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[Eclipse of science]. [科学的衰落]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025074
Alain Fischer
{"title":"[Eclipse of science].","authors":"Alain Fischer","doi":"10.1051/medsci/2025074","DOIUrl":"https://doi.org/10.1051/medsci/2025074","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"303-304"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Has the Holy Grail of humanized mice been found ?] [人类化老鼠的圣杯找到了吗？]
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025050
Marie Naturel, Gilles Marodon
{"title":"[Has the Holy Grail of humanized mice been found ?]","authors":"Marie Naturel, Gilles Marodon","doi":"10.1051/medsci/2025050","DOIUrl":"https://doi.org/10.1051/medsci/2025050","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"308-309"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Increasing social inequalities in quality of life after early breast cancer]. [早期乳腺癌后生活质量的社会不平等加剧]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025041
Gwenn Menvielle, José Luis Sandoval
{"title":"[Increasing social inequalities in quality of life after early breast cancer].","authors":"Gwenn Menvielle, José Luis Sandoval","doi":"10.1051/medsci/2025041","DOIUrl":"https://doi.org/10.1051/medsci/2025041","url":null,"abstract":"<p><p>Using data from the French CANTO cohort (n=5,915), we assessed the socioeconomic inequalities in quality of life after breast cancer and their time trends over two years after diagnosis. Socioeconomic position was measured using self-reported financial difficulties. Quality of life was assessed with the QLQ-C30 summary score. Social inequalities were quantified using the slope index of inequality (SII). Social inequalities in QLQ-C30 summary score at baseline were observed after adjustment for age at diagnosis, Charlson Comorbidity Index, disease stage, and treatment. These inequalities significantly increased in year 1 and year 2 postdiagnosis.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"380-383"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cellular models used to study the pathogenesis associated with ocular inflammation in the anterior part of the eye]. [用于研究眼部前部炎症发病机制的细胞模型]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025046
Gabrielle Raîche-Marcoux, Sylvain Guérin, Élodie Boisselier
{"title":"[Cellular models used to study the pathogenesis associated with ocular inflammation in the anterior part of the eye].","authors":"Gabrielle Raîche-Marcoux, Sylvain Guérin, Élodie Boisselier","doi":"10.1051/medsci/2025046","DOIUrl":"https://doi.org/10.1051/medsci/2025046","url":null,"abstract":"<p><p>Several multifactorial pathologies in ophthalmology that affect the anterior segment of the eye are partly inflammatory. To better understand the role and impact of inflammation in dry eye and corneal healing, many research teams have used in vitro models to mimic different aspects of these diseases. Several in vitro models have been developed to elucidate the signaling cascades involved in pathogenesis. They also offer the experimental flexibility to adjust environmental parameters, facilitating the validation of innovative therapies and the identification of new pharmacological targets. This review focuses on two-dimensional in vitro models, but also highlights the progress made in 3D models obtained by tissue engineering, which mimic inflammation in these ocular pathologies. The origin of the cells (human or animal), their tissue source, the type of cells (epithelial, endothelial, vascular, conjunctival), as well as the various experimental conditions used to mimic an inflammatory aspect according to the stages of progression of these pathologies, are thoroughly reported in this review of the literature.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"327-335"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Sepsis-trained macrophages promote antitumoral tissue-resident T cells]. [脓毒症训练的巨噬细胞促进抗肿瘤组织驻留T细胞]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025056
Jérémie Poschmann, Alexis Broquet, Antoine Roquilly
{"title":"[Sepsis-trained macrophages promote antitumoral tissue-resident T cells].","authors":"Jérémie Poschmann, Alexis Broquet, Antoine Roquilly","doi":"10.1051/medsci/2025056","DOIUrl":"https://doi.org/10.1051/medsci/2025056","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"321-323"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Matilda effect]. [玛蒂尔达效应]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025054
Anna Salvetti
{"title":"[The Matilda effect].","authors":"Anna Salvetti","doi":"10.1051/medsci/2025054","DOIUrl":"https://doi.org/10.1051/medsci/2025054","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"385"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The circadian clock: a new therapeutic target for liver fibrosis]. [生物钟：肝纤维化的新治疗靶点]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025052
Émilie Crouchet, Catherine Schuster, Thomas F Baumert
{"title":"[The circadian clock: a new therapeutic target for liver fibrosis].","authors":"Émilie Crouchet, Catherine Schuster, Thomas F Baumert","doi":"10.1051/medsci/2025052","DOIUrl":"https://doi.org/10.1051/medsci/2025052","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"312-315"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hepatitis E: Epidemiology, pathology and prevention]. [戊型肝炎：流行病学、病理学和预防]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025047
Nancy León-Janampa, Denys Brand, Julien Marlet
{"title":"[Hepatitis E: Epidemiology, pathology and prevention].","authors":"Nancy León-Janampa, Denys Brand, Julien Marlet","doi":"10.1051/medsci/2025047","DOIUrl":"https://doi.org/10.1051/medsci/2025047","url":null,"abstract":"<p><p>Hepatitis E virus (HEV) is a major cause of acute hepatitis. HEV genotypes 1 and 2 are associated with oro-faecal epidemics and fulminant hepatitis in pregnant women. HEV genotypes 3 and 4 are a zoonosis transmitted by uncooked pork. Infection is usually spontaneously resolutive. Chronic hepatitis may occur in immunocompromised patients. Extrahepatic disease is also possible. Prevention is based on hygiene, especially in high-risk patients, and access to safe drinking water for all. A recombinant vaccine against HEV has been developed and is currently being validated by the WHO.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"346-354"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Finally, an understanding of Huntington's disease!] 终于了解了亨廷顿舞蹈症！］
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025059
Bertrand Jordan
{"title":"[Finally, an understanding of Huntington's disease!]","authors":"Bertrand Jordan","doi":"10.1051/medsci/2025059","DOIUrl":"https://doi.org/10.1051/medsci/2025059","url":null,"abstract":"<p><p>A beautiful piece of work using extensive single-cell studies illuminates the mechanism of Huntington's disease: the somatic expansion of the (CAG)n tract, very slow at first but accelerating once a critical repeat length is reached, drives extensive changes in gene expression in striatal neurons and eventually leads to cell death and atrophy of the striatum. This explains many puzzling features of the disease and may have important implications for possible therapy and for the understanding of other triplet repeat disorders.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"394-397"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Membrane protrusions and myoblast fusion: a new role of phosphoinositides in myogenesis]. 膜突出和成肌细胞融合：磷酸肌苷在肌发生中的新作用。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1051/medsci/2025049
Mélanie Mansat, Afi Oportune Kpotor, Gaëtan Chicanne, Anne Mazars, Bernard Payrastre, Julien Viaud
{"title":"[Membrane protrusions and myoblast fusion: a new role of phosphoinositides in myogenesis].","authors":"Mélanie Mansat, Afi Oportune Kpotor, Gaëtan Chicanne, Anne Mazars, Bernard Payrastre, Julien Viaud","doi":"10.1051/medsci/2025049","DOIUrl":"https://doi.org/10.1051/medsci/2025049","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 4","pages":"305-307"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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