, in a monthly magazine format (10 issues / year). m/s is read by the whole French-speaking community, in France but also in Belgium, Switzerland, Canada, Morocco, Algeria, Tunisia etc. m/s is not a primary publication, and thus will not consider unpublished data. Most articles are invited by the Editors, but spontaneous proposals are welcomed. Each issue combines news and views on the most recent scientific publications, as well as broadly accessible and updated review articles on a specific topic, and essays on science and society, history of science, public health, or reactions to published articles. Each year, m/s also publishes one or two thematic issues focused on a research topic of high interest. All review articles and essays are peer-reviewed.

[Drug repurposing to combat viral infectious diseases: principles and illustration with Prozac®].

Abstract

[Drug repurposing to combat viral infectious diseases: principles and illustration with Prozac^®].