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[Epigenetics and cancer: the role of DNA methylation]. [表观遗传学与癌症：DNA 甲基化的作用]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-12-01 Epub Date: 2024-12-20 DOI: 10.1051/medsci/2024180
Marine Gorse, Charline Bianchi, Charlotte Proudhon
{"title":"[Epigenetics and cancer: the role of DNA methylation].","authors":"Marine Gorse, Charline Bianchi, Charlotte Proudhon","doi":"10.1051/medsci/2024180","DOIUrl":"https://doi.org/10.1051/medsci/2024180","url":null,"abstract":"<p><p>Alterations in DNA methylation profiles are typically found in cancer cells, combining genome-wide hypomethylation with hypermethylation of specific regions, such as CpG islands, which are normally unmethylated. Driving effects in cancer development have been associated with alteration of DNA methylation in certain regions, inducing, for example, the repression of tumor suppressor genes or the activation of oncogenes and retrotransposons. These alterations represent prime candidates for the development of specific markers for the detection, diagnosis and prognosis of cancer. In particular, these markers, distributed along the genome, provide a wealth of information that offers potential for innovation in the field of liquid biopsy, in particular thanks to the emergence of artificial intelligence for diagnostic purposes. This could overcome the limitations related to sensitivities and specificities, which remain too low for the most difficult applications in oncology: the detection of cancers at an early stage, the monitoring of residual disease and the analysis of brain tumors. In addition, targeting the enzymatic processes that control the epigenome offers new therapeutic strategies that could reverse the regulatory anomalies of these altered epigenomes.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"925-934"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Heterochromatin and epigenetic control of repeat sequences]. [异染色质和重复序列的表观遗传控制]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-12-01 Epub Date: 2024-12-20 DOI: 10.1051/medsci/2024176
Constance Kleijwegt, Jérôme Déjardin
{"title":"[Heterochromatin and epigenetic control of repeat sequences].","authors":"Constance Kleijwegt, Jérôme Déjardin","doi":"10.1051/medsci/2024176","DOIUrl":"https://doi.org/10.1051/medsci/2024176","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"904-913"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Epigenetics: Development and cell fate]. [表观遗传学：发育和细胞命运]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-12-01 Epub Date: 2024-12-20 DOI: 10.1051/medsci/2024205
Déborah Bourchis, Claire Rougeulle
{"title":"[Epigenetics: Development and cell fate].","authors":"Déborah Bourchis, Claire Rougeulle","doi":"10.1051/medsci/2024205","DOIUrl":"https://doi.org/10.1051/medsci/2024205","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"883-884"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[When vitamin D modulates the microbiota for therapeutic purposes]. [当维生素D调节微生物群以达到治疗目的]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-12-01 Epub Date: 2024-12-20 DOI: 10.1051/medsci/2024167
Emmanuelle Vigne, Patrick Lécine
{"title":"[When vitamin D modulates the microbiota for therapeutic purposes].","authors":"Emmanuelle Vigne, Patrick Lécine","doi":"10.1051/medsci/2024167","DOIUrl":"https://doi.org/10.1051/medsci/2024167","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"976-978"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[X chromosome regulation and female functional specificities: Are two Xs better than one?] X染色体调节与女性功能特异性：两个X比一个好吗？］
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-12-01 Epub Date: 2024-12-20 DOI: 10.1051/medsci/2024179
Julie Chaumeil, Céline Morey
{"title":"[X chromosome regulation and female functional specificities: Are two Xs better than one?]","authors":"Julie Chaumeil, Céline Morey","doi":"10.1051/medsci/2024179","DOIUrl":"https://doi.org/10.1051/medsci/2024179","url":null,"abstract":"<p><p>What if the presence of two X chromosomes confers functional specificities on female cells and contributes to the different susceptibilites of men and women to certain diseases? One of the X chromosomes is randomly silenced in each female cell from the embryonic stage, theoretically making the sexes equal. This silencing of the X chromosome is a unique epigenetic process, affecting an entire chromosome and resulting in mosaic expression of X-linked genes throughout the body. However, some genes escape this process and X-inactivation appears to be somewhat labile in certain cell types. What are the physiological implications of these observations? This question is beginning to be explored, particularly in the immune and nervous systems, where several pathologies have sexual bias.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"935-946"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regardless of genetic susceptibility to Alzheimer's disease, a better lifestyle is associated with a lower risk of dementia and less cognitive decline]. [不考虑阿尔茨海默病的遗传易感性，更好的生活方式与更低的痴呆症风险和更少的认知能力下降有关]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-12-01 Epub Date: 2024-12-20 DOI: 10.1051/medsci/2024174
Jeanne Neuffer, Cécilia Samieri
{"title":"[Regardless of genetic susceptibility to Alzheimer's disease, a better lifestyle is associated with a lower risk of dementia and less cognitive decline].","authors":"Jeanne Neuffer, Cécilia Samieri","doi":"10.1051/medsci/2024174","DOIUrl":"https://doi.org/10.1051/medsci/2024174","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"988-990"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Two is better than one: CaBP1 and CaBP2 control calcium signaling in auditory inner hair cells]. [两个比一个好：CaBP1和CaBP2控制听觉内毛细胞钙信号传导]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-12-01 Epub Date: 2024-12-20 DOI: 10.1051/medsci/2024165
Régis Nouvian
{"title":"[Two is better than one: CaBP1 and CaBP2 control calcium signaling in auditory inner hair cells].","authors":"Régis Nouvian","doi":"10.1051/medsci/2024165","DOIUrl":"https://doi.org/10.1051/medsci/2024165","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"971-972"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Interleukin 27: a key factor of the immune response to Epstein-Barr virus]. [白细胞介素27：爱泼斯坦-巴尔病毒免疫反应的关键因子]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-12-01 Epub Date: 2024-12-20 DOI: 10.1051/medsci/2024169
Emmanuel Martin, Sylvain Latour
{"title":"[Interleukin 27: a key factor of the immune response to Epstein-Barr virus].","authors":"Emmanuel Martin, Sylvain Latour","doi":"10.1051/medsci/2024169","DOIUrl":"https://doi.org/10.1051/medsci/2024169","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"982-985"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Paleoepigenetics: when DNA damages become epigenetic traces]. [古表观遗传学：当DNA损伤成为表观遗传痕迹]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-12-01 Epub Date: 2024-12-20 DOI: 10.1051/medsci/2024171
Céline Bon
{"title":"[Paleoepigenetics: when DNA damages become epigenetic traces].","authors":"Céline Bon","doi":"10.1051/medsci/2024171","DOIUrl":"https://doi.org/10.1051/medsci/2024171","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"965-970"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A Second Look at the Origins of the Concept of Epigenetics']. [再看一下表观遗传学概念的起源]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-12-01 Epub Date: 2024-12-20 DOI: 10.1051/medsci/2024175
Laurent Loison
{"title":"[A Second Look at the Origins of the Concept of Epigenetics'].","authors":"Laurent Loison","doi":"10.1051/medsci/2024175","DOIUrl":"10.1051/medsci/2024175","url":null,"abstract":"<p><p>Even today, 'epigenetics' is a rather difficult field to define. The explosive growth of epigenetics over the last twenty years is sometimes seen as a revolutionary event in the life sciences, a paradigm shift that would devalue genetics or the standard view of the evolutionary synthesis. The aim of this paper is to place this controversial issue in its historical context. Building on the excellent work of David Haig, I will show that in the late 1950s, the modern concept of epigenetics emerged as an extension of the nascent theory of molecular biology. Given that genetic information was assimilated to the DNA sequence, and that each cell of an organism was supposed to possess a complete genome, it was thought that certain as yet undiscovered molecular mechanisms were necessary to regulate gene expression. These hypothetical \"epigenetic systems\", which would not modify the DNA sequence, should also have heritable effect on gene expression, which would explain the stability of cell differentiation during embryogenesis.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"885-891"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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