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[Serial cloners of Yamanashi]. [山梨的连续克隆者]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-06-01 Epub Date: 2026-07-17 DOI: 10.1051/medsci/2026107
Bertrand Jordan
{"title":"[Serial cloners of Yamanashi].","authors":"Bertrand Jordan","doi":"10.1051/medsci/2026107","DOIUrl":"10.1051/medsci/2026107","url":null,"abstract":"<p><p>Serial cloning of mice by nuclear transfer has been pursued for 20 years and almost 60 successive generations by a highly dedicated Japanese team. Cloning has been successful up to the 57<sup>th</sup> generation, although with increasing difficulty from generation 25 onward. Thorough phenotypic and molecular analysis of the successive clones reveals the progressive accumulation of a large number of point mutations and structural variants. This finding has several implications and underlines the necessity of sexual reproduction to ensure continued fitness in successive generations.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 6-7","pages":"644-647"},"PeriodicalIF":0.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Edmonton transplantation protocol, 25 years later: toward remission of type 1 diabetes?] 25年后的埃德蒙顿移植方案：迈向1型糖尿病的缓解？］
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-06-01 Epub Date: 2026-07-17 DOI: 10.1051/medsci/2026111
Meriem Fassy El Fehri, Mourad Ferdaoussi
{"title":"[The Edmonton transplantation protocol, 25 years later: toward remission of type 1 diabetes?]","authors":"Meriem Fassy El Fehri, Mourad Ferdaoussi","doi":"10.1051/medsci/2026111","DOIUrl":"https://doi.org/10.1051/medsci/2026111","url":null,"abstract":"<p><p>Type 1 diabetes is a disease caused by the autoimmune destruction of insulin-secreting pancreatic beta cells. The replacement of beta cells according to the Edmonton protocol has opened new therapeutic avenues for restoring physiological regulation of insulin secretion and reducing comorbidities. Current advancements in stem cell differentiation and transplantation hold promise for overcoming the limitations of the Edmonton protocol and improving disease remission. This review analyzes clinical data, highlighting the benefits and challenges of these approaches, twenty-five years after their implementation.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 6-7","pages":"630-636"},"PeriodicalIF":0.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Astrocytes, the conductors of neuronal networks]. [星形胶质细胞，神经网络的导体]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-06-01 Epub Date: 2026-07-17 DOI: 10.1051/medsci/2026099
Karin Pernet Gallay
{"title":"[Astrocytes, the conductors of neuronal networks].","authors":"Karin Pernet Gallay","doi":"10.1051/medsci/2026099","DOIUrl":"https://doi.org/10.1051/medsci/2026099","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 6-7","pages":"550-551"},"PeriodicalIF":0.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[How to redraw the brain's map by listening to the activity of single neurons?] 如何通过聆听单个神经元的活动来重新绘制大脑的地图？］
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-06-01 Epub Date: 2026-07-17 DOI: 10.1051/medsci/2026097
Nicolas Guyon, Pierre Le Merre
{"title":"[How to redraw the brain's map by listening to the activity of single neurons?]","authors":"Nicolas Guyon, Pierre Le Merre","doi":"10.1051/medsci/2026097","DOIUrl":"https://doi.org/10.1051/medsci/2026097","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 6-7","pages":"544-547"},"PeriodicalIF":0.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[How does adrenaline accelerate the heart rate? Unraveling the role of "pacemaker" ion channels]. 肾上腺素是如何加速心率的？揭示“起搏器”离子通道的作用。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-06-01 Epub Date: 2026-07-17 DOI: 10.1051/medsci/2026103
Mélanie Faure, Isabelle Bidaud, Eleonora Torre, Pietro Mesirca, Matteo E Mangoni
{"title":"[How does adrenaline accelerate the heart rate? Unraveling the role of \"pacemaker\" ion channels].","authors":"Mélanie Faure, Isabelle Bidaud, Eleonora Torre, Pietro Mesirca, Matteo E Mangoni","doi":"10.1051/medsci/2026103","DOIUrl":"https://doi.org/10.1051/medsci/2026103","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 6-7","pages":"561-564"},"PeriodicalIF":0.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Contributions of seeding amplification assays to the diagnosis of synucleinopathies]. [种子扩增法对突触核蛋白病诊断的贡献]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-06-01 Epub Date: 2026-07-17 DOI: 10.1051/medsci/2026095
Emma Lamard, Daisy Bougard
{"title":"[Contributions of seeding amplification assays to the diagnosis of synucleinopathies].","authors":"Emma Lamard, Daisy Bougard","doi":"10.1051/medsci/2026095","DOIUrl":"https://doi.org/10.1051/medsci/2026095","url":null,"abstract":"<p><p>Synucleinopathies comprise three distinct disorders: Parkinson's disease, Lewy body dementia and multiple system atrophy, all of which involve the pathological aggregation of a protein called alpha-synuclein (α-syn). In order to establish an accurate diagnosis of these disorders, and thus improve patient care or inclusion in therapeutic trials, methods based on the in vitro amplification of pathological α-syn have been developed. In this review, we will discuss the history and development of these techniques, their strengths, and the promising prospects they offer for early patient screening using a simple blood sample.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 6-7","pages":"600-607"},"PeriodicalIF":0.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[When a eukaryotic cell adopts a bacterial chromosome]. [当真核细胞采用细菌染色体时]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-06-01 Epub Date: 2026-07-17 DOI: 10.1051/medsci/2026096
Léa Meneu, Jacques Serizay, Romain Koszul
{"title":"[When a eukaryotic cell adopts a bacterial chromosome].","authors":"Léa Meneu, Jacques Serizay, Romain Koszul","doi":"10.1051/medsci/2026096","DOIUrl":"https://doi.org/10.1051/medsci/2026096","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 6-7","pages":"541-543"},"PeriodicalIF":0.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The anorectal junction : an inflammatory line favoring carcinogenesis]. [肛肠结：一条有利于癌变的炎性线]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-06-01 Epub Date: 2026-07-17 DOI: 10.1051/medsci/2026110
Chloé Petitpas, Géraldine Guasch
{"title":"[The anorectal junction : an inflammatory line favoring carcinogenesis].","authors":"Chloé Petitpas, Géraldine Guasch","doi":"10.1051/medsci/2026110","DOIUrl":"https://doi.org/10.1051/medsci/2026110","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 6-7","pages":"565-568"},"PeriodicalIF":0.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Bioinformatics and omics analyses: chronology of a new scientific approach]. [生物信息学和组学分析：一种新科学方法的年表]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-06-01 Epub Date: 2026-07-17 DOI: 10.1051/medsci/2026105
Sylvère Bastien, Marouchka Gourinovitch, François Vandenesch, Karen Moreau
{"title":"[Bioinformatics and omics analyses: chronology of a new scientific approach].","authors":"Sylvère Bastien, Marouchka Gourinovitch, François Vandenesch, Karen Moreau","doi":"10.1051/medsci/2026105","DOIUrl":"https://doi.org/10.1051/medsci/2026105","url":null,"abstract":"<p><p>From the early debates of the 1940s-1970s on the nature of the genetic information carrier - opposing proteins and DNA - to the rise of \"omics\" approaches now widely used to explore the complexity of genomes and their expression, molecular biology has undergone profound developments and true technological revolutions. These advances have enabled an increasingly precise and comprehensive understanding of living systems, while also creating new challenges related to the development of bioinformatics tools capable of analyzing ever-growing volumes of data. By providing unprecedented access to the organization and functioning of biological systems, they also pave the way for numerous applications, particularly in medical research.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 6-7","pages":"621-629"},"PeriodicalIF":0.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Astrocytes as unexpected actors of the stress response]. [星形胶质细胞作为应激反应的意外参与者]。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-06-01 Epub Date: 2026-07-17 DOI: 10.1051/medsci/2026098
Valentin Grelot, Alexandre Charlet
{"title":"[Astrocytes as unexpected actors of the stress response].","authors":"Valentin Grelot, Alexandre Charlet","doi":"10.1051/medsci/2026098","DOIUrl":"https://doi.org/10.1051/medsci/2026098","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 6-7","pages":"548-549"},"PeriodicalIF":0.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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