M S-medecine Sciences最新文献

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[From the emergence of mpox in the Democratic Republic of the Congo to global health emergencies]. [从刚果民主共和国出现麻疹到全球突发卫生事件]。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2025-08-01 Epub Date: 2025-09-08 DOI: 10.1051/medsci/2025106
Eddy Kinganda-Lusamaki, Ahidjo Ayouba, Placide Mbala-Kingebeni, Steve Ahuka-Mundeke, Jean-Jacques Muyembe-Tamfum, Eric Delaporte, Martine Peeters
{"title":"[From the emergence of mpox in the Democratic Republic of the Congo to global health emergencies].","authors":"Eddy Kinganda-Lusamaki, Ahidjo Ayouba, Placide Mbala-Kingebeni, Steve Ahuka-Mundeke, Jean-Jacques Muyembe-Tamfum, Eric Delaporte, Martine Peeters","doi":"10.1051/medsci/2025106","DOIUrl":"https://doi.org/10.1051/medsci/2025106","url":null,"abstract":"<p><p>For a long time neglected, the mpox virus has caused two public health emergency declarations by the World Health Organization in just two years. Rapid detection and characterization of the viral strains involved are crucial for better control of the disease. Recent work on viral genome sequencing in the Democratic Republic of the Congo (DRC) has shown the emergence in 2023 of clade Ib, with sustained human-to-human transmission and rapid spread to several other non-endemic neighboring countries, as well as outside Africa. On the other hand, variants of clade Ia, which is predominant in the DRC and associated with zoonotic transmission, are beginning to emerge in large urban areas such as Kinshasa. The observed adaptation to humans raises concerns about the exportation and globalization of the epidemic.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 8-9","pages":"666-675"},"PeriodicalIF":0.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Autoantibodies in autoimmune inflammatory myopathies]. 自身免疫性炎症性肌病的自身抗体
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2025-08-01 Epub Date: 2025-09-08 DOI: 10.1051/medsci/2025105
Romain Batton, Sarah Julien
{"title":"[Autoantibodies in autoimmune inflammatory myopathies].","authors":"Romain Batton, Sarah Julien","doi":"10.1051/medsci/2025105","DOIUrl":"https://doi.org/10.1051/medsci/2025105","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 8-9","pages":"643-645"},"PeriodicalIF":0.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Teeth at the bedside of the ear]. [牙齿长在耳旁]。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2025-08-01 Epub Date: 2025-09-08 DOI: 10.1051/medsci/2025101
Yassine Messat, Pierre-Yves Collart Dutilleul, Azel Zine
{"title":"[Teeth at the bedside of the ear].","authors":"Yassine Messat, Pierre-Yves Collart Dutilleul, Azel Zine","doi":"10.1051/medsci/2025101","DOIUrl":"https://doi.org/10.1051/medsci/2025101","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 8-9","pages":"628-630"},"PeriodicalIF":0.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Transitioning to adult oncology for adolescents and young adults (AYAs): The experience of an AYA unit]. [过渡到成人肿瘤的青少年和年轻人(AYAs): AYA单位的经验]。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2025-08-01 Epub Date: 2025-09-08 DOI: 10.1051/medsci/2025112
Séverine Chiesa, Natacha Naoun, Fanny Morin, Carine Da Fonseca, Gwladys Rousseau, Anna Patrikidou, Brice Fresneau, Benjamin Verret, Sarah Dumont, Lucy Metayer, Nathalie Gaspar
{"title":"[Transitioning to adult oncology for adolescents and young adults (AYAs): The experience of an AYA unit].","authors":"Séverine Chiesa, Natacha Naoun, Fanny Morin, Carine Da Fonseca, Gwladys Rousseau, Anna Patrikidou, Brice Fresneau, Benjamin Verret, Sarah Dumont, Lucy Metayer, Nathalie Gaspar","doi":"10.1051/medsci/2025112","DOIUrl":"https://doi.org/10.1051/medsci/2025112","url":null,"abstract":"<p><p>Supporting the transition from pediatric to adult oncology presents challenges for all stakeholders, including adolescent and young adult (AYA) patients, their parents, pediatric oncologists, and medical oncologists. In this article, we describe the different stages of this transition and the transfer of care, the obstacles to the transition, and potential solutions. We discuss the contribution of AYA care in oncology through collaborations between pediatric and medical oncologists, and the importance of multidisciplinary support for patient empowerment. We draw on the example of the SPIAJA team at Gustave Roussy, whose flexible transition process adapts to each young person and provides avenues for discussion about a structured transition program. \"The transition from pediatrics to adult medicine must be planned, coordinated and supported,\" as recommended in the 2009/2013 Cancer Plan.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 8-9","pages":"676-682"},"PeriodicalIF":0.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The internal condom: overview, practical aspects and analysis of the barriers to its use]. [内套:概述、实用方面及使用障碍分析]。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2025-08-01 Epub Date: 2025-09-08 DOI: 10.1051/medsci/2025108
Emilie Arnaud, Jacky Nizard, Valentine Faure Bardon
{"title":"[The internal condom: overview, practical aspects and analysis of the barriers to its use].","authors":"Emilie Arnaud, Jacky Nizard, Valentine Faure Bardon","doi":"10.1051/medsci/2025108","DOIUrl":"https://doi.org/10.1051/medsci/2025108","url":null,"abstract":"<p><p>The internal condom (commonly referred to as the female condom), which can be used by both men and women, is a single-use medical device that can be inserted several hours before sexual intercourse for the prevention of sexually transmitted infections (STIs) and for contraception. This review presents an overview of its use, and a summary of the technical and regulatory aspects. We will see that this device is almost as effective as its external counterpart and offers better protection against STIs, but that it remains very underused in the general population. The potential barriers to its use will also be analyzed and discussed.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 8-9","pages":"683-689"},"PeriodicalIF":0.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Kupffer cells, a new player in hypercholesterolemia and atherosclerosis]. [Kupffer细胞,高胆固醇血症和动脉粥样硬化的新参与者]。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2025-08-01 Epub Date: 2025-09-08 DOI: 10.1051/medsci/2025104
Rebecca Fima, Thierry Huby
{"title":"[Kupffer cells, a new player in hypercholesterolemia and atherosclerosis].","authors":"Rebecca Fima, Thierry Huby","doi":"10.1051/medsci/2025104","DOIUrl":"https://doi.org/10.1051/medsci/2025104","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 8-9","pages":"637-639"},"PeriodicalIF":0.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Harnessing retroviral engineering for genome reprogramming]. 利用逆转录病毒工程进行基因组重编程。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2025-08-01 Epub Date: 2025-09-08 DOI: 10.1051/medsci/2025098
Philippe-Emmanuel Mangeot, Théophile Ohlmann
{"title":"[Harnessing retroviral engineering for genome reprogramming].","authors":"Philippe-Emmanuel Mangeot, Théophile Ohlmann","doi":"10.1051/medsci/2025098","DOIUrl":"https://doi.org/10.1051/medsci/2025098","url":null,"abstract":"<p><p>The accumulated knowledge on the biology of the HIV-1 virus has led to the emergence of technologies that exploit the architecture of retroviruses and their integration or vectorization properties. This field of study constitutes retroviral vectorology, democratized in laboratories by the use of lentiviral vectors. By hijacking retroviral assembly, other systems are emerging and are increasingly mentioned in recent literature. In particular, defective retroviral particles are capable of transiently delivering effectors that act on the genome: they thus appear to be more suitable tools for delivering genetic scalpels, whose persistence in the target cell or organism is not required. Since the description of the CRISPR Cas9 system in 2012, genome engineering techniques have continued to evolve in terms of capacity and reliability. Several derivatives of the CRISPR system can now modify the human genome with nucleotide-level precision. Introducing these effectors into the cell or organism remains a major technical challenge that vector scientists are striving to overcome. This review describes the major retroviral systems used for genome manipulation. Following an overview of genetic engineering techniques, we will see how researchers have developed a wide range of genomic tools by manipulating different processes in the retroviral architecture.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 8-9","pages":"647-656"},"PeriodicalIF":0.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New therapeutic approaches for the treatment of primary biliary cholangitis]. 原发性胆道胆管炎的新治疗方法
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2025-08-01 Epub Date: 2025-09-08 DOI: 10.1051/medsci/2025109
Corentin Brice, Alexandre Louvet
{"title":"[New therapeutic approaches for the treatment of primary biliary cholangitis].","authors":"Corentin Brice, Alexandre Louvet","doi":"10.1051/medsci/2025109","DOIUrl":"https://doi.org/10.1051/medsci/2025109","url":null,"abstract":"<p><p>Primary biliary cholangitis (PBC) is a rare disease for which management long consisted of a single treatment: ursodeoxycholic acid. In 2015-2016, this disease regained interest with the first studies on obeticholic acid (FXR agonist) and then on bezafibrate (PPAR agonist). Subsequently, over the past five years, significant progress has been made in the management of PBC. Major studies have helped better predict disease progression and its response to treatment through the development of prognostic tools. Additionally, the therapeutic arsenal has expanded with the arrival of selective PPAR agonists.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 8-9","pages":"693-700"},"PeriodicalIF":0.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Preschool-age children maintain a distinct immunological memory after SARS-CoV-2 infection]. [学龄前儿童在SARS-CoV-2感染后保持明显的免疫记忆]。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2025-08-01 Epub Date: 2025-09-08 DOI: 10.1051/medsci/2025102
Benoît Manfroi, Simon Fillatreau
{"title":"[Preschool-age children maintain a distinct immunological memory after SARS-CoV-2 infection].","authors":"Benoît Manfroi, Simon Fillatreau","doi":"10.1051/medsci/2025102","DOIUrl":"https://doi.org/10.1051/medsci/2025102","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 8-9","pages":"631-634"},"PeriodicalIF":0.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cellular models of inflammation in the posterior segment of the eye: exploring pathogenic mechanisms]. 眼后段炎症的细胞模型:探索致病机制。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2025-08-01 Epub Date: 2025-09-08 DOI: 10.1051/medsci/2025099
Gabrielle Raîche-Marcoux, Sylvain Guérin, Élodie Boisselier
{"title":"[Cellular models of inflammation in the posterior segment of the eye: exploring pathogenic mechanisms].","authors":"Gabrielle Raîche-Marcoux, Sylvain Guérin, Élodie Boisselier","doi":"10.1051/medsci/2025099","DOIUrl":"https://doi.org/10.1051/medsci/2025099","url":null,"abstract":"<p><p>Glaucoma, age-related macular degeneration, and diabetic retinopathy are complex eye diseases that involve inflammation. Several cellular models are developed to study inflammation mechanisms in the posterior segment of the eye. These models, are composed of cells of various origins (human or animal), derived from different tissues (retina, choroid, skin, and umbilical cord) and belonging to different cell types (epithelial, endothelial, vascular, and neuronal). Multiple culture techniques are employed to analyze specific inflammatory responses. Various experimental approaches are used to induce inflammation in these cellular models and identify underlying molecular mechanisms. This review highlights the diversity of cell models used to study posterior ocular inflammation. It emphasizes the use of primary cell cultures, established cell lines, and different co-culture approaches. The goal is to further increase our understanding of these diseases which affect millions of people worldwide.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 8-9","pages":"657-665"},"PeriodicalIF":0.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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